Enteroendocrine cells: a review of their role in brain–gut communication

Neurogastroenterology and Motility - Tập 28 Số 5 - Trang 620-630 - 2016
Rocco Latorre1, Catia Sternini2, Roberto De Giorgio3, Beverley Greenwood‐Van Meerveld4,1
1Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
2CURE Digestive Diseases Research Center, Division of Digestive Diseases and Departments of Medicine and Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
3Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
4Department of Physiology, Veterans Affairs Medical Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

Tóm tắt

AbstractBackgroundSpecialized endoderm‐derived epithelial cells, that is, enteroendocrine cells (EECs), are widely distributed throughout the gastrointestinal (GI) tract. Enteroendocrine cells form the largest endocrine organ in the body and play a key role in the control of GI secretion and motility, the regulation of food intake, postprandial glucose levels and metabolism. EECs sense luminal content and release signaling molecules that can enter the circulation to act as classic hormones on distant targets, act locally on neighboring cells and on distinct neuronal pathways including enteric and extrinsic neurons. Recent studies have shed light on EEC sensory transmission by showing direct connections between EECs and the nervous system via axon‐like processes that form a well‐defined neuroepithelial circuits through which EECs can directly communicate with the neurons innervating the GI tract to initiate appropriate functional responses.PurposeThis review will highlight the role played by the EECs in the complex and integrated sensory information responses, and discuss the new findings regarding EECs in the brain–gut axis bidirectional communication.

Từ khóa


Tài liệu tham khảo

10.1055/s-2004-826154

10.1016/j.tem.2012.11.006

10.1097/MED.0b013e3282f43a73

10.1126/science.382360

10.1016/0167-0115(84)90034-X

10.1002/cne.902360308

10.1007/s10735-010-9302-6

10.1007/s00441-010-0997-1

10.1016/j.coph.2013.09.007

10.1038/nrgastro.2013.180

10.1172/JCI76309

10.1007/s00418-012-0954-z

10.1172/JCI76304

10.1113/jphysiol.2014.270850

10.1111/j.1463-1326.2011.01438.x

10.1126/science.284.5415.770

Höfer D, 1999, Chemosensory perception in the gut, News Physiol Sci, 14, 18

10.1146/annurev-physiol-021115-105439

10.1371/journal.pone.0089881

10.1172/JCI78361

10.1210/en.2012-1595

10.1210/en.2011-2170

10.1007/s00441-014-2033-3

10.1152/physrev.1996.76.3.767

10.1113/expphysiol.1994.sp003795

10.1111/nmo.12617

10.1097/MED.0b013e32835bc703

10.1053/j.gastro.2009.09.020

10.1152/ajpgi.00101.2011

10.1038/nrgastro.2013.105

10.1111/j.1467-789X.2006.00270.x

10.1172/JCI30227

10.1016/S0196-9781(01)00633-7

10.1038/ijo.2012.208

10.1152/ajpgi.00530.2006

10.1152/ajpgi.00039.2011

10.1053/j.gastro.2009.05.051

10.1056/NEJMoa030204

10.1016/j.cmet.2005.02.003

10.1136/gut.25.4.365

10.1023/A:1026654417697

10.1007/s11894-006-0021-9

10.1113/EP085029

10.1080/00365520310000799

10.1073/pnas.1011508108

10.1152/ajpregu.00675.2007

10.1152/ajpregu.90423.2008

10.1016/j.physbeh.2007.11.029

10.1371/journal.ppat.1002115

10.1097/MCO.0000000000000058

10.1007/978-3-642-14426-4_8

10.1152/ajpgi.00074.2006

10.1073/pnas.0706678104

10.1371/journal.pone.0107732

10.1073/pnas.072090199

10.1016/S0092-8674(01)00451-2

10.1016/j.peptides.2015.01.013

10.1146/annurev.nutr.26.061505.111329

10.1093/chemse/bjp092

10.1016/j.beem.2013.05.005

10.3389/fphys.2012.00065

10.2337/db08-0307

10.1371/journal.pone.0040168

10.1038/nm1168

10.1074/jbc.M211609200

10.1007/s10735-007-9145-y

10.2220/biomedres.30.149

10.2337/db11-1019

10.1073/pnas.0808567105

10.1016/j.coph.2013.09.008

Carabotti M, 2015, The gut‐brain axis: interactions between enteric microbiota, central and enteric nervous systems, Ann Gastroenterol, 28, 203

10.1210/en.2013-1142

10.1038/nrn3071

10.1146/annurev-med-012309-103958

10.1016/B978-012088394-3/50028-3

10.1016/j.autneu.2009.07.007

Dockray GJ, 2003, Luminal sensing in the gut: an overview, J Physiol Pharmacol, 54, 9

10.1152/ajpgi.00569.2005

10.1016/j.physbeh.2006.06.017

10.1046/j.0953-816x.2001.01628.x

10.1016/j.cmet.2009.07.005

10.1053/j.gastro.2011.12.053

10.1016/j.npep.2012.08.005

10.1016/S0196-9781(01)00601-5

10.1038/nature00887

10.1210/en.2006-1665

10.1016/j.brainres.2005.03.011

10.1152/physrev.00034.2006

10.1152/ajpgi.1997.273.4.G920

10.1016/B978-0-12-800101-1.00002-8

10.1007/s00125-005-1705-7

10.1111/j.1752-8062.2011.00299.x

10.1111/j.1463-1326.2012.01663.x

10.1016/j.coph.2013.09.014

10.1016/j.metabol.2015.05.012

10.1111/j.1365-2982.2006.00771.x

10.1124/jpet.114.216028

10.1111/nmo.12458

10.1111/nmo.12600

Thông tin
Thông tin xuất bản

Neurogastroenterology and Motility

Tập 28 Số 5

620-630

Thông tin tác giả