Overlap between functional GI disorders and other functional syndromes: what are the underlying mechanisms?

Neurogastroenterology and Motility - Tập 24 Số 10 - Trang 895-913 - 2012
S. E. Kim1,2, Lin Chang3,2
1Department of Medicine, Greater Los Angeles Veterans Administration Medical Center, Los Angeles, CA, USA
2Oppenheimer Family Center of Neurobiology of Stress, Los Angeles, CA, USA
3Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA;

Tóm tắt

Abstract  Background  Irritable bowel syndrome and other gastrointestinal (GI) and non‐GI disorders such as functional dyspepsia, fibromyalgia, temporomandibular joint disorder, interstitial cystitis/painful bladder syndrome, and chronic fatigue syndrome are known as functional pain syndromes. They commonly coexist within the same individual. The pathophysiologic mechanisms of these disorders are not well understood, but it has been hypothesized that they share a common pathogenesis.Purpose  The objective of this review is to discuss the proposed pathophysiologic mechanisms, which have been similarly studied in these conditions. These mechanisms include enhanced pain perception, altered regional brain activation, infectious etiologies, dysregulations in immune and neuroendocrine function, and genetic susceptibility. Studies suggest that these functional disorders are multifactorial, but factors which increase the vulnerability of developing these conditions are shared.

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