NMR in Biomedicine
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Fiber tracking: principles and strategies – a technical review
NMR in Biomedicine - Tập 15 Số 7-8 - Trang 468-480 - 2002
AbstractThe state of the art of reconstruction of the axonal tracts in the
central nervous system (CNS) using diffusion tensor imaging (DTI) is reviewed.
This relatively new technique has generated much enthusiasm and high
expectations because it presently is the only approach available to
non‐invasively study the three‐dimensional architecture of white matter tracts.
While there is no doubt that ...
Reduction in myocardial high energy phosphate spin lattice relaxation times using manganese
NMR in Biomedicine - Tập 7 Số 3 - Trang 137-140 - 1994
AbstractParamagnetic contrast agents are being widely used in proton magnetic
resonance imaging. The present study demonstrates the potential usefulness of
paramagnetic contrast agents in 31P NMR spectroscopy. Using the Langendorff
perfused rat heart, manganese chloride (Mn2+) at a concentration of 50 μM/L was
added to the perfusate for 10 or 30 min. 31P NMR Ti relaxation times were
subsequently m...
Diffusion tensor fiber tracking of human brain connectivity: aquisition methods, reliability analysis and biological results
NMR in Biomedicine - Tập 15 Số 7-8 - Trang 494-515 - 2002
AbstractWe present a description, biological results and a reliability analysis
for the method of diffusion tensor tracking (DTT) of white matter fiber
pathways. In DTT, diffusion‐tensor MRI (DT‐MRI) data are collected and processed
to visualize the line trajectories of fiber bundles within white matter (WM)
pathways of living humans. A detailed description of the data acquisition is
given. Techni...
Diffusion‐tensor MRI: theory, experimental design and data analysis – a technical review
NMR in Biomedicine - Tập 15 Số 7-8 - Trang 456-467 - 2002
AbstractThis article treats the theoretical underpinnings of diffusion‐tensor
magnetic resonance imaging (DT‐MRI), as well as experimental design and data
analysis issues. We review the mathematical model underlying DT‐MRI, discuss the
quantitative parameters that are derived from the measured effective diffusion
tensor, and describe artifacts thet arise in typical DT‐MRI acquisitions. We
also dis...
13C MRS studies of neuroenergetics and neurotransmitter cycling in humans
NMR in Biomedicine - Tập 24 Số 8 - Trang 943-957 - 2011
In the last 25 years, 13 C MRS has been established as the only noninvasive
method for the measurement of glutamate neurotransmission and cell‐specific
neuroenergetics. Although technically and experimentally challenging, 13 C MRS
has already provided important new information on the relationship between
neuroenergetics and neuronal function, the energy cost of brain function, the
high neuronal ac...
Neurochemical changes in the rat prefrontal cortex following acute phencyclidine treatment: an in vivo localized 1H MRS study
NMR in Biomedicine - Tập 22 Số 7 - Trang 737-744 - 2009
AbstractAcute phencyclidine (PCP) administration mimics some aspects of
schizophrenia in rats, such as behavioral alterations, increased dopaminergic
activity and prefrontal cortex dysfunction. In this study, we used single‐voxel
1H‐MRS to investigate neurochemical changes in rat prefrontal cortex in vivo
before and after an acute injection of PCP. A short‐echo time sequence (STEAM)
was used to ac...
Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications
NMR in Biomedicine - Tập 17 Số 5 - Trang 240-262 - 2004
AbstractThis review paper attempts to provide an overview of the principles and
techniques that are often termed electron paramagnetic resonance (EPR) oximetry.
The paper discusses the potential of such methods and illustrates they have been
successfully applied to measure oxygen tension, an essential parameter of the
tumor microenvironment. To help the reader understand the motivation for
carryin...
Reliability and spatial specificity of rat brain sensorimotor functional connectivity networks are superior under sedation compared with general anesthesia
NMR in Biomedicine - Tập 26 Số 6 - Trang 638-650 - 2013
Functional connectivity networks derived from resting‐state functional MRI
(rsfMRI) have received increasing interest to further our understanding of brain
function. The anesthesia in rodent models may influence the interpretation and
comparison of results from functional connectivity MRI (fcMRI). More research is
required on this aspect. In this study, we investigated rat brain connectivity
netwo...
Role of proton MR for the study of muscle lipid metabolism
NMR in Biomedicine - Tập 19 Số 7 - Trang 968-988 - 2006
Abstract1H‐MR spectroscopy (MRS) of intramyocellular lipids (IMCL) became
particularly important when it was recognized that IMCL levels are related to
insulin sensitivity. While this relation is rather complex and depends on the
training status of the subjects, various other influences such as exercise and
diet also influence IMCL concentrations. This may open insight into many
metabolic interact...
Addressing spontaneous signal voids in repetitive single‐shot DWI of musculature: spatial and temporal patterns in the calves of healthy volunteers and consideration of unintended muscle activities as underlying mechanism
NMR in Biomedicine - Tập 28 Số 7 - Trang 801-810 - 2015
Single‐shot diffusion‐weighted MRI sensitive to different types of incoherent
motion inside tissue shows sporadic signal voids with a considerable size (>1
cm) in calf musculature at rest. Spatial and temporal patterns of these signal
voids and their dependence on measurement conditions were tested systematically
in order to obtain more insight into the underlying mechanism. Lower leg muscles
of 1...
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