NMR in Biomedicine

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Fiber tracking: principles and strategies – a technical review
NMR in Biomedicine - Tập 15 Số 7-8 - Trang 468-480 - 2002
Susumu Mori, Peter C.M. van Zijl
AbstractThe state of the art of reconstruction of the axonal tracts in the central nervous system (CNS) using diffusion tensor imaging (DTI) is reviewed. This relatively new technique has generated much enthusiasm and high expectations because it presently is the only approach available to non‐invasively study the three‐dimensional architecture of white matter trac...... hiện toàn bộ
Reduction in myocardial high energy phosphate spin lattice relaxation times using manganese
NMR in Biomedicine - Tập 7 Số 3 - Trang 137-140 - 1994
Thomas Scholz
AbstractParamagnetic contrast agents are being widely used in proton magnetic resonance imaging. The present study demonstrates the potential usefulness of paramagnetic contrast agents in 31P NMR spectroscopy. Using the Langendorff perfused rat heart, manganese chloride (Mn2+) at a concentration of 50 μM/...... hiện toàn bộ
Diffusion tensor fiber tracking of human brain connectivity: aquisition methods, reliability analysis and biological results
NMR in Biomedicine - Tập 15 Số 7-8 - Trang 494-515 - 2002
Nicolás Lori, Erbil Akbudak, Joshua S. Shimony, Thomas S. Cull, Abraham Z. Snyder, R. K. Guillory, Thomas E. Conturo
AbstractWe present a description, biological results and a reliability analysis for the method of diffusion tensor tracking (DTT) of white matter fiber pathways. In DTT, diffusion‐tensor MRI (DT‐MRI) data are collected and processed to visualize the line trajectories of fiber bundles within white matter (WM) pathways of living humans. A detailed description of the ...... hiện toàn bộ
Diffusion‐tensor MRI: theory, experimental design and data analysis – a technical review
NMR in Biomedicine - Tập 15 Số 7-8 - Trang 456-467 - 2002
Peter J. Basser, Derek K. Jones
AbstractThis article treats the theoretical underpinnings of diffusion‐tensor magnetic resonance imaging (DT‐MRI), as well as experimental design and data analysis issues. We review the mathematical model underlying DT‐MRI, discuss the quantitative parameters that are derived from the measured effective diffusion tensor, and describe artifacts thet arise in typical...... hiện toàn bộ
13C MRS studies of neuroenergetics and neurotransmitter cycling in humans
NMR in Biomedicine - Tập 24 Số 8 - Trang 943-957 - 2011
Douglas L. Rothman, Henk M. De Feyter, Robin A. de Graaf, Graeme F. Mason, Kevin L. Behar
In the last 25 years, 13 C MRS has been established as the only noninvasive method for the measurement of glutamate neurotransmission and cell‐specific neuroenergetics. Although technically and experimentally challenging, 13 C MRS has already provided important new information on the relationship between neuroenergetics and neuronal function, the e...... hiện toàn bộ
Neurochemical changes in the rat prefrontal cortex following acute phencyclidine treatment: an in vivo localized 1H MRS study
NMR in Biomedicine - Tập 22 Số 7 - Trang 737-744 - 2009
Isabelle Iltis, Dee M. Koski, Lynn E. Eberly, Christopher D. Nelson, Dinesh K. Deelchand, Julien Valette, Kâmil Uǧurbil, Kelvin O. Lim, Pierre‐Gilles Henry
AbstractAcute phencyclidine (PCP) administration mimics some aspects of schizophrenia in rats, such as behavioral alterations, increased dopaminergic activity and prefrontal cortex dysfunction. In this study, we used single‐voxel 1H‐MRS to investigate neurochemical changes in rat prefrontal cortex in vivo before and a...... hiện toàn bộ
Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications
NMR in Biomedicine - Tập 17 Số 5 - Trang 240-262 - 2004
Bernard Gallez, Christine Baudelet, Bénédicte F. Jordan
AbstractThis review paper attempts to provide an overview of the principles and techniques that are often termed electron paramagnetic resonance (EPR) oximetry. The paper discusses the potential of such methods and illustrates they have been successfully applied to measure oxygen tension, an essential parameter of the tumor microenvironment. To help the reader unde...... hiện toàn bộ
Reliability and spatial specificity of rat brain sensorimotor functional connectivity networks are superior under sedation compared with general anesthesia
NMR in Biomedicine - Tập 26 Số 6 - Trang 638-650 - 2013
Daniel Kalthoff, Chrystelle Po, Dirk Wiedermann, Mathias Hoehn
Functional connectivity networks derived from resting‐state functional MRI (rsfMRI) have received increasing interest to further our understanding of brain function. The anesthesia in rodent models may influence the interpretation and comparison of results from functional connectivity MRI (fcMRI). More research is required on this aspect. In this study, we investigated rat brain connectivi...... hiện toàn bộ
Role of proton MR for the study of muscle lipid metabolism
NMR in Biomedicine - Tập 19 Số 7 - Trang 968-988 - 2006
Chris Boesch, J Machann, Peter Vermathen, Fritz Schick
Abstract1H‐MR spectroscopy (MRS) of intramyocellular lipids (IMCL) became particularly important when it was recognized that IMCL levels are related to insulin sensitivity. While this relation is rather complex and depends on the training status of the subjects, various other influences such as exercise and diet also influence IMCL concentratio...... hiện toàn bộ
Addressing spontaneous signal voids in repetitive single‐shot DWI of musculature: spatial and temporal patterns in the calves of healthy volunteers and consideration of unintended muscle activities as underlying mechanism
NMR in Biomedicine - Tập 28 Số 7 - Trang 801-810 - 2015
Günter Steidle, Fritz Schick
Single‐shot diffusion‐weighted MRI sensitive to different types of incoherent motion inside tissue shows sporadic signal voids with a considerable size (>1 cm) in calf musculature at rest. Spatial and temporal patterns of these signal voids and their dependence on measurement conditions were tested systematically in order to obtain more insight into the underlying mechanism. Lower leg m...... hiện toàn bộ
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