Molecular Oncology
SCIE-ISI SCOPUS (2007-2025)
1574-7891
1878-0261
Hà Lan
Cơ quản chủ quản: WILEY , John Wiley and Sons Ltd
Lĩnh vực:
GeneticsOncologyMedicine (miscellaneous)Molecular MedicineCancer Research
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Deconstructing the molecular portraits of breast cancer
Tập 5 Số 1 - Trang 5-23 - 2011
Breast cancer is a heterogeneous disease in terms of histology, therapeutic
response, dissemination patterns to distant sites, and patient outcomes. Global
gene expression analyses using high‐throughput technologies have helped to
explain much of this heterogeneity and provided important new classifications of
cancer patients. In the last decade, genomic studies have established five
breast cancer...
Emerging functions of the EGFR in cancer
Tập 12 Số 1 - Trang 3-20 - 2018
The physiological function of the epidermal growth factor receptor (EGFR) is to
regulate epithelial tissue development and homeostasis. In pathological
settings, mostly in lung and breast cancer and in glioblastoma, the EGFR is a
driver of tumorigenesis. Inappropriate activation of the EGFR in cancer mainly
results from amplification and point mutations at the genomic locus, but
transcriptional up...
MicroRNA and cancer
Tập 6 Số 6 - Trang 590-610 - 2012
With the advent of next generation sequencing techniques a previously unknown
world of non‐coding RNA molecules have been discovered. Non‐coding RNA
transcripts likely outnumber the group of protein coding sequences and hold
promise of many new discoveries and mechanistic explanations for essential
biological phenomena and pathologies. The best characterized non‐coding RNA
family consists in human...
The morphologies of breast cancer cell lines in three‐dimensional assays correlate with their profiles of gene expression
Tập 1 Số 1 - Trang 84-96 - 2007
Abstract3D cell cultures are rapidly becoming the method of choice for the
physiologically relevant modeling of many aspects of non‐malignant and malignant
cell behavior ex vivo. Nevertheless, only a limited number of distinct cell
types have been evaluated in this assay to date. Here we report the first large
scale comparison of the transcriptional profiles and 3D cell culture phenotypes
of a sub...
Cancer biomarkers
Tập 6 Số 2 - Trang 140-146 - 2012
Biomarkers have many potential applications in oncology, including risk
assessment, screening, differential diagnosis, determination of prognosis,
prediction of response to treatment, and monitoring of progression of disease.
Because of the critical role that biomarkers play at all stages of disease, it
is important that they undergo rigorous evaluation, including analytical
validation, clinical v...
Targeting immunogenic cell death in cancer
Tập 14 Số 12 - Trang 2994-3006 - 2020
Immunogenic cell death (ICD) is a type of cancer cell death triggered by certain
chemotherapeutic drugs, oncolytic viruses, physicochemical therapies,
photodynamic therapy, and radiotherapy. It involves the activation of the immune
system against cancer in immunocompetent hosts. ICD comprises the release of
damage‐associated molecular patterns (DAMPs) from dying tumor cells that result
in the acti...
Exosome‐delivered circRNA promotes glycolysis to induce chemoresistance through the miR‐122‐PKM2 axis in colorectal cancer
Tập 14 Số 3 - Trang 539-555 - 2020
Malignant tumors, including colorectal cancer (CRC), usually rely on ATP
generation through aerobic glycolysis for both rapid growth and chemotherapy
resistance. The M2 isoform of pyruvate kinase (PKM2) has a key role in
catalyzing glycolysis, and PKM2 expression varies even within a single tumor. In
this study, we confirmed that expression of PKM2 is heterogeneous in CRC cells,
namely high in oxa...
Autophagy induction impairs migration and invasion by reversing EMT in glioblastoma cells
Tập 9 Số 8 - Trang 1612-1625 - 2015
Cell migration and invasion are highly regulated processes involved in both
physiological and pathological conditions. Here we show that autophagy
modulation regulates the migration and invasion capabilities of glioblastoma
(GBM) cells. We observed that during autophagy occurrence, obtained by nutrient
deprivation or by pharmacological inhibition of the mTOR complexes, GBM
migration and chemokine‐...
Autophagy in tumour suppression and promotion
Tập 3 Số 4 - Trang 366-375 - 2009
Autophagy, a well‐described cellular mechanism for lysosomal degradation of
cytoplasmic content, has emerged as a tumour suppression pathway. Recent
evidence indicates that the tumour suppressor function of autophagy is mediated
by scavenging of damaged oxidative organelles, thereby preventing accumulation
of toxic oxygen radicals that would cause genome instability. Paradoxically,
however, in som...
Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages
Tập 1 Số 3 - Trang 288-302 - 2007
Genetic depletion of macrophages in Polyoma Middle T oncoprotein (PyMT)‐induced
mammary tumors in mice delayed the angiogenic switch and the progression to
malignancy. To determine whether vascular endothelial growth factor A (VEGF‐A)
produced by tumor‐associated macrophages regulated the onset of the angiogenic
switch, a genetic approach was used to restore expression of VEGF‐A into tumors
at the...