Molecular Oncology
SCIE-ISI SCOPUS (2007-2023)
1574-7891
1878-0261
Hà Lan
Cơ quản chủ quản: WILEY , John Wiley and Sons Ltd
Lĩnh vực:
GeneticsOncologyMedicine (miscellaneous)Molecular MedicineCancer Research
Các bài báo tiêu biểu
Deconstructing the molecular portraits of breast cancerBreast cancer is a heterogeneous disease in terms of histology, therapeutic response, dissemination patterns to distant sites, and patient outcomes. Global gene expression analyses using high‐throughput technologies have helped to explain much of this heterogeneity and provided important new classifications of cancer patients. In the last decade, genomic studies have established five breas... ... hiện toàn bộ
Tập 5 Số 1 - Trang 5-23 - 2011
Emerging functions of the EGFR in cancerThe physiological function of the epidermal growth factor receptor (EGFR ) is to regulate epithelial tissue development and homeostasis. In pathological settings, mostly in lung and breast cancer and in glioblastoma, the EGFR is a driver of tumorigenesis. Inappropriate... ... hiện toàn bộ
Tập 12 Số 1 - Trang 3-20 - 2018
MicroRNA and cancerWith the advent of next generation sequencing techniques a previously unknown world of non‐coding RNA molecules have been discovered. Non‐coding RNA transcripts likely outnumber the group of protein coding sequences and hold promise of many new discoveries and mechanistic explanations for essential biological phenomena and pathologies. The best characterized non‐coding RNA family consists ... ... hiện toàn bộ
Tập 6 Số 6 - Trang 590-610 - 2012
The morphologies of breast cancer cell lines in three‐dimensional assays correlate with their profiles of gene expressionAbstract 3D cell cultures are rapidly becoming the method of choice for the physiologically relevant modeling of many aspects of non‐malignant and malignant cell behavior ex vivo. Nevertheless, only a limited number of distinct cell types have been evaluated in this assay to date. Here we report the first large scale comparison of the transcriptional profiles and 3D... ... hiện toàn bộ
Tập 1 Số 1 - Trang 84-96 - 2007
Cancer biomarkersBiomarkers have many potential applications in oncology, including risk assessment, screening, differential diagnosis, determination of prognosis, prediction of response to treatment, and monitoring of progression of disease. Because of the critical role that biomarkers play at all stages of disease, it is important that they undergo rigorous evaluation, including analytical validation, cl... ... hiện toàn bộ
Tập 6 Số 2 - Trang 140-146 - 2012
Targeting immunogenic cell death in cancerImmunogenic cell death (ICD) is a type of cancer cell death triggered by certain chemotherapeutic drugs, oncolytic viruses, physicochemical therapies, photodynamic therapy, and radiotherapy. It involves the activation of the immune system against cancer in immunocompetent hosts. ICD comprises the release of damage‐associated molecular patterns (DAMPs) from dying tumor cells that result in ... ... hiện toàn bộ
Tập 14 Số 12 - Trang 2994-3006 - 2020
Exosome‐delivered circRNA promotes glycolysis to induce chemoresistance through the miR‐122‐PKM2 axis in colorectal cancerMalignant tumors, including colorectal cancer (CRC), usually rely on ATP generation through aerobic glycolysis for both rapid growth and chemotherapy resistance. The M2 isoform of pyruvate kinase (PKM2) has a key role in catalyzing glycolysis, and PKM2 expression varies even within a single tumor. In this study, we confirmed that expression of PKM2 is heterogeneous in CRC cells, namely hig... ... hiện toàn bộ
Tập 14 Số 3 - Trang 539-555 - 2020
Autophagy induction impairs migration and invasion by reversing EMT in glioblastoma cellsCell migration and invasion are highly regulated processes involved in both physiological and pathological conditions. Here we show that autophagy modulation regulates the migration and invasion capabilities of glioblastoma (GBM) cells. We observed that during autophagy occurrence, obtained by nutrient deprivation or by pharmacological inhibition of the mTOR complexes, GBM migration and ch... ... hiện toàn bộ
Tập 9 Số 8 - Trang 1612-1625 - 2015
Autophagy in tumour suppression and promotionAutophagy, a well‐described cellular mechanism for lysosomal degradation of cytoplasmic content, has emerged as a tumour suppression pathway. Recent evidence indicates that the tumour suppressor function of autophagy is mediated by scavenging of damaged oxidative organelles, thereby preventing accumulation of toxic oxygen radicals that would cause genome instability. Paradoxically, however... ... hiện toàn bộ
Tập 3 Số 4 - Trang 366-375 - 2009
Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophagesGenetic depletion of macrophages in Polyoma Middle T oncoprotein (PyMT)‐induced mammary tumors in mice delayed the angiogenic switch and the progression to malignancy. To determine whether vascular endothelial growth factor A (VEGF‐A) produced by tumor‐associated macrophages regulated the onset of the angiogenic switch, a genetic approach was used to restore expression of VEGF‐A into tumor... ... hiện toàn bộ
Tập 1 Số 3 - Trang 288-302 - 2007