Molecular Oncology
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Targeting immunogenic cell death in cancer
Molecular Oncology - Tập 14 Số 12 - Trang 2994-3006 - 2020
Immunogenic cell death (ICD) is a type of cancer cell death triggered by certain
chemotherapeutic drugs, oncolytic viruses, physicochemical therapies,
photodynamic therapy, and radiotherapy. It involves the activation of the immune
system against cancer in immunocompetent hosts. ICD comprises the release of
damage‐associated molecular patterns (DAMPs) from dying tumor cells that result
in the acti...
Expression and hypoxic up‐regulation of neuroglobin in human glioblastoma cells
Molecular Oncology - Tập 3 - Trang 45-53 - 2009
Neuroglobin is a recently identified globin molecule that is expressed
predominantly in the vertebrate brain. Neuroglobin expression increases in
oxygen‐deprived neurons, suggesting it protects neurons from ischemic cell
death. We report that neuroglobin transcript and protein are expressed in human
glioblastoma cells, and that this expression increases in hypoxia in vitro. We
also show that neuro...
The canonical Wnt pathway regulates the metastasis‐promoting mucin MUC4 in pancreatic ductal adenocarcinoma
Molecular Oncology - Tập 10 Số 2 - Trang 224-239 - 2016
Aberrant Wnt signaling frequently occurs in pancreatic cancer (PC) and
contributes to disease progression/metastases. Likewise, the transmembrane‐mucin
MUC4 is expressed de novo in early pancreatic intraepithelial neoplasia (PanINs)
and incrementally increases with PC progression, contributing to metastasis. To
determine the mechanism of MUC4 upregulation in PC, we examined factors
deregulated in ...
AURKA regulates JAK2–STAT3 activity in human gastric and esophageal cancers
Molecular Oncology - Tập 8 - Trang 1419-1428 - 2014
Aurora kinase A is a frequently amplified and overexpressed gene in upper
gastrointestinal adenocarcinomas (UGCs). Using in vitro cell models of UGCs, we
investigated whether AURKA can regulate Signal Transducer and Activator of
Transcription 3 (STAT3). Our data indicate that overexpression of AURKA in FLO‐1
and AGS cells increase STAT3 phosphorylation at the Tyr705 site, whereas AURKA
genetic dep...
hnRNPA2/B1 activates cyclooxygenase‐2 and promotes tumor growth in human lung cancers
Molecular Oncology - Tập 10 - Trang 610-624 - 2016
Cyclooxygenase‐2 (COX‐2) is highly expressed in tumor cells and has been
regarded as a hallmarker for cancers, but the excise regulatory mechanism of
COX‐2 in tumorigenesis remains largely unknown. Here, we pulled down and
identified a novel COX‐2 regulator, heterogeneous nuclear ribonucleoprotein
A2/B1 (hnRNPA2/B1), which could specifically bind to COX‐2 core promoter and
regulate tumor growth in...
Activation of androgen receptor induces ID1 and promotes hepatocellular carcinoma cell migration and invasion
Molecular Oncology - Tập 6 - Trang 507-515 - 2012
A single lysis solution for the analysis of tissue samples by different proteomic technologies
Molecular Oncology - Tập 2 - Trang 368-379 - 2008
Cancer, being a major healthcare concern worldwide, is one of the main targets
for the application of emerging proteomic technologies and these tools promise
to revolutionize the way cancer will be diagnosed and treated in the near
future. Today, as a result of the unprecedented advances that have taken place
in molecular biology, cell biology and genomics there is a pressing need to
accelerate th...
DNA damage signalling barrier, oxidative stress and treatment‐relevant DNA repair factor alterations during progression of human prostate cancer
Molecular Oncology - Tập 10 - Trang 879-894 - 2016
The DNA damage checkpoints provide an anti‐cancer barrier in diverse tumour
types, however this concept has remained unexplored in prostate cancer (CaP).
Furthermore, targeting DNA repair defects by PARP1 inhibitors (PARPi) as a
cancer treatment strategy is emerging yet requires suitable predictive
biomarkers. To address these issues, we performed immunohistochemical analysis
of multiple markers o...
Tumor Suppressors Status in Cancer Cell Line Encyclopedia
Molecular Oncology - Tập 7 - Trang 791-798 - 2013
Tumor suppressors play a major role in the etiology of human cancer, and
typically achieve a tumor‐promoting effect upon complete functional
inactivation. Bi‐allelic inactivation of tumor suppressors may occur through
genetic mechanisms (such as loss of function mutation, copy number (CN) loss, or
loss of heterozygosity (LOH)), epigenetic mechanisms (such as promoter
methylation or histone modific...
Citral reduces breast tumor growth by inhibiting the cancer stem cell marker ALDH1A3
Molecular Oncology - Tập 10 - Trang 1485-1496 - 2016
Breast cancer stem cells (CSCs) can be identified by increased Aldefluor
fluorescence caused by increased expression of aldehyde dehydrogenase 1A3
(ALDH1A3), as well as ALDH1A1 and ALDH2. In addition to being a CSC marker,
ALDH1A3 regulates gene expression via retinoic acid (RA) signaling and plays a
key role in the progression and chemotherapy resistance of cancer. Therefore,
ALDH1A3 represents a...
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