Molecular Oncology

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Targeting immunogenic cell death in cancer
Molecular Oncology - Tập 14 Số 12 - Trang 2994-3006 - 2020
Asma Ahmed, Stephen W. G. Tait
Immunogenic cell death (ICD) is a type of cancer cell death triggered by certain chemotherapeutic drugs, oncolytic viruses, physicochemical therapies, photodynamic therapy, and radiotherapy. It involves the activation of the immune system against cancer in immunocompetent hosts. ICD comprises the release of damage‐associated molecular patterns (DAMPs) from dying tumor cells that result in ...... hiện toàn bộ
AURKA regulates JAK2–STAT3 activity in human gastric and esophageal cancers
Molecular Oncology - Tập 8 - Trang 1419-1428 - 2014
Ahmed Katsha, Janet Arras, Mohammed Soutto, Abbes Belkhiri, Wael El-Rifai
Aurora kinase A is a frequently amplified and overexpressed gene in upper gastrointestinal adenocarcinomas (UGCs). Using in vitro cell models of UGCs, we investigated whether AURKA can regulate Signal Transducer and Activator of Transcription 3 (STAT3). Our data indicate that overexpression of AURKA in FLO‐1 and AGS cells increase STAT3 phosphorylation at the Tyr705 site, whereas AURKA gen...... hiện toàn bộ
Activation of androgen receptor induces ID1 and promotes hepatocellular carcinoma cell migration and invasion
Molecular Oncology - Tập 6 - Trang 507-515 - 2012
Junping Ao, Jiao Meng, Lei Zhu, Huizhen Nie, Chenchen Yang, Jinjun Li, Jianren Gu, Qiushi Lin, Weiwen Long, Xiaoqun Dong, Chao Li
A single lysis solution for the analysis of tissue samples by different proteomic technologies
Molecular Oncology - Tập 2 - Trang 368-379 - 2008
Pavel Gromov, Julio E. Celis, Irina Gromova, Fritz Rank, Vera Timmermans-Wielenga, José M.A. Moreira
Cancer, being a major healthcare concern worldwide, is one of the main targets for the application of emerging proteomic technologies and these tools promise to revolutionize the way cancer will be diagnosed and treated in the near future. Today, as a result of the unprecedented advances that have taken place in molecular biology, cell biology and genomics there is a pressing need to accel...... hiện toàn bộ
DNA damage signalling barrier, oxidative stress and treatment‐relevant DNA repair factor alterations during progression of human prostate cancer
Molecular Oncology - Tập 10 - Trang 879-894 - 2016
Daniela Kurfurstova, Jirina Bartkova, Radek Vrtel, Alena Mickova, Alena Burdova, Dusana Majera, Martin Mistrik, Milan Kral, Frederic R. Santer, Jan Bouchal, Jiri Bartek
The DNA damage checkpoints provide an anti‐cancer barrier in diverse tumour types, however this concept has remained unexplored in prostate cancer (CaP). Furthermore, targeting DNA repair defects by PARP1 inhibitors (PARPi) as a cancer treatment strategy is emerging yet requires suitable predictive biomarkers. To address these issues, we performed immunohistochemical analysis of multiple m...... hiện toàn bộ
Tumor Suppressors Status in Cancer Cell Line Encyclopedia
Molecular Oncology - Tập 7 - Trang 791-798 - 2013
Dmitriy Sonkin, Mehedi Hassan, Denis J. Murphy, Tatiana V. Tatarinova
Tumor suppressors play a major role in the etiology of human cancer, and typically achieve a tumor‐promoting effect upon complete functional inactivation. Bi‐allelic inactivation of tumor suppressors may occur through genetic mechanisms (such as loss of function mutation, copy number (CN) loss, or loss of heterozygosity (LOH)), epigenetic mechanisms (such as promoter methylation or histone...... hiện toàn bộ
Citral reduces breast tumor growth by inhibiting the cancer stem cell marker ALDH1A3
Molecular Oncology - Tập 10 - Trang 1485-1496 - 2016
Margaret Lois Thomas, Roberto de Antueno, Krysta Mila Coyle, Mohammad Sultan, Brianne Marie Cruickshank, Michael Anthony Giacomantonio, Carman Anthony Giacomantonio, Roy Duncan, Paola Marcato
Breast cancer stem cells (CSCs) can be identified by increased Aldefluor fluorescence caused by increased expression of aldehyde dehydrogenase 1A3 (ALDH1A3), as well as ALDH1A1 and ALDH2. In addition to being a CSC marker, ALDH1A3 regulates gene expression via retinoic acid (RA) signaling and plays a key role in the progression and chemotherapy resistance of cancer. Therefore, ALDH1A3 repr...... hiện toàn bộ
Detection of glyco‐mucin profiles improves specificity of MUC16 and MUC1 biomarkers in ovarian serous tumours
Molecular Oncology - Tập 9 - Trang 503-512 - 2015
Sara Ricardo, Lara Marcos-Silva, Daniela Pereira, Rita Pinto, Raquel Almeida, Ola Söderberg, Ulla Mandel, Henrik Clausen, Ana Felix, Nuno Lunet, Leonor David
The CA125 assay detects circulating MUC16 and is one of the most widely used cancer biomarkers for the follow‐up of ovarian cancer. We previously demonstrated that detection of aberrant cancer‐associated glycoforms of MUC16 as well as MUC1 in circulation could improve the yield of these serum assays. Our aim was to refine ovarian cancer biomarkers by detection of aberrant glycoforms (Tn, S...... hiện toàn bộ
Pre‐clinical efficacy of PU‐H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma
Molecular Oncology - Tập 8 - Trang 323-336 - 2014
Srikanth R. Ambati, Eloisi Caldas Lopes, Kohji Kosugi, Ullas Mony, Ahmet Zehir, Smit K. Shah, Tony Taldone, Andre L. Moreira, Paul A. Meyers, Gabriela Chiosis, Malcolm A.S. Moore
Ewing sarcoma is characterized by multiple deregulated pathways that mediate cell survival and proliferation. Heat shock protein 90 (HSP90) is a critical component of the multi‐chaperone complexes that regulate the disposition and activity of a large number of proteins involved in cell‐signaling systems. We tested the efficacy of PU‐H71, a novel HSP90 inhibitor in Ewing sarcoma cell lines,...... hiện toàn bộ
Identification of major factors associated with failed clinical molecular oncology testing performed by next generation sequencing (NGS)
Molecular Oncology - Tập 9 - Trang 1737-1743 - 2015
Hussam Al-Kateb, TuDung T. Nguyen, Karen Steger-May, John D. Pfeifer
PurposeDNA analysis by NGS has become important to direct the clinical care of cancer patients. However, NGS is not successful in all cases, and the factors responsible for test failures have not been systematically evaluated.Materials and methodsA series of 1528 solid and hematolymphoid tumor...... hiện toàn bộ
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