Molecular Oncology
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Aberrations of ERBB2 and TOP2A genes in breast cancerAbstract Copy number changes in TOP2A have frequently been linked to ERBB2 (HER2) amplified breast cancers. To study this relationship, copy number changes of ERBB2 and TOP2A were investigated by fluorescence in situ hybridization (FISH) in two cell lines; one characterized by having amplification of both genes and the other by having amplification of ERBB2 and dele... ... hiện toàn bộ
Molecular Oncology - Tập 4 - Trang 161-168 - 2010
Bioinformatics and systems biologyDelivering personalized therapeutic options to cancer patients based on the genetic and molecular aberrations of the tumor offers great promise to improve the outcomes of cancer therapy. Significant progress in biotechnology has allowed the measurement of tens of thousands of “omic” data points across multiple levels (DNA, RNA protein, metabolomics) from a single tumor biopsy sample in a r... ... hiện toàn bộ
Molecular Oncology - Tập 6 - Trang 147-154 - 2012
The biology of personalized cancer medicine: Facing individual complexities underlying hallmark capabilitiesIt is a time of great promise and expectation for the applications of knowledge about mechanisms of cancer toward more effective and enduring therapies for human disease. Conceptualizations such as the hallmarks of cancer are providing an organizing principle with which to distill and rationalize the abject complexities of cancer phenotypes and genotypes across the spectrum of the human di... ... hiện toàn bộ
Molecular Oncology - Tập 6 - Trang 111-127 - 2012
Serum N‐glycan analysis in breast cancer patients – Relation to tumour biology and clinical outcomeGlycosylation and related processes play important roles in cancer development and progression, including metastasis. Several studies have shown that N‐glycans have potential diagnostic value as cancer serum biomarkers. We have explored the significance of the abundance of particular serum N‐glycan structures as important features of breast tumour biology by studying the serum glycome and ... ... hiện toàn bộ
Molecular Oncology - Tập 10 - Trang 59-72 - 2016
Anticancer activity of pyrithione zinc in oral cancer cells identified in small molecule screens and xenograft model: Implications for oral cancer therapyOral squamous cell carcinoma (OSCC) patients diagnosed in late stages have limited chemotherapeutic options, underscoring the great need for development of new anticancer agents for more effective disease management. We aimed to identify novel anticancer agents for OSCC using quantitative high throughput assays for screening six chemical libraries consisting of 5170 small molecule inhibito... ... hiện toàn bộ
Molecular Oncology - Tập 9 - Trang 1720-1735 - 2015
Validation of a prognostic multi‐gene signature in high‐risk neuroblastoma using the high throughput digital NanoString nCounter™ systemMicroarray‐based molecular signatures have not been widely integrated into neuroblastoma diagnostic classification systems due to the complexities of the assay and requirement for high‐quality RNA. New digital technologies that accurately quantify gene expression using RNA isolated from formalin‐fixed paraffin embedded (FFPE) tissues are now available. In this study, we describe the first ... ... hiện toàn bộ
Molecular Oncology - Tập 8 - Trang 669-678 - 2014
Acquired resistance to EGFR‐targeted therapies in colorectal cancerCetuximab and panitumumab are anti‐epidermal growth factor receptor (anti‐EGFR) monoclonal antibodies used as therapies for metastatic colorectal cancer patients. Intrinsic mechanisms of resistance, such as RAS mutations, can prevent patients from having a response with clinical benefit. The clinical efficacy of EGFR targeted antibodies is limited by the development of acquired (secondary)... ... hiện toàn bộ
Molecular Oncology - Tập 8 - Trang 1084-1094 - 2014
KRAS and HRAS mutations confer resistance to MET targeting in preclinical models of MET‐expressing tumor cellsThe MET receptor tyrosine kinase is often deregulated in human cancers and several MET inhibitors are evaluated in clinical trials. Similarly to EGFR, MET signals through the RAS‐RAF‐ERK/MAPK pathway which plays key roles in cell proliferation and survival. Mutations of genes encoding for RAS proteins, particularly in KRAS, are commonly found in various tumors and are associated with const... ... hiện toàn bộ
Molecular Oncology - Tập 9 - Trang 1434-1446 - 2015
Glioma‐derived macrophage migration inhibitory factor (MIF) promotes mast cell recruitment in a STAT5‐dependent mannerRecently, glioma research has increased its focus on the diverse types of cells present in brain tumors. We observed previously that gliomas are associated with a profound accumulation of mast cells (MCs) and here we investigate the underlying mechanism. Gliomas express a plethora of chemoattractants. First, we demonstrated pronounced migration of human MCs toward condition... ... hiện toàn bộ
Molecular Oncology - Tập 8 - Trang 50-58 - 2014
Improving fascin inhibitors to block tumor cell migration and metastasisTumor metastasis is the major cause of mortality of cancer patients, being responsible for ∼90% of all cancer deaths. One of the key steps during tumor metastasis is tumor cell migration which requires actin cytoskeletal reorganization. Among the critical actin cytoskeletal protrusion structures are antenna‐like filopodia. Fascin protein is the main actin‐bundling protein in filopodia. Her... ... hiện toàn bộ
Molecular Oncology - Tập 10 - Trang 966-980 - 2016
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