Molecular Oncology

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Targeting immunogenic cell death in cancer
Molecular Oncology - Tập 14 Số 12 - Trang 2994-3006 - 2020
Asma Ahmed, Stephen W. G. Tait
Immunogenic cell death (ICD) is a type of cancer cell death triggered by certain chemotherapeutic drugs, oncolytic viruses, physicochemical therapies, photodynamic therapy, and radiotherapy. It involves the activation of the immune system against cancer in immunocompetent hosts. ICD comprises the release of damage‐associated molecular patterns (DAMPs) from dying tumor cells that result in ...... hiện toàn bộ
Expression and hypoxic up‐regulation of neuroglobin in human glioblastoma cells
Molecular Oncology - Tập 3 - Trang 45-53 - 2009
Marwan Emara, Nicole Salloum, Joan Allalunis-Turner
Neuroglobin is a recently identified globin molecule that is expressed predominantly in the vertebrate brain. Neuroglobin expression increases in oxygen‐deprived neurons, suggesting it protects neurons from ischemic cell death. We report that neuroglobin transcript and protein are expressed in human glioblastoma cells, and that this expression increases in hypoxia in vitro. We also show th...... hiện toàn bộ
The canonical Wnt pathway regulates the metastasis‐promoting mucin MUC4 in pancreatic ductal adenocarcinoma
Molecular Oncology - Tập 10 Số 2 - Trang 224-239 - 2016
Priya Pai, Satyanarayana Rachagani, Imayavaramban Lakshmanan, Muzafar A. Macha, Yuri Sheinin, Lynette M. Smith, Moorthy P. Ponnusamy, Surinder K. Batra
Aberrant Wnt signaling frequently occurs in pancreatic cancer (PC) and contributes to disease progression/metastases. Likewise, the transmembrane‐mucin MUC4 is expressed de novo in early pancreatic intraepithelial neoplasia (PanINs) and incrementally increases with PC progression, contributing to metastasis. To determine the mechanism of MUC4 upregulation in PC, we examined factors deregul...... hiện toàn bộ
AURKA regulates JAK2–STAT3 activity in human gastric and esophageal cancers
Molecular Oncology - Tập 8 - Trang 1419-1428 - 2014
Ahmed Katsha, Janet Arras, Mohammed Soutto, Abbes Belkhiri, Wael El-Rifai
Aurora kinase A is a frequently amplified and overexpressed gene in upper gastrointestinal adenocarcinomas (UGCs). Using in vitro cell models of UGCs, we investigated whether AURKA can regulate Signal Transducer and Activator of Transcription 3 (STAT3). Our data indicate that overexpression of AURKA in FLO‐1 and AGS cells increase STAT3 phosphorylation at the Tyr705 site, whereas AURKA gen...... hiện toàn bộ
hnRNPA2/B1 activates cyclooxygenase‐2 and promotes tumor growth in human lung cancers
Molecular Oncology - Tập 10 - Trang 610-624 - 2016
Yang Xuan, Jingshu Wang, Liying Ban, Jian-Jun Lu, Canhui Yi, Zhenglin Li, Wendan Yu, Mei Li, Tingting Xu, Wenjing Yang, Zhipeng Tang, Ranran Tang, Xiangsheng Xiao, Songshu Meng, Yiming Chen, Quentin Liu, Wenlin Huang, Wei Guo, Xiaonan Cui, Wuguo Deng
Cyclooxygenase‐2 (COX‐2) is highly expressed in tumor cells and has been regarded as a hallmarker for cancers, but the excise regulatory mechanism of COX‐2 in tumorigenesis remains largely unknown. Here, we pulled down and identified a novel COX‐2 regulator, heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2/B1), which could specifically bind to COX‐2 core promoter and regulate tumor g...... hiện toàn bộ
Activation of androgen receptor induces ID1 and promotes hepatocellular carcinoma cell migration and invasion
Molecular Oncology - Tập 6 - Trang 507-515 - 2012
Junping Ao, Jiao Meng, Lei Zhu, Huizhen Nie, Chenchen Yang, Jinjun Li, Jianren Gu, Qiushi Lin, Weiwen Long, Xiaoqun Dong, Chao Li
A single lysis solution for the analysis of tissue samples by different proteomic technologies
Molecular Oncology - Tập 2 - Trang 368-379 - 2008
Pavel Gromov, Julio E. Celis, Irina Gromova, Fritz Rank, Vera Timmermans-Wielenga, José M.A. Moreira
Cancer, being a major healthcare concern worldwide, is one of the main targets for the application of emerging proteomic technologies and these tools promise to revolutionize the way cancer will be diagnosed and treated in the near future. Today, as a result of the unprecedented advances that have taken place in molecular biology, cell biology and genomics there is a pressing need to accel...... hiện toàn bộ
DNA damage signalling barrier, oxidative stress and treatment‐relevant DNA repair factor alterations during progression of human prostate cancer
Molecular Oncology - Tập 10 - Trang 879-894 - 2016
Daniela Kurfurstova, Jirina Bartkova, Radek Vrtel, Alena Mickova, Alena Burdova, Dusana Majera, Martin Mistrik, Milan Kral, Frederic R. Santer, Jan Bouchal, Jiri Bartek
The DNA damage checkpoints provide an anti‐cancer barrier in diverse tumour types, however this concept has remained unexplored in prostate cancer (CaP). Furthermore, targeting DNA repair defects by PARP1 inhibitors (PARPi) as a cancer treatment strategy is emerging yet requires suitable predictive biomarkers. To address these issues, we performed immunohistochemical analysis of multiple m...... hiện toàn bộ
Tumor Suppressors Status in Cancer Cell Line Encyclopedia
Molecular Oncology - Tập 7 - Trang 791-798 - 2013
Dmitriy Sonkin, Mehedi Hassan, Denis J. Murphy, Tatiana V. Tatarinova
Tumor suppressors play a major role in the etiology of human cancer, and typically achieve a tumor‐promoting effect upon complete functional inactivation. Bi‐allelic inactivation of tumor suppressors may occur through genetic mechanisms (such as loss of function mutation, copy number (CN) loss, or loss of heterozygosity (LOH)), epigenetic mechanisms (such as promoter methylation or histone...... hiện toàn bộ
Citral reduces breast tumor growth by inhibiting the cancer stem cell marker ALDH1A3
Molecular Oncology - Tập 10 - Trang 1485-1496 - 2016
Margaret Lois Thomas, Roberto de Antueno, Krysta Mila Coyle, Mohammad Sultan, Brianne Marie Cruickshank, Michael Anthony Giacomantonio, Carman Anthony Giacomantonio, Roy Duncan, Paola Marcato
Breast cancer stem cells (CSCs) can be identified by increased Aldefluor fluorescence caused by increased expression of aldehyde dehydrogenase 1A3 (ALDH1A3), as well as ALDH1A1 and ALDH2. In addition to being a CSC marker, ALDH1A3 regulates gene expression via retinoic acid (RA) signaling and plays a key role in the progression and chemotherapy resistance of cancer. Therefore, ALDH1A3 repr...... hiện toàn bộ
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