Molecular Oncology

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Targeting immunogenic cell death in cancer
Molecular Oncology - Tập 14 Số 12 - Trang 2994-3006 - 2020
Asma Ahmed, Stephen W. G. Tait
Immunogenic cell death (ICD) is a type of cancer cell death triggered by certain chemotherapeutic drugs, oncolytic viruses, physicochemical therapies, photodynamic therapy, and radiotherapy. It involves the activation of the immune system against cancer in immunocompetent hosts. ICD comprises the release of damage‐associated molecular patterns (DAMPs) from dying tumor cells that result in ...... hiện toàn bộ
Activation of androgen receptor induces ID1 and promotes hepatocellular carcinoma cell migration and invasion
Molecular Oncology - Tập 6 - Trang 507-515 - 2012
Junping Ao, Jiao Meng, Lei Zhu, Huizhen Nie, Chenchen Yang, Jinjun Li, Jianren Gu, Qiushi Lin, Weiwen Long, Xiaoqun Dong, Chao Li
A single lysis solution for the analysis of tissue samples by different proteomic technologies
Molecular Oncology - Tập 2 - Trang 368-379 - 2008
Pavel Gromov, Julio E. Celis, Irina Gromova, Fritz Rank, Vera Timmermans-Wielenga, José M.A. Moreira
Cancer, being a major healthcare concern worldwide, is one of the main targets for the application of emerging proteomic technologies and these tools promise to revolutionize the way cancer will be diagnosed and treated in the near future. Today, as a result of the unprecedented advances that have taken place in molecular biology, cell biology and genomics there is a pressing need to accel...... hiện toàn bộ
DNA damage signalling barrier, oxidative stress and treatment‐relevant DNA repair factor alterations during progression of human prostate cancer
Molecular Oncology - Tập 10 - Trang 879-894 - 2016
Daniela Kurfurstova, Jirina Bartkova, Radek Vrtel, Alena Mickova, Alena Burdova, Dusana Majera, Martin Mistrik, Milan Kral, Frederic R. Santer, Jan Bouchal, Jiri Bartek
The DNA damage checkpoints provide an anti‐cancer barrier in diverse tumour types, however this concept has remained unexplored in prostate cancer (CaP). Furthermore, targeting DNA repair defects by PARP1 inhibitors (PARPi) as a cancer treatment strategy is emerging yet requires suitable predictive biomarkers. To address these issues, we performed immunohistochemical analysis of multiple m...... hiện toàn bộ
Citral reduces breast tumor growth by inhibiting the cancer stem cell marker ALDH1A3
Molecular Oncology - Tập 10 - Trang 1485-1496 - 2016
Margaret Lois Thomas, Roberto de Antueno, Krysta Mila Coyle, Mohammad Sultan, Brianne Marie Cruickshank, Michael Anthony Giacomantonio, Carman Anthony Giacomantonio, Roy Duncan, Paola Marcato
Breast cancer stem cells (CSCs) can be identified by increased Aldefluor fluorescence caused by increased expression of aldehyde dehydrogenase 1A3 (ALDH1A3), as well as ALDH1A1 and ALDH2. In addition to being a CSC marker, ALDH1A3 regulates gene expression via retinoic acid (RA) signaling and plays a key role in the progression and chemotherapy resistance of cancer. Therefore, ALDH1A3 repr...... hiện toàn bộ
Detection of glyco‐mucin profiles improves specificity of MUC16 and MUC1 biomarkers in ovarian serous tumours
Molecular Oncology - Tập 9 - Trang 503-512 - 2015
Sara Ricardo, Lara Marcos-Silva, Daniela Pereira, Rita Pinto, Raquel Almeida, Ola Söderberg, Ulla Mandel, Henrik Clausen, Ana Felix, Nuno Lunet, Leonor David
The CA125 assay detects circulating MUC16 and is one of the most widely used cancer biomarkers for the follow‐up of ovarian cancer. We previously demonstrated that detection of aberrant cancer‐associated glycoforms of MUC16 as well as MUC1 in circulation could improve the yield of these serum assays. Our aim was to refine ovarian cancer biomarkers by detection of aberrant glycoforms (Tn, S...... hiện toàn bộ
Pre‐clinical efficacy of PU‐H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma
Molecular Oncology - Tập 8 - Trang 323-336 - 2014
Srikanth R. Ambati, Eloisi Caldas Lopes, Kohji Kosugi, Ullas Mony, Ahmet Zehir, Smit K. Shah, Tony Taldone, Andre L. Moreira, Paul A. Meyers, Gabriela Chiosis, Malcolm A.S. Moore
Ewing sarcoma is characterized by multiple deregulated pathways that mediate cell survival and proliferation. Heat shock protein 90 (HSP90) is a critical component of the multi‐chaperone complexes that regulate the disposition and activity of a large number of proteins involved in cell‐signaling systems. We tested the efficacy of PU‐H71, a novel HSP90 inhibitor in Ewing sarcoma cell lines,...... hiện toàn bộ
Exon 2 deletion splice variant of γ‐glutamyl carboxylase causes des‐γ‐carboxy prothrombin production in hepatocellular carcinoma cell lines
Molecular Oncology - Tập 2 - Trang 241-249 - 2008
Naoki Ueda, Hidenori Shiraha, Tatsuya Fujikawa, Nobuyuki Takaoka, Yutaka Nakanishi, Mayumi Suzuki, Noriyuki Matsuo, Shigetomi Tanaka, Shin-ichi Nishina, Masayuki Uemura, Akinobu Takaki, Yasushi Shiratori, Kazuhide Yamamoto
Using GGCX gene‐specific real‐time PCR, exon 2 deletion splice variant of vitamin K‐dependent γ‐glutamyl carboxylase (GGCX) mRNA was identified in HCC cell lines. Expressions of wild type and exon 2 deletion variant of GGCX were analyzed with relevance to DCP production in HCC cell lines. Hep3B, HepG2, HuH1, HuH7, and PLC/PRF/5 produced DCP, while SK‐Hep‐1, HLE, HLF, and JHH1 produced no d...... hiện toàn bộ
The morphologies of breast cancer cell lines in three‐dimensional assays correlate with their profiles of gene expression
Molecular Oncology - Tập 1 Số 1 - Trang 84-96 - 2007
Paraic A. Kenny, Genee Y. Lee, Connie A. Myers, Richard M. Neve, Jeremy R. Semeiks, Paul T. Spellman, Katrin Lorenz, Eva H. Lee, Mary Helen Barcellos‐Hoff, Ole W. Petersen, Joe W. Gray, Mina J. Bissell
Abstract3D cell cultures are rapidly becoming the method of choice for the physiologically relevant modeling of many aspects of non‐malignant and malignant cell behavior ex vivo. Nevertheless, only a limited number of distinct cell types have been evaluated in this assay to date. Here we report the first large scale comparison of the transcriptional profiles and 3D...... hiện toàn bộ
Topoisomerase‐1 and ‐2A gene copy numbers are elevated in mismatch repair‐proficient colorectal cancers
Molecular Oncology - Tập 9 - Trang 1207-1217 - 2015
Ida Marie Heeholm Sønderstrup, Sune Boris Nygård, Tim Svenstrup Poulsen, Dorte Linnemann, Jan Stenvang, Hans Jørgen Nielsen, Jiri Bartek, Nils Brünner, Peter Nørgaard, Lene Riis
Introduction Topoisomerase 1 (TOP1) and 2A (TOP2A) are potential predictive biomarkers for irinotecan and anthracycline treatment, respectively, in colorectal cancer (CRC), and we have recently reported a high frequency of gene gain of the TOP1 and TOP2A genes in CRC. Furthermore, Mismatch Repair (MMR) subtypes of CRC have been associated with benefit fro...... hiện toàn bộ
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