Microbial Cell Factories

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Increased production of inosine and guanosine by means of metabolic engineering of the purine pathway in Ashbya gossypii
Microbial Cell Factories - - 2015
Rodrigo Ledesma‐Amaro, Rubén M. Buey, José Luis Revuelta
Design of an efficient medium for heterologous protein production in Yarrowia lipolytica: case of human interferon alpha 2b
Microbial Cell Factories - Tập 10 - Trang 1-13 - 2011
Najla Gasmi, Atef Ayed, Jean-Marc Nicaud, Héla Kallel
The non conventional yeast Yarrowia lipolytica has aroused a strong industrial interest for heterologous protein production. However most of the studies describing recombinant protein production by this yeast rely on the use of complex media, such media are not convenient for large scale production particularly for products intended for pharmaceutical applications. In addition medium composition c...... hiện toàn bộ
Dynamic control of ERG9 expression for improved amorpha-4,11-diene production in Saccharomyces cerevisiae
Microbial Cell Factories - Tập 14 Số 1 - 2015
Jifeng Yuan, Chi‐Bun Ching
Rhamnolipid thiết kế thông qua giảm đa dạng congener: sản xuất và đặc trưng Dịch bởi AI
Microbial Cell Factories - Tập 16 - Trang 1-14 - 2017
Till Tiso, Rabea Zauter, Hannah Tulke, Bernd Leuchtle, Wing-Jin Li, Beate Behrens, Andreas Wittgens, Frank Rosenau, Heiko Hayen, Lars Mathias Blank
Rhamnolipid là các biosurfactant có tính chất hoạt động bề mặt làm cho chúng phù hợp cho một loạt các ứng dụng công nghiệp. Những tính chất này bao gồm khả năng nhũ hóa và tạo bọt, nồng độ micelle quan trọng, và khả năng giảm sức căng bề mặt. Hơn nữa, các khía cạnh như độ tương thích sinh học và tính thân thiện với môi trường đang ngày càng trở nên quan trọng. Rhamnolipid chủ yếu được sản xuất bởi...... hiện toàn bộ
#rhamnolipid #biosurfactant #Pseudomonas putida #sinh học tổng hợp #carbon bền vững
Construction and characterization of a novel glucose dehydrogenase-leucine dehydrogenase fusion enzyme for the biosynthesis of l-tert-leucine
Microbial Cell Factories - - 2021
Liping Liao, Yonghui Zhang, Yali Wang, Yousi Fu, Aihui Zhang, Ruodian Qiu, Shuhao Yang, Baishan Fang
Abstract Background Biosynthesis of l-tert-leucine (l-tle), a significant pharmaceutical intermediate, by a cofactor regeneration system friendly and efficiently is a worthful goal all the time. The cofactor regeneration system of leuc...... hiện toàn bộ
Improving l-serine formation by Escherichia coli by reduced uptake of produced l-serine
Microbial Cell Factories - Tập 19 Số 1 - 2020
Chenyang Wang, Junjun Wu, Shi Binchao, Jiping Shi, Zhiyang Zhao
Abstract Background Microbial de novo production of l-serine, which is widely used in a range of cosmetic and pharmaceutical products, has attracted increasing attention due to its environmentally friendly characteristics. Previous pioneering work mainly focused on l-serine anabolism; however,...... hiện toàn bộ
A recombinant Bifidobacterium bifidum BGN4 strain expressing the streptococcal superoxide dismutase gene ameliorates inflammatory bowel disease
Microbial Cell Factories - Tập 21 - Trang 1-11 - 2022
Sini Kang, Zhaoyan Lin, Yang Xu, Minju Park, Geun Eog Ji, Tony V. Johnston, Seockmo Ku, Myeong Soo Park
Inflammatory bowel disease (IBD) is a gastrointestinal disease characterized by diarrhea, rectal bleeding, abdominal pain, and weight loss. Recombinant probiotics producing specific proteins with IBD therapeutic potential are currently considered novel drug substitutes. In this study, a Bifidobacterium bifidum BGN4-SK strain was designed to produce the antioxidant enzymes streptococcal superoxide ...... hiện toàn bộ
Assessing methanotrophy and carbon fixation for biofuel production by Methanosarcina acetivorans
Microbial Cell Factories - Tập 15 - Trang 1-13 - 2016
Hadi Nazem-Bokaee, Saratram Gopalakrishnan, James G. Ferry, Thomas K. Wood, Costas D. Maranas
Methanosarcina acetivorans is a model archaeon with renewed interest due to its unique reversible methane production pathways. However, the mechanism and relevant pathways implicated in (co)utilizing novel carbon substrates in this organism are still not fully understood. This paper provides...... hiện toàn bộ
Immunization with Leishmania tarentolae-derived norovirus virus-like particles elicits high humoral response and stimulates the production of neutralizing antibodies
Microbial Cell Factories - Tập 20 - Trang 1-11 - 2021
Mirosława Panasiuk, Karolina Zimmer, Anna Czarnota, Katarzyna Grzyb, Magdalena Narajczyk, Grażyna Peszyńska-Sularz, Sabina Żołędowska, Dawid Nidzworski, Lilit Hovhannisyan, Beata Gromadzka
Noroviruses are a major cause of epidemic and sporadic acute non-bacterial gastroenteritis worldwide. Unfortunately, the development of an effective norovirus vaccine has proven difficult and no prophylactic vaccine is currently available. Further research on norovirus vaccine development should be considered an absolute priority and novel vaccine candidates are needed. One of the recent approache...... hiện toàn bộ
Redirection of the central metabolism of Klebsiella pneumoniae towards dihydroxyacetone production
Microbial Cell Factories - Tập 20 - Trang 1-16 - 2021
Shaoqi Sun, Yike Wang, Lin Shu, Xiyang Lu, Qinghui Wang, Chenguang Zhu, Jiping Shi, Gary J. Lye, Frank Baganz, Jian Hao
Klebsiella pneumoniae is a bacterium that can be used as producer for numerous chemicals. Glycerol can be catabolised by K. pneumoniae and dihydroxyacetone is an intermediate of this catabolism pathway. Here dihydroxyacetone and glycerol were produced from glucose by this bacterium based a redirected glycerol catabolism pathway. tpiA, encoding triosephosphate isomerase, was knocked out to block th...... hiện toàn bộ
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