Microbial Cell Factories

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Increased production of inosine and guanosine by means of metabolic engineering of the purine pathway in Ashbya gossypii
Microbial Cell Factories - - 2015
Rodrigo Ledesma‐Amaro, Rubén M. Buey, José Luis Revuelta
Design of an efficient medium for heterologous protein production in Yarrowia lipolytica: case of human interferon alpha 2b
Microbial Cell Factories - Tập 10 - Trang 1-13 - 2011
Najla Gasmi, Atef Ayed, Jean-Marc Nicaud, Héla Kallel
The non conventional yeast Yarrowia lipolytica has aroused a strong industrial interest for heterologous protein production. However most of the studies describing recombinant protein production by this yeast rely on the use of complex media, such media are not convenient for large scale production particularly for products intended for pharmaceutical applications. In addition medium composition c...... hiện toàn bộ
Dynamic control of ERG9 expression for improved amorpha-4,11-diene production in Saccharomyces cerevisiae
Microbial Cell Factories - Tập 14 Số 1 - 2015
Jifeng Yuan, Chi‐Bun Ching
Rhamnolipid thiết kế thông qua giảm đa dạng congener: sản xuất và đặc trưng Dịch bởi AI
Microbial Cell Factories - Tập 16 - Trang 1-14 - 2017
Till Tiso, Rabea Zauter, Hannah Tulke, Bernd Leuchtle, Wing-Jin Li, Beate Behrens, Andreas Wittgens, Frank Rosenau, Heiko Hayen, Lars Mathias Blank
Rhamnolipid là các biosurfactant có tính chất hoạt động bề mặt làm cho chúng phù hợp cho một loạt các ứng dụng công nghiệp. Những tính chất này bao gồm khả năng nhũ hóa và tạo bọt, nồng độ micelle quan trọng, và khả năng giảm sức căng bề mặt. Hơn nữa, các khía cạnh như độ tương thích sinh học và tính thân thiện với môi trường đang ngày càng trở nên quan trọng. Rhamnolipid chủ yếu được sản xuất bởi...... hiện toàn bộ
#rhamnolipid #biosurfactant #Pseudomonas putida #sinh học tổng hợp #carbon bền vững
Xylitol production from waste xylose mother liquor containing miscellaneous sugars and inhibitors: one-pot biotransformation by Candida tropicalis and recombinant Bacillus subtilis
Microbial Cell Factories - Tập 15 - Trang 1-12 - 2016
Hengwei Wang, Lijuan Li, Lebin Zhang, Jin An, Hairong Cheng, Zixin Deng
The process of industrial xylitol production is a massive source of organic pollutants, such as waste xylose mother liquor (WXML), a viscous reddish-brown liquid. Currently, WXML is difficult to reuse due to its miscellaneous low-cost sugars, high content of inhibitors and complex composition. WXML, as an organic pollutant of hemicellulosic hydrolysates, accumulates and has become an issue of indu...... hiện toàn bộ
Construction and characterization of a novel glucose dehydrogenase-leucine dehydrogenase fusion enzyme for the biosynthesis of l-tert-leucine
Microbial Cell Factories - - 2021
Liping Liao, Yonghui Zhang, Yali Wang, Yousi Fu, Aihui Zhang, Ruodian Qiu, Shuhao Yang, Baishan Fang
Abstract Background Biosynthesis of l-tert-leucine (l-tle), a significant pharmaceutical intermediate, by a cofactor regeneration system friendly and efficiently is a worthful goal all the time. The cofactor regeneration system of leuc...... hiện toàn bộ
A purified and lyophilized Pseudomonas aeruginosa derived pyocyanin induces promising apoptotic and necrotic activities against MCF-7 human breast adenocarcinoma
Microbial Cell Factories - Tập 21 - Trang 1-16 - 2022
Ahmed A. Abdelaziz, Amal M. Abo Kamer, Khaled B. Al-Monofy, Lamiaa A. Al-Madboly
Pyocyanin, a specific extracellular secondary metabolite pigment produced by Pseudomonas aeruginosa, exhibits redox activity and has toxic effects on mammalian cells, making it a new and potent alternative for treating cancer. Breast cancer (BC) treatment is now defied by acquired and de novo resistance to chemotherapy, radiation, or targeted therapies. Therefore, the anticancer activity of purifi...... hiện toàn bộ
Improving l-serine formation by Escherichia coli by reduced uptake of produced l-serine
Microbial Cell Factories - Tập 19 Số 1 - 2020
Chenyang Wang, Junjun Wu, Shi Binchao, Jiping Shi, Zhiyang Zhao
Abstract Background Microbial de novo production of l-serine, which is widely used in a range of cosmetic and pharmaceutical products, has attracted increasing attention due to its environmentally friendly characteristics. Previous pioneering work mainly focused on l-serine anabolism; however,...... hiện toàn bộ
A recombinant Bifidobacterium bifidum BGN4 strain expressing the streptococcal superoxide dismutase gene ameliorates inflammatory bowel disease
Microbial Cell Factories - Tập 21 - Trang 1-11 - 2022
Sini Kang, Zhaoyan Lin, Yang Xu, Minju Park, Geun Eog Ji, Tony V. Johnston, Seockmo Ku, Myeong Soo Park
Inflammatory bowel disease (IBD) is a gastrointestinal disease characterized by diarrhea, rectal bleeding, abdominal pain, and weight loss. Recombinant probiotics producing specific proteins with IBD therapeutic potential are currently considered novel drug substitutes. In this study, a Bifidobacterium bifidum BGN4-SK strain was designed to produce the antioxidant enzymes streptococcal superoxide ...... hiện toàn bộ
A secretion biosensor for monitoring Sec-dependent protein export in Corynebacterium glutamicum
Microbial Cell Factories - Tập 19 - Trang 1-15 - 2020
Doris Dohmen-Olma, Astrid Bida, Janko Potzkei, Georg Schaumann, Roland Freudl, Britta Kleine, Sarah Jurischka, Stephan Binder, Patrick J. Bakkes
In recent years, the industrial workhorse Corynebacterium glutamicum has gained increasing interest as a host organism for the secretory production of heterologous proteins. Generally, the yield of a target protein in the culture supernatant depends on a multitude of interdependent biological and bioprocess parameters which have to be optimized. So far, the monitoring of such optimization processe...... hiện toàn bộ
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