Increased production of inosine and guanosine by means of metabolic engineering of the purine pathway in Ashbya gossypii
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Ledesma-Amaro R, Jimenez A, Santos MA, Revuelta JL. Biotechnological production of feed nucleotides by microbial strain improvement. Process Biochem. 2013;48:1263–70.
Jinap S, Hajeb P. Glutamate. Its applications in food and contribution to health. Appetite. 2010;55:1–10.
Hasko G, Sitkovsky MV, Szabo C. Immunomodulatory and neuroprotective effects of inosine. Trends Pharmacol Sci. 2004;25:152–7.
Tsuda K. Inosine, calcium channels, and neuroprotection against ischemic brain injury. Stroke. 2005;36:1823. author reply 1823.
DM A. Inosine: a naturally occurring cardiotonic agent. J Pharmacol. 1983;14:24.
Asahara T, Mori Y, Zakataeva NP, Livshits VA, Yoshida K, Matsuno K. Accumulation of gene-targeted Bacillus subtilis mutations that enhance fermentative inosine production. Appl Microbiol Biotechnol. 2010;87:2195–207.
Shimaoka M, Takenaka Y, Kurahashi O, Kawasaki H, Matsui H. Effect of amplification of desensitized purF and prs on inosine accumulation in Escherichia coli. J Biosci Eng. 2007;103:255–61.
Rolfes RJ. Regulation of purine nucleotide biosynthesis: in yeast and beyond. Biochem Soc Trans. 2006;34:786–90.
Li H, Zhang G, Deng A, Chen N, Wen T. De novo engineering and metabolic flux analysis of inosine biosynthesis in Bacillus subtilis. Biotechnol Lett. 2011;33:1575–80.
Sheremet AS, Gronskiy SV, Akhmadyshin RA, Novikova AE, Livshits VA, Shakulov RS, et al. Enhancement of extracellular purine nucleoside accumulation by Bacillus strains through genetic modifications of genes involved in nucleoside export. J Ind Microbiol Biotechnol. 2011;38:65–70.
Peifer S, Barduhn T, Zimmet S, Volmer DA, Heinzle E, Schneider K. Metabolic engineering of the purine biosynthetic pathway in Corynebacterium glutamicum results in increased intracellular pool sizes of IMP and hypoxanthine. Microb Cell Fact. 2012;11:138.
Kamada N, Yasuhara A, Takano Y, Nakano T, Ikeda M. Effect of transketolase modifications on carbon flow to the purine-nucleotide pathway in Corynebacterium ammoniagenes. Appl Microbiol Biotechnol. 2001;56:710–7.
Ledesma-Amaro R, Jimenez A, Santos M, Revuelta J. Microbial Production of Vitamins. In: Book Chapter in: Microbial Production of Food Ingredients, Enzymes and Nutraceuticals. Sawston, Cambridge, UK: Woodhead Publishing Series in Food Science Technology and Nutrition No 246; 2013. p. 571–94.
Dietrich FS, Voegeli S, Brachat S, Lerch A, Gates K, Steiner S, et al. The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome. Science. 2004;304:304–7.
Jimenez A, Santos MA, Pompejus M, Revuelta JL. Metabolic engineering of the purine pathway for riboflavin production in Ashbya gossypii. Appl Environ Microbiol. 2005;71:5743–51.
Jimenez A, Santos MA, Revuelta JL. Phosphoribosyl pyrophosphate synthetase activity affects growth and riboflavin production in Ashbya gossypii. BMC Biotechnol. 2008;8:67.
Dunkler A, Wendland J. Use of MET3 promoters for regulated gene expression in Ashbya gossypii. Curr Genet. 2007;52:1–10.
Ledesma-Amaro R, Santos MA, Jimenez A, Revuelta JL. Strain design of Ashbya gossypii for single-cell oil production. Appl Environ Microbiol. 2014;80:1237–44.
Ming H, Lara Pizarro AV, Park EY. Application of waste activated bleaching earth containing rapeseed oil on riboflavin production in the culture of Ashbya gossypii. Biotechnol Prog. 2003;19:410–7.
Ledesma-Amaro R, Kerkhoven EJ, Revuelta JL, Nielsen J. Genome scale metabolic modeling of the riboflavin overproducer Ashbya gossypii. Biotechnol Bioeng. 2013;111:1191–99.
Abbas CA, Sibirny AA. Genetic control of biosynthesis and transport of riboflavin and flavin nucleotides and construction of robust biotechnological producers. Microbiol Mol Biol Rev. 2011;75:321–60.
Lim SH, Choi JS, Park EY. Microbial Production of Riboflavin Using Riboflavin Overproducers, Ashbya gossypii, Bacillus subtilis, and Candida famate: An Overview. Biotechnology Bioprocess Engineering. 2001;6:75–88.
Forster C, Santos MA, Ruffert S, Kramer R, Revuelta JL. Physiological consequence of disruption of the VMA1 gene in the riboflavin overproducer Ashbya gossypii. J Biol Chem. 1999;274:9442–8.
Santos M, Mateos L, Stahmann K, Revuelta J. Insertional mutagenesis in the vitamin B2 producer fungus Ashbya gossypii. Methods Biotechnol. 2004;18:283–300.
Ledesma-Amaro R, Santos MA, Jimenez A, Revuelta JL. Tuning single-cell oil production in Ashbya gossypii by engineering the elongation and desaturation systems. Biotechnol Bioeng. 2014;111:1782–91.
Canelas A, Ras C, ten Pierick A, van Dam J, Heijnen J, Van Gulik W. Leakage-free rapid quenching technique for yeast metabolomics. Metabolomics. 2008;4:226–39.
Lazzarino G, Amorini AM, Fazzina G, Vagnozzi R, Signoretti S, Donzelli S, et al. Single-sample preparation for simultaneous cellular redox and energy state determination. Anal Biochem. 2003;322:51–9.