Macromolecular Bioscience

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pH‐temperature Responsive Hydrogel‐Mediated Delivery of Exendin‐4 Encapsulated Chitosan Nanospheres for Sustained Therapeutic Efficacy in Type 2 Diabetes Mellitus
Macromolecular Bioscience - Tập 23 Số 11 - 2023
Thuy An Trinh, Thai Minh Duy Le, Hien Thi‐Thanh Nguyen, Thanh Loc Nguyen, Jaeyun Kim, Dai Phu Huynh, Thavasyappan Thambi
AbstractType 2 Diabetes Mellitus (T2D) is a chronic, obesity‐related, and inflammatory disorder characterize by insulin resistance, inadequate insulin secretion, hyperglycemia, and excessive glucagon secretion. Exendin‐4 (EX), a clinically established antidiabetic medication that acts as a glucagon‐like peptide‐1 receptor agonist, is effective in lowering glucose l...... hiện toàn bộ
Mitogenic Activity of Sulfated Chitosan and Cellulose Derivatives is Related to Protection of FGF‐2 from Proteolytic Cleavage
Macromolecular Bioscience - Tập 12 Số 6 - Trang 740-750 - 2012
Annett Weltrowski, Sidalina Almeida, Dieter Peschel, Kai Zhang, Steffen Fischer, Thomas Groth
AbstractNovel chitosan (CHS) and cellulose sulfates (CSs) are studied regarding their mitogenic activity and their protective effect against proteolytic digestion of FGF‐2. An intermediate degree of sulfation (DSS) and lower concentration of CHS have superior effect on 3T3 cell growth while the mitogenic activity of CS increases with DS... hiện toàn bộ
Super-Anticoagulant Heparin-Mimicking Hydrogel Thin Film Attached Substrate Surfaces to Improve Hemocompatibility
Macromolecular Bioscience - Tập 17 Số 2 - Trang 1600281 - 2017
Min He, Xiaofei Cui, Huiyi Jiang, Xuelian Huang, Weifeng Zhao, Changsheng Zhao
The Effect of Ligand Mobility on the Cellular Interaction of Multivalent Nanoparticles
Macromolecular Bioscience - Tập 20 Số 4 - 2020
Sara Maslanka Figueroa, Daniel F. Fleischmann, Sebastian Beck, Achim Goepferich
AbstractMultivalent nanoparticle binding to cells can be of picomolar avidity making such interactions almost as intense as those seen with antibodies. However, reducing nanoparticle design exclusively to avidity optimization by the choice of ligand and its surface density does not sufficiently account for controlling and understanding cell–particle interactions. C...... hiện toàn bộ
Significant Role of Bacterial Undecaprenyl Diphosphate (C55‐UPP) for Rubber Synthesis by Hevea Latex Enzymes
Macromolecular Bioscience - Tập 4 Số 11 - Trang 1039-1052 - 2004
Atiya Rattanapittayaporn, Dhirayos Wititsuwannakul, Rapepun Wititsuwannakul
AbstractSummary: Washed bottom fraction (BF) membrane‐bound particles of centrifuged fresh Hevea latex were found to be very active in rubber biosynthesis (RB). The washed BF membrane (WBM) showed higher RB activity and is strongly stimulated by anionic surfactants – more by DOC than SDS. WBM enzymes system can synt...... hiện toàn bộ
Present and Future Role of Chitin and Chitosan in Food
Macromolecular Bioscience - Tập 3 Số 10 - Trang 521-530 - 2003
E. Agulló, Maite Rodriguez, Viviana Ramos, Liliana Albertengo
AbstractThe conversion of processed discarded material into valuable by‐products and alternative specialty materials has been identified as a timely challenge for food research and development associated with numerous applications of chitinous products. Chitin, chitosan, calcareous chitin, and chitosan, N‐acetylated chitosan, ... hiện toàn bộ
Plasma Surface Modification of Chitosan Membranes: Characterization and Preliminary Cell Response Studies
Macromolecular Bioscience - Tập 8 Số 6 - Trang 568-576 - 2008
Simone S. Silva, Sandra M. Luna, Manuela E. Gomes, J. Benesch, Iva Pashkuleva, João F. Mano, Rui L. Reis
AbstractSurface modification of biomaterials is a way to tailor cell responses whilst retaining the bulk properties. In this work, chitosan membranes were prepared by solvent casting and treated with nitrogen or argon plasma at 20 W for 10–40 min. AFM indicated an increase in the surface roughness as a result of the ongoing etching process. XPS and contact angle me...... hiện toàn bộ
Tubule Nanoclay‐Organic Heterostructures for Biomedical Applications
Macromolecular Bioscience - Tập 19 Số 4 - 2019
Mingxian Liu, Rawil Fakhrullin, А. А. Новиков, Abhishek Panchal, Yuri Lvov
AbstractNatural halloysite nanotubes (HNTs) show unique hollow structure, high aspect ratio and adsorption ability, good biocompatibility, and low toxicity, which allow for various biomedical applications in the diagnosis and treatment of diseases. Here, advances in self‐assembly of halloysite for cell capturing and bacterial proliferation, coating on biological su...... hiện toàn bộ
Polymer Alloys of Nodax Copolymers and Poly(lactic acid)
Macromolecular Bioscience - Tập 4 Số 3 - Trang 269-275 - 2004
Isao Noda, Michael M. Satkowski, Anthony E. Dowrey, Curtis Marcott
AbstractSummary: Properties of polymer alloys comprising poly(lactic acid) and Nodax copolymers are investigated. Nodax is a family of bacterially produced polyhydroxyalkanoate (PHA) copolymers comprising 3‐hydroxybutyrate (3HB) and other 3‐hydroxyalkanoate (3HA) units with side groups greater than or equal to three carbon units. The incorpor...... hiện toàn bộ
Covalent Growth Factor Immobilization Strategies for Tissue Repair and Regeneration
Macromolecular Bioscience - Tập 11 Số 9 - Trang 1149-1163 - 2011
Kristyn S. Masters
AbstractGrowth factors play a critical role in regulating processes involved in cellular differentiation and tissue regeneration, and are therefore considered essential elements in many tissue engineering strategies. The covalent immobilization of growth factors to biomaterial matrices addresses many of the challenges associated with delivering freely‐diffusible gr...... hiện toàn bộ
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