Macromolecular Bioscience

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Mitogenic Activity of Sulfated Chitosan and Cellulose Derivatives is Related to Protection of FGF‐2 from Proteolytic Cleavage
Macromolecular Bioscience - Tập 12 Số 6 - Trang 740-750 - 2012
Annett Weltrowski, Sidalina Almeida, Dieter Peschel, Kai Zhang, Steffen Fischer, Thomas Groth
AbstractNovel chitosan (CHS) and cellulose sulfates (CSs) are studied regarding their mitogenic activity and their protective effect against proteolytic digestion of FGF‐2. An intermediate degree of sulfation (DSS) and lower concentration of CHS have superior effect on 3T3 cell growth while the mitogenic activity of CS increases with DS... hiện toàn bộ
Plasma Surface Modification of Chitosan Membranes: Characterization and Preliminary Cell Response Studies
Macromolecular Bioscience - Tập 8 Số 6 - Trang 568-576 - 2008
Simone S. Silva, Sandra M. Luna, Manuela E. Gomes, J. Benesch, Iva Pashkuleva, João F. Mano, Rui L. Reis
AbstractSurface modification of biomaterials is a way to tailor cell responses whilst retaining the bulk properties. In this work, chitosan membranes were prepared by solvent casting and treated with nitrogen or argon plasma at 20 W for 10–40 min. AFM indicated an increase in the surface roughness as a result of the ongoing etching process. XPS and contact angle me...... hiện toàn bộ
Covalent Growth Factor Immobilization Strategies for Tissue Repair and Regeneration
Macromolecular Bioscience - Tập 11 Số 9 - Trang 1149-1163 - 2011
Kristyn S. Masters
AbstractGrowth factors play a critical role in regulating processes involved in cellular differentiation and tissue regeneration, and are therefore considered essential elements in many tissue engineering strategies. The covalent immobilization of growth factors to biomaterial matrices addresses many of the challenges associated with delivering freely‐diffusible gr...... hiện toàn bộ
Electrospun Gelatin Fibers with a Multiple Release of Antibiotics Accelerate Dermal Regeneration in Infected Deep Burns
Macromolecular Bioscience - Tập 16 Số 9 - Trang 1368-1380 - 2016
Jianmei Chen, Zongguang Liu, Maohua Chen, Hong Zhang, Xiaohong Li
Electrospun fibers of hydrophilic polymers meet challenges in a rapid degradation of fiber matrices and discharge of antibiotics to comply with requirements of infection control as a dermal regeneration template. In the current study, a pH conversion process is initially developed to ensure fluent electrospinning, an efficient in situ cross‐linking of electrospun gelatin fibers with oxidiz...... hiện toàn bộ
Self‐Association of Unfolded Outer Membrane Proteins
Macromolecular Bioscience - Tập 10 Số 7 - Trang 763-767 - 2010
Alexandra Ebie Tan, N. K. Burgess, Diana S. DeAndrade, Jacob D. Marold, Karen G. Fleming
AbstractWe have investigated self‐association propensities of aqueous unfolded (UAQ) forms of eight outer membrane proteins (OMPs), OmpA, OmpW, OmpX, PagP, OmpT, OmpLa, FadL, and Omp85. We found that high urea concentrations maintain all of these OMPs as monomers and that OmpA and OmpX remain monomeric upon dilution to 1 M ur...... hiện toàn bộ
Characterization of Methyl Methacrylate Grafting onto Preirradiated Biodegradable Lignocellulose Fiber by γ‐Radiation
Macromolecular Bioscience - Tập 5 Số 1 - Trang 78-89 - 2005
Ferdous Khan
AbstractSummary: Gamma‐radiation‐induced graft copolymerization of methyl methacrylate onto natural lignocellulose (jute) fiber was carried out by the preirradiation method in an aqueous medium by using octylphenoxy‐polyethoxyethanol as an emulsifier. The different factors that influenced the graft copolymer reaction process were investigated...... hiện toàn bộ
Template‐Directed Control of Crystal Morphologies
Macromolecular Bioscience - Tập 7 Số 2 - Trang 152-162 - 2007
Fiona C. Meldrum, Sabine Ludwigs
AbstractBiominerals are characterised by unique morphologies, and it is a long‐term synthetic goal to reproduce these synthetically. We here apply a range of templating routes to investigate whether a fascinating category of biominerals, the single crystals with complex forms, can be produced using simple synthetic methods. Macroporous crystals with sponge‐like mor...... hiện toàn bộ
Characterization of Ultra‐Thin Temperature‐Responsive Polymer Layer and Its Polymer Thickness Dependency on Cell Attachment/Detachment Properties
Macromolecular Bioscience - Tập 10 Số 10 - Trang 1117-1129 - 2010
Kenzo Fukumori, Yoshikatsu Akiyama, Yoshikazu Kumashiro, Jun Kobayashi, Masayuki Yamato, Kiyotaka Sakai, Teruo Okano
AbstractUltra thin poly(N‐isopropylacrylamide) (PIPAAm) modified glass coverslips (PIAPAm‐CS) using electron beam irradiation exhibited a clear relationship between the polymer thickness and thermal cell adhesion/detachment behavior. The polymer thickness dependency and the characteristic of ultra thin PIPAAm layer, has been illustrated i...... hiện toàn bộ
Manipulation of Electrostatic and Saccharide Linker Interactions in the Design of Efficient Glycopolypeptide‐Based Cholera Toxin Inhibitors
Macromolecular Bioscience - Tập 10 Số 1 - Trang 68-81 - 2010
Ronak Maheshwari, Eric A. Levenson, Kristi L. Kiick
AbstractMultivalent, glycopolymer inhibitors designed for the treatment of disease and pathogen infection have shown improvements in binding correlated with general changes in glycopolymer architecture and composition. We have previously demonstrated that control of glycopolypeptide backbone extension and ligand spacing significantly impacts the inhibition of the c...... hiện toàn bộ
Macromolecular Dimensions and Mechanical Properties of Monolayer Films of Sonorean Mesquite Gum
Macromolecular Bioscience - Tập 4 Số 9 - Trang 865-874 - 2004
Yolanda L. López‐Franco, Miguel A. Váldez, Javier Hernández, Calderón de la Barca, Marguerite Rinaudo, Francisco M. Goycoolea
AbstractSummary: Mesquite gum sourced from Prosopis velutina trees and gum arabic (Acacia spp.) were characterized using light scattering and Langmuir isotherms. Both gum materials were fractionated by hydrophobic interaction chromatography, yielding four fractions for both gums: FI, FIIa,...... hiện toàn bộ
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