Learning and Memory
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Role of matrix metalloproteinases in the acquisition and reconsolidation of cocaine-induced conditioned place preference
Learning and Memory - Tập 14 Số 3 - Trang 214-223 - 2007
Persistent drug seeking/taking behavior involves the consolidation of memory.
With each drug use, the memory may be reactivated and reconsolidated to maintain
the original memory. During reactivation, the memory may become labile and
susceptible to disruption; thus, molecules involved in plasticity should
influence acquisition and/or reconsolidation. Recently, matrix
metalloproteinases (MMPs) have...
Temporary basolateral amygdala lesions disrupt acquisition of socially transmitted food preferences in rats
Learning and Memory - Tập 13 Số 6 - Trang 794-800 - 2006
Lesions of the basolateral amygdala (BLA) have long been associated with
abnormalities of taste-related behaviors and with failure in a variety of taste-
and odor-related learning paradigms, including taste-potentiated odor aversion,
conditioned taste preference, and conditioned taste aversion. Still, the general
role of the amygdala in chemosensory learning remains somewhat controversial. In
part...
AX+/BX− discrimination learning in the fear-potentiated startle paradigm in monkeys
Learning and Memory - Tập 15 Số 2 - Trang 63-66 - 2008
Individuals with anxiety disorders often do not respond to safety signals and
hence continue to be afraid and anxious. Consequently, it is important to
develop paradigms in animals that can directly study brain systems involved in
learning about, and responding to, safety signals. We previously developed a
discrimination procedure in rats of the form AX+/BX−, where cues A and X
presented together ...
Stimulus similarity and encoding time influence incidental recognition memory in adult monkeys with selective hippocampal lesions
Learning and Memory - Tập 18 Số 3 - Trang 170-180 - 2011
Recognition memory impairment after selective hippocampal lesions in monkeys is
more profound when measured with visual paired-comparison (VPC) than with
delayed nonmatching-to-sample (DNMS). To clarify this issue, we assessed the
impact of stimuli similarity and encoding duration on the VPC performance in
monkeys with hippocampal lesions and sham-operated controls. The novelty
preference was comp...
AX+, BX- Discrimination Learning in the Fear-Potentiated Startle Paradigm: Possible Relevance to Inhibitory Fear Learning in Extinction
Learning and Memory - Tập 11 Số 4 - Trang 464-475 - 2004
The neural mechanisms of fear suppression most commonly are studied through the
use of extinction, a behavioral procedure in which a feared stimulus (i.e., one
previously paired with shock) is nonreinforced repeatedly, leading to a
reduction or elimination of the fear response. Although extinction is perhaps
the most convenient index of fear inhibition, a great deal of behavioral work
suggests tha...
Amyloid beta mediates memory formation
Learning and Memory - Tập 16 Số 4 - Trang 267-272 - 2009
The amyloid precursor protein (APP) undergoes sequential cleavages to generate
various polypeptides, including the amyloid β (1–42) peptide (Aβ[1–42]), which
is believed to play a major role in amyloid plaque formation in Alzheimer's
disease (AD). Here we provide evidence that, in contrast with its pathological
role when accumulated, endogenous Aβ in normal hippocampi mediates learning and
memory ...
CREB down-regulation in the laterodorsal thalamic nucleus deteriorates memory consolidation in rats
Learning and Memory - Tập 26 Số 6 - Trang 182-186 - 2019
The laterodorsal thalamic nucleus (LD) is believed to play roles in learning and
memory, especially spatial tasks. However, the molecular mechanism that
underlies the cognitive process in the LD remains unclear and needs to be
investigated. So far, there is plenty of evidence indicating that plasticity has
been in some of the cortical or subcortical regions closely related to the LD,
particularly ...
Enhanced Human Memory Consolidation With Post-Learning Stress: Interaction With the Degree of Arousal at Encoding
Learning and Memory - Tập 10 Số 4 - Trang 270-274 - 2003
Abundant evidence indicates that endogenous stress hormones such as epinephrine
and corticosterone modulate memory consolidation in animals. We recently
provided the first demonstration that an endogenous stress hormone (epinephrine)
can enhance human memory consolidation. However, these findings also suggested
that post-learning stress hormone activation does not uniformly enhance memory
for all ...
Stress modulates the use of spatial versus stimulus-response learning strategies in humans
Learning and Memory - Tập 14 Số 1-2 - Trang 109-116 - 2007
Animal studies provided evidence that stress modulates multiple memory systems,
favoring caudate nucleus-based “habit” memory over hippocampus-based “cognitive”
memory. However, effects of stress on learning strategy and memory consolidation
were not differentiated. We specifically address the effects of psychosocial
stress on the applied learning strategy in humans. We designed a spatial
learning...
Sex influences on the neurobiology of learning and memory
Learning and Memory - Tập 16 Số 4 - Trang 248-266 - 2009
In essentially every domain of neuroscience, the generally implicit assumption
that few, if any, meaningful differences exist between male and female brain
function is being challenged. Here we address how this development is
influencing studies of the neurobiology of learning and memory. While it has
been commonly held that males show an advantage on spatial tasks, and females on
verbal tasks, th...
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