Learning and Memory

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A New Group-Training Procedure for Habituation Demonstrates That Presynaptic Glutamate Release Contributes to Long-Term Memory in Caenorhabditis elegans
Learning and Memory - Tập 9 Số 3 - Trang 130-137 - 2002
Jacqueline K. Rose, Karla R. Kaun, Catharine H. Rankin
In the experiments reported here we have developed a new group-training protocol for assessing long-term memory for habituation in Caenorhabditis elegans. We have replicated all of the major findings of the original single-worm protocol using the new protocol: (1) distributed training produced long-term retention of training, massed training did not; (2) distribu...... hiện toàn bộ
Activation of BDNF signaling prevents the return of fear in female mice
Learning and Memory - Tập 20 Số 5 - Trang 237-240 - 2013
Danay Baker‐Andresen, Charlotte R. Flavell, Xiang Li, Timothy W. Bredy
There are significant sex differences in vulnerability to develop fear-related anxiety disorders. Females exhibit twice the rate of post-traumatic stress disorder (PTSD) as males and sex differences have been observed in fear extinction learning in both humans and rodents, with a failure to inhibit fear emerging as a precipitating factor in the development of PTSD. Here we report that fema...... hiện toàn bộ
From Acquisition to Consolidation: On the Role of Brain-Derived Neurotrophic Factor Signaling in Hippocampal-Dependent Learning
Learning and Memory - Tập 9 Số 5 - Trang 224-237 - 2002
William J. Tyler, Mariana Alonso, Clive R. Bramham, Lucas Pozzo‐Miller
One of the most rigorously investigated problems in modern neuroscience is to decipher the mechanisms by which experience-induced changes in the central nervous system are translated into behavioral acquisition, consolidation, retention, and subsequent recall of information. Brain-derived neurotrophic factor (BDNF) has recently emerged as one of the most potent molecular mediators of not o...... hiện toàn bộ
A Nitric Oxide-Independent and β-Adrenergic Receptor-Sensitive Form of Metaplasticity Limits θ-Frequency Stimulation-Induced LTP in the Hippocampal CA1 Region
Learning and Memory - Tập 6 Số 6 - Trang 619-633 - 1999
Teena D. Moody, Holly J. Carlisle, Thomas J. O’Dell
The induction of long-term potentiation (LTP) and long-term depression (LTD) at excitatory synapses in the hippocampus can be strongly modulated by patterns of synaptic stimulation that otherwise have no direct effect on synaptic strength. Likewise, patterns of synaptic stimulation that induce LTP or LTD not only modify synaptic strength but can also induce lasting changes that regulate ho...... hiện toàn bộ
“Silent” Metaplasticity of the Late Phase of Long-Term Potentiation Requires Protein Phosphatases
Learning and Memory - Tập 9 Số 4 - Trang 202-213 - 2002
Newton H. Woo, Peter Nguyen
The late phase of long-term potentiation (L-LTP) is correlated with some types of long-term memory, but the mechanisms by which L-LTP is modulated by prior synaptic activity are undefined. Activation of protein phosphatases by low-frequency stimulation (LFS) given before induction of L-LTP may significantly modify L-LTP. Using cellular electrophysiological recording methods in mouse hippoc...... hiện toàn bộ
Disruption of the perineuronal net in the hippocampus or medial prefrontal cortex impairs fear conditioning
Learning and Memory - Tập 20 Số 5 - Trang 267-273 - 2013
Michael J. Hylin, Sara A. Orsi, Anthony N. Moore, Pramod K. Dash
The perineuronal net (PNN) surrounds neurons in the central nervous system and is thought to regulate developmental plasticity. A few studies have shown an involvement of the PNN in hippocampal plasticity and memory storage in adult animals. In addition to the hippocampus, plasticity in the medial prefrontal cortex (mPFC) has been demonstrated to be critical for the storage of long-term me...... hiện toàn bộ
Enhanced CREB-dependent gene expression increases the excitability of neurons in the basal amygdala and primes the consolidation of contextual and cued fear memory
Learning and Memory - Tập 16 Số 3 - Trang 193-197 - 2009
José Viosca, Mikel López de Armentia, Dragana Jančić, Ángel Barco
Regulated expression of a constitutively active form of cAMP response element-binding protein (CREB), VP16-CREB, lowers the threshold for the late phase of long-term potentiation in the Schaffer collateral pathway in a de novo gene expression-independent manner, and increases the excitability and reduces afterhyperpolarization of neurons at the amygdala and the hippocampus. We explore the ...... hiện toàn bộ
Long-term potentiation and evidence for novel synaptic association in CA1 stratum oriens of rat hippocampus.
Learning and Memory - Tập 2 Số 2 - Trang 101-106 - 1995
Satoru Otani, J. A. Connor, William B. Levy
In CA1 stratum oriens of hippocampal slices, a robust long-term potentiation (LTP) induced by tetanic stimulation (20 pulses at 100 Hz, 10 trains delivered at 0.1 Hz) was accompanied by a slowly developing potentiation in a second, untetanized pathway. N-methyl-D-aspartate (NMDA) receptor antagonist DL-2-amino-5-phosphonovaleric acid (D-APV, 50 or 100 microM) reduced the homosynaptic LTP b...... hiện toàn bộ
Proactive and retrograde effects on LTP produced by theta pulse stimulation: mechanisms and characteristics of LTP reversal in vitro.
Learning and Memory - Tập 3 Số 2-3 - Trang 96-105 - 1996
Ursula Stäubli, Daniel Chun
Simultaneous training on two hippocampus-dependent tasks facilitates acquisition of trace eyeblink conditioning
Learning and Memory - Tập 13 Số 2 - Trang 201-207 - 2006
Amy G. Kuo, Grace Lee, John F. Disterhoft
A common cellular alteration, reduced post-burst afterhyperpolarization (AHP) in CA1 neurons, is associated with acquisition of the hippocampus-dependent tasks trace eyeblink conditioning and the Morris water maze. As a similar increase in excitability is correlated with these two learning paradigms, we sought to determine the interactive behavioral effects of training animals on both task...... hiện toàn bộ
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