Learning and Memory
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Role of matrix metalloproteinases in the acquisition and reconsolidation of cocaine-induced conditioned place preferencePersistent drug seeking/taking behavior involves the consolidation of memory. With each drug use, the memory may be reactivated and reconsolidated to maintain the original memory. During reactivation, the memory may become labile and susceptible to disruption; thus, molecules involved in plasticity should influence acquisition and/or reconsolidation. Recently, matrix metalloproteinases (MM... ...
Learning and Memory - Tập 14 Số 3 - Trang 214-223 - 2007
Temporary basolateral amygdala lesions disrupt acquisition of socially transmitted food preferences in ratsLesions of the basolateral amygdala (BLA) have long been associated with abnormalities of taste-related behaviors and with failure in a variety of taste- and odor-related learning paradigms, including taste-potentiated odor aversion, conditioned taste preference, and conditioned taste aversion. Still, the general role of the amygdala in chemosensory learning remains somewhat controversial.... ...
Learning and Memory - Tập 13 Số 6 - Trang 794-800 - 2006
AX+/BX− discrimination learning in the fear-potentiated startle paradigm in monkeysIndividuals with anxiety disorders often do not respond to safety signals and hence continue to be afraid and anxious. Consequently, it is important to develop paradigms in animals that can directly study brain systems involved in learning about, and responding to, safety signals. We previously developed a discrimination procedure in rats of the form AX+/BX−, where cues A and X presented t... ...
Learning and Memory - Tập 15 Số 2 - Trang 63-66 - 2008
Stimulus similarity and encoding time influence incidental recognition memory in adult monkeys with selective hippocampal lesionsRecognition memory impairment after selective hippocampal lesions in monkeys is more profound when measured with visual paired-comparison (VPC) than with delayed nonmatching-to-sample (DNMS). To clarify this issue, we assessed the impact of stimuli similarity and encoding duration on the VPC performance in monkeys with hippocampal lesions and sham-operated controls. The novelty preference ... ...
Learning and Memory - Tập 18 Số 3 - Trang 170-180 - 2011
AX+, BX- Discrimination Learning in the Fear-Potentiated Startle Paradigm: Possible Relevance to Inhibitory Fear Learning in ExtinctionThe neural mechanisms of fear suppression most commonly are studied through
the use of extinction, a behavioral procedure in which a feared stimulus
(i.e., one previously paired with shock) is nonreinforced repeatedly, leading
to a reduction or elimination of the fear response. Although extinction is
perhaps the most convenient index of fear inhibition, a great deal of
behavioral work sugg... ...
Learning and Memory - Tập 11 Số 4 - Trang 464-475 - 2004
Amyloid beta mediates memory formationThe amyloid precursor protein (APP) undergoes sequential cleavages to generate various polypeptides, including the amyloid β (1–42) peptide (Aβ[1–42]), which is believed to play a major role in amyloid plaque formation in Alzheimer's disease (AD). Here we provide evidence that, in contrast with its pathological role when accumulated, endogenous Aβ in normal hippocampi mediates learning and... ...
Learning and Memory - Tập 16 Số 4 - Trang 267-272 - 2009
CREB down-regulation in the laterodorsal thalamic nucleus deteriorates memory consolidation in ratsThe laterodorsal thalamic nucleus (LD) is believed to play roles in learning and memory, especially spatial tasks. However, the molecular mechanism that underlies the cognitive process in the LD remains unclear and needs to be investigated. So far, there is plenty of evidence indicating that plasticity has been in some of the cortical or subcortical regions closely related to the LD, parti... ...
Learning and Memory - Tập 26 Số 6 - Trang 182-186 - 2019
Enhanced Human Memory Consolidation With Post-Learning Stress: Interaction With the Degree of Arousal at EncodingAbundant evidence indicates that endogenous stress hormones such as
epinephrine and corticosterone modulate memory consolidation in animals. We
recently provided the first demonstration that an endogenous stress hormone
(epinephrine) can enhance human memory consolidation. However, these findings
also suggested that post-learning stress hormone activation does not uniformly
enhance memory ... ...
Learning and Memory - Tập 10 Số 4 - Trang 270-274 - 2003
Stress modulates the use of spatial versus stimulus-response learning strategies in humansAnimal studies provided evidence that stress modulates multiple memory systems, favoring caudate nucleus-based “habit” memory over hippocampus-based “cognitive” memory. However, effects of stress on learning strategy and memory consolidation were not differentiated. We specifically address the effects of psychosocial stress on the applied learning strategy in humans. We designed a spatial ... ...
Learning and Memory - Tập 14 Số 1-2 - Trang 109-116 - 2007
Sex influences on the neurobiology of learning and memoryIn essentially every domain of neuroscience, the generally implicit assumption that few, if any, meaningful differences exist between male and female brain function is being challenged. Here we address how this development is influencing studies of the neurobiology of learning and memory. While it has been commonly held that males show an advantage on spatial tasks, and females on verbal t... ...
Learning and Memory - Tập 16 Số 4 - Trang 248-266 - 2009
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