Amyloid beta mediates memory formation

Learning and Memory - Tập 16 Số 4 - Trang 267-272 - 2009
Ana García‐Osta1, Cristina M. Alberini2
1Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
2Neural Science

Tóm tắt

The amyloid precursor protein (APP) undergoes sequential cleavages to generate various polypeptides, including the amyloid β (1–42) peptide (Aβ[1–42]), which is believed to play a major role in amyloid plaque formation in Alzheimer's disease (AD). Here we provide evidence that, in contrast with its pathological role when accumulated, endogenous Aβ in normal hippocampi mediates learning and memory formation. Furthermore, hippocampal injection of picomolar concentrations of exogenous Aβ(1–42) enhances memory consolidation. Correlative data suggest that Aβ peptides may exert their function via nicotinic acethylcoline receptors. Hence, Aβ peptides, including Aβ(1–42), play an important physiological role in hippocampal memory formation.

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Learning and Memory

Tập 16 Số 4

267-272

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