Learning and Memory
SCIE-ISI SCOPUS (1994-2025)
1072-0502
1549-5485
Mỹ
Cơ quản chủ quản: Cold Spring Harbor Laboratory Press , COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Lĩnh vực:
Neuropsychology and Physiological PsychologyCellular and Molecular NeuroscienceCognitive Neuroscience
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Các bài báo tiêu biểu
Context and Behavioral Processes in Extinction: Table 1.
Tập 11 Số 5 - Trang 485-494 - 2004
This article provides a selective review and integration of the behavioral
literature on Pavlovian extinction. The first part reviews evidence that
extinction does not destroy the original learning, but instead generates new
learning that is especially context-dependent. The second part examines insights
provided by research on several related behavioral phenomena (the interference
paradigms, cond...
From Acquisition to Consolidation: On the Role of Brain-Derived Neurotrophic Factor Signaling in Hippocampal-Dependent Learning
Tập 9 Số 5 - Trang 224-237 - 2002
One of the most rigorously investigated problems in modern neuroscience is to
decipher the mechanisms by which experience-induced changes in the central
nervous system are translated into behavioral acquisition, consolidation,
retention, and subsequent recall of information. Brain-derived neurotrophic
factor (BDNF) has recently emerged as one of the most potent molecular mediators
of not only cent...
Enhanced Human Memory Consolidation With Post-Learning Stress: Interaction With the Degree of Arousal at Encoding
Tập 10 Số 4 - Trang 270-274 - 2003
Abundant evidence indicates that endogenous stress hormones such as epinephrine
and corticosterone modulate memory consolidation in animals. We recently
provided the first demonstration that an endogenous stress hormone (epinephrine)
can enhance human memory consolidation. However, these findings also suggested
that post-learning stress hormone activation does not uniformly enhance memory
for all ...
Sex influences on the neurobiology of learning and memory
Tập 16 Số 4 - Trang 248-266 - 2009
In essentially every domain of neuroscience, the generally implicit assumption
that few, if any, meaningful differences exist between male and female brain
function is being challenged. Here we address how this development is
influencing studies of the neurobiology of learning and memory. While it has
been commonly held that males show an advantage on spatial tasks, and females on
verbal tasks, th...
Different Training Procedures Recruit Either One or Two Critical Periods for Contextual Memory Consolidation, Each of Which Requires Protein Synthesis and PKA
Tập 5 Số 4 - Trang 365-374 - 1998
We have used a combined genetic and pharmacological approach to define the time
course of the requirement for protein kinase A (PKA) and protein synthesis in
long-term memory for contextual fear conditioning in mice. The time course of
amnesia in transgenic mice that express R(AB) and have genetically reduced PKA
activity in the hippocampus parallels that observed both in mice treated with
inhibit...
Spontaneous Recovery
Tập 11 Số 5 - Trang 501-509 - 2004
Spontaneous recovery from extinction is one of the most basic phenomena of
Pavlovian conditioning. Although it can be studied by using a variety of
designs, some procedures are better than others for identifying the involvement
of underlying learning processes. A wide range of different learning mechanisms
has been suggested as being engaged by extinction, most of which have
implications for the n...
Running is the neurogenic and neurotrophic stimulus in environmental enrichment
Tập 18 Số 9 - Trang 605-609 - 2011
Environmental enrichment (EE) increases dentate gyrus (DG) neurogenesis and
brain-derived neurotrophic factor (BDNF) levels. However, running is considered
an element of EE. To dissociate effects of physical activity and enrichment on
hippocampal neurogenesis and BDNF levels, young female C57Bl/6 mice were housed
under control, running, enrichment, or enrichment plus running conditions, and
inject...
Working memory, long-term memory, and medial temporal lobe function
Tập 19 Số 1 - Trang 15-25 - 2012
Early studies of memory-impaired patients with medial temporal lobe (MTL) damage
led to the view that the hippocampus and related MTL structures are involved in
the formation of long-term memory and that immediate memory and working memory
are independent of these structures. This traditional idea has recently been
revisited. Impaired performance in patients with MTL lesions on tasks with short
re...
Environmental Enrichment Modifies the PKA-Dependence of Hippocampal LTP and Improves Hippocampus-Dependent Memory
Tập 8 Số 1 - Trang 26-34 - 2001
cAMP-dependent protein kinase (PKA) is critical for the expression of some forms
of long-term potentiation (LTP) in area CA1 of the mouse hippocampus and for
hippocampus-dependent memory. Exposure to spatially enriched environments can
modify LTP and improve behavioral memory in rodents, but the molecular bases for
the enhanced memory performance seen in enriched animals are undefined. We
tested t...
Different mechanisms of fear extinction dependent on length of time since fear acquisition
Tập 13 Số 2 - Trang 216-223 - 2006
Fear extinction is defined as a decline in conditioned fear responses (CRs)
following nonreinforced exposure to a feared conditioned stimulus (CS).
Behavioral evidence indicates that extinction is a form of inhibitory learning:
Extinguished fear responses reappear with the passage of time (spontaneous
recovery), a shift of context (renewal), and unsignaled presentations of the
unconditioned stimul...