Kinetoplastid Biology and Disease
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Species concepts for trypanosomes: from morphological to molecular definitions?
Kinetoplastid Biology and Disease - Tập 2 - Trang 1-6 - 2003
The way species and subspecies names are applied in African trypanosomes of
subgenera Trypanozoon and Nannomonas is reviewed in the light of data from
molecular taxonomy. In subgenus Trypanozoon the taxonomic importance of
pathogenicity, host range and distribution appear to have been inflated relative
to actual levels of genetic divergence. The opposite is true for subgenus
Nannomonas, where curr...
Evaluation of a polymerase chain reaction assay for the diagnosis of bovine trypanosomiasis and epidemiological surveillance in Bolivia
Kinetoplastid Biology and Disease - Tập 2 - Trang 1-14 - 2003
Sporadic outbreaks of bovine trypanosomiasis have been reported in Bolivia since
1996 when T. vivax and T. evansi were identified for the first time by
parasitological means. However, comprehensive epidemiological information
concerning T. vivax and T. evansi in the country is lacking. Current
parasitological and serological diagnostic methods for trypanosomiasis have
important limitations either ...
The cysteine proteinase inhibitor Z-Phe-Ala-CHN2 alters cell morphology and cell division activity of Trypanosoma brucei bloodstream forms in vivo
Kinetoplastid Biology and Disease - Tập 6 - Trang 1-6 - 2007
Current chemotherapy of human African trypanosomiasis or sleeping sickness
relies on drugs developed decades ago, some of which show toxic side effects.
One promising line of research towards the development of novel
anti-trypanosomal drugs are small-molecule inhibitors of Trypanosoma brucei
cysteine proteinases. In this study, we demonstrate that treatment of T.
brucei-infected mice with the inhi...
Chagas' disease and AIDS
Kinetoplastid Biology and Disease - Tập 3 - Trang 1-6 - 2004
Chagas' disease caused by Trypanosoma cruzi is an opportunistic infection in the
setting of HIV/AIDS. Some individuals with HIV and chronic T. cruzi infection
may experience a reactivation, which is most commonly manifested by
meningoencephalitis. A reactivation myocarditis is the second most common
manifestation. These presentations may be difficult to distinguish from
toxoplasmosis in individual...
Dự án Transcriptome của Trypanosoma rangeli: Tạo ra và phân tích các thẻ chuỗi biểu hiện Dịch bởi AI
Kinetoplastid Biology and Disease - - 2004
Trypanosoma rangeli là một loài động vật nguyên sinh gây bệnh quan trọng đối với
nhiều loài động vật có vú ở các vùng Trung và Nam Mỹ, chia sẻ khu vực địa lý,
véc tơ và bể chứa với T. cruzi, tác nhân gây bệnh Chagas. Do đó, sự xuất hiện
của các nhiễm trùng đơn lẻ và/hoặc hỗn hợp, bao gồm ở người, phải được dự kiến
và có tầm quan trọng lớn cho chẩn đoán chuyên biệt và dịch tễ học. So với nhiều
loài...
#Trypanosoma rangeli #hemoflagellate #Chagas disease #gene discovery #transcriptome #expressed sequence tags #epimastigote #trypomastigote
Application of Direct Agglutination Test (DAT) and Fast Agglutination Screening Test (FAST) for sero-diagnosis of visceral leishmaniasis in endemic area of Minas Gerais, Brazil
Kinetoplastid Biology and Disease - - 2005
The direct agglutination test (DAT) has proved to be a very important
sero-diagnostic tool combining high levels of intrinsic validity and ease of
performance. Otherwise, fast agglutination screening test (FAST) utilises only
one serum dilution making the test very suitable for the screening of large
populations. We have tested FAST and DAT for the detection anti-Leishmania
antibodies in serum sam...
A method for the identification of guinea pig blood meal in the Chagas disease vector, Triatoma infestans
Kinetoplastid Biology and Disease - Tập 6 - Trang 1-6 - 2007
In a SINE-based PCR assay, a primer set specific for guinea pig genome short
interspersed elements DNA was used to test the utility of genomic markers for
identifying the source of vertebrate blood meals of Triatoma infestans. The
investigation consisted of two assays. In Assay 1, thirty-six insects, collected
from the Province of Zudáñez in Chuquisaca, Bolivia were frozen 1–40 hours after
feeding...
What can we hope to gain for trypanosomiasis control from molecular studies on tsetse biology ?
Kinetoplastid Biology and Disease - Tập 1 Số 1 - Trang 1-8 - 2002
At times of crisis when epidemics rage and begin to take their toll on affected
populations, as we have been witnessing with African trypanosomiasis in
subSahara, the dichotomy of basic versus applied research deepens. While
undoubtedly the treatment of thousands of infected people is the top priority,
without continued research and development on the biology of disease agents and
on ecological an...
In vitro growth inhibition of bloodstream forms of Trypanosoma brucei and Trypanosoma congolenseby iron chelators
Kinetoplastid Biology and Disease - Tập 5 - Trang 1-5 - 2006
African trypanosomes exert significant morbidity and mortality in man and
livestock. Only a few drugs are available for the treatment of trypanosome
infections and therefore, the development of new anti-trypanosomal agents is
required. Previously it has been shown that bloodstream-form trypanosomes are
sensitive to the iron chelator deferoxamine. In this study the effect of 13 iron
chelators on th...
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