Kinetoplastid Biology and Disease
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Species concepts for trypanosomes: from morphological to molecular definitions?
Kinetoplastid Biology and Disease - Tập 2 - Trang 1-6 - 2003
The way species and subspecies names are applied in African trypanosomes of subgenera Trypanozoon and Nannomonas is reviewed in the light of data from molecular taxonomy. In subgenus Trypanozoon the taxonomic importance of pathogenicity, host range and distribution appear to have been inflated relative to actual levels of genetic divergence. The opposite is true for subgenus Nannomonas, where curr......
Evaluation of a polymerase chain reaction assay for the diagnosis of bovine trypanosomiasis and epidemiological surveillance in Bolivia
Kinetoplastid Biology and Disease - Tập 2 - Trang 1-14 - 2003
Sporadic outbreaks of bovine trypanosomiasis have been reported in Bolivia since 1996 when T. vivax and T. evansi were identified for the first time by parasitological means. However, comprehensive epidemiological information concerning T. vivax and T. evansi in the country is lacking. Current parasitological and serological diagnostic methods for trypanosomiasis have important limitations either ......
The cysteine proteinase inhibitor Z-Phe-Ala-CHN2 alters cell morphology and cell division activity of Trypanosoma brucei bloodstream forms in vivo
Kinetoplastid Biology and Disease - Tập 6 - Trang 1-6 - 2007
Current chemotherapy of human African trypanosomiasis or sleeping sickness relies on drugs developed decades ago, some of which show toxic side effects. One promising line of research towards the development of novel anti-trypanosomal drugs are small-molecule inhibitors of Trypanosoma brucei cysteine proteinases. In this study, we demonstrate that treatment of T. brucei-infected mice with the inhi......
Chagas' disease and AIDS
Kinetoplastid Biology and Disease - Tập 3 - Trang 1-6 - 2004
Chagas' disease caused by Trypanosoma cruzi is an opportunistic infection in the setting of HIV/AIDS. Some individuals with HIV and chronic T. cruzi infection may experience a reactivation, which is most commonly manifested by meningoencephalitis. A reactivation myocarditis is the second most common manifestation. These presentations may be difficult to distinguish from toxoplasmosis in individual......
Dự án Transcriptome của Trypanosoma rangeli: Tạo ra và phân tích các thẻ chuỗi biểu hiện Dịch bởi AI
Kinetoplastid Biology and Disease - - 2004
Trypanosoma rangeli là một loài động vật nguyên sinh gây bệnh quan trọng đối với nhiều loài động vật có vú ở các vùng Trung và Nam Mỹ, chia sẻ khu vực địa lý, véc tơ và bể chứa với T. cruzi, tác nhân gây bệnh Chagas. Do đó, sự xuất hiện của các nhiễm trùng đơn lẻ và/hoặc hỗn hợp, bao gồm ở người, phải được dự kiến và có tầm quan trọng lớn cho chẩn đoán chuyên biệt và dịch tễ học. So với nhiều loài......
#Trypanosoma rangeli #hemoflagellate #Chagas disease #gene discovery #transcriptome #expressed sequence tags #epimastigote #trypomastigote
Application of Direct Agglutination Test (DAT) and Fast Agglutination Screening Test (FAST) for sero-diagnosis of visceral leishmaniasis in endemic area of Minas Gerais, Brazil
Kinetoplastid Biology and Disease - - 2005
The direct agglutination test (DAT) has proved to be a very important sero-diagnostic tool combining high levels of intrinsic validity and ease of performance. Otherwise, fast agglutination screening test (FAST) utilises only one serum dilution making the test very suitable for the screening of large populations. We have tested FAST and DAT for the detection anti-Leishmania antibodies in serum sam......
A method for the identification of guinea pig blood meal in the Chagas disease vector, Triatoma infestans
Kinetoplastid Biology and Disease - Tập 6 - Trang 1-6 - 2007
In a SINE-based PCR assay, a primer set specific for guinea pig genome short interspersed elements DNA was used to test the utility of genomic markers for identifying the source of vertebrate blood meals of Triatoma infestans. The investigation consisted of two assays. In Assay 1, thirty-six insects, collected from the Province of Zudáñez in Chuquisaca, Bolivia were frozen 1–40 hours after feeding......
What can we hope to gain for trypanosomiasis control from molecular studies on tsetse biology ?
Kinetoplastid Biology and Disease - Tập 1 Số 1 - Trang 1-8 - 2002
At times of crisis when epidemics rage and begin to take their toll on affected populations, as we have been witnessing with African trypanosomiasis in subSahara, the dichotomy of basic versus applied research deepens. While undoubtedly the treatment of thousands of infected people is the top priority, without continued research and development on the biology of disease agents and on ecological an......
In vitro growth inhibition of bloodstream forms of Trypanosoma brucei and Trypanosoma congolenseby iron chelators
Kinetoplastid Biology and Disease - Tập 5 - Trang 1-5 - 2006
African trypanosomes exert significant morbidity and mortality in man and livestock. Only a few drugs are available for the treatment of trypanosome infections and therefore, the development of new anti-trypanosomal agents is required. Previously it has been shown that bloodstream-form trypanosomes are sensitive to the iron chelator deferoxamine. In this study the effect of 13 iron chelators on th......
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