Journal of extracellular vesicles

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An experimental strategy unveiling exosomal microRNAs 486‐5p, 181a‐5p and 30d‐5p from hypoxic tumour cells as circulating indicators of high‐risk rectal cancer
Journal of extracellular vesicles - Tập 8 Số 1 - 2019
Tonje Bjørnetrø, Kathrine Røe Redalen, Sebastian Meltzer, Nirujah Sivarajah Thusyanthan, Rampradeep Samiappan, Caroline Jegerschöld, K. Risberg Handeland, Anne Hansen Ree
ABSTRACTTumour hypoxia contributes to poor treatment outcome in locally advanced rectal cancer (LARC) and circulating extracellular vesicles (EVs) as potential biomarkers of tumour hypoxia and adverse prognosis have not been fully explored. We examined EV miRNAs from hypoxic colorectal cancer cell lines as template for relevant miRNAs in LARC patients participating in a prospective biomarker study... hiện toàn bộ
Prostate cancer extracellular vesicles mediate intercellular communication with bone marrow cells and promote metastasis in a cholesterol‐dependent manner
Journal of extracellular vesicles - Tập 10 Số 2 - 2020
Stephen E. Henrich, Kaylin M. McMahon, Michael P. Plebanek, Andrea E. Calvert, Timothy Joel Feliciano, Samuel K. Parrish, Fabio Tavora, Anthony Mega, André De Souza, Benedito A. Carneiro, C. Shad Thaxton
AbstractPrimary tumours can establish long‐range communication with distant organs to transform them into fertile soil for circulating tumour cells to implant and proliferate, a process called pre‐metastatic niche (PMN) formation. Tumour‐derived extracellular vesicles (EV) are potent mediators of PMN formation due to their diverse complement of pro‐malignant molecular cargo and their propensity to... hiện toàn bộ
Role of Mac‐1 integrin in generation of extracellular vesicles with antibacterial capacity from neutrophilic granulocytes
Journal of extracellular vesicles - Tập 9 Số 1 - 2020
Ákos M. Lőrincz, Balázs Bartos, Dávid Szombath, Viktòria Szeifert, Csaba I. Tímár, Lilla Turiák, László Drahos, Ágnes Kittel, Dániel Sándor Veres, Ferenc Kolonics, Attila Mócsai, Erzsébet Ligeti
ABSTRACTProduction of extracellular vesicles (EVs) involved in intercellular communication is a common capacity of most cell types. Upon encountering opsonized microorganisms, neutrophilic granulocytes release EVs that compromise bacterial growth. We carried out a systematic investigation of the involvement of potential opsonin receptors in EV‐generation from human and murine neutrophils. Applying... hiện toàn bộ
Sja‐miR‐71a in Schistosome egg‐derived extracellular vesicles suppresses liver fibrosis caused by schistosomiasis via targeting semaphorin 4D
Journal of extracellular vesicles - Tập 9 Số 1 - 2020
Lifu Wang, Yao Liao, Ruibing Yang, Zilong Yu, Lichao Zhang, Zifeng Zhu, Xiaoying Wu, Jia Shen, Jiahua Liu, Lian Xu, Zhongdao Wu, Xi Sun
ABSTRACTSchistosomiasis is characterized by liver fibrosis, and studies have indicated that Schistosoma japonicum (S. japonicum) eggs can limit the progression of liver fibrosis. However, the detailed molecular mechanisms are yet unclear. Extracellular vesicles (EVs) contain a selection of miRNAs for long‐distance exchange of information and act as an important pathway for host‐parasite communicat... hiện toàn bộ
Evaluation of circulating small extracellular vesicles derived miRNAs as biomarkers of early colon cancer: a comparison with plasma total miRNAs
Journal of extracellular vesicles - Tập 8 Số 1 - 2019
Li Min, Shengtao Zhu, Lei Chen, Xiang Liu, Rui Wei, Libo Zhao, Yuqing Yang, Zheng Zhang, Guanyi Kong, Peng Li, Shutian Zhang
ABSTRACTEarly diagnosis of colon cancer (CC) is clinically important, as it can significantly improve patients' survival rate and quality of life. Although the potential role for small extracellular vesicles (sEVs) in early detection of many diseases has been repeatedly mentioned, systematic screening of plasma sEVs derived early CC specific biomarkers has not yet been reported. In this work, plas... hiện toàn bộ
MiR155‐5p in adventitial fibroblasts‐derived extracellular vesicles inhibits vascular smooth muscle cell proliferation via suppressing angiotensin‐converting enzyme expression
Journal of extracellular vesicles - Tập 9 Số 1 - 2020
Xingsheng Ren, Ying Tong, Yun Qiu, Chao Ye, Nan Wu, Xiao‐Qing Xiong, Juejin Wang, Ying Han, Ye‐Bo Zhou, Feng Zhang, Hai‐Jian Sun, Xing‐Ya Gao, Qi Chen, Yuehua Li, Yu‐Ming Kang, Guo‐Qing Zhu
ABSTRACTProliferation of vascular smooth muscle cells (VSMCs) plays crucial roles in vascular remodelling and stiffening in hypertension. Vascular adventitial fibroblasts are a key regulator of vascular wall function and structure. This study is designed to investigate the roles of adventitial fibroblasts‐derived extracellular vesicles (EVs) in VSMC proliferation and vascular remodelling in normot... hiện toàn bộ
CD73+ extracellular vesicles inhibit angiogenesis through adenosine A2B receptor signalling
Journal of extracellular vesicles - Tập 9 Số 1 - 2020
Roberta Angioni, Cristina Liboni, Stéphanie Herkenne, Ricardo Sánchez‐Rodríguez, Giulia Borile, Elisabetta Marcuzzi, Bianca Calì, Maurizio Muraca, Antonella Viola
ABSTRACTPathological angiogenesis is a hallmark of several conditions including eye diseases, inflammatory diseases, and cancer. Stromal cells play a crucial role in regulating angiogenesis through the release of soluble factors or direct contact with endothelial cells. Here, we analysed the properties of the extracellular vesicles (EVs) released by bone marrow mesenchymal stromal cells (MSCs) and... hiện toàn bộ
Erratum: Arrdc4-dependent extracellular vesicle biogenesis is required for sperm maturation.
Journal of extracellular vesicles - - 2021
[This corrects the article DOI: 10.1002/jev2.12113.].
WJMSC‐derived small extracellular vesicle enhance T cell suppression through PD‐L1
Journal of extracellular vesicles - Tập 10 Số 4 - 2021
Meizhang Li, Rupal P. Soder, Sunil Abhyankar, Haitham Abdelhakim, Mitchell W. Braun, Camille V. Trinidad, Harsh B. Pathak, Ziyan Y. Pessetto, Clayton Deighan, Siddhartha Ganguly, Buddhadeb Dawn, Joseph P. McGuirk, Neil Dunavin, Andrew K. Godwin
AbstractBoth mesenchymal stem cells (MSCs) and their corresponding small extracellular vesicles (sEVs, commonly referred to as exosomes) share similar immunomodulatory properties that are potentially beneficial for the treatment of acute graft versus host disease (aGvHD). We report that clinical grade Wharton's Jelly‐derived MSCs (WJMSCs) secrete sEVs enriched in programmed death‐ligand 1 (PD‐L1),... hiện toàn bộ
Neutral sphingomyelinases control extracellular vesicles budding from the plasma membrane
Journal of extracellular vesicles - Tập 6 Số 1 - 2017
Kerstin Menck, Can Sönmezer, Thomas Worst, Matthias Schulz, Gry H. Dihazi, Frank Streit, Gerrit Erdmann, Simon Kling, Michael Boutros, Claudia R. Binder, Julia Christina Gross
ABSTRACTExtracellular vesicles (EVs) are membrane particles secreted from cells into all body fluids. Several EV populations exist differing in size and cellular origin. Using differential centrifugation EVs pelleting at 14,000 g (“microvesicles” (MV)) and 100,000 g (“exosomes”) are distinguishable by protein markers. Neutral sphingomyelinase (nSMase) inhibition has been shown to inhibit exosome r... hiện toàn bộ
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