Sja‐miR‐71a in Schistosome egg‐derived extracellular vesicles suppresses liver fibrosis caused by schistosomiasis via targeting semaphorin 4D

Journal of extracellular vesicles - Tập 9 Số 1 - 2020
Lifu Wang1,2,3,4, Yao Liao1,2,3,4, Ruibing Yang5,4, Zilong Yu6,4, Lichao Zhang1,2,3, Zifeng Zhu1,2,3, Xiaoying Wu7, Jia Shen1,2,3, Jiahua Liu1,2,3, Lian Xu8, Zhongdao Wu1,2,3, Xi Sun1,2,3
1Department of Parasitology of Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
2Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-sen University, Guangzhou, China
3Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China
4these authors contributed equally to this work
5Medical Department of Xizang Minzu University, Xianyang, China
6Guangdong second provincial general Hospital, Guangzhou, China
7The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
8Nantong University, Nantong, China

Tóm tắt

ABSTRACT

Schistosomiasis is characterized by liver fibrosis, and studies have indicated that Schistosoma japonicum (S. japonicum) eggs can limit the progression of liver fibrosis. However, the detailed molecular mechanisms are yet unclear. Extracellular vesicles (EVs) contain a selection of miRNAs for long‐distance exchange of information and act as an important pathway for host‐parasite communication. This study aimed to explore the potential role of S. japonicum egg‐derived EVs and its key miRNA in liver fibrosis. Herein, we found that S. japonicum egg‐derived EVs can inhibit the activation of hepatic stellate cells, which is mediated via the high expression of Sja‐miR‐71a. Sja‐miR‐71a in EVs attenuates the pathological progression and liver fibrosis in S. japonicum infection. Sja‐miR‐71a inhibiting TGF‐β1/SMAD and interleukin (IL)‐13/STAT6 pathways via directly targeting semaphorin 4D (Sema4D). In addition, Sja‐miR‐71a can also suppress liver fibrosis by regulating Th1/Th2/Th17 and Treg balance. This study contributes to further understanding of the molecular mechanisms underlying Schistosoma‐host interactions, and Sema4D may be a potential target for schistosomiasis liver fibrosis treatment.

Từ khóa


Tài liệu tham khảo

10.1073/pnas.1708578114

10.1371/journal.pone.0068479

10.1016/j.exppara.2009.12.009

10.1371/journal.pntd.0005268

10.1038/srep30957

10.1371/journal.pntd.0003106

10.1080/20013078.2019.1698889

10.1016/j.jhep.2019.09.014

10.1016/j.jprot.2014.02.012

10.3389/fimmu.2018.00850

Ding J, 2019, miRNA‐seq of Echinococcus multilocularis extracellular vesicles and immunomodulatory effects of miR‐4989, Front Microbiol, 10, 2707, 10.3389/fmicb.2019.02707

10.1080/20013078.2019.1578116

10.1038/ncomms6488

10.1007/s00436-015-4373-7

Meningher T, 2016, Schistosomal MicroRNAs isolated from extracellular vesicles in sera of infected patients: a new tool for diagnosis and follow‐up of human schistosomiasis, J Infect Dis, 215, 378

10.1038/srep25885

10.3402/jev.v4.28665

10.1038/s41598-018-21587-4

10.1371/journal.ppat.1007817

10.1186/s13071-016-1845-2

10.15252/embr.201947882

10.1038/s41556-018-0250-9

10.1080/20013078.2019.1698795

10.1016/j.cell.2009.01.002

10.1080/20013078.2017.1401897

10.1080/20013078.2019.1643670

10.1002/hep.27671

10.1016/j.ijpara.2017.05.007

10.1016/j.intimp.2019.01.007

10.1007/s00011-016-0983-5

10.18632/oncotarget.24277

10.1016/j.molimm.2013.05.228

10.1016/j.ejphar.2016.11.018

10.3748/wjg.v19.i9.1405

10.1038/nri3545

10.1038/ni.1731

10.1086/510313

10.1371/journal.pone.0039307

10.1111/imr.12029

10.1016/j.ijpara.2013.11.003

10.1016/j.actatropica.2019.05.004

He X, A schistosome miRNA promotes host hepatic fibrosis by targeting transforming growth factor beta receptor III, J Hepatol

10.1038/s41598-019-41800-2

10.1038/srep23550

10.1016/j.drudis.2019.06.010

Samoil V, 2018, Vesicle‐based secretion in schistosomes: analysis of protein and microRNA (miRNA) content of exosome‐like vesicles derived from Schistosoma mansoni, Sci Rep, 8, 1, 10.1038/s41598-018-21587-4

10.1016/j.ijpara.2015.06.002

10.4161/rna.23716

10.1016/j.jhep.2015.08.026

Attisano L, 2002, Signal transduction by the TGF‐β superfamily, Science, 296, 10.1126/science.1071809

10.1016/S0002-9440(10)62324-3

10.1369/0022155415627681

10.1084/jem.20040104

10.1183/09059180.00007609

10.1016/j.immuni.2012.05.026

10.1111/j.0105-2896.2004.00176.x

10.1111/imm.12105

10.1038/nm1332

Thông tin
Thông tin xuất bản

Journal of extracellular vesicles

Tập 9 Số 1

Thông tin tác giả