Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines Tập 7 Số 1 - 2018
Clotilde Théry, Kenneth W. Witwer, Elena Aïkawa, María José Alcaraz, Johnathon D. Anderson, Ramaroson Andriantsitohaina, Anna Antoniou, Tanina Arab, Fabienne Archer, Georgia K. Atkin‐Smith, D. Craig Ayre, Jean‐Marie Bach, Daniel Bachurski, Hossein Baharvand, Leonora Balaj, Shawn Baldacchino, Natalie Bauer, Amy A. Baxter, Mary Bebawy, Carla Beckham, Apolonija Bedina Zavec, Abderrahim Benmoussa, Anna C. Berardi, Paolo Bergese, Ewa Bielska, Cherie Blenkiron, Sylwia Bobis‐Wozowicz, Éric Boilard, Wilfrid Boireau, Antonella Bongiovanni, Francesc E. Borràs, Steffi Bösch, Chantal M. Boulanger, Xandra O. Breakefield, Andrew Breglio, Meadhbh Á. Brennan, David R. Brigstock, Alain Brisson, Marike L. D. Broekman, Jacqueline Bromberg, Paulina Bryl‐Górecka, Shilpa Buch, Amy H. Buck, Dylan Burger, Sara Busatto, Dominik Buschmann, Benedetta Bussolati, Edit I. Buzás, James Brian Byrd, Giovanni Camussi, David R. F. Carter, Sarah Caruso, Lawrence W. Chamley, Yu‐Ting Chang, Chihchen Chen, Daiwen Chen, Lesley Cheng, Aled Clayton, Stefano Piatto Clerici, Alex Cocks, Emanuele Cocucci, Anabela Cordeiro‐da‐Silva, Yvonne Couch, Frank A. W. Coumans, Beth Coyle, Rossella Crescitelli, Miriã Ferreira Criado, Crislyn D’Souza‐Schorey, Saumya Das, Amrita Datta Chaudhuri, Paola de Candia, Eliezer F De Santana, Olivier De Wever, Hernando A. del Portillo, Tanguy Demaret, Sarah Deville, Andrew Devitt, Bert Dhondt, Dolores Di Vizio, Lothar C. Dieterich, Vincenza Dolo, Ana Paula Domínguez Rubio, Massimo Dominici, Maurício Rocha Dourado, Tom A. P. Driedonks, Filipe V. Duarte, Heather M. Duncan, Ramon M. Eichenberger, Karin M. Ekström, Samir EL Andaloussi, Céline Elie-Caille, Uta Erdbrügger, Juan Manuel Falcón‐Pérez, Farah Fatima, Jason E. Fish, Miguel Flores‐Bellver, András Försönits, Annie Frelet-Barrand, Fabia Fricke, Gregor Fuhrmann, Susanne Gabrielsson, Ana Gámez‐Valero, Chris Gardiner, Kathrin Gärtner, Raphaël Gaudin, Yong Song Gho, Bernd Giebel, Caroline Gilbert, Mario Gimona, Ilaria Giusti, Deborah C. I. Goberdhan, André Görgens, Sharon M. Gorski, David W. Greening, Julia Christina Gross, Alice Gualerzi, Gopal N. Gupta, Dakota Gustafson, Aase Handberg, Reka A. Haraszti, Paul Harrison, Hargita Hegyesi, An Hendrix, Andrew F. Hill, Fred H. Hochberg, Karl F. Hoffmann, Beth Holder, Harry Holthöfer, Baharak Hosseinkhani, Guoku Hu, Yiyao Huang, Veronica Huber, Stuart Hunt, Ahmed Ibrahim, Tsuneya Ikezu, Jameel M. Inal, Mustafa Işın, Alena Ivanova, Hannah K Jackson, Søren Jacobsen, Steven M. Jay, Muthuvel Jayachandran, Guido Jenster, Lanzhou Jiang, Suzanne M. Johnson, Jennifer Jones, Ambrose Jong, Tijana Jovanović‐Talisman, Stephanie Jung, Raghu Kalluri, Shin‐ichi Kano, Sukhbir Kaur, Yumi Kawamura, Evan T. Keller, Delaram Khamari, Elena Khomyakova, Anastasia Khvorova, Peter Kierulf, Kwang Pyo Kim, Thomas Kislinger, Mikael Klingeborn, David J. Klinke, Miroslaw Kornek, Maja Kosanović, Árpád Ferenc Kovács, Eva‐Maria Krämer‐Albers, Susanne Krasemann, Mirja Krause, Igor V. Kurochkin, Gina D. Kusuma, Sören Kuypers, Saara Laitinen, Scott M. Langevin, Lucia R. Languino, Joanne Lannigan, Cecilia Lässer, Louise C. Laurent, Grégory Lavieu, Elisa Lázaro‐Ibáñez, Soazig Le Lay, Myung‐Shin Lee, Fiona Lee, Débora S. Lemos, Metka Lenassi, Aleksandra Leszczynska, Isaac T. S. Li, Ke Liao, Sten F.W.M. Libregts, Erzsébet Ligeti, Rebecca Lim, Sai Kiang Lim, Aija Linē, Karen Linnemannstöns, Alicia Llorente, Catherine Lombard, Magdalena J. Lorenowicz, Ákos M. Lőrincz, Jan Lötvall, Jason Lovett, Michelle C. Lowry, Xavier Loyer, Quan Lu, Barbara Łukomska, Taral R. Lunavat, Sybren L. N. Maas, Harmeet Malhi, Antonio Marcilla, Jacopo Mariani, Javier Mariscal, Elena S. Martens‐Uzunova, Lorena Martín‐Jaular, Dominique Meyer, Vilma R. Martins, Mathilde Mathieu, Suresh Mathivanan, Marco Maugeri, Lynda K. McGinnis, Mark J. McVey, David G. Meckes, Katie Meehan, Inge Mertens, Valentina R. Minciacchi, Andreas Möller, Maléne Møller Jørgensen, Aizea Morales‐Kastresana, Jess Morhayim, François Mullier, Maurizio Muraca, Luca Musante, Veronika Mussack, Dillon C. Muth, Kathryn H. Myburgh, Tanbir Najrana, Muhammad Nawaz, Irina Nazarenko, Peter Nejsum, Christian Néri, Tommaso Neri, Rienk Nieuwland, Leonardo Nimrichter, John P. Nolan, Esther Nm Nolte-'t Hoen, Nicole Noren Hooten, Lorraine O’Driscoll, Tina O’Grady, Ana O’Loghlen, Takahiro Ochiya, Martin Olivier, Alberto Ortíz, Luis A. Ortiz, Xabier Osteikoetxea, Ole Østergaard, Matías Ostrowski, Jaesung Park, D. Michiel Pegtel, Héctor Peinado, Francesca Perut, Michael W. Pfaffl, Donald G. Phinney, Bartijn C. H. Pieters, Ryan Pink, David S. Pisetsky, Elke Pogge von Strandmann, Iva Polakovičová, Ivan K. H. Poon, Bonita H. Powell, Ilaria Prada, Lynn Pulliam, Peter J. Quesenberry, Annalisa Radeghieri, Robert L. Raffaı̈, Stefania Raimondo, Janusz Rak, Marcel I. Ramirez, Graça Raposo, Morsi S Rayyan, Neta Regev‐Rudzki, Franz Ricklefs, Paul D. Robbins, David D. Roberts, Sílvia C. Rodrigues, Eva Rohde, Sophie Rome, Kasper M.A. Rouschop, Aurelia Rughetti, Ashley E. Russell, Paula Saá, Susmita Sahoo, Edison Salas‐Huenuleo, Catherine Sánchez, Julie A. Saugstad, Meike J. Saul, Raymond M. Schiffelers, Raphaël Schneider, Tine Hiorth Schøyen, Aaron Scott, Eriomina Shahaj, Shivani Sharma, Olga Shatnyeva, Faezeh Shekari, Ganesh Vilas Shelke, Ashok K. Shetty, Kiyotaka Shiba, Pia Siljander, Andreia Silva, Agata Skowronek, Orman L. Snyder, Rodrigo Pedro Soares, Barbara W. Sódar, Carolina Soekmadji, Javier Sotillo, Philip D. Stahl, Willem Stoorvogel, Shannon L. Stott, Erwin Strasser, Simon Swift, Hidetoshi Tahara, Muneesh Tewari, Kate Timms, Swasti Tiwari, Rochelle Tixeira, Mercedes Tkach, Wei Seong Toh, Richard Tomasini, Ana Cláudia Torrecilhas, Juan Pablo Tosar, Vasilis Toxavidis, Lorena Urbanelli, Pieter Vader, Bas W. M. van Balkom, Susanne G van der Grein, Jan Van Deun, Martijn J. C. van Herwijnen, Kendall Van Keuren‐Jensen, Guillaume van Niel, Martin E. van Royen, André J. van Wijnen, M. Helena Vasconcelos, Ivan J. Vechetti, Tiago Degani Veit, Laura J. Vella, Émilie Velot, Frederik J. Verweij, Beate Vestad, Jose Luis Viñas, Tamás Visnovitz, Krisztina V. Vukman, Jessica Wahlgren, Dionysios C. Watson, Marca H. M. Wauben, Alissa M. Weaver, Jason Webber, Viktoria Weber, Ann M. Wehman, Daniel J. Weiss, Joshua A Welsh, Sebastian Wendt, Åsa M. Wheelock, Zoltán Wiener, Leonie Witte, Joy Wolfram, Angeliki Xagorari, Patrícia Xander, Jing Xu, Xiaomei Yan, María Yáñez‐Mó, Hang Yin, Yuana Yuana, Valentina Zappulli, Jana Zárubová, Vytautas Žėkas, Jianye Zhang, Zezhou Zhao, Lei Zheng, Alexander R. Zheutlin, Antje M. Zickler, Pascale Zimmermann, Angela M. Zivkovic, Davide Zocco, Ewa Zuba‐Surma
ABSTRACTThe last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell‐released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV‐associated functional activities. Finally, a checklist is provided with summaries of key points.