Journal of Systems Chemistry
SCOPUS (2011-2015)
1759-2208
Cơ quản chủ quản: N/A
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Serial transfer can aid the evolution of autocatalytic setsAbstract
Background
The concept of an autocatalytic set of molecules has been posited theoretically and demonstrated empirically with catalytic RNA molecules. For this concept to have significance in a realistic origins-of-life scenario, it will be important to demonstrate the evolvability of suc... ...
- 2014
Systems chemistry: using thermodynamically controlled networks to assess molecular similarityAbstract
Background
The assessment of molecular similarity is a key step in the drug discovery process that has thus far relied almost exclusively on computational approaches. We now report an experimental method for similarity assessment based on dynamic combinatorial chemistry.
... ...
Tập 4 Số 1 - 2013
On the propagation of a conceptual error concerning hypercycles and cooperation
Tập 4 - Trang 1-4 - 2013
The hypercycle is a system of replicators, whose members are auto- and cross-catalytic: replication of each member is catalyzed by at least one other member of the system. Therefore, the kinetics of growth of every member is at least second order. In ecology such systems are called mutualistic whose members are cooperating with each other. The dynamics of such systems are described broadly by the ......
Synthesis of information-carrying polymers of mixed sequences from double stranded short deoxynucleotides
Tập 1 - Trang 1-16 - 2010
The "RNA World" hypothesis suggests that an early form of life on Earth was based on nucleic acid strands able to store genetic information and catalyze a wide range of reactions including those which lead to self-replication. For this hypothesis to be true there must exist an efficient process for creating RNA or RNA-like polymers of mixed sequences from short precursors, where these polymers hav......
Autocatalytic sets in a partitioned biochemical network
Tập 5 - Trang 1-18 - 2014
In previous work, RAF theory has been developed as a tool for making theoretical progress on the origin of life question, providing insight into the structure and occurrence of self-sustaining and collectively autocatalytic sets within catalytic polymer networks. We present here an extension in which there are two “independent” polymer sets, where catalysis occurs within and between the sets, but ......
Organoautocatalysis: Challenges for experiment and theory
Tập 1 - Trang 1-7 - 2010
Recent reports about enantioselective organoautocatalytic systems, in which small organic molecules assist in their own formation and under conservation of their absolute configuration, are discussed. This process, appearing as a natural extension to non-covalent enantioselective organocatalysis, seems analogous to template-directed self-replication, previously observed in simple organic molecules......
Pathway control in the self-construction of complex precipitation forms in a Cu(II)-oxalate system
Tập 3 - Trang 1-6 - 2012
Many biological systems contain complex precipitation patterns. These structures are considered to be the result of finely tuned and genetically encoded developmental pathways. The amount of encoded information needed to generate and manipulate these structures is poorly understood. Investigating the dynamics of spontaneous pattern formation in non-biological systems provides insights to the physi......
Design and synthesis of nucleolipids as possible activated precursors for oligomer formation via intramolecular catalysis: stability study and supramolecular organization
Tập 5 - Trang 1-23 - 2014
Fatty acid vesicles are an important part of protocell models currently studied. As protocells can be considered as pre-biological precursors of cells, the models try to contribute to a better understanding of the (cellular) origin of life and emphasize on 2 major aspects: compartmentalization and replication. It has been demonstrated that lipid-based membranes are amenable to growth and division ......