Journal of Systems Chemistry
1759-2208
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Các bài báo tiêu biểu
Serial transfer can aid the evolution of autocatalytic setsAbstract
Background
The concept of an autocatalytic set of molecules has been posited theoretically and demonstrated empirically with catalytic RNA molecules. For this concept to have significance in a realistic origins-of-life scenario, it will be important to demonstrate the evolvability of suc... ...
- 2014
Systems chemistry: using thermodynamically controlled networks to assess molecular similarityAbstract
Background
The assessment of molecular similarity is a key step in the drug discovery process that has thus far relied almost exclusively on computational approaches. We now report an experimental method for similarity assessment based on dynamic combinatorial chemistry.
... ...
Tập 4 Số 1 - 2013
On the propagation of a conceptual error concerning hypercycles and cooperation
Tập 4 - Trang 1-4 - 2013
The hypercycle is a system of replicators, whose members are auto- and cross-catalytic: replication of each member is catalyzed by at least one other member of the system. Therefore, the kinetics of growth of every member is at least second order. In ecology such systems are called mutualistic whose members are cooperating with each other. The dynamics of such systems are described broadly by the ......
Suitable energetic conditions for dynamic chemical complexity and the living state
Tập 3 - Trang 1-5 - 2012
Any living organism can be considered as a component of a dissipative process coupling an irreversible consumption of energy to the growth, reproduction and evolution of living things. Close interactions between metabolism and reproduction are thus required, which means that metabolism has two main functions. The first one, which is the most easily perceptible, corresponds to the synthesis of the ......
Pathway control in the self-construction of complex precipitation forms in a Cu(II)-oxalate system
Tập 3 - Trang 1-6 - 2012
Many biological systems contain complex precipitation patterns. These structures are considered to be the result of finely tuned and genetically encoded developmental pathways. The amount of encoded information needed to generate and manipulate these structures is poorly understood. Investigating the dynamics of spontaneous pattern formation in non-biological systems provides insights to the physi......
Unravelling a fulvene based Replicator: Experiment and Theory in Interplay
Tập 1 - Trang 1-6 - 2010
A self-replicating system based on a cycloaddition of a fulvene derivative and a maleinimide is investigated using a two-pronged approach combining NMR spectroscopy with computer simulations. In the course of the reaction, two diastereomers are formed with identical rates in the absence of replication. When replication is enabled, a network emerges in which one diastereomer takes over the resource......
Is the transition from chemistry to biology a mystery?
Tập 1 - Trang 1-11 - 2010
Today most chemists think that the answer to how life on earth emerged is still unknown. They assume a gap between chemistry and biology that is still unbridged. For chemists, understanding the origin of life requires the experimental modeling of a process that bridges this gap. They will not consider the problem solved before they are able to perform such tasks. No gap appears when we are pursuin......
On the divide between animate and inanimate
Tập 6 - Trang 1-3 - 2015
Vitalism was abandoned already for a long time ago, yet the impression that animate beings differ in some fundamental way from inanimate objects continues to thrive. Here, we argue that scale free patterns, found throughout nature, present convincing evidence that this demarcation is only imaginary. Therefore, all systems ought to be regarded alike, i.e., all are consuming free energy in least tim......