Alessandro Filisetti, Alex Graudenzi, Roberto Serra, Marco Villani, Davide De Lucrezia, Rudolf Marcel Füchslin, Stuart Kauffman, Norman H. Packard, Irene Poli
AbstractBackgroundThe concept of an autocatalytic set of molecules has been posited theoretically and demonstrated empirically with catalytic RNA molecules. For this concept to have significance in a realistic origins-of-life scenario, it will be important to demonstrate the evolvability of suc...... hiện toàn bộ
Vittorio Saggiomo, Yana R. Hristova, R. Frederick Ludlow, Sijbren Otto
AbstractBackgroundThe assessment of molecular similarity is a key step in the drug discovery process that has thus far relied almost exclusively on computational approaches. We now report an experimental method for similarity assessment based on dynamic combinatorial chemistry.
...... hiện toàn bộ
The hypercycle is a system of replicators, whose members are auto- and cross-catalytic: replication of each member is catalyzed by at least one other member of the system. Therefore, the kinetics of growth of every member is at least second order. In ecology such systems are called mutualistic whose members are cooperating with each other. The dynamics of such systems are described broadly by the ...... hiện toàn bộ
Vitalism was abandoned already for a long time ago, yet the impression that animate beings differ in some fundamental way from inanimate objects continues to thrive. Here, we argue that scale free patterns, found throughout nature, present convincing evidence that this demarcation is only imaginary. Therefore, all systems ought to be regarded alike, i.e., all are consuming free energy in least tim...... hiện toàn bộ
Grace Eckhoff, Vlad Codrea, Andrew D Ellington, Xi Chen
The programmability and replicability of RNA and DNA have respectively enabled the design and selection of a number of allosteric ribozymes and deoxyribozymes. These catalysts have been adapted to function as signal transducers in biosensors and biochemical reaction networks both in vitro and in vivo. However, allosteric control of nucleic acid catalysts is currently limited by the fact that one m...... hiện toàn bộ
Christoph Flamm, Alexander Ullrich, Heinz Ekker, Martin Mann, Daniel Högerl, Markus Rohrschneider, Sebastian Sauer, Gerik Scheuermann, Konstantin Klemm, Ivo L Hofacker, Peter F Stadler
The metabolic architectures of extant organisms share many key pathways such as the citric acid cycle, glycolysis, or the biosynthesis of most amino acids. Several competing hypotheses for the evolutionary mechanisms that shape metabolic networks have been discussed in the literature, each of which finds support from comparative analysis of extant genomes. Alternatively, the principles of metaboli...... hiện toàn bộ
The mathematical form of the energy-entropy relationship is that of the relationship between the difference and the ratio of any two 'entities' x and y creating a geometrical 3D projection x = y·z, i.e., a surface of the shape of a hyperbolic paraboloid being a particular form of a quadric. The significance of this relationship is discussed here in a realm beyond thermodynamics. Somewhat intuitive...... hiện toàn bộ
Olga Taran, Oliver Thoennessen, Karin Achilles, Günter von Kiedrowski
The "RNA World" hypothesis suggests that an early form of life on Earth was based on nucleic acid strands able to store genetic information and catalyze a wide range of reactions including those which lead to self-replication. For this hypothesis to be true there must exist an efficient process for creating RNA or RNA-like polymers of mixed sequences from short precursors, where these polymers hav...... hiện toàn bộ
Chỉ số ảnh hưởng
Số bài báo
25
Số trích dẫn
74
Avg. Citation
2.96
Impact Factor (IF)
0
H-index
4
H-index (5 năm)
4
i10
4
i10-index (5 năm)
0
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