Journal of Systems Chemistry
SCOPUS (2011-2015)
1759-2208
Cơ quản chủ quản: N/A
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Serial transfer can aid the evolution of autocatalytic sets
- 2014
Abstract Background The concept of an autocatalytic set of molecules has been
posited theoretically and demonstrated empirically with catalytic RNA molecules.
For this concept to have significance in a realistic origins-of-life scenario,
it will be important to demonstrate the evolvability of such sets. Here, we
employ a Gillespie algorithm to improve and expand on previous simulations of an
empir...
Systems chemistry: using thermodynamically controlled networks to assess molecular similarity
Tập 4 Số 1 - 2013
Abstract Background The assessment of molecular similarity is a key step in the
drug discovery process that has thus far relied almost exclusively on
computational approaches. We now report an experimental method for similarity
assessment based on dynamic combinatorial chemistry. Results In order to assess
molecular similarity directly in solution, a dynamic molecular network was used
in a two-ste...
Maximizing output and recognizing autocatalysis in chemical reaction networks is NP-complete
Tập 3 - Trang 1-9 - 2012
A classical problem in metabolic design is to maximize the production of a
desired compound in a given chemical reaction network by appropriately directing
the mass flow through the network. Computationally, this problem is addressed as
a linear optimization problem over the flux cone. The prior construction of the
flux cone is computationally expensive and no polynomial-time algorithms are
known....
Autocatalytic sets in a partitioned biochemical network
Tập 5 - Trang 1-18 - 2014
In previous work, RAF theory has been developed as a tool for making theoretical
progress on the origin of life question, providing insight into the structure
and occurrence of self-sustaining and collectively autocatalytic sets within
catalytic polymer networks. We present here an extension in which there are two
“independent” polymer sets, where catalysis occurs within and between the sets,
but ...
The relationship between difference and ratio and a proposal: Equivalence of temperature and time, and the first spontaneous symmetry breaking
Tập 1 - Trang 1-7 - 2010
The mathematical form of the energy-entropy relationship is that of the
relationship between the difference and the ratio of any two 'entities' x and y
creating a geometrical 3D projection x = y·z, i.e., a surface of the shape of a
hyperbolic paraboloid being a particular form of a quadric. The significance of
this relationship is discussed here in a realm beyond thermodynamics. Somewhat
intuitive...
Evolution of metabolic networks: a computational frame-work
Tập 1 - Trang 1-14 - 2010
The metabolic architectures of extant organisms share many key pathways such as
the citric acid cycle, glycolysis, or the biosynthesis of most amino acids.
Several competing hypotheses for the evolutionary mechanisms that shape
metabolic networks have been discussed in the literature, each of which finds
support from comparative analysis of extant genomes. Alternatively, the
principles of metaboli...
Design and synthesis of nucleolipids as possible activated precursors for oligomer formation via intramolecular catalysis: stability study and supramolecular organization
Tập 5 - Trang 1-23 - 2014
Fatty acid vesicles are an important part of protocell models currently studied.
As protocells can be considered as pre-biological precursors of cells, the
models try to contribute to a better understanding of the (cellular) origin of
life and emphasize on 2 major aspects: compartmentalization and replication. It
has been demonstrated that lipid-based membranes are amenable to growth and
division ...
Suitable energetic conditions for dynamic chemical complexity and the living state
Tập 3 - Trang 1-5 - 2012
Any living organism can be considered as a component of a dissipative process
coupling an irreversible consumption of energy to the growth, reproduction and
evolution of living things. Close interactions between metabolism and
reproduction are thus required, which means that metabolism has two main
functions. The first one, which is the most easily perceptible, corresponds to
the synthesis of the ...