Alessandro Filisetti, Alex Graudenzi, Roberto Serra, Marco Villani, Davide De Lucrezia, Rudolf Marcel Füchslin, Stuart Kauffman, Norman H. Packard, Irene Poli
AbstractBackgroundThe concept of an autocatalytic set of molecules has been posited theoretically and demonstrated empirically with catalytic RNA molecules. For this concept to have significance in a realistic origins-of-life scenario, it will be important to demonstrate the evolvability of suc...... hiện toàn bộ
Vittorio Saggiomo, Yana R. Hristova, R. Frederick Ludlow, Sijbren Otto
AbstractBackgroundThe assessment of molecular similarity is a key step in the drug discovery process that has thus far relied almost exclusively on computational approaches. We now report an experimental method for similarity assessment based on dynamic combinatorial chemistry.
...... hiện toàn bộ
The hypercycle is a system of replicators, whose members are auto- and cross-catalytic: replication of each member is catalyzed by at least one other member of the system. Therefore, the kinetics of growth of every member is at least second order. In ecology such systems are called mutualistic whose members are cooperating with each other. The dynamics of such systems are described broadly by the ...... hiện toàn bộ
Any living organism can be considered as a component of a dissipative process coupling an irreversible consumption of energy to the growth, reproduction and evolution of living things. Close interactions between metabolism and reproduction are thus required, which means that metabolism has two main functions. The first one, which is the most easily perceptible, corresponds to the synthesis of the ...... hiện toàn bộ
Agota Toth, Dezso Horvath, Akos Kukovecz, Maciej Maselko, Anne Baker, Shareen Ali, Jerzy Maselko
Many biological systems contain complex precipitation patterns. These structures are considered to be the result of finely tuned and genetically encoded developmental pathways. The amount of encoded information needed to generate and manipulate these structures is poorly understood. Investigating the dynamics of spontaneous pattern formation in non-biological systems provides insights to the physi...... hiện toàn bộ
Arne Dieckmann, Sabrina Beniken, Christian Lorenz, Nikos L Doltsinis, Günter von Kiedrowski
A self-replicating system based on a cycloaddition of a fulvene derivative and a maleinimide is investigated using a two-pronged approach combining NMR spectroscopy with computer simulations. In the course of the reaction, two diastereomers are formed with identical rates in the absence of replication. When replication is enabled, a network emerges in which one diastereomer takes over the resource...... hiện toàn bộ
Today most chemists think that the answer to how life on earth emerged is still unknown. They assume a gap between chemistry and biology that is still unbridged. For chemists, understanding the origin of life requires the experimental modeling of a process that bridges this gap. They will not consider the problem solved before they are able to perform such tasks. No gap appears when we are pursuin...... hiện toàn bộ
Vitalism was abandoned already for a long time ago, yet the impression that animate beings differ in some fundamental way from inanimate objects continues to thrive. Here, we argue that scale free patterns, found throughout nature, present convincing evidence that this demarcation is only imaginary. Therefore, all systems ought to be regarded alike, i.e., all are consuming free energy in least tim...... hiện toàn bộ
Chỉ số ảnh hưởng
Số bài báo
25
Số trích dẫn
74
Avg. Citation
2.96
Impact Factor (IF)
0
H-index
4
H-index (5 năm)
4
i10
4
i10-index (5 năm)
0
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