Journal of Systems Chemistry
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Systems chemistry: using thermodynamically controlled networks to assess molecular similarityAbstract
Background
The assessment of molecular similarity is a key step in the drug discovery process that has thus far relied almost exclusively on computational approaches. We now report an experimental method for similarity assessment based on dynamic combinatorial chemistry.
... ...
Journal of Systems Chemistry - Tập 4 Số 1 - 2013
Testing for adaptive signatures of amino acid alphabet evolution using chemistry space
Journal of Systems Chemistry - - 2014
Organoautocatalysis: Challenges for experiment and theory
Journal of Systems Chemistry - Tập 1 - Trang 1-7 - 2010
Recent reports about enantioselective organoautocatalytic systems, in which small organic molecules assist in their own formation and under conservation of their absolute configuration, are discussed. This process, appearing as a natural extension to non-covalent enantioselective organocatalysis, seems analogous to template-directed self-replication, previously observed in simple organic molecules......
Serial transfer can aid the evolution of autocatalytic setsAbstract
Background
The concept of an autocatalytic set of molecules has been posited theoretically and demonstrated empirically with catalytic RNA molecules. For this concept to have significance in a realistic origins-of-life scenario, it will be important to demonstrate the evolvability of suc... ...
Journal of Systems Chemistry - - 2014
Suitable energetic conditions for dynamic chemical complexity and the living state
Journal of Systems Chemistry - Tập 3 - Trang 1-5 - 2012
Any living organism can be considered as a component of a dissipative process coupling an irreversible consumption of energy to the growth, reproduction and evolution of living things. Close interactions between metabolism and reproduction are thus required, which means that metabolism has two main functions. The first one, which is the most easily perceptible, corresponds to the synthesis of the ......
Pathway control in the self-construction of complex precipitation forms in a Cu(II)-oxalate system
Journal of Systems Chemistry - Tập 3 - Trang 1-6 - 2012
Many biological systems contain complex precipitation patterns. These structures are considered to be the result of finely tuned and genetically encoded developmental pathways. The amount of encoded information needed to generate and manipulate these structures is poorly understood. Investigating the dynamics of spontaneous pattern formation in non-biological systems provides insights to the physi......
The relationship between difference and ratio and a proposal: Equivalence of temperature and time, and the first spontaneous symmetry breaking
Journal of Systems Chemistry - Tập 1 - Trang 1-7 - 2010
The mathematical form of the energy-entropy relationship is that of the relationship between the difference and the ratio of any two 'entities' x and y creating a geometrical 3D projection x = y·z, i.e., a surface of the shape of a hyperbolic paraboloid being a particular form of a quadric. The significance of this relationship is discussed here in a realm beyond thermodynamics. Somewhat intuitive......
Autocatalytic sets in E. coli metabolism
Journal of Systems Chemistry - Tập 6 - Trang 1-21 - 2015
A central unsolved problem in early evolution concerns self-organization towards higher complexity in chemical reaction networks. In theory, autocatalytic sets have useful properties to help model such transitions. Autocatalytic sets are chemical reaction systems in which molecules belonging to the set catalyze the synthesis of other members of the set. Given an external supply of starting molecul......
Is the transition from chemistry to biology a mystery?
Journal of Systems Chemistry - Tập 1 - Trang 1-11 - 2010
Today most chemists think that the answer to how life on earth emerged is still unknown. They assume a gap between chemistry and biology that is still unbridged. For chemists, understanding the origin of life requires the experimental modeling of a process that bridges this gap. They will not consider the problem solved before they are able to perform such tasks. No gap appears when we are pursuin......
Tổng số: 25
- 1
- 2
- 3