Journal of Neuroscience Research
SCIE-ISI SCOPUS (1975-2023)
1097-4547
0360-4012
Mỹ
Cơ quản chủ quản: WILEY , Wiley-Liss Inc.
Lĩnh vực:
Cellular and Molecular Neuroscience
Các bài báo tiêu biểu
Optimized survival of hippocampal neurons in B27‐supplemented neurobasal™, a new serum‐free medium combinationAbstract We have systematically optimized the concentrations of 20 components of a previously published serumfree medium (Brewer and Cotman, Brain Res 494: 65‐74, 1989) for survival of rat embryonic hippocampal neurons after 4 days in culture. This serum‐freemedium Supplement, B27, produced neuron survival above 60% independent of plating ... ...
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Curcumin có hiệu quả ức chế tạo ra fibril β-amyloid liên quan đến Alzheimer trong thí nghiệm in vitro Dịch bởi AI Trừu tượng Việc ức chế tích tụ peptide amyloid β (Aβ) và sự hình thành các sợi fibril β-amyloid (fAβ) từ Aβ, cũng như sự bất ổn của những fAβ đã hình thành trước đó trong hệ thần kinh trung ương, sẽ là những đích điều trị hấp dẫn để điều trị bệnh Alzheimer (AD). Chúng tôi đã báo cáo trước đây rằng axit nordihydroguaiaretic (NDGA) và các polyphenol liên quan đến rượu... ...
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#amyloid β-peptide; β-amyloid fibrils; nordihydroguaiaretic acid; wine-related polyphenols; curcumin; rosmarinic acid; Alzheimer's disease; in vitro studies
T‐lymphocyte entry into the central nervous systemAbstract The entry of T‐lymphocytes into the parenchyma of the central nervous system is a critical early feature in the pathogenesis of many experimental and spontaneously occurring immune‐mediated illnesses. The physiological mechanisms controlling this entry have not been elucidated. This study reports that T‐cell entry into the rat CNS appears to be primarily de... ...
Tập 28 Số 2 - Trang 254-260 - 1991
Microglia in health and diseaseAbstract Microglia, one of three glial cell types in the central nervous system (CNS), play an important role as resident immunocompetent and phagocytic cells in the CNS in the event of injury and disease. It was del Rio Hortega in 1927 who determined that microglia belong a distinct glial cell type apart from astrocytes and oligodendrocytes, and since 1970s there h... ...
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Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female ratAbstract The present study investigates the induction of neurogenesis, reduction of apoptosis, and promotion of basic fibroblast growth factor (bFGF) expression as possible mechanisms by which treatment of stroke with bone marrow stromal cells (MSCs) improves neurological functional recovery. Additionally, for the first time, we treated cerebral ischemia in female r... ...
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Serum‐free B27/neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum, and dentate gyrusAbstract Two fundamental questions about neuron cell culture were addressed. Can one serum‐free medium that was developed for optimum growth of hippocampal neurons support the growth of neurons from other regions of the brain? Is the region specific state of differentiation maintained in culture? To answer these questions, we isolated neurons from six other rat brai... ...
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Receptor‐mediated transcytosis of transferrin across the blood‐brain barrierAbstract The perfusion of rat brain with 125 I‐transferrin resulted in a receptor‐mediated uptake of transferrin into the endothelium of the blood‐brain barrier followed by its detecation in the brain. During a pulsechase experiment, 125 I‐transferrin accumulated in the endothelial cells during the pulse, with a decrease of th... ...
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Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: Transcription and neurotrophic factor down‐regulation and up‐regulation of apoptotic and pro‐inflammatory signalingAbstract Alterations in transcription, RNA editing, translation, protein processing, and clearance are a consistent feature of Alzheimer's disease (AD) brain. To extend our initial study (Alzheimer Reports [2000] 3:161‐167), RNA samples isolated from control and AD hippocampal cornu ammonis 1 (CA1) were analyzed for 12633 gene and expressed sequence tag (EST) expres... ...
Tập 70 Số 3 - Trang 462-473 - 2002
The interaction of circRNAs and RNA binding proteins: An important part of circRNA maintenance and functionAbstract The widespread expression of circular RNAs (circRNAs) is regarded as a feature of gene expression in highly diverged eukaryotes. Recent studies have shown that circRNAs can act as a miRNA sponge to repress miRNA function, participate in splicing of target genes, translate genes into protein and interact with RNA binding proteins (RBPs). RBPs are a broad cla... ...
Tập 98 Số 1 - Trang 87-97 - 2020
Peroxide detoxification by brain cellsAbstract Peroxides are generated continuously in cells that consume oxygen. Among the different peroxides, hydrogen peroxide is the molecule that is formed in highest quantities. In addition, organic hydroperoxides are synthesized as products of cellular metabolism. Generation and disposal of peroxides is a very important process in the human brain, because cells of... ...
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