Journal of Neuroscience Research

SCIE-ISI SCOPUS (1975-2023)

  1097-4547

  0360-4012

  Mỹ

Cơ quản chủ quản:  WILEY , Wiley-Liss Inc.

Lĩnh vực:
Cellular and Molecular Neuroscience

Các bài báo tiêu biểu

Optimized survival of hippocampal neurons in B27‐supplemented neurobasal™, a new serum‐free medium combination
Tập 35 Số 5 - Trang 567-576 - 1993
Gregory J. Brewer, John R. Torricelli, E K Evege, Paul J. Price
AbstractWe have systematically optimized the concentrations of 20 components of a previously published serumfree medium (Brewer and Cotman, Brain Res 494: 65‐74, 1989) for survival of rat embryonic hippocampal neurons after 4 days in culture. This serum‐freemedium Supplement, B27, produced neuron survival above 60% independent of plating ...... hiện toàn bộ
Curcumin có hiệu quả ức chế tạo ra fibril β-amyloid liên quan đến Alzheimer trong thí nghiệm in vitro Dịch bởi AI
Tập 75 Số 6 - Trang 742-750 - 2004
Kenjiro Ono, Kazuhiro Hasegawa, Hironobu Naiki, Masahito Yamada
Trừu tượngViệc ức chế tích tụ peptide amyloid β (Aβ) và sự hình thành các sợi fibril β-amyloid (fAβ) từ Aβ, cũng như sự bất ổn của những fAβ đã hình thành trước đó trong hệ thần kinh trung ương, sẽ là những đích điều trị hấp dẫn để điều trị bệnh Alzheimer (AD). Chúng tôi đã báo cáo trước đây rằng axit nordihydroguaiaretic (NDGA) và các polyphenol liên quan đến rượu...... hiện toàn bộ
#amyloid β-peptide; β-amyloid fibrils; nordihydroguaiaretic acid; wine-related polyphenols; curcumin; rosmarinic acid; Alzheimer's disease; in vitro studies
T‐lymphocyte entry into the central nervous system
Tập 28 Số 2 - Trang 254-260 - 1991
William F. Hickey, Benjamin Hsu, Hironobu Kimura
AbstractThe entry of T‐lymphocytes into the parenchyma of the central nervous system is a critical early feature in the pathogenesis of many experimental and spontaneously occurring immune‐mediated illnesses. The physiological mechanisms controlling this entry have not been elucidated. This study reports that T‐cell entry into the rat CNS appears to be primarily de...... hiện toàn bộ
Microglia in health and disease
Tập 81 Số 3 - Trang 302-313 - 2005
Seung Up Kim, Jean de Vellis
AbstractMicroglia, one of three glial cell types in the central nervous system (CNS), play an important role as resident immunocompetent and phagocytic cells in the CNS in the event of injury and disease. It was del Rio Hortega in 1927 who determined that microglia belong a distinct glial cell type apart from astrocytes and oligodendrocytes, and since 1970s there h...... hiện toàn bộ
Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat
Tập 73 Số 6 - Trang 778-786 - 2003
Jieli Chen, Yi Li, Mark Katakowski, Xiaoguang Chen, Lei Wang, Dunyue Lu, Mei Lü, Subhash C. Gautam, Michael Chopp
AbstractThe present study investigates the induction of neurogenesis, reduction of apoptosis, and promotion of basic fibroblast growth factor (bFGF) expression as possible mechanisms by which treatment of stroke with bone marrow stromal cells (MSCs) improves neurological functional recovery. Additionally, for the first time, we treated cerebral ischemia in female r...... hiện toàn bộ
Serum‐free B27/neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum, and dentate gyrus
Tập 42 Số 5 - Trang 674-683 - 1995
Gregory J. Brewer
AbstractTwo fundamental questions about neuron cell culture were addressed. Can one serum‐free medium that was developed for optimum growth of hippocampal neurons support the growth of neurons from other regions of the brain? Is the region specific state of differentiation maintained in culture? To answer these questions, we isolated neurons from six other rat brai...... hiện toàn bộ
Receptor‐mediated transcytosis of transferrin across the blood‐brain barrier
Tập 18 Số 2 - Trang 299-304 - 1987
Jordan B. Fishman, Joshua B. Rubin, J. V. Handrahan, James R. Connor, Richard E. Fine
AbstractThe perfusion of rat brain with 125I‐transferrin resulted in a receptor‐mediated uptake of transferrin into the endothelium of the blood‐brain barrier followed by its detecation in the brain. During a pulsechase experiment, 125I‐transferrin accumulated in the endothelial cells during the pulse, with a decrease of th...... hiện toàn bộ
Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: Transcription and neurotrophic factor down‐regulation and up‐regulation of apoptotic and pro‐inflammatory signaling
Tập 70 Số 3 - Trang 462-473 - 2002
Vittorio Colangelo, Jill R. Schurr, Melvyn J. Ball, Ricardo Palacios Peláez, Nicolás G. Bazán, Walter J. Lukiw
AbstractAlterations in transcription, RNA editing, translation, protein processing, and clearance are a consistent feature of Alzheimer's disease (AD) brain. To extend our initial study (Alzheimer Reports [2000] 3:161‐167), RNA samples isolated from control and AD hippocampal cornu ammonis 1 (CA1) were analyzed for 12633 gene and expressed sequence tag (EST) expres...... hiện toàn bộ
The interaction of circRNAs and RNA binding proteins: An important part of circRNA maintenance and function
Tập 98 Số 1 - Trang 87-97 - 2020
Jiankun Zang, Dan Lu, Chunxue Wang
AbstractThe widespread expression of circular RNAs (circRNAs) is regarded as a feature of gene expression in highly diverged eukaryotes. Recent studies have shown that circRNAs can act as a miRNA sponge to repress miRNA function, participate in splicing of target genes, translate genes into protein and interact with RNA binding proteins (RBPs). RBPs are a broad cla...... hiện toàn bộ
Peroxide detoxification by brain cells
Tập 79 Số 1-2 - Trang 157-165 - 2005
Ralf Dringen, Petra G. Pawlowski, Johannes Hirrlinger
AbstractPeroxides are generated continuously in cells that consume oxygen. Among the different peroxides, hydrogen peroxide is the molecule that is formed in highest quantities. In addition, organic hydroperoxides are synthesized as products of cellular metabolism. Generation and disposal of peroxides is a very important process in the human brain, because cells of...... hiện toàn bộ