Curcumin có hiệu quả ức chế tạo ra fibril β-amyloid liên quan đến Alzheimer trong thí nghiệm in vitro Dịch bởi AI Tập 75 Số 6 - Trang 742-750 - 2004
Kenjiro Ono, Kazuhiro Hasegawa, Hironobu Naiki, Masahito Yamada
Trừu tượngViệc ức chế tích tụ peptide amyloid β (Aβ) và sự hình thành các sợi fibril β-amyloid (fAβ) từ Aβ, cũng như sự bất ổn của những fAβ đã hình thành trước đó trong hệ thần kinh trung ương, sẽ là những đích điều trị hấp dẫn để điều trị bệnh Alzheimer (AD). Chúng tôi đã báo cáo trước đây rằng axit nordihydroguaiaretic (NDGA) và các polyphenol liên quan đến rượu...... hiện toàn bộ #amyloid β-peptide; β-amyloid fibrils; nordihydroguaiaretic acid; wine-related polyphenols; curcumin; rosmarinic acid; Alzheimer's disease; in vitro studies
T‐lymphocyte entry into the central nervous system Tập 28 Số 2 - Trang 254-260 - 1991
William F. Hickey, Benjamin Hsu, Hironobu Kimura
AbstractThe entry of T‐lymphocytes into the parenchyma of the central nervous system is a critical early feature in the pathogenesis of many experimental and spontaneously occurring immune‐mediated illnesses. The physiological mechanisms controlling this entry have not been elucidated. This study reports that T‐cell entry into the rat CNS appears to be primarily de...... hiện toàn bộ Microglia in health and disease Tập 81 Số 3 - Trang 302-313 - 2005
Seung Up Kim, Jean de Vellis
AbstractMicroglia, one of three glial cell types in the central nervous system (CNS), play an important role as resident immunocompetent and phagocytic cells in the CNS in the event of injury and disease. It was del Rio Hortega in 1927 who determined that microglia belong a distinct glial cell type apart from astrocytes and oligodendrocytes, and since 1970s there h...... hiện toàn bộ Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat Tập 73 Số 6 - Trang 778-786 - 2003
Jieli Chen, Yi Li, Mark Katakowski, Xiaoguang Chen, Lei Wang, Dunyue Lu, Mei Lü, Subhash C. Gautam, Michael Chopp
AbstractThe present study investigates the induction of neurogenesis, reduction of apoptosis, and promotion of basic fibroblast growth factor (bFGF) expression as possible mechanisms by which treatment of stroke with bone marrow stromal cells (MSCs) improves neurological functional recovery. Additionally, for the first time, we treated cerebral ischemia in female r...... hiện toàn bộ Receptor‐mediated transcytosis of transferrin across the blood‐brain barrier Tập 18 Số 2 - Trang 299-304 - 1987
Jordan B. Fishman, Joshua B. Rubin, J. V. Handrahan, James R. Connor, Richard E. Fine
AbstractThe perfusion of rat brain with 125I‐transferrin resulted in a receptor‐mediated uptake of transferrin into the endothelium of the blood‐brain barrier followed by its detecation in the brain. During a pulsechase experiment, 125I‐transferrin accumulated in the endothelial cells during the pulse, with a decrease of th...... hiện toàn bộ Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: Transcription and neurotrophic factor down‐regulation and up‐regulation of apoptotic and pro‐inflammatory signaling Tập 70 Số 3 - Trang 462-473 - 2002
Vittorio Colangelo, Jill R. Schurr, Melvyn J. Ball, Ricardo Palacios Peláez, Nicolás G. Bazán, Walter J. Lukiw
AbstractAlterations in transcription, RNA editing, translation, protein processing, and clearance are a consistent feature of Alzheimer's disease (AD) brain. To extend our initial study (Alzheimer Reports [2000] 3:161‐167), RNA samples isolated from control and AD hippocampal cornu ammonis 1 (CA1) were analyzed for 12633 gene and expressed sequence tag (EST) expres...... hiện toàn bộ Peroxide detoxification by brain cells Tập 79 Số 1-2 - Trang 157-165 - 2005
Ralf Dringen, Petra G. Pawlowski, Johannes Hirrlinger
AbstractPeroxides are generated continuously in cells that consume oxygen. Among the different peroxides, hydrogen peroxide is the molecule that is formed in highest quantities. In addition, organic hydroperoxides are synthesized as products of cellular metabolism. Generation and disposal of peroxides is a very important process in the human brain, because cells of...... hiện toàn bộ