Microglia in health and disease
Tóm tắt
Microglia, one of three glial cell types in the central nervous system (CNS), play an important role as resident immunocompetent and phagocytic cells in the CNS in the event of injury and disease. It was del Rio Hortega in 1927 who determined that microglia belong a distinct glial cell type apart from astrocytes and oligodendrocytes, and since 1970s there has been wide recognition that microglia are immune effectors in the CNS that respond to pathological conditions and participate in initiation and progression of neurological disorders including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and acquired immune deficiency syndrome dementia complex by releasing potentially cytotoxic molecules such as proinflammatory cytokines, reactive oxygen intermediates, proteinases and complement proteins. There is also evidence to suggest that microglia are capable of secreting neurotrophic or neuron survival factors upon activation via inflammation or injury. It is thus timely to review current status of knowledge on biology and immunology of microglia, and consider new directions of investigation on microglia in health and disease. © 2005 Wiley‐Liss, Inc.
Từ khóa
Tài liệu tham khảo
Barron K, 1982, The microglial cell: a historical review, J Neurol Sci, 134, 57, 10.1016/0022-510X(95)00209-K
del Rio Hortega P, 1927, Cerebral cicatrix. The reaction of neuroglia and microglia to brain wounds, Bull Johns Hopkins Hosp, 41, 278
del Rio Hortega P, 1932, 481
Dickson D, 1991, Microglia in human disease, with an emphasis on acquired immune deficiency syndrome, Lab Invest, 64, 135
Glees P, 1955, Neuroglia
Merrill JE, 1993, Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide, J Immunol, 151, 2132, 10.4049/jimmunol.151.4.2132
Nissl F, 1899, Ueber einige Beziehungen zwishcen Nerven zellerkrankungen und glioesen Erscheinungen bei verschiedenen Psychosen, Arch Psychiat, 32, 1
Penfield W, 1932, Cytology and cellular pathology of the nervous system
Peters A, 1991, The fine structure of the nervous system: neurons and their supporting cells, 304