Journal of Neuroscience Research

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Brain dysmyelination and recovery assessment by noninvasive in vivo diffusion tensor magnetic resonance imaging
Journal of Neuroscience Research - Tập 83 Số 3 - Trang 392-402 - 2006
Laura Harsan, P. Poulet, Blandine Guignard, J. Steibel, Nathalie Parizel, Paulo Loureiro de Sousa, Nelly Boehm, Daniel Grucker, M. Saïd Ghandour
AbstractDiffusion tensor magnetic resonance imaging (DT‐MRI) was applied for in vivo quantification of myelin loss and regeneration. A transgenic mouse line (Oligo‐TTK) expressing a truncated form of the herpes simplex virus 1 thymidine kinase gene (hsv1‐tk) in oligodendrocytes was studied along with two induced phenotypes of myelin patho...... hiện toàn bộ
Embryonic cerebrospinal fluid collaborates with the isthmic organizer to regulate mesencephalic gene expression
Journal of Neuroscience Research - Tập 82 Số 3 - Trang 333-345 - 2005
Carolina Parada, C. Martín, M.I. Alonso, J.A. Moro, David Bueno, Á. Gato
p35/Cdk5 pathway mediates soluble amyloid‐β peptide‐induced tau phosphorylation in vitro
Journal of Neuroscience Research - Tập 69 Số 3 - Trang 362-372 - 2002
Terrence Town, Joseph Zolton, Reed Shaffner, Billy Schnell, Robert M. Crescentini, Yajuan Wu, Jin Zeng, Anthony DelleDonne, Demian Obregon, Jun Tan, Michael Mullan
AbstractAlzheimer's disease (AD) is pathologically characterized by deposition of amyloid‐β peptides (Aβ) as senile plaques and by the occurrence of neurofibrillary tangles (NFTs) composed primarily of hyperphosphorylated tau protein. Activation of cyclin‐dependent kinase 5 (Cdk5) via its potent activator p25 has recently been shown to promote phosphorylation of ta...... hiện toàn bộ
The interaction of circRNAs and RNA binding proteins: An important part of circRNA maintenance and function
Journal of Neuroscience Research - Tập 98 Số 1 - Trang 87-97 - 2020
Jiankun Zang, Dan Lu, Chunxue Wang
AbstractThe widespread expression of circular RNAs (circRNAs) is regarded as a feature of gene expression in highly diverged eukaryotes. Recent studies have shown that circRNAs can act as a miRNA sponge to repress miRNA function, participate in splicing of target genes, translate genes into protein and interact with RNA binding proteins (RBPs). RBPs are a broad cla...... hiện toàn bộ
Effect of neurosphere size on the growth rate of human neural stem/progenitor cells
Journal of Neuroscience Research - Tập 84 Số 8 - Trang 1682-1691 - 2006
Hideki Mori, Kazuaki Ninomiya, Masahiro Kino‐oka, Tomoko Shofuda, Mohammed Omedul Islam, Mami Yamasaki, Hideyuki Okano, Masahito Taya, Yonehiro Kanemura
AbstractNeural stem/progenitor cells (NSPCs) proliferate as aggregates in vitro, but the mechanism of aggregation is not fully understood. Here, we report that aggregation promotes the proliferation of NSPCs. We found that the proliferation rate was linear and depended on the size of the aggregate; that is, the population doubling time of the NSPCs gradually decrea...... hiện toàn bộ
Murine neocortical histogenesis is perturbed by prenatal exposure to low doses of bisphenol A
Journal of Neuroscience Research - Tập 84 Số 6 - Trang 1197-1205 - 2006
Keiko Nakamura, Kyoko Itoh, Takeshi Yaoi, Yasuhiro Fujiwara, Tohru Sugimoto, Shinji Fushiki
AbstractBisphenol A (BPA) has been shown to disrupt thyroid hormone function. We therefore studied whether prenatal exposure to low‐doses of BPA affects the morphology and the expression of some genes related to brain development in the murine fetal neocortex. Pregnant mice were injected subcutaneously with 20 μg/kg of BPA daily from embryonic day 0 (E0). Control a...... hiện toàn bộ
Neuronal differentiation of stem cells isolated from adult muscle
Journal of Neuroscience Research - Tập 69 Số 6 - Trang 894-907 - 2002
Marina Romero‐Ramos, Patrick Vourc’h, Warren Young, Paul A. Lucas, Young Wu, Onanong Chivatakarn, Rumina Zaman, Noushin Dunkelman, Mohammad El-Kalay, Marie‐Françoise Chesselet
AbstractLineage uncommitted pluripotent stem cells reside in the connective tissue of skeletal muscle. The present study was carried out with pluripotent stem cells (PPSCs) isolated from 6‐month old rat muscle. Before differentiation, these cells were vimentin+, CD90+, CD45−, and varied in their expression of CD34. The PPSCs were expanded as non‐adherent aggregates...... hiện toàn bộ
The vimentin‐GFA protein transition in rat neuroglia cytoskeleton occurs at the time of myelination
Journal of Neuroscience Research - Tập 6 Số 6 - Trang 741-748 - 1981
D. Dahl
AbstractExtraction with Triton, a nonionic detergent, is a common procedure to prepare intermediate filament enriched fractions from cells maintained in culture. The Triton‐Insoluble fraction is called a cytoskeletal preparation. Using this procedure, we previously demonstrated that vimentin and glial fibrillary acidic protein (GFA) are major cytoskeletal proteins ...... hiện toàn bộ
Function and evolution in the NGF family and its receptors
Journal of Neuroscience Research - Tập 32 Số 4 - Trang 461-470 - 1992
Ted Ebendal
AbstractThe gene family of neurotrophins includes nerve growth factor (NGF), brain‐derived neurotrophic factor (BDNF), neurotrophin‐3 (NT‐3), and neurotrophin‐4 (NT‐4). Recently, neurotrophin‐5 (NT‐5), a possible mammalian homologue to NT‐4 described in the frog Xenopus, has been cloned in man and rat. The neurotrophins stimulate survival...... hiện toàn bộ
Sự trầm cảm synap glutamatergic do peptide amyloid β tổng hợp trong vùng vách giữa Dịch bởi AI
Journal of Neuroscience Research - Tập 85 Số 3 - Trang 634-648 - 2007
Julio Santos‐Torres, Antonio de la Fuente, José María Criado, Adelaida Sánchez Riolobos, Margarita Heredia, Javier Yajeya
Tóm tắtKhu vực vách giữa/băng chéo, tham gia vào các quá trình học tập và ghi nhớ thông qua sự chiếu xạ cholinergic và GABAergic đến hồi hải mã, là một trong những cấu trúc bị ảnh hưởng bởi sự lắng đọng beta amyloid (βA) trong bệnh Alzheimer (AD). Các tác động cấp tính của βA (25–35 và 1–40) lên việc tạo ra thế hoạt động và truyền dẫn synap glutamatergic trong các ...... hiện toàn bộ
Tổng số: 190   
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