Journal of Neuroscience Research
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Brain dysmyelination and recovery assessment by noninvasive in vivo diffusion tensor magnetic resonance imaging
Journal of Neuroscience Research - Tập 83 Số 3 - Trang 392-402 - 2006
AbstractDiffusion tensor magnetic resonance imaging (DT‐MRI) was applied for in
vivo quantification of myelin loss and regeneration. A transgenic mouse line
(Oligo‐TTK) expressing a truncated form of the herpes simplex virus 1 thymidine
kinase gene (hsv1‐tk) in oligodendrocytes was studied along with two induced
phenotypes of myelin pathology. Myelin loss and axonal abnormalities
differentially af...
Estrogen provides neuroprotection against activated microglia‐induced dopaminergic neuronal injury through both estrogen receptor‐α and estrogen receptor‐β in microglia
Journal of Neuroscience Research - Tập 81 Số 5 - Trang 653-665 - 2005
AbstractEstrogen provides neuroprotection against neurodegenerative diseases,
including Parkinson's disease. Its effects may stem from interactions with
neurons, astrocytes, and microglia. We demonstrate here in primary cultures of
rat mesencephalic neurons that estrogen protects them from injury induced by
conditioned medium obtained from lipopolysaccharide (LPS)‐activated microglia.
LPS‐induced ...
Embryonic cerebrospinal fluid collaborates with the isthmic organizer to regulate mesencephalic gene expression
Journal of Neuroscience Research - Tập 82 Số 3 - Trang 333-345 - 2005
p35/Cdk5 pathway mediates soluble amyloid‐β peptide‐induced tau phosphorylation in vitro
Journal of Neuroscience Research - Tập 69 Số 3 - Trang 362-372 - 2002
AbstractAlzheimer's disease (AD) is pathologically characterized by deposition
of amyloid‐β peptides (Aβ) as senile plaques and by the occurrence of
neurofibrillary tangles (NFTs) composed primarily of hyperphosphorylated tau
protein. Activation of cyclin‐dependent kinase 5 (Cdk5) via its potent activator
p25 has recently been shown to promote phosphorylation of tau at AD‐specific
phosphoepitopes,...
The FE65 proteins and Alzheimer's disease
Journal of Neuroscience Research - Tập 86 Số 4 - Trang 744-754 - 2008
AbstractThe FE65s (FE65, FE65L1, and FE65L2) are a family of multidomain adaptor
proteins that form multiprotein complexes with a range of functions. FE65 is
brain‐enriched, whereas FE65L1 and FE65L2 are more widely expressed. All three
members contain a WW domain and two PTB domains. Through the PTB2 domain, they
all interact with the Alzheimer's disease amyloid precursor protein (APP)
intracellu...
The interaction of circRNAs and RNA binding proteins: An important part of circRNA maintenance and function
Journal of Neuroscience Research - Tập 98 Số 1 - Trang 87-97 - 2020
AbstractThe widespread expression of circular RNAs (circRNAs) is regarded as a
feature of gene expression in highly diverged eukaryotes. Recent studies have
shown that circRNAs can act as a miRNA sponge to repress miRNA function,
participate in splicing of target genes, translate genes into protein and
interact with RNA binding proteins (RBPs). RBPs are a broad class of proteins
involved in gene t...
Effect of neurosphere size on the growth rate of human neural stem/progenitor cells
Journal of Neuroscience Research - Tập 84 Số 8 - Trang 1682-1691 - 2006
AbstractNeural stem/progenitor cells (NSPCs) proliferate as aggregates in vitro,
but the mechanism of aggregation is not fully understood. Here, we report that
aggregation promotes the proliferation of NSPCs. We found that the proliferation
rate was linear and depended on the size of the aggregate; that is, the
population doubling time of the NSPCs gradually decreased as the diameter
approached 25...
Glass micro‐fibers: A model system for study of early events in myelination
Journal of Neuroscience Research - Tập 27 Số 3 - Trang 383-393 - 1990
AbstractA system was developed to analyze early events in the process of
myelination. Primary cultures of rat oligodendrocytes were maintained in the
presence of glass micro‐fibers which served as artificial axons. A culture
chamber was constructed which allowed the close apposition of fibers and cells
in a three‐dimensional arrangement designed to resemble an in vivo environment.
Cells cultured i...
Identification of living oligodendrocyte developmental stages by fractal analysis of cell morphology
Journal of Neuroscience Research - Tập 65 Số 5 - Trang 439-445 - 2001
AbstractThe Mandelbrot's fractal dimension (D), a measure of shape complexity,
has been used to quantify the complex morphology of living cells. Previous
studies on glial cells have shown that as cells increase in morphological
complexity, their “D” value increases, suggesting that “D” could be used to
estimate their stage of differentiation. In the present study the box‐counting
method was used t...
The neuroprotective role of melatonin in neurological disorders
Journal of Neuroscience Research - Tập 96 Số 7 - Trang 1136-1149 - 2018
AbstractMelatonin is a neurohormone secreted from the pineal gland and has a
wide‐ranging regulatory and neuroprotective role. It has been reported that
melatonin level is disturbed in some neurological conditions such as stroke,
Alzheimer's disease, and Parkinson's disease, which indicates its involvement in
the pathophysiology of these diseases. Its properties qualify it to be a
promising potent...
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