Journal of Neuroscience Research

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Brain dysmyelination and recovery assessment by noninvasive in vivo diffusion tensor magnetic resonance imaging
Journal of Neuroscience Research - Tập 83 Số 3 - Trang 392-402 - 2006
Laura Harsan, P. Poulet, Blandine Guignard, J. Steibel, Nathalie Parizel, Paulo Loureiro de Sousa, Nelly Boehm, Daniel Grucker, M. Saïd Ghandour
AbstractDiffusion tensor magnetic resonance imaging (DT‐MRI) was applied for in vivo quantification of myelin loss and regeneration. A transgenic mouse line (Oligo‐TTK) expressing a truncated form of the herpes simplex virus 1 thymidine kinase gene (hsv1‐tk) in oligodendrocytes was studied along with two induced phenotypes of myelin patho...... hiện toàn bộ
Estrogen provides neuroprotection against activated microglia‐induced dopaminergic neuronal injury through both estrogen receptor‐α and estrogen receptor‐β in microglia
Journal of Neuroscience Research - Tập 81 Số 5 - Trang 653-665 - 2005
Xuan Liu, Xiao‐Lan Fan, Yan Zhao, Guangrui Luo, Xu‐Ping Li, Rui Li, Weidong Le
AbstractEstrogen provides neuroprotection against neurodegenerative diseases, including Parkinson's disease. Its effects may stem from interactions with neurons, astrocytes, and microglia. We demonstrate here in primary cultures of rat mesencephalic neurons that estrogen protects them from injury induced by conditioned medium obtained from lipopolysaccharide (LPS)‐...... hiện toàn bộ
Embryonic cerebrospinal fluid collaborates with the isthmic organizer to regulate mesencephalic gene expression
Journal of Neuroscience Research - Tập 82 Số 3 - Trang 333-345 - 2005
Carolina Parada, C. Martín, M.I. Alonso, J.A. Moro, David Bueno, Á. Gato
p35/Cdk5 pathway mediates soluble amyloid‐β peptide‐induced tau phosphorylation in vitro
Journal of Neuroscience Research - Tập 69 Số 3 - Trang 362-372 - 2002
Terrence Town, Joseph Zolton, Reed Shaffner, Billy Schnell, Robert M. Crescentini, Yajuan Wu, Jin Zeng, Anthony DelleDonne, Demian Obregon, Jun Tan, Michael Mullan
AbstractAlzheimer's disease (AD) is pathologically characterized by deposition of amyloid‐β peptides (Aβ) as senile plaques and by the occurrence of neurofibrillary tangles (NFTs) composed primarily of hyperphosphorylated tau protein. Activation of cyclin‐dependent kinase 5 (Cdk5) via its potent activator p25 has recently been shown to promote phosphorylation of ta...... hiện toàn bộ
The FE65 proteins and Alzheimer's disease
Journal of Neuroscience Research - Tập 86 Số 4 - Trang 744-754 - 2008
Declan M. McLoughlin, Christopher Miller
AbstractThe FE65s (FE65, FE65L1, and FE65L2) are a family of multidomain adaptor proteins that form multiprotein complexes with a range of functions. FE65 is brain‐enriched, whereas FE65L1 and FE65L2 are more widely expressed. All three members contain a WW domain and two PTB domains. Through the PTB2 domain, they all interact with the Alzheimer's disease amyloid p...... hiện toàn bộ
The interaction of circRNAs and RNA binding proteins: An important part of circRNA maintenance and function
Journal of Neuroscience Research - Tập 98 Số 1 - Trang 87-97 - 2020
Jiankun Zang, Dan Lu, Chunxue Wang
AbstractThe widespread expression of circular RNAs (circRNAs) is regarded as a feature of gene expression in highly diverged eukaryotes. Recent studies have shown that circRNAs can act as a miRNA sponge to repress miRNA function, participate in splicing of target genes, translate genes into protein and interact with RNA binding proteins (RBPs). RBPs are a broad cla...... hiện toàn bộ
Effect of neurosphere size on the growth rate of human neural stem/progenitor cells
Journal of Neuroscience Research - Tập 84 Số 8 - Trang 1682-1691 - 2006
Hideki Mori, Kazuaki Ninomiya, Masahiro Kino‐oka, Tomoko Shofuda, Mohammed Omedul Islam, Mami Yamasaki, Hideyuki Okano, Masahito Taya, Yonehiro Kanemura
AbstractNeural stem/progenitor cells (NSPCs) proliferate as aggregates in vitro, but the mechanism of aggregation is not fully understood. Here, we report that aggregation promotes the proliferation of NSPCs. We found that the proliferation rate was linear and depended on the size of the aggregate; that is, the population doubling time of the NSPCs gradually decrea...... hiện toàn bộ
Glass micro‐fibers: A model system for study of early events in myelination
Journal of Neuroscience Research - Tập 27 Số 3 - Trang 383-393 - 1990
P. N. Bullock, Leonard H. Rome
AbstractA system was developed to analyze early events in the process of myelination. Primary cultures of rat oligodendrocytes were maintained in the presence of glass micro‐fibers which served as artificial axons. A culture chamber was constructed which allowed the close apposition of fibers and cells in a three‐dimensional arrangement designed to resemble an in v...... hiện toàn bộ
Identification of living oligodendrocyte developmental stages by fractal analysis of cell morphology
Journal of Neuroscience Research - Tập 65 Số 5 - Trang 439-445 - 2001
Frédéric Bernard, Jean‐Louis Bossu, Stéphane Gaillard
AbstractThe Mandelbrot's fractal dimension (D), a measure of shape complexity, has been used to quantify the complex morphology of living cells. Previous studies on glial cells have shown that as cells increase in morphological complexity, their “D” value increases, suggesting that “D” could be used to estimate their stage of differentiation. In the present study t...... hiện toàn bộ
The neuroprotective role of melatonin in neurological disorders
Journal of Neuroscience Research - Tập 96 Số 7 - Trang 1136-1149 - 2018
Badrah S. Alghamdi
AbstractMelatonin is a neurohormone secreted from the pineal gland and has a wide‐ranging regulatory and neuroprotective role. It has been reported that melatonin level is disturbed in some neurological conditions such as stroke, Alzheimer's disease, and Parkinson's disease, which indicates its involvement in the pathophysiology of these diseases. Its properties qu...... hiện toàn bộ
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