Brain dysmyelination and recovery assessment by noninvasive in vivo diffusion tensor magnetic resonance imagingJournal of Neuroscience Research - Tập 83 Số 3 - Trang 392-402 - 2006
Laura Harsan, P. Poulet, Blandine Guignard, J. Steibel, Nathalie Parizel, Paulo Loureiro de Sousa, Nelly Boehm, Daniel Grucker, M. Saïd Ghandour
AbstractDiffusion tensor magnetic resonance imaging (DT‐MRI) was applied for in vivo quantification of myelin loss and regeneration. A transgenic mouse line (Oligo‐TTK) expressing a truncated form of the herpes simplex virus 1 thymidine kinase gene (hsv1‐tk) in oligodendrocytes was studied along with two induced phenotypes of myelin patho...... hiện toàn bộ
p35/Cdk5 pathway mediates soluble amyloid‐β peptide‐induced tau phosphorylation in vitroJournal of Neuroscience Research - Tập 69 Số 3 - Trang 362-372 - 2002
Terrence Town, Joseph Zolton, Reed Shaffner, Billy Schnell, Robert M. Crescentini, Yajuan Wu, Jin Zeng, Anthony DelleDonne, Demian Obregon, Jun Tan, Michael Mullan
AbstractAlzheimer's disease (AD) is pathologically characterized by deposition of amyloid‐β peptides (Aβ) as senile plaques and by the occurrence of neurofibrillary tangles (NFTs) composed primarily of hyperphosphorylated tau protein. Activation of cyclin‐dependent kinase 5 (Cdk5) via its potent activator p25 has recently been shown to promote phosphorylation of ta...... hiện toàn bộ
Murine neocortical histogenesis is perturbed by prenatal exposure to low doses of bisphenol AJournal of Neuroscience Research - Tập 84 Số 6 - Trang 1197-1205 - 2006
Keiko Nakamura, Kyoko Itoh, Takeshi Yaoi, Yasuhiro Fujiwara, Tohru Sugimoto, Shinji Fushiki
AbstractBisphenol A (BPA) has been shown to disrupt thyroid hormone function. We therefore studied whether prenatal exposure to low‐doses of BPA affects the morphology and the expression of some genes related to brain development in the murine fetal neocortex. Pregnant mice were injected subcutaneously with 20 μg/kg of BPA daily from embryonic day 0 (E0). Control a...... hiện toàn bộ
Sự trầm cảm synap glutamatergic do peptide amyloid β tổng hợp trong vùng vách giữa Dịch bởi AI Journal of Neuroscience Research - Tập 85 Số 3 - Trang 634-648 - 2007
Julio Santos‐Torres, Antonio de la Fuente, José María Criado, Adelaida Sánchez Riolobos, Margarita Heredia, Javier Yajeya
Tóm tắtKhu vực vách giữa/băng chéo, tham gia vào các quá trình học tập và ghi nhớ thông qua sự chiếu xạ cholinergic và GABAergic đến hồi hải mã, là một trong những cấu trúc bị ảnh hưởng bởi sự lắng đọng beta amyloid (βA) trong bệnh Alzheimer (AD). Các tác động cấp tính của βA (25–35 và 1–40) lên việc tạo ra thế hoạt động và truyền dẫn synap glutamatergic trong các ...... hiện toàn bộ
Developmental and regional expression of choline acetyltransferase mRNA in the rat central nervous systemJournal of Neuroscience Research - Tập 29 Số 2 - Trang 163-171 - 1991
Carlos F. Ibáñez, Patrik Ernfors, Håkan Persson
AbstractThe developmental and regional expression of choline acetyltransferase (ChAT) mRNA was examined in the rat brain and spinal cord by northern blot analysis and in situ hybridization. ChAT mRNA expression in the brain showed a biphasic increase during development, with a first peak at two weeks postnatally, a marked decrease by the third week, and a second in...... hiện toàn bộ
The basolateral amygdala γ‐aminobutyric acidergic system in health and diseaseJournal of Neuroscience Research - Tập 94 Số 6 - Trang 548-567 - 2016
Eric M. Prager, Hadley C. Bergstrom, Gary H. Wynn, Maria F. M. Braga
The brain comprises an excitatory/inhibitory neuronal network that maintains a finely tuned balance of activity critical for normal functioning. Excitatory activity in the basolateral amygdala (BLA), a brain region that plays a central role in emotion and motivational processing, is tightly regulated by a relatively small population of γ‐aminobutyric acid (GABA) inhibitory neurons. Disrupt...... hiện toàn bộ
Hippocampal brain‐derived neurotrophic factor gene regulation by exercise and the medial septumJournal of Neuroscience Research - Tập 68 Số 5 - Trang 511-521 - 2002
Nicole C. Berchtold, J. Patrick Kesslak, Carl W. Cotman
AbstractBrain‐derived neurotrophic factor (BDNF) enhances synaptic plasticity and neuron function. We have reported that voluntary exercise increases BDNF mRNA levels in the hippocampus; however, mechanisms underlying this regulation have not been defined. We hypothesized that medial septal cholinergic and/or gamma amino butyric acid (GABA)ergic neurons, which prov...... hiện toàn bộ