Journal of Leukocyte Biology

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Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases
Journal of Leukocyte Biology - Tập 86 Số 3 - Trang 513-528 - 2009
Bin Gao, Svetlana Radaeva, O. Park
Insulin-like growth factor-I stimulates IL-10 production in human T cells
Journal of Leukocyte Biology - Tập 76 Số 4 - Trang 862-867 - 2004
Ron Kooijman, Astrid Coppens
AbstractThere is vast body of evidence that the insulin-like growth factor (IGF)-I exerts immunomodulatory effects in vitro and in vivo. In vitro studies indicate that stimulatory effects of IGF-I may be exerted through augmentation of inflammatory cytokine production. To further explore the immunomodulatory effects of IGF-I through regulation of cytokine production, we tested the in vitro effects... hiện toàn bộ
A leading role for the immune system in the pathophysiology of preeclampsia
Journal of Leukocyte Biology - Tập 94 Số 2 - Trang 247-257 - 2013
Estibalitz Laresgoiti‐Servitje
ABSTRACTPreeclampsia syndrome is characterized by inadequate placentation, because of deficient trophoblastic invasion of the uterine spiral arteries, leading to placental hypoxia, secretion of proinflammatory cytokines, the release of angiogenic and antiangiogenic factors and miRNAs. Although immune-system alterations are associated with the origin of preeclampsia, other factors, including proinf... hiện toàn bộ
Requirement for STAT1 in LPS-induced gene expression in macrophages
Journal of Leukocyte Biology - Tập 69 Số 4 - Trang 598-604 - 2001
Yoshihiro Ohmori, Thomas A. Hamilton
AbstractThis study examines the role of the signal transducer and activator of transcription 1 (STAT1) in induction of lipopolysaccharide (LPS)-stimulated gene expression both in vitro and in vivo. LPS-induced expression of an interferon (IFN)-inducible 10-kDa protein (IP-10), IFN regulatory factor-1 (IRF-1), and inducible nitric oxide synthase (iNOS) mRNAs was severely impaired in macrophages pre... hiện toàn bộ
Fibronectin and Complement Secretion By Monocytes and Peritoneal Macrophages In Vitro From Patients Undergoing Continuous Ambulatory Peritoneal Dialysis
Journal of Leukocyte Biology - Tập 39 Số 4 - Trang 457-464 - 1986
Carl Goldstein, R. Garrick, Richard A. Polin, Jeffrey S. Gerdes, Gerald B. Kolski, Eric G. Neilson, Steven D. Douglas
Abstract We investigated the role of the opsonic glycoprotein fibronectin in the host defense of the peritoneum in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Fibronectin concentration in peritoneal dialysate from hight infection rate CAPD patients (>1.50 episodes peritonitis per year) was significantly less than from low infection rate CAPD patients (<0.55 episodes... hiện toàn bộ
Distinct Subpopulations of Elicited Human Macrophages in Peritoneal Dialysis Patients and Women Undergoing Laparoscopy: A Study on Peroxidatic Activity
Journal of Leukocyte Biology - Tập 43 Số 2 - Trang 172-178 - 1988
H J Bos, H van Bronswijk, T J Helmerhorst, P. L. Oe, E.C.M. Hoefsmit, R.H.J. Beelen
Abstract The endogenous peroxidatic activity (PA) pattern of peritoneal macrophages from 24 continuous ambulatory peritoneal dialysis (CAPD) patients and from five healthy women undergoing laparoscopy was studied. In general, the macrophages showed two different PA patterns in vivo: exudate and negative macrophages. However, two of 24 CAPD patients showed resident macrophages, the first described ... hiện toàn bộ
Adiponectin is produced by lymphocytes and is a negative regulator of granulopoiesis
Journal of Leukocyte Biology - Tập 88 Số 4 - Trang 807-811 - 2010
Lisa Crawford, Roy W A Peake, Susan Price, T. C. M. Morris, Alexandra E. Irvine
Abstract Transcription, translation, and secretion of adiponectin by lymphocytes is shown with receptors for adiponectin expressed on bone marrow mononuclear cells. Lymphocytes have long been established to play an important role in the regulation of hematopoiesis and produce many cytokines that act on hematopoietic progenitor cells. Previous studies by our group have shown that normal, unstimulat... hiện toàn bộ
Accelerated wound closure in neutrophil-depleted mice
Journal of Leukocyte Biology - Tập 73 Số 4 - Trang 448-455 - 2003
Julia V. Dovi, Li‐Ke He, Luisa A. DiPietro
Abstract The infiltration of neutrophils into injured tissue is known to protect wounds from invading pathogens. However, more recent studies suggest that neutrophils might inhibit the wound repair process. To investigate the role of neutrophils in wounds, mice were neutrophil-depleted by injection with rabbit anti-mouse neutrophil serum. Remarkably, epidermal healing, measured by wound closure, p... hiện toàn bộ
Monocyte heterogeneity and functions in cancer
Journal of Leukocyte Biology - Tập 106 Số 2 - Trang 309-322 - 2019
Claire Olingy, Huy Q. Dinh, Catherine C. Hedrick
Abstract Monocytes are innate immune cells of the mononuclear phagocyte system that have emerged as important regulators of cancer development and progression. Our understanding of monocytes has advanced from viewing these cells as a homogenous population to a heterogeneous system of cells that display diverse responses to different stimuli. During cancer, different monocyte subsets perform functi... hiện toàn bộ
Endothelins modulate inflammatory reaction in zymosan-induced arthritis: participation of LTB4, TNF-α, and CXCL-1
Journal of Leukocyte Biology - Tập 84 Số 3 - Trang 652-660 - 2008
Fernando Conte, Christina Barja‐Fidalgo, Waldiceu A. Verri, Fernando Q. Cunha, Giles A. Rae, Carmen Penido, Maria das Graças
AbstractEndothelins (ETs) are involved in inflammatory events, including pain, fever, edema, and cell migration. ET-1 levels are increased in plasma and synovial membrane of rheumatoid arthritis (RA) patients, but the evidence that ETs participate in RA physiopathology is limited. The present study investigated the involvement of ETs in neutrophil accumulation and edema formation in the murine mod... hiện toàn bộ
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