Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanismsJournal of Leukocyte Biology - Tập 76 Số 5 - Trang 994-1001 - 2004
Chen Guo-qian, Jianhua Li, Mahendar Ochani, B. Rendon-Mitchell, Xiaoling Qiang, Srinivas M. Susarla, Luis Ulloa, Huan Yang, Saijun Fan, Sanna M. Goyert, Ping Wang, Kevin J. Tracey, Andrew E. Sama, Haichao Wang
AbstractBacterial endotoxin [lipopolysaccharide (LPS)] stimulates macrophages to sequentially release early [tumor necrosis factor (TNF)] and late [high mobility group box 1 (HMGB1)] proinflammatory cytokines. The requirement of CD14 and mitogen-activated protein kinases [MAPK; e.g., p38 and extracellular signal-regulated kinase (ERK)1/2] for endotoxin-induced TNF ...... hiện toàn bộ
Human blood monocytes are able to form extracellular trapsJournal of Leukocyte Biology - Tập 102 Số 3 - Trang 775-781 - 2017
Vanessa Granger, Dorothée Faille, Vanessa Marani, Benoît Noël, Yann Gallais, Natacha Szely, Héloïse Flament, Marc Pallardy, Sylvie Chollet‐Martin, Luc de Chaisemartin
Abstract
Neutrophil extracellular traps (NETs) are extracellular DNA filaments formed during neutrophil activation. This process, called netosis, was originally associated with neutrophil antibacterial properties. However, several lines of evidence now suggest a major role for netosis in thrombosis, autoimmune diseases, and cancer. We demonstrate her...... hiện toàn bộ
Insights into molecular mechanisms of contact hypersensitivity gained from gene knockout studiesJournal of Leukocyte Biology - Tập 70 Số 2 - Trang 185-191 - 2001
Binghe Wang, Claudio Feliciani, Irwin Freed, Qinchao Cai, Daniel N. Sauder
AbstractContact hypersensitivity (CHS), a dendritic-cell (DC)-dependent, T-cell-mediated skin immune response to reactive haptens, has been a subject of intense research for many years. The molecular mechanisms underlying CHS are complicated and are not fully understood. During the past few years, varieties of gene-targeted knockout mice have been used in the study...... hiện toàn bộ
Insulin-like growth factor-I stimulates IL-10 production in human T cellsJournal of Leukocyte Biology - Tập 76 Số 4 - Trang 862-867 - 2004
Ron Kooijman, Astrid Coppens
AbstractThere is vast body of evidence that the insulin-like growth factor (IGF)-I exerts immunomodulatory effects in vitro and in vivo. In vitro studies indicate that stimulatory effects of IGF-I may be exerted through augmentation of inflammatory cytokine production. To further explore the immunomodulatory effects of IGF-I through regulation of cytokine productio...... hiện toàn bộ
A leading role for the immune system in the pathophysiology of preeclampsiaJournal of Leukocyte Biology - Tập 94 Số 2 - Trang 247-257 - 2013
Estibalitz Laresgoiti‐Servitje
ABSTRACTPreeclampsia syndrome is characterized by inadequate placentation, because of deficient trophoblastic invasion of the uterine spiral arteries, leading to placental hypoxia, secretion of proinflammatory cytokines, the release of angiogenic and antiangiogenic factors and miRNAs. Although immune-system alterations are associated with the origin of preeclampsia...... hiện toàn bộ
Requirement for STAT1 in LPS-induced gene expression in macrophagesJournal of Leukocyte Biology - Tập 69 Số 4 - Trang 598-604 - 2001
Yoshihiro Ohmori, Thomas A. Hamilton
AbstractThis study examines the role of the signal transducer and activator of transcription 1 (STAT1) in induction of lipopolysaccharide (LPS)-stimulated gene expression both in vitro and in vivo. LPS-induced expression of an interferon (IFN)-inducible 10-kDa protein (IP-10), IFN regulatory factor-1 (IRF-1), and inducible nitric oxide synthase (iNOS) mRNAs was sev...... hiện toàn bộ