Requirement for STAT1 in LPS-induced gene expression in macrophages

Adams, 1984, The cell biology of macrophage activation, Annu. Rev. Immunol., 2, 283, 10.1146/annurev.iy.02.040184.001435

Hamilton, 1995, Signal Transduction in Leukocytes : Role of G-Protein Related and Other Pathways, 325

Ulevitch, 1995, Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin, Annu. Rev. Immunol., 13, 437, 10.1146/annurev.iy.13.040195.002253

Sweet, 1996, Endotoxin signal transduction in macrophages, J. Leukoc. Biol., 60, 8, 10.1002/jlb.60.1.8

Poltorak, 1998, Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene, Science, 282, 2085, 10.1126/science.282.5396.2085

Qureshi, 1999, Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4), J. Exp. Med., 189, 615, 10.1084/jem.189.4.615

Hoshino, 1999, Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the LPS gene product, J. Immunol., 162, 3749, 10.4049/jimmunol.162.7.3749

Medzhitov, 1998, MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways, Mol. Cell, 2, 253, 10.1016/S1097-2765(00)80136-7

Baeuerle, 1994, Function and activation of NF-κB in the immune system, Annu. Rev. Immunol., 12, 141, 10.1146/annurev.iy.12.040194.001041

Karin, 1998, The NF-κB activation pathway: its regulation and role in inflammation and cell survival, Cancer. J. Sci. Am., 4, S92

Ohmori, 1994, kB binding activity in a murine macrophage-like cell line: sequence-specific differences in kB binding and transcriptional activation functions, J. Biol. Chem., 269, 17684, 10.1016/S0021-9258(17)32495-X

Matsusaka, 1993, Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc. Natl. Acad. Sci, USA, 90, 10193, 10.1073/pnas.90.21.10193

Ohmori, 1997, Synergy between interferon-γ and tumor necrosis factor-α in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor kB, J. Biol. Chem., 272, 14899, 10.1074/jbc.272.23.14899

Lodie, 1997, Stimulation of macrophages by lipopolysaccharide alters the phosphorylation state, conformation, and function of PU.1 via activation of casein kinase II, J. Immunol., 158, 1848, 10.4049/jimmunol.158.4.1848

Kovarik, 1998, Stat1 combines signals derived from IFN-γ and LPS receptors during macrophage activation, EMBO. J., 17, 3660, 10.1093/emboj/17.13.3660

Fujihara, 1994, Role of endogenous interferon-beta in lipopolysaccharide-triggered activation of the inducible nitric-oxide synthase gene in a mouse macrophage cell line, J774. J. Biol, Chem., 269, 12773

de Waal Malefyt, 1991, Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes, J. Exp. Med., 174, 1209, 10.1084/jem.174.5.1209

Darnell, 1994, Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins, Science, 264, 1415, 10.1126/science.8197455

Meraz, 1996, Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway, Cell, 84, 431, 10.1016/S0092-8674(00)81288-X

Durbin, 1996, Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease, Cell, 84, 443, 10.1016/S0092-8674(00)81289-1

Tsukada, 1996, A novel STAT-like factor mediates lipopolysaccharide, interleukin 1 (IL-1), and IL-6 signaling and recognizes a gamma interferon activation site-like element in the IL1B gene. Mol. Cell, Biol., 16, 2183

Ruff-Jamison, 1994, Epidermal growth factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver, J. Biol. Chem., 269, 21933, 10.1016/S0021-9258(17)31735-0

Deng, 1996, LPS does not directly induce STAT activity in mouse macrophages, Cell. Immunol., 170, 20, 10.1006/cimm.1996.0129

Yamaoka, 1998, Activation of STAT5 by lipopolysaccharide through granulocyte-macrophage colony-stimulating factor production in human monocytes, J. Immunol., 160, 838, 10.4049/jimmunol.160.2.838

Gao, 1998, Autocrine/paracrine IFN-αβ mediates the lipopolysaccharide-induced activation of transcription factor Stat1α in mouse macrophages: pivotal role of Stat1a in induction of the inducible nitric oxide synthase gene. J, Immunol., 161, 4803, 10.4049/jimmunol.161.9.4803

Gessani, 1989, Bacterial lipopolysaccharide and gamma interferon induce transcription of beta interferon mRNA and interferon secretion in murine macrophages, J. Virol., 63, 2785, 10.1128/jvi.63.6.2785-2789.1989

Trinchieri, 1996, Immunoregulation by interleukin-12, J. Leukoc. Biol., 59, 505, 10.1002/jlb.59.4.505

Muller, 1994, Functional role of type I and type II interferons in antiviral defense, Science, 264, 1918, 10.1126/science.8009221

Ohmori, 1994, IFN-gamma selectively inhibits lipopolysaccharide-inducible JE/monocyte chemoattractant protein-1 and KC/GRO/melanoma growth-stimulating activity gene expression in mouse peritoneal macrophages. J, Immunol., 153, 2204, 10.4049/jimmunol.153.5.2204

Chirgwin, 1979, Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease, Biochemistry, 18, 5294, 10.1021/bi00591a005

Ohmori, 1990, A macrophage LPS-inducible early gene encodes the murine homologue of IP-10, Biochem. Biophys. Res. Commun., 168, 1261, 10.1016/0006-291X(90)91164-N

Deng, 1993, Synergistic cooperation between T cell lymphokines for induction of the nitric oxide synthase gene in murine peritoneal macrophages, J. Immunol., 151, 322, 10.4049/jimmunol.151.1.322

Higashi, 1983, Structure and expression of a cloned cDNA for mouse interferon-beta, J. Biol. Chem., 258, 9522, 10.1016/S0021-9258(17)44698-9

Dignam, 1983, Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei, Nucleic Acids Res., 11, 1475, 10.1093/nar/11.5.1475

Bradford, 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem., 72, 248, 10.1016/0003-2697(76)90527-3

Ohmori, 1993, Cooperative interaction between interferon (IFN) stimulus response element and κB sequence motifs controls IFN γ- and lipopolysaccharide-stimulated transcription from the murine IP-10 promoter. J. Biol, Chem., 268, 6677

Sims, 1993, A novel interferon-inducible domain: structural and functional analysis of the human interferon regulatory factor 1 gene promoter, Mol. Cell. Biol., 13, 690

Muller, 1993, Nuclear factor kappa B, a mediator of lipopolysaccharide effects, Immunobiology, 187, 233, 10.1016/S0171-2985(11)80342-6

Pine, 1997, Convergence of TNFa and IFNγ signalling pathways through synergistic induction of IRF-1/ISGF-2 is mediated by a composite GAS/kB promoter element, Nucleic. Acids. Res., 25, 4346, 10.1093/nar/25.21.4346

Lowenstein, 1993, Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide, Proc. Natl. Acad. Sci. USA, 90, 9730, 10.1073/pnas.90.20.9730

Xie, 1994, Role of transcription factor NF-KB/Rel in induction of nitric oxide synthase, J. Biol. Chem., 269, 4705, 10.1016/S0021-9258(17)37600-7

Ohmori, 1995, The interferon-stimulated response element and a kB site mediate synergistic induction of murine IP-10 gene transcription by IFN-γ and TNF-α, J. Immunol., 154, 5235, 10.4049/jimmunol.154.10.5235

Fu, 1990, ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains, Proc. Natl. Acad. Sci. USA, 87, 8555, 10.1073/pnas.87.21.8555

Fu, 1992, The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction, Proc. Natl. Acad. Sci. USA, 89, 7840, 10.1073/pnas.89.16.7840

Cho, 1996, Activation of STAT4 by IL-12 and IFN-α: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation, J. Immunol., 157, 4781, 10.4049/jimmunol.157.11.4781

Rani, 1999, Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase. J. Biol, Chem., 274, 32507

Jahnke, 1994, Synergistic activation of intercellular adhesion molecule 1 (ICAM-1) by TNF-α and IFN-γ is mediated by p65/p50 and p65/c-Rel and interferon-responsive factor Stat1-a (p91) that can be activated by both IFN-γ and IFN-α, FEBS Lett., 354, 220, 10.1016/0014-5793(94)01130-3

Kamijo, 1994, Requirement for transcription factor IRF-1 in NO synthase induction in macrophages, Science, 263, 1612, 10.1126/science.7510419

Gao, 1997, An interferon-gamma-activated site (GAS) is necessary for full expression of the mouse iNOS gene in response to interferon-gamma and lipopolysaccharide, J. Biol. Chem., 272, 1226, 10.1074/jbc.272.2.1226

Cousens, 1997, Interferon-α/β inhibition of interleukin 12 and interferon-γ production in vitro and endogenously during viral infection, Proc. Natl. Acad. Sci. USA, 94, 634, 10.1073/pnas.94.2.634

Faure, 1997, Inhibition of inducible nitric oxide synthase expression by interferons alpha and beta in bovine retinal pigmented epithelial cells, J. Biol. Chem., 272, 32169, 10.1074/jbc.272.51.32169

Lopez-Collazo, 1998, Triggering of peritoneal macrophages with IFN-α/β attenuates the expression of inducible nitric oxide synthase through a decrease in NF-κB activation. J, Immunol., 160, 2889, 10.4049/jimmunol.160.6.2889