A leading role for the immune system in the pathophysiology of preeclampsia

Davey, 1989, Classification of hypertensive disorders in pregnancy, Lancet, 334, 112, 10.1016/S0140-6736(89)90360-7

Chappell, 2008, Adverse perinatal outcomes and risk factors for preeclampsia in women with chronic hypertension: a prospective study, Hypertension, 51, 1002, 10.1161/HYPERTENSIONAHA.107.107565

James, 2005, Cytotrophoblast differentiation in the first trimester of pregnancy: evidence for separate progenitors of extravillous trophoblasts and syncytiotrophoblast, Reproduction, 130, 95, 10.1530/rep.1.00723

Roberts, 2005, Preeclampsia: recent insights, Hypertension, 46, 1243, 10.1161/01.HYP.0000188408.49896.c5

Kaufmann, 2003, Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia, Biol. Reprod., 69, 1, 10.1095/biolreprod.102.014977

Odegard, 2000, Preeclampsia and fetal growth, Obstet. Gynecol., 96, 950

Rolfo, 2010, Abnormalities in oxygen sensing define early and late onset preeclampsia as distinct pathologies, PLoS ONE, 5, 13288, 10.1371/journal.pone.0013288

Laresgoiti-Servitje, 2010, An immunological insight into the origins of pre-eclampsia, Hum. Reprod. Update, 16, 510, 10.1093/humupd/dmq007

Mellembakken, 2001, Chemokines and leukocyte activation in the fetal circulation during preeclampsia, Hypertension, 38, 394, 10.1161/01.HYP.38.3.394

Sargent, 2006, Immunoregulation in normal pregnancy and pre-eclampsia: an overview, Rep. BioMed. Online, 13, 680, 10.1016/S1472-6483(10)60659-1

Srinivas, 2009, Rethinking IUGR in preeclampsia: dependent or independent of maternal hypertension?, J. Perinatol., 29, 680, 10.1038/jp.2009.83

Van der Merwe, 2010, Are early and late preeclampsia distinct subclasses of the disease—what does the placenta reveal?, Hypertens. Pregnancy, 29, 457, 10.3109/10641950903572282

Parrish, 2010, The effect of immune factors, tumor necrosis factor-α, and agonistic autoantibodies to the angiotensin II type I receptor on soluble fms-like tyrosine-1 and soluble endoglin production in response to hypertension during pregnancy, Am. J. Hypertens., 23, 911, 10.1038/ajh.2010.70

Parrish, 2011, Hypertension in response to AT1-AA: role of reactive oxygen species in pregnancy-induced hypertension, Am. J. Hypertens., 24, 835, 10.1038/ajh.2011.62

Sela, 2008, A novel human-specific soluble vascular endothelial growth factor receptor 1: cell type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsia, Circ. Res., 102, 1566, 10.1161/CIRCRESAHA.108.171504

Noack, 2011, miRNA expression profiling in formalin-fixed and paraffin-embedded placental tissue samples from pregnancies with severe preeclampsia, J. Perinat. Med., 39, 267, 10.1515/jpm.2011.012

Zhang, 2009, MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT, Cell Cycle, 8, 756, 10.4161/cc.8.17.9387

Nevo, 2006, Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1, Am. J. Physiol., 291, R1085

Levine, 2006, Soluble endoglin and other circulating antiangiogenic factors in preeclampsia, N. Engl. J. Med., 355, 992, 10.1056/NEJMoa055352

Gould, 2010, Upregulation of urotensin II receptor in preeclampsia causes in vitro placental release of soluble vascular endothelial growth factor receptor 1 in hypoxia, Hypertension, 56, 172, 10.1161/HYPERTENSIONAHA.110.152074

Sela, 2011, Local retention versus systemic release of soluble VEGF receptor-1 are mediated by heparin-binding and regulated by heparanase, Circ. Res., 108, 1063, 10.1161/CIRCRESAHA.110.239665

Maynard, 2003, Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia, J. Clin. Invest., 111, 649, 10.1172/JCI17189

Wang, 2009, Preeclampsia: the role of angiogenic factors in its pathogenesis, Physiology, 24, 147, 10.1152/physiol.00043.2008

Gu, 2008, Placental productions and expressions of soluble endoglin, soluble fms-like tyrosine kinase receptor-1, and placental growth factor in normal and preeclamptic pregnancies, J. Clin. Endocrinol. Metab., 93, 260, 10.1210/jc.2007-1550

Fujita, 2010, Role of extracellular signal-regulated kinase and AKT cascades in regulating hypoxia-induced angiogenic factors produced by a trophoblast-derived cell line, J. Endocrinol., 206, 131, 10.1677/JOE-10-0027

Jung, 2012, Secretion of soluble vascular endothelial growth factor receptor 1 (sVEGFR1/sFlt1) requires Arf1, Arf6, and Rab11 GTPases, PLoS ONE, 7, 44572, 10.1371/journal.pone.0044572

Munaut, 2008, Hypoxia is responsible for soluble vascular endothelial growth factor receptor-1 (VEGFR-1) but not for soluble endoglin induction in villous trophoblast, Hum. Reprod., 23, 1407, 10.1093/humrep/den114

Thomas, 2009, A recently evolved novel trophoblast-enriched secreted form of fms-Like tyrosine kinase-1 variant is up-regulated in hypoxia and preeclampsia, J. Clin. Endocrinol. Metab., 94, 2524, 10.1210/jc.2009-0017

Levine, 2004, Circulating angiogenic factors and the risk of preeclampsia, N. Engl. J. Med., 350, 672, 10.1056/NEJMoa031884

Herse, 2009, Prevalence of agonistic autoantibodies against the angiotensin II type 1 receptor and soluble fms-like tyrosine kinase 1 in a gestational age-matched case study, Hypertension, 53, 393, 10.1161/HYPERTENSIONAHA.108.124115

Murphy, 2013, Control of soluble fms-like tyrosine-1 (sFlt-1) production response to placental ischemia/hypoxia: role of tumor necrosis factor-α, Am. J. Physiol., 304, R130

Zhou, 2008, Autoantibody from women with preeclampsia induces soluble Fms-Like tyrosine kinase-1 production via angiotensin type 1 receptor and calcineurin/nuclear factor of activated T-cells signaling, Hypertension, 51, 1010, 10.1161/HYPERTENSIONAHA.107.097790

Irani, 2010, Autoantibody-mediated angiotensin receptor activation contributes to preeclampsia through tumor necrosis factor-α signaling, Hypertension, 55, 1246, 10.1161/HYPERTENSIONAHA.110.150540

Gilad, 2008, Serum microRNAs are promising novel biomarkers, PLoS ONE, 3, 3148, 10.1371/journal.pone.0003148

Hu, 2009, Differential expression of microRNAs in the placentae of Chinese patients with severe pre-eclampsia, Clin. Chem. Lab. Med., 47, 923, 10.1515/CCLM.2009.228

Pineles, 2007, Distinct subsets of microRNAs are expressed differentially in the human placentas of patients with preeclampsia, Am. J. Obstet. Gynecol., 196, 10.1016/j.ajog.2007.01.008

O'Neill, 2010, Outfoxing Foxo1 with miR-182, Nat. Immunol., 11, 983, 10.1038/ni1110-983

Tang, 2013, MicroRNA-182 plays an onco-miRNA role in cervical cancer, Gynecol. Oncol., 129, 199, 10.1016/j.ygyno.2012.12.043

Zhang, 2012, Elevated levels of hypoxia-inducible microRNA-210 in pre-eclampsia: new insights into molecular mechanisms for the disease, J. Cell. Mol. Med., 16, 249, 10.1111/j.1582-4934.2011.01291.x

Zhang, 2010, MicroRNA-155 contributes to preeclampsia by down-regulating CYR61, Am. J. Obstet. Gynecol., 202, 466, 10.1016/j.ajog.2010.01.057

Messerli, 2010, Feto-maternal interactions in pregnancies: placental microparticles activate peripheral blood monocytes, Placenta, 31, 106, 10.1016/j.placenta.2009.11.011

Germain, 2007, Systemic inflammatory priming in normal pregnancy and preeclampsia: the role of circulating syncytiotrophoblast microparticles, J. Immunol., 178, 5949, 10.4049/jimmunol.178.9.5949

Southcombe, 2011, The immunomodulatory role of syncytiotrophoblast microvesicles, PLoS ONE, 6, e20245, 10.1371/journal.pone.0020245

Guller, 2011, Protein composition of microparticles shed from human placenta during placental perfusion: potential role in angiogenesis and fibrinolysis in preeclampsia, Placenta, 32, 63, 10.1016/j.placenta.2010.10.011

Lee, 2012, Systemic inflammatory stimulation by microparticles derived from hypoxic trophoblast as a model for inflammatory response in preeclampsia, Am. J. Obstet. Gynecol., 207, 337, 10.1016/j.ajog.2012.06.047

Holder, 2012, Heightened pro-inflammatory effect of preeclamptic placental microvesicles on peripheral blood immune cells in humans, Biol. Reprod., 86, 101

Von Dadelszen, 1999, Supernatants from co-cultured endothelial cells and syncytiotrophoblast microvillous membranes activate peripheral blood leukocytes in vitro, Hum. Reprod., 14, 919, 10.1093/humrep/14.4.919

Matzinger, 2002, The danger model: a renewed sense of self, Science, 296, 301, 10.1126/science.1071059

Bonney, 2007, Preeclampsia: a view through the danger model, J. Reprod. Immunol., 76, 68, 10.1016/j.jri.2007.03.006

Lotze, 2007, Damage associated molecular pattern molecules, Clin. Immunol., 124, 1, 10.1016/j.clim.2007.02.006

Yang, 2005, The cytokine activity of HMGB1, J. Leukoc. Biol., 78, 1, 10.1189/jlb.1104648

Schmidt, 2004, Serum S100B in pregnancy-related hypertensive disorders: a case-control study, Clin. Chem., 50, 435, 10.1373/clinchem.2003.027391

Holmlund, 2007, The novel inflammatory cytokine high mobility group box protein 1 (HMGB1) is expressed by human term placenta, Immunology, 122, 430, 10.1111/j.1365-2567.2007.02662.x

Tskitishvili, 2006, S100B protein expression in the amnion and amniotic fluid in pregnancies complicated by pre-eclampsia, Mol. Hum. Reprod., 12, 755, 10.1093/molehr/gal083

Tskitishvili, 2010, Oxidative stress-induced S100B protein from placenta and amnion affects soluble endoglin release from endothelial cells, Mol. Hum. Reprod., 16, 188, 10.1093/molehr/gap104

Kim, 2005, Toll-like receptor 4: a potential link between “danger signals,” the innate immune system, and preeclampsia?, Am. J. Obstet. Gynecol., 193, 921, 10.1016/j.ajog.2005.07.076

Pineda, 2011, Expression of Toll-like receptor TLR-2, TLR-3, TLR-4 and TLR-9 is increased in placentas from patients with preeclampsia, Arch. Med. Res., 42, 382, 10.1016/j.arcmed.2011.08.003

Chatterjee, 2011, Interleukin 10 deficiency exacerbates Toll-like receptor 3-induced preeclampsia-like symptoms in mice, Hypertension, 58, 489, 10.1161/HYPERTENSIONAHA.111.172114

Hennessy, 1999, A deficiency of placental IL-10 in preeclampsia, J. Immunol., 163, 3491, 10.4049/jimmunol.163.6.3491

Chatterjee, 2012, Placental Toll-like receptor 3 and Toll-like receptor 7/8 activation contributes to preeclampsia in humans and mice, PLoS ONE, 7, 41884, 10.1371/journal.pone.0041884

Scharfe-Nugent, 2012, TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia, J. Immunol., 188, 5706, 10.4049/jimmunol.1103454

Leung, 2001, Increased maternal plasma fetal DNA concentrations in women who eventually develop preeclampsia, Clin. Chem., 47, 137, 10.1093/clinchem/47.1.137

Conde-Agudelo, 2008, Maternal infection and risk of preeclampsia: systematic review and metaanalysis, Am. J. Obstet. Gynecol., 198, 7, 10.1016/j.ajog.2007.07.040

Kawai, 2009, The roles of TLRs, RLRs and NLRs in pathogen recognition, Int. Immunol., 21, 317, 10.1093/intimm/dxp017

Vásárhelyi, 2006, Three mechanisms in the pathogenesis of pre-eclampsia sug gested by over-represented transcription factor-binding sites detected with comparative promoter analysis, Mol. Hum. Reprod., 12, 31, 10.1093/molehr/gal001

Li, 2002, NF-κB regulation in the immune system, Nat. Rev. Immunol., 2, 25

Luppi, 2006, Preeclampsia activates circulating immune cells with engagement of the NF-κB pathway, Am. J. Reprod. Immunol., 56, 135, 10.1111/j.1600-0897.2006.00386.x

Vaughan, 2012, Activation of NF-κB in placentas of women with preeclampsia, Hypertens. Pregnancy, 31, 243, 10.3109/10641955.2011.642436

Kawai, 2007, Signaling to NF-κB by Toll-like receptors, Trends Mol. Med., 13, 460, 10.1016/j.molmed.2007.09.002

Sykes, 2012, Changes in the Th1: Th2 cytokine bias in pregnancy and the effects of the anti-inflammatory cyclopentenone prostaglandin 15-deoxy-Δ(12,14)-prostaglandin J2, Mediators Inflamm., 2012, 416739, 10.1155/2012/416739

Gomez-Lopez, 2010, Invasion of the leukocytes into the fetal-maternal interface during pregnancy, J. Leukoc. Biol., 88, 625, 10.1189/jlb.1209796

Abrahams, 2005, A role for TLRs in the regulation of immune cell migration by first trimester trophoblast cells, J. Immunol., 175, 8096, 10.4049/jimmunol.175.12.8096

Bowen, 2005, Hypoxia promotes interleukin-6 and -8 but reduces interleukin-10 production by placental trophoblast cells from preeclamptic pregnancies, J. Soc. Gynecol. Investig., 12, 428, 10.1016/j.jsgi.2005.04.001

Benyo, 2001, Expression of inflammatory cytokines in placentas from women with preeclampsia, J. Clin. Endocrinol. Metab., 86, 2505

Luppi, 2006, Monocytes of preeclamptic women spontaneously synthesize pro-inflammatory cytokines, Clin. Immunol., 118, 268, 10.1016/j.clim.2005.11.001

Ziegler-Heitbrock, 2010, Nomenclature of monocytes and dendritic cells in blood, Blood, 116, e74, 10.1182/blood-2010-02-258558

Melgert, 2012, Pregnancy and preeclampsia affect monocyte subsets in humans and rats, PLoS ONE, 7, 45229, 10.1371/journal.pone.0045229

Al-Ofi, 2012, Monocyte subpopulations from pre-eclamptic patients are abnormally skewed and exhibit exaggerated responses to Toll-like receptor ligands, PLoS ONE, 7, 42217, 10.1371/journal.pone.0042217

Zawada, 2011, SuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subset, Blood, 118, 10.1182/blood-2011-01-326827

Ancuta, 2000, CD14+CD16++ cells derived in vitro from peripheral blood monocytes exhibit phenotypic and functional dendritic cell-like characteristics, Eur. J. Immunol., 30, 1872, 10.1002/1521-4141(200007)30:7<1872::AID-IMMU1872>3.0.CO;2-2

Khalil, 2002, Vascular mechanisms of increased arterial pressure in preeclampsia: lessons from animal models, Am. J. Physiol., 283

Vila, 2005, Cytokines and vascular reactivity in resistance arteries, Am. J. Physiol. Heart Circ. Physiol., 288, 10.1152/ajpheart.00779.2004

Greer, 1989, Neutrophil activation in pregnancy-induced hypertension, Br. J. Obstet. Gynaecol., 96, 978, 10.1111/j.1471-0528.1989.tb03358.x

Greer, 1991, Neutrophil activation is confined to the maternal circulation in pregnancy-induced hypertension, Obstet. Gynecol., 78, 28

Butterworth, 1991, Immunocytochemical localization of neutrophil elastase in term placenta decidua and myometrium in pregnancy-induced hypertension, Br. J. Obstet. Gynaecol., 98, 929, 10.1111/j.1471-0528.1991.tb13516.x

Cadden, 2008, Neutrophils, but not lymphocytes or monocytes, infiltrate maternal systemic vasculature in women with preeclampsia, Hypertens. Pregnancy, 27, 396, 10.1080/10641950801958067

Tsukimori, 2008, Neutrophil-derived reactive oxygen species can modulate neutrophil adhesion to endothelial cells in preeclampsia, Am. J. Hypertens., 21, 587, 10.1038/ajh.2007.87

Quinn, 1995, Immunocytochemical detection of lipid peroxidation in phagosomes of human neutrophils: correlation with expression of flavocyto-chrome b, J. Leukoc. Biol., 57, 415, 10.1002/jlb.57.3.415

Barden, 2001, Study of plasma factors associated with neutrophil activation and lipid peroxidation in preeclampsia, Hypertension, 38, 803, 10.1161/hy1101.092969

Leik, 2004, Neutrophils infiltrate resistance-sized vessels of subcutaneous fat in women with preeclampsia, Hypertension, 44, 72, 10.1161/01.HYP.0000130483.83154.37

Gupta, 2005, Induction of neutrophil extracellular DNA lattices by placental microparticles and IL-8 and their presence in preeclampsia, Hum. Immunol., 66, 1146, 10.1016/j.humimm.2005.11.003

Fuchs, 2007, Novel cell death program leads to neutrophil extracellular traps, J. Cell Biol., 176, 231, 10.1083/jcb.200606027

Kaplan, 2012, Neutrophil extracellular traps: doubleedged swords of innate immunity, J. Immunol., 189, 2689, 10.4049/jimmunol.1201719

Gupta, 2007, Neutrophil NETs: a novel contributor to preeclampsia-associated placental hypoxia?, Semin. Immunopathol., 29, 163, 10.1007/s00281-007-0073-4

Saffarzadeh, 2012, Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones, PLoS ONE, 7, 32366, 10.1371/journal.pone.0032366

Remijsen, 2011, Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality, Cell Death Differ., 18, 581, 10.1038/cdd.2011.1

Gandley, 2008, Increased myeloperoxidase in the placenta and circulation of women with preeclampsia, Hypertension, 52, 387, 10.1161/HYPERTENSIONAHA.107.107532

Guleria, 2007, Maternal acceptance of the fetus: true human tolerance, J. Immunol., 178, 3345, 10.4049/jimmunol.178.6.3345

Lash, 2006, Interferon-γ inhibits extravillous trophoblast cell invasion by a mechanism that involves both changes in apoptosis and protease levels, FASEB J., 20, 2512, 10.1096/fj.06-6616com

Molvarec, 2010, Decreased proportion of peripheral blood vascular endothelial growth factor-expressing T and natural killer cells in preeclampsia, Am. J. Obstet. Gynecol., 203, 567, 10.1016/j.ajog.2010.07.019

Sivori, 2004, CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: induction of cytokine release and cytotoxicity against tumors and dendritic cells, Proc. Natl. Acad. Sci. USA, 101, 10116, 10.1073/pnas.0403744101

Hedlund, 2009, Human placenta expresses and secretes NKG2D ligands via exosomes that down-modulate the cognate receptor expression: evidence for immunosuppressive function, J. Immunol., 183, 340, 10.4049/jimmunol.0803477

Jurewicz, 2007, Human T and natural killer cells possess a functional renin-angiotensin system: further mechanisms of angiotensin II-induced inflammation, J. Am. Soc. Nephrol., 18, 1093, 10.1681/ASN.2006070707

Herse, 2007, Dysregulation of the circulating and tissue-based renin-angiotensin system in preeclampsia, Hypertension, 49, 604, 10.1161/01.HYP.0000257797.49289.71

Blois, 2007, Dendritic cells: key to fetal tolerance?, Biol. Reprod., 77, 590, 10.1095/biolreprod.107.060632

Steinman, 2006, Dendritic cells: translating innate to adaptive immunity, Curr. Top. Microbiol. Immunol., 311, 17

Blois, 2005, Intercellular adhesion molecule-1/LFA-1 cross talk is a proximate mediator capable of disrupting immune integration and tolerance mechanism at the feto-maternal interface in murine pregnancies, J. Immunol., 174, 1820, 10.4049/jimmunol.174.4.1820

Hsu, 2012, Altered decidual DC-SIGN+ antigen-presenting cells and impaired regulatory T-cell induction in preeclampsia, Am. J. Pathol., 181, 2149, 10.1016/j.ajpath.2012.08.032

Kludka-Sternik, 2010, The expression of B7-H1 and B7-H4 molecules on immature myeloid and lymphoid dendritic cells in cord blood of healthy neonates, Folia Histochem. Cytobiol., 48, 658

Darmochwal-Kolarz, 2003, Myeloid and lymphoid dendritic cells in normal pregnancy and pre-eclampsia, Clin. Exp. Immunol., 132, 339, 10.1046/j.1365-2249.2003.02136.x

Leslie, 2002, CD1-mediated γ/δ T cell maturation of dendritic cells, J. Exp. Med., 196, 1575, 10.1084/jem.20021515

Banchereau, 2000, Immunobiology of dendritic cells, Annu. Rev. Immunol., 18, 767, 10.1146/annurev.immunol.18.1.767

Schroder, 2010, A physiological function of inflammation-associated SerpinB2 is regulation of adaptive immunity, J. Immunol., 184, 2663, 10.4049/jimmunol.0902187

Ohkuchi, 2001, Expansion of the fraction of Th1 cells in women with preeclampsia: inverse correlation between the percentage of Th1 cells and the plasma level of PAI-2, Am. J. Reprod. Immunol., 46, 252, 10.1034/j.1600-0897.2001.d01-10.x

Jarrossay, 2001, Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells, Eur. J. Immunol., 31, 3388, 10.1002/1521-4141(200111)31:11<3388::AID-IMMU3388>3.0.CO;2-Q

Panda, 2012, Dendritic cells in the circulation of women with preeclampsia demonstrate a pro-inflammatory bias secondary to dysregulation of TLR receptors, J. Reprod. Immunol., 94, 210, 10.1016/j.jri.2012.01.008

Berghöfer, 2007, Natural and synthetic TLR7 ligands inhibit CpG-A- and CpG-C-oligodeoxynucleotide-induced IFN-α production, J. Immunol., 178, 4072, 10.4049/jimmunol.178.7.4072

Rutella, 2006, Tolerogenic dendritic cells: cytokine modulation comes of age, Blood, 108, 1435, 10.1182/blood-2006-03-006403

Muthuswamy, 2008, Ability of mature dendritic cells to interact with regulatory T cells is imprinted during maturation, Cancer Res., 68, 5972, 10.1158/0008-5472.CAN-07-6818

Verlohren, 2009, Immunology in hypertension, preeclampsia, and target-organ damage, Hypertension, 54, 439, 10.1161/HYPERTENSIONAHA.108.120253

Banerjee, 2005, Placental expression of interferon-γ (IFN-γ) and its receptor IFN-γ R2 fail to switch from early hypoxic to late normotensive development in preeclampsia, J. Clin. Endocrinol. Metab., 90, 944, 10.1210/jc.2004-1113

Arriaga-Pizano, 2005, The predominant Th1 cytokine profile in maternal plasma of preeclamptic women is not reflected in the choriodecidual and fetal compartments, J. Soc. Gynecol. Invest., 12, 335, 10.1016/j.jsgi.2005.02.005

Murphy, 2009, Interferon γ in successful pregnancies, Biol. Reprod., 80, 848, 10.1095/biolreprod.108.073353

Moreau, 1999, IL-10 selectively induces HLA-G expression in human trophoblasts and monocytes, Int. Immunol., 11, 803, 10.1093/intimm/11.5.803

Steinborn, 2012, Pregnancy-associated diseases are characterized by the composition of the systemic regulatory T cell (Treg) pool with distinct subsets of Tregs, Clin. Exp. Immunol., 167, 84, 10.1111/j.1365-2249.2011.04493.x

Paeschke, 2005, Pre-eclampsia is not associated with changes in the levels of regulatory T cells in peripheral blood, Am. J. Reprod. Immunol., 54, 384, 10.1111/j.1600-0897.2005.00334.x

Steinborn, 2008, Distinct subsets of regulatory T cells during pregnancy: is the imbalance of these subsets involved in the pathogenesis of preeclampsia?, Clin. Immunol., 129, 401, 10.1016/j.clim.2008.07.032

Toldi, 2008, Decreased number of FoxP3+ regulatory T cells in preeclampsia, Acta Obstet. Gynecol. Scand., 87, 1229, 10.1080/00016340802389470

Darmochwal-Kolarz, 2012, The predominance of Th17 lymphocytes and decreased number and function of Treg cells in preeclampsia, J. Reprod. Immunol., 93, 75, 10.1016/j.jri.2012.01.006

Saito, 2011, Clinical implication of recent advances in our understanding of IL-17 and reproductive immunology, Exp. Rev. Clin. Immunol., 7, 49, 10.1586/eci.11.49

Santner-Nanan, 2009, Systemic increase in the ratio between Foxp3+ and IL-17-producing CD4+ T cells in healthy pregnancy but not in preeclampsia, J. Immunol., 183, 7023, 10.4049/jimmunol.0901154

Jianjun, 2010, Imbalance of T-cell transcription factors contributes to the Th1 type immunity predominant in pre-eclampsia, Am. J. Reprod. Immunol., 63, 38, 10.1111/j.1600-0897.2009.00763.x

Saito, 2010, Th17 cells and regulatory T cells: new light on pathophysiology of preeclampsia, Immunol. Cell Biol., 88, 615, 10.1038/icb.2010.68

Toldi, 2011, Increased prevalence of IL-17-producing peripheral blood lymphocytes in pre-eclampsia, Am. J. Reprod. Immunol., 66, 223, 10.1111/j.1600-0897.2011.00987.x

Jensen, 2012, CD19 + CD5+ cells as indicators of preeclampsia, Hypertension, 59, 861, 10.1161/HYPERTENSIONAHA.111.188276

Berland, 2002, Origins and functions of B-1 cells with notes on the role of CD5, Annu. Rev. Immunol., 20, 253, 10.1146/annurev.immunol.20.100301.064833

Sato, 1996, CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity, J. Immunol., 157, 4371, 10.4049/jimmunol.157.10.4371

Vinuesa, 2009, Dysregulation of germinal centres in autoimmune disease, Nat. Rev. Immunol., 9, 45, 10.1038/nri2637

Ebeling, 1993, The majority of human tonsillar CD5+ B cells express somatically mutated V κ 4 genes, Eur. J. Immunol., 23, 1405, 10.1002/eji.1830230636

Casali, 1987, Human lymphocytes making rheumatoid factor and antibody to ssDNA belong to Leu-1+ B-cell subset, Science, 236, 77, 10.1126/science.3105056

Wallukat, 1999, Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor, J. Clin. Invest., 103, 945, 10.1172/JCI4106

Siddiqui, 2010, Angiotensin receptor agonistic autoantibody is highly prevalent in preeclampsia: correlation with disease severity, Hypertension, 55, 386, 10.1161/HYPERTENSIONAHA.109.140061

Dechend, 2006, Agonistic antibodies directed at the angiotensin II, AT1 receptor in preeclampsia, J. Soc. Gynecol. Investig., 13, 79, 10.1016/j.jsgi.2005.11.006

Zhou, 2011, Autoantibody-mediated IL-6-dependent endothelin-1 elevation underlies pathogenesis in a mouse model of preeclampsia, J. Immunol., 186, 6024, 10.4049/jimmunol.1004026

Yang, 2008, Autoantibody against AT1 receptor from preeclamptic patients induces vasoconstriction through angiotensin receptor activation, J. Hypertens., 26, 1629, 10.1097/HJH.0b013e328304dbff

LaMarca, 2011, Hypertension in response to placental ischemia during pregnancy, Hypertension, 57, 865, 10.1161/HYPERTENSIONAHA.110.167569

Irani, 2009, The detrimental role of angiotensin receptor agonistic autoantibodies in intrauterine growth restriction seen in preeclampsia, J. Exp. Med., 206, 2809, 10.1084/jem.20090872

Hubel, 2007, Agonistic angiotensin II type 1 receptor autoantibodies in postpartum women with a history of preeclampsia, Hypertension, 49, 612, 10.1161/01.HYP.0000256565.20983.d4

Ma, 2013, Association between the presence of autoantibodies against adrenoreceptors and severe pre-eclampsia: a pilot study, PLoS ONE, 8, 57983, 10.1371/journal.pone.0057983