Adiponectin is produced by lymphocytes and is a negative regulator of granulopoiesis

Journal of Leukocyte Biology - Tập 88 Số 4 - Trang 807-811 - 2010
Lisa Crawford1, Roy W A Peake1, Susan Price1, T. C. M. Morris2, Alexandra E. Irvine1
1Centre for Cancer Research and Cell Biology, Queenˈs University Belfast , Belfast, Northern Ireland
2Department of Haematology, Belfast City Hospital, Belfast, Northern Ireland

Tóm tắt

Abstract Transcription, translation, and secretion of adiponectin by lymphocytes is shown with receptors for adiponectin expressed on bone marrow mononuclear cells. Lymphocytes have long been established to play an important role in the regulation of hematopoiesis and produce many cytokines that act on hematopoietic progenitor cells. Previous studies by our group have shown that normal, unstimulated lymphocytes produce a protein that inhibits normal bone marrow GM colony formation. Adiponectin is an adipokine that has been demonstrated to act as a negative regulator of hematopoiesis and immune function. This study aimed to determine if the inhibitory molecule that we described previously was adiponectin. Here, we show transcription, translation, and secretion of adiponectin from lymphocytes and demonstrate that its receptors, AdipoR1 and AdipoR2, are expressed by bone marrow MNCs. We show that although the adiponectin expression is low in lymphocytes, it is sufficient to induce a significant inhibitory effect on GM precursors (CFU-GM) and activate the AMPK pathway in these cells. The regulation of adiponectin production by lymphocytes and its detailed function in suppressing GM colony formation need to be elucidated now. Our findings suggest a functional role for adiponectin as a negative regulator of granulopoiesis.

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Journal of Leukocyte Biology

Tập 88 Số 4

807-811

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