Monocyte heterogeneity and functions in cancer

Shi, 2011, Monocyte recruitment during infection and inflammation, Nat Rev Immunol, 11, 762, 10.1038/nri3070

Qian, 2011, CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis, Nature, 475, 222, 10.1038/nature10138

Hanna, 2015, Patrolling monocytes control tumor metastasis to the lung, Science, 350, 985, 10.1126/science.aac9407

Engblom, 2016, The role of myeloid cells in cancer therapies, Nat Rev Cancer, 16, 447, 10.1038/nrc.2016.54

Ziegler-Heitbrock, 2010, Nomenclature of monocytes and dendritic cells in blood, Blood, 116, e74, 10.1182/blood-2010-02-258558

Passlick, 1989, Identification and characterization of a novel monocyte subpopulation in human peripheral blood, Blood, 74, 2527, 10.1182/blood.V74.7.2527.2527

Palframan, 2001, Inflammatory chemokine transport and presentation in hev: A remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues, J Exp Med, 194, 1361, 10.1084/jem.194.9.1361

Geissmann, 2003, Blood monocytes consist of two principal subsets with distinct migratory properties, Immunity, 19, 71, 10.1016/S1074-7613(03)00174-2

Sunderkötter, 2004, Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response, J Immunol, 172, 4410, 10.4049/jimmunol.172.7.4410

Ingersoll, 2010, Comparison of gene expression profiles between human and mouse monocyte subsets, Blood, 115, e10, 10.1182/blood-2009-07-235028

Mildner, 2017, Genomic characterization of murine monocytes reveals C/EBPβ transcription factor dependence of Ly6C− cells, Immunity, 46, 849, 10.1016/j.immuni.2017.04.018

Cros, 2010, Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors, Immunity, 33, 375, 10.1016/j.immuni.2010.08.012

Thomas, 2017, Human blood monocyte subsets: a new gating strategy defined using cell surface markers identified by mass cytometry, Arterioscler Thromb Vasc Biol, 37, 1548, 10.1161/ATVBAHA.117.309145

Jakubzick, 2017, Monocyte differentiation and antigen-presenting functions, Nat Rev Immunol, 2018, 349, 10.1038/nri.2017.28

Briseño, 2016, Distinct transcriptional programs control cross-priming in classical and monocyte-derived dendritic cells, Cell Rep, 15, 2462, 10.1016/j.celrep.2016.05.025

Villani, 2017, Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors, Science, 356, eaah4573, 10.1126/science.aah4573

Menezes, 2016, The heterogeneity of Ly6Chi monocytes controls their differentiation into iNOS+ macrophages or monocyte-derived dendritic cells, Immunity, 45, 1205, 10.1016/j.immuni.2016.12.001

Hettinger, 2013, Origin of monocytes and macrophages in a committed progenitor, Nat Immunol, 14, 821, 10.1038/ni.2638

Kawamura, 2017, Identification of a human clonogenic progenitor with strict monocyte differentiation potential: a counterpart of mouse cMoPs, Immunity, 46, 835, 10.1016/j.immuni.2017.04.019

Zhu, 2016, 2014 Jeffrey M. Hoeg award lecture: transcriptional control of monocyte development, Arterioscler Thromb Vasc Biol, 36, 1722, 10.1161/ATVBAHA.116.304054

Scott, 1994, Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages, Science, 265, 1573, 10.1126/science.8079170

Kurotaki, 2014, IRF8 inhibits C/EBPα activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils, Nat Commun, 5, 4978, 10.1038/ncomms5978

Kurotaki, 2013, Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation, Blood, 121, 1839, 10.1182/blood-2012-06-437863

Lee, 2015, Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow, J Exp Med, 212, 385, 10.1084/jem.20141442

Yáñez, 2017, Granulocyte-Monocyte progenitors and monocyte-dendritic cell progenitors independently produce functionally distinct monocytes, Immunity, 47, 890, 10.1016/j.immuni.2017.10.021

Yona, 2013, Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis, Immunity, 38, 79, 10.1016/j.immuni.2012.12.001

Varol, 2007, Monocytes give rise to mucosal, but not splenic, conventional dendritic cells, J Exp Med, 204, 171, 10.1084/jem.20061011

Patel, 2017, The fate and lifespan of human monocyte subsets in steady state and systemic inflammation, J Exp Med, 214, 1913, 10.1084/jem.20170355

Hanna, 2011, The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes, Nat Immunol, 12, 778, 10.1038/ni.2063

Thomas, 2016, Deleting an Nr4a1 super-enhancer subdomain ablates Ly6Clow monocytes while preserving macrophage gene function, Immunity, 45, 975, 10.1016/j.immuni.2016.10.011

Tamura, 2017, C/EBPβ is required for survival of Ly6C− monocytes, Blood, 130, 1809, 10.1182/blood-2017-03-772962

Gamrekelashvili, 2016, Regulation of monocyte cell fate by blood vessels mediated by Notch signalling, Nat Commun, 7, 12597, 10.1038/ncomms12597

Satoh, 2017, Identification of an atypical monocyte and committed progenitor involved in fibrosis, Nature, 541, 96, 10.1038/nature20611

Serbina, 2006, Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2, Nat Immunol, 7, 311, 10.1038/ni1309

Jakubzick, 2013, Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes, Immunity, 39, 599, 10.1016/j.immuni.2013.08.007

Auffray, 2007, Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior, Science, 317, 666, 10.1126/science.1142883

Debien, 2013, S1PR5 is pivotal for the homeostasis of patrolling monocytes, Eur J Immunol, 43, 1667, 10.1002/eji.201343312

Lavin, 2017, Innate immune landscape in early lung adenocarcinoma by paired single-cell analyses, Cell, 169, 750, 10.1016/j.cell.2017.04.014

Azizi, 2018, Single-Cell map of diverse immune phenotypes in the breast tumor microenvironment, Cell, 174, 1293, 10.1016/j.cell.2018.05.060

Jakubzick, 2008, Blood monocyte subsets differentially give rise to CD103+ and CD103− pulmonary dendritic cell populations, J Immunol, 180, 3019, 10.4049/jimmunol.180.5.3019

Guilliams, 2014, Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny, Nat Rev Immunol, 14, 571, 10.1038/nri3712

Guilliams, 2017, Does niche competition determine the origin of tissue-resident macrophages?, Nat Rev Immunol, 17, 451, 10.1038/nri.2017.42

van de Laar, 2016, Yolk sac macrophages, fetal liver, and adult monocytes can colonize an empty niche and develop into functional tissue-resident macrophages, Immunity, 44, 755, 10.1016/j.immuni.2016.02.017

Goudot, 2017, Aryl hydrocarbon receptor controls monocyte differentiation into dendritic cells versus macrophages, Immunity, 47, 582, 10.1016/j.immuni.2017.08.016

Carlin, 2013, Nr4a1-Dependent Ly6Clow monocytes monitor endothelial cells and orchestrate their disposal, Cell, 153, 362, 10.1016/j.cell.2013.03.010

Misharin, 2014, Nonclassical Ly6C− monocytes drive the development of inflammatory arthritis in mice, Cell Rep, 9, 591, 10.1016/j.celrep.2014.09.032

Olingy, 2017, Non-classical monocytes are biased progenitors of wound healing macrophages during soft tissue injury, Sci Rep, 7, 447, 10.1038/s41598-017-00477-1

Franklin, 2014, The cellular and molecular origin of tumor-associated macrophages, Science, 344, 921, 10.1126/science.1252510

Martinez, 2006, Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: New molecules and patterns of gene expression, J Immunol, 177, 7303, 10.4049/jimmunol.177.10.7303

Guilliams, 2018, Developmental and functional heterogeneity of monocytes, Immunity, 49, 595, 10.1016/j.immuni.2018.10.005

Movahedi, 2010, Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes, Cancer Res, 70, 5728, 10.1158/0008-5472.CAN-09-4672

Kitamura, 2018, Monocytes differentiate to immune suppressive precursors of metastasis-associated macrophages in mouse models of metastatic breast cancer, Front. Immunol., 8, 69, 10.3389/fimmu.2017.02004

Chun, 2015, CCL2 promotes colorectal carcinogenesis by enhancing polymorphonuclear myeloid-derived suppressor cell population and function, Cell Rep, 12, 244, 10.1016/j.celrep.2015.06.024

Cortez-Retamozo, 2012, Origins of tumor-associated macrophages and neutrophils, Proc Natl Acad Sci USA, 109, 2491, 10.1073/pnas.1113744109

Wu, 2018, Spleen mediates a distinct hematopoietic progenitor response supporting tumor-promoting myelopoiesis, J Clin Invest, 128, 3425, 10.1172/JCI97973

Shand, 2014, Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes, Proc Natl Acad Sci USA, 111, 7771, 10.1073/pnas.1402914111

Griffith, 1999, Monocyte-mediated tumoricidal activity via the tumor necrosis factor–related cytokine, TRAIL, J Exp Med, 189, 1343, 10.1084/jem.189.8.1343

Hartwig, 2017, The TRAIL-Induced cancer secretome promotes a tumor-supportive immune microenvironment via CCR2, Mol Cell, 65, 730, 10.1016/j.molcel.2017.01.021

Gordon, 2006, Defective antitumor function of monocyte-derived macrophages from epithelial ovarian cancer patients, Clin Cancer Res, 12, 1515, 10.1158/1078-0432.CCR-05-2254

Yeap, 2016, CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes, Sci Rep, 6, 34310, 10.1038/srep34310

Chittezhath, 2014, Molecular profiling reveals a tumor-promoting phenotype of monocytes and macrophages in human cancer progression, Immunity, 41, 815, 10.1016/j.immuni.2014.09.014

Lee, 2012, Protumoral role of monocytes in human B-cell precursor acute lymphoblastic leukemia: involvement of the chemokine CXCL10, Blood, 119, 227, 10.1182/blood-2011-06-357442

Hamm, 2016, Tumour-educated circulating monocytes are powerful candidate biomarkers for diagnosis and disease follow-up of colorectal cancer, Gut, 65, 990, 10.1136/gutjnl-2014-308988

Headley, 2016, Visualization of immediate immune responses to pioneer metastatic cells in the lung, Nature, 531, 513, 10.1038/nature16985

Jaiswal, 2009, CD47 is up-regulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis, Cell, 138, 271, 10.1016/j.cell.2009.05.046

Chao, 2010, Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-hodgkin lymphoma, Cell, 142, 699, 10.1016/j.cell.2010.07.044

Willingham, 2012, The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors, Proc Natl Acad Sci USA, 109, 6662, 10.1073/pnas.1121623109

Zhao, 2016, CD47 promotes tumor invasion and metastasis in non-small cell lung cancer, Sci Rep, 6, 29719, 10.1038/srep29719

Kubo, 2017, Primary tumors limit metastasis formation through induction of IL15-Mediated cross-talk between patrolling monocytes and NK cells, Cancer Immunol Res, 5, 812, 10.1158/2326-6066.CIR-17-0082

Plebanek, 2017, Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche, Nat Commun, 8, 1319, 10.1038/s41467-017-01433-3

Veglia, 2018, Myeloid-derived suppressor cells coming of age, Nat Immunol, 19, 108, 10.1038/s41590-017-0022-x

Mitchem, 2012, Targeting tumor-infiltrating macrophages decreases tumor-Initiating cells, relieves immunosuppression and improves chemotherapeutic response, Cancer Res, 73, 2012

Li, 2017, Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma, Gut, 66, 157, 10.1136/gutjnl-2015-310514

Lesokhin, 2012, Monocytic CCR2(+) myeloid-derived suppressor cells promote immune escape by limiting activated CD8 T-cell infiltration into the tumor microenvironment, Cancer Res, 72, 876, 10.1158/0008-5472.CAN-11-1792

Sawanobori, 2008, Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice, Blood, 111, 5457, 10.1182/blood-2008-01-136895

Sanford, 2013, Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2/CCR2 axis, Clin Cancer Res, 19, 3404, 10.1158/1078-0432.CCR-13-0525

Weber, 2016, Phase I/II study of metastatic melanoma patients treated with nivolumab who had progressed after ipilimumab, Cancer Immunol Res, 4, 345, 10.1158/2326-6066.CIR-15-0193

Schlecker, 2012, Tumor-Infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-Dependent recruitment of regulatory T Cells favoring tumor growth, J Immunol, 189, 5602, 10.4049/jimmunol.1201018

Pommier, 2013, Inflammatory monocytes are potent antitumor effectors controlled by regulatory CD4+ T cells, Proc Natl Acad Sci USA, 110, 13085, 10.1073/pnas.1300314110

Tiemessen, 2007, CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages, Proc Natl Acad Sci USA, 104, 19446, 10.1073/pnas.0706832104

Romano, 2015, Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients, Proc Natl Acad Sci USA, 112, 6140, 10.1073/pnas.1417320112

Kuhn, 2015, Monocyte-Derived dendritic cells are essential for CD8+ T cell activation and antitumor responses after local immunotherapy, Frontiers in Immunology, 6, e17515, 10.3389/fimmu.2015.00584

Sheng, 2017, A discrete subset of monocyte-derived cells among typical conventional type 2 dendritic cells can efficiently cross-present, Cell Rep, 21, 1203, 10.1016/j.celrep.2017.10.024

Westhorpe, 2018, Effector CD4 + T cells recognize intravascular antigen presented by patrolling monocytes, Nat Commun, 9, 747, 10.1038/s41467-018-03181-4

Rivera, 2015, Intertwined regulation of angiogenesis and immunity by myeloid cells, Trends Immunol, 36, 240, 10.1016/j.it.2015.02.005

Du, 2008, HIF1α induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion, Cancer Cell, 13, 206, 10.1016/j.ccr.2008.01.034

Sidibe, 2018, Angiogenic factor-driven inflammation promotes extravasation of human proangiogenic monocytes to tumours, Nat Commun, 9, 355, 10.1038/s41467-017-02610-0

Zhang, 2010, Depletion of tumor-associated macrophages enhances the effect of sorafenib in metastatic liver cancer models by antimetastatic and antiangiogenic effects, Clin Cancer Res, 16, 3420, 10.1158/1078-0432.CCR-09-2904

Gazzaniga, 2007, Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft, J Invest Dermatol, 127, 2031, 10.1038/sj.jid.5700827

Arwert, 2018, A unidirectional transition from migratory to perivascular macrophage is required for tumor cell intravasation, Cell Rep, 23, 1239, 10.1016/j.celrep.2018.04.007

De Palma, 2005, Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors, Cancer Cell, 8, 211, 10.1016/j.ccr.2005.08.002

Venneri, 2007, Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer, Blood, 109, 5276, 10.1182/blood-2006-10-053504

Coffelt, 2010, Angiopoietin-2 regulates gene expression in TIE2-Expressing monocytes and augments their inherent proangiogenic functions, Cancer Res, 70, 5270, 10.1158/0008-5472.CAN-10-0012

Harney, 2015, Real-Time imaging reveals local, transient vascular permeability, and tumor cell intravasation stimulated by TIE2hi macrophage–derived VEGFA, Cancer Discov, 5, 932, 10.1158/2159-8290.CD-15-0012

Coffelt, 2011, Angiopoietin 2 stimulates TIE2-Expressing monocytes to suppress T Cell activation and to promote regulatory T cell expansion, J Immunol, 186, 4183, 10.4049/jimmunol.1002802

Bergers, 2008, Modes of resistance to anti-angiogenic therapy, Nat Rev Cancer, 8, 592, 10.1038/nrc2442

Jung, 2017, Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy, J Clin Invest, 127, 3039, 10.1172/JCI93182

Xu, 2009, Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1α, CXCR4, CXCL6, and Neuropilin 1 in tumors from patients with rectal cancer, Cancer Res, 69, 7905, 10.1158/0008-5472.CAN-09-2099

Shojaei, 2007, Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells, Nat Biotechnol, 25, 911, 10.1038/nbt1323

Zeisberger, 2006, Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach, Br J Cancer, 95, 272, 10.1038/sj.bjc.6603240

Lu, 2012, The extracellular matrix: a dynamic niche in cancer progression, J Cell Biol, 196, 395, 10.1083/jcb.201102147

Porrello, 2018, Factor XIIIA—expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking, Nat Commun, 9, 1988, 10.1038/s41467-018-04355-w

Madsen, 2017, Tumor-associated macrophages derived from circulating inflammatory monocytes degrade collagen through cellular uptake, Cell Rep, 21, 3662, 10.1016/j.celrep.2017.12.011

Loyher, 2018, Macrophages of distinct origins contribute to tumor development in the lung, J Exp Med, 87, jem.20180534

Lu, 2014, A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages, Nat Cell Biol, 16, 1105, 10.1038/ncb3041

Lapenna, 2018, Perivascular macrophages in health and disease, Nat Rev Immunol, 2018, 689, 10.1038/s41577-018-0056-9

Forssell, 2007, High macrophage infiltration along the tumor front correlates with improved survival in colon cancer, Clin Cancer Res, 13, 1472, 10.1158/1078-0432.CCR-06-2073

Noy, 2014, Tumor-Associated macrophages: from mechanisms to therapy, Immunity, 41, 49, 10.1016/j.immuni.2014.06.010

Mantovani, 2017, Tumour-associated macrophages as treatment targets in oncology, Nat Rev Clin Oncol, 14, 399, 10.1038/nrclinonc.2016.217

Broz, 2014, Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity, Cancer Cell, 26, 638, 10.1016/j.ccell.2014.09.007

Sharma, 2018, Activation of p53 in immature myeloid precursor cells controls differentiation into Ly6c+CD103+ monocytic antigen-presenting cells in tumors, Immunity, 48, 91, 10.1016/j.immuni.2017.12.014

Wilcox, 2011, The absolute monocyte and lymphocyte prognostic score predicts survival and identifies high-risk patients in diffuse large-B-cell lymphoma, Leukemia, 25, 1502, 10.1038/leu.2011.112

Lee, 2012, Prognostic value of pre-treatment circulating monocyte count in patients with cervical cancer: comparison with SCC-Ag level, Gynecol Oncol, 124, 92, 10.1016/j.ygyno.2011.09.034

Li, 2012, Blood lymphocyte-to-monocyte ratio identifies high-risk patients in diffuse large B-cell lymphoma treated with R-CHOP, PLoS One, 7, e41658, 10.1371/journal.pone.0041658

Stotz, 2014, The preoperative lymphocyte to monocyte ratio predicts clinical outcome in patients with stage III colon cancer, Br J Cancer, 110, 435, 10.1038/bjc.2013.785

Hu, 2014, Prognostic significance of systemic inflammation-based lymphocyte- monocyte ratio in patients with lung cancer: based on a large cohort study, PLoS One, 9, e108062, 10.1371/journal.pone.0108062

Eo, 2016, The lymphocyte-monocyte ratio predicts patient survival and aggressiveness of ovarian cancer, J Cancer, 7, 289, 10.7150/jca.13432

Lu, 2007, CCR2 expression correlates with prostate cancer progression, J Cell Biochem, 101, 676, 10.1002/jcb.21220

Krieg, 2018, High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy, Nat Med, 9, 2579

Schmall, 2015, Macrophage and cancer cell cross-talk via CCR2 and CX3CR1 is a fundamental mechanism driving lung cancer, Am J Respir Crit Care Med, 191, 437, 10.1164/rccm.201406-1137OC

Loberg, 2007, Targeting CCL2 with systemic delivery of neutralizing antibodies induces prostate cancer tumor regression in vivo, Cancer Res, 67, 9417, 10.1158/0008-5472.CAN-07-1286

Leuschner, 2011, Therapeutic siRNA silencing in inflammatory monocytes in mice, Nat Biotechnol, 29, 1005, 10.1038/nbt.1989

Pienta, 2012, Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer, Invest New Drugs, 31, 760, 10.1007/s10637-012-9869-8

Nywening, 2016, Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial, Lancet Oncol, 17, 651, 10.1016/S1470-2045(16)00078-4

Bonapace, 2014, Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis, Nature, 515, 130, 10.1038/nature13862

Yu, 2007, Defective antitumor responses in CX3CR1-deficient mice, Int J Cancer, 121, 316, 10.1002/ijc.22660

Hyakudomi, 2008, Increased expression of fractalkine is correlated with a better prognosis and an increased number of both CD8+ T cells and natural killer cells in gastric adenocarcinoma, Ann Surg Oncol, 15, 1775, 10.1245/s10434-008-9876-3

Park, 2012, High expression of CX3CL1 by tumor cells correlates with a good prognosis and increased tumor-infiltrating CD8+ T cells, natural killer cells, and dendritic cells in breast carcinoma, J Surg Oncol, 106, 386, 10.1002/jso.23095

Jung, 2017, Targeting CXCR4-dependent immunosuppressive Ly6Clow monocytes improves antiangiogenic therapy in colorectal cancer, Proc Natl Acad Sci USA, 114, 10455, 10.1073/pnas.1710754114

Welford, 2011, TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice, J Clin Invest, 121, 1969, 10.1172/JCI44562

Van Overmeire, 2016, M-CSF and GM-CSF receptor signaling differentially regulate monocyte maturation and macrophage polarization in the tumor microenvironment, Cancer Res, 76, 35, 10.1158/0008-5472.CAN-15-0869

Cannarile, 2017, Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy, J Immunother Cancer, 5, 705, 10.1186/s40425-017-0257-y

Aharinejad, 2004, Colony-stimulating factor-1 blockade by antisense oligonucleotides and small interfering RNAs suppresses growth of human mammary tumor xenografts in mice, Cancer Res, 64, 5378, 10.1158/0008-5472.CAN-04-0961

DeNardo, 2011, Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy, Cancer Discov, 1, 54, 10.1158/2159-8274.CD-10-0028

Pyonteck, 2013, CSF-1R inhibition alters macrophage polarization and blocks glioma progression, Nat Med, 2018, 1264, 10.1038/nm.3337

Ries, 2014, Targeting tumor-associated macrophages with Anti-CSF-1R antibody reveals a strategy for cancer therapy, Cancer Cell, 25, 846, 10.1016/j.ccr.2014.05.016

Neubert, 2018, T cell-induced CSF1 promotes melanoma resistance to PD1 blockade, Sci Transl Med, 10, 10.1126/scitranslmed.aan3311

Zhu, 2014, CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models, Cancer Res, 74, 5057, 10.1158/0008-5472.CAN-13-3723

Beffinger, 2018, CSF1R-dependent myeloid cells are required for NK-mediated control of metastasis, JCI Insight, 3, 97792, 10.1172/jci.insight.97792

Quail, 2016, The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas, Science, 352, aad3018, 10.1126/science.aad3018

Kumar, 2017, Cancer-Associated fibroblasts neutralize the anti-tumor effect of CSF1 receptor blockade by inducing PMN-MDSC infiltration of tumors, Cancer Cell, 32, 654, 10.1016/j.ccell.2017.10.005

June, 2018, Chimeric antigen receptor therapy, N Engl J Med, 379, 64, 10.1056/NEJMra1706169

Green, 2018, A phase 1 trial of autologous monocytes stimulated ex vivo with Sylatron ® (peginterferon alfa-2b) and Actimmune ® (interferon gamma-1b) for intra-peritoneal administration in recurrent ovarian cancer, J. Transl. Med., 16, 196, 10.1186/s12967-018-1569-5

Norelli, 2018, Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells, Nat Med, 118, 1

Long, 2016, Reduction of MDSCs with all-trans retinoic acid improves CAR therapy efficacy for sarcomas, Cancer Immunol Res, 4, 869, 10.1158/2326-6066.CIR-15-0230

Dietrich, 2018, Bone marrow drives central nervous system regeneration after radiation injury, J Clin Invest, 128, 281, 10.1172/JCI90647