Journal of Clinical Medicine
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MicroRNAs in the Cholangiopathies: Pathogenesis, Diagnosis, and Treatment
Journal of Clinical Medicine - Tập 4 Số 9 - Trang 1688-1712
The cholangiopathies are a group of liver diseases resulting from different
etiologies but with the cholangiocyte as the primary target. As a group, the
cholangiopathies result in significant morbidity and mortality and represent one
of the main indications for liver transplant in both children and adults.
Contributing to this situation is the absence of a thorough understanding of
their pathogene...
Immune-Inflammatory Responses in Atherosclerosis: The Role of Myeloid Cells
Journal of Clinical Medicine - Tập 8 Số 11 - Trang 1798
Inflammation plays a key role in the initiation and progression of
atherosclerosis and can be caused by multiple agents, including increased
concentration of circulating low-density lipoprotein (LDL) cholesterol. Areas of
the arterial wall affected by atherosclerosis are enriched with lymphocytes and
dendritic cells (DCs). Atherosclerotic plaques contain a variety of
proinflammatory immune cells, ...
Electric Scooter-Related Injuries: A New Epidemic in Orthopedics
Journal of Clinical Medicine - Tập 10 Số 15 - Trang 3283
Background: The use of electric scooters has increased considerably as they are
an accessible means of transportation. The number of injuries from falls and
collisions has risen significantly. Therefore, the aim of the study was to
describe demographics injury patterns of electric scooter accidents produced
over one year. Methods: A prospective observational study of electric scooter-
related inju...
Gut Microbiota and Risk of Persistent Nonalcoholic Fatty Liver Diseases
Journal of Clinical Medicine - Tập 8 Số 8 - Trang 1089
Gut dysbiosis is regarded as a pathogenetic factor of nonalcoholic fatty liver
disease (NAFLD), but its role in NAFLD persistence is unknown. We investigated
the influence of the gut microbiota on persistent NAFLD. This cohort study
included 766 subjects with 16S ribosomal RNA (rRNA) gene sequencing data from
fecal samples at baseline who underwent repeated health check-up examinations.
Fatty live...
Current Approaches in the Treatment of Relapsed and Refractory Acute Myeloid Leukemia
Journal of Clinical Medicine - Tập 4 Số 4 - Trang 665-695
The limited sensitivity of the historical treatment response criteria for acute
myeloid leukemia (AML) has resulted in a different paradigm for treatment
compared with most other cancers presenting with widely disseminated disease.
Initial cytotoxic induction chemotherapy is often able to reduce tumor burden to
a level sufficient to meet the current criteria for “complete” remission.
Nevertheless,...
A Systematic Review of COVID-19 Infection in Kidney Transplant Recipients: A Universal Effort to Preserve Patients’ Lives and Allografts
Journal of Clinical Medicine - Tập 9 Số 9 - Trang 2986
The coronavirus disease 2019 (COVID-19) pandemic has posed a significant
challenge to physicians and healthcare systems worldwide. Evidence about kidney
transplant (KTx) recipients is still limited. A systematic literature review was
performed. We included 63 articles published from 1 January until 7 July 2020,
reporting on 420 adult KTx recipients with confirmed COVID-19. The mean age of
patients...
Microvascular and Structural Alterations of the Macula in Early to Moderate Glaucoma: An Optical Coherence Tomography-Angiography Study
Journal of Clinical Medicine - Tập 10 Số 21 - Trang 5017
In glaucoma, macular optical coherence tomography (OCT) typically shows a
thinning of the three inner segments and OCT-angiography (OCTA) a reduction of
the vascular density (VD). It is still unclear if glaucoma directly affects
macular VD. This retrospective study included 31 glaucoma patients of early and
moderate stage (GS1, GS2, Mills et al.) and 39 healthy individuals. Macular
segments’ thick...
Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review
Journal of Clinical Medicine - Tập 10 Số 5 - Trang 1085
Background: The first objective of this review was to present, based on recent
literature, the most frequently applied medical options (oral contraceptive
pills (OCPs) and progestogens) for the management of symptomatic endometriosis,
and evaluate their effectiveness in treating premenopausal women with
endometriosis-associated pelvic pain, dysmenorrhea, non-menstrual pelvic pain
and dyspareunia. ...
Current and Prospective Treatment of Adenomyosis
Journal of Clinical Medicine - Tập 10 Số 15 - Trang 3410
(1) Background: Adenomyosis is a poorly understood entity which makes it
difficult to standardize treatment. In this paper we review and compare the
currently approved medical and surgical treatments of adenomyosis and present
the evidence behind them. (2) Methods: A PubMed search was conducted to identify
papers related to the different treatments of adenomyosis. The search was
limited to the Eng...
The Roles of Vitamin A in the Regulation of Carbohydrate, Lipid, and Protein Metabolism
Journal of Clinical Medicine - Tập 3 Số 2 - Trang 453-479
Currently, two-thirds of American adults are overweight or obese. This high
prevalence of overweight/obesity negatively affects the health of the
population, as obese individuals tend to develop several chronic diseases, such
as type 2 diabetes and cardiovascular diseases. Due to obesity’s impact on
health, medical costs, and longevity, the rise in the number of obese people has
become a public he...
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