Journal of Clinical Medicine

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MicroRNAs in the Cholangiopathies: Pathogenesis, Diagnosis, and Treatment
Journal of Clinical Medicine - Tập 4 Số 9 - Trang 1688-1712
María J. Lorenzo Pisarello, Lorena Loarca, Tommy Ivanics, Leslie A. Morton, Nicholas F. LaRusso
The cholangiopathies are a group of liver diseases resulting from different etiologies but with the cholangiocyte as the primary target. As a group, the cholangiopathies result in significant morbidity and mortality and represent one of the main indications for liver transplant in both children and adults. Contributing to this situation is the absence of a thorough understanding of their p...... hiện toàn bộ
Immune-Inflammatory Responses in Atherosclerosis: The Role of Myeloid Cells
Journal of Clinical Medicine - Tập 8 Số 11 - Trang 1798
Dimitry A. Chistiakov, Dmitry Kashirskikh, Victoria A. Khotina, Andrey V. Grechko, Alexander N. Orekhov
Inflammation plays a key role in the initiation and progression of atherosclerosis and can be caused by multiple agents, including increased concentration of circulating low-density lipoprotein (LDL) cholesterol. Areas of the arterial wall affected by atherosclerosis are enriched with lymphocytes and dendritic cells (DCs). Atherosclerotic plaques contain a variety of proinflammatory immune...... hiện toàn bộ
Electric Scooter-Related Injuries: A New Epidemic in Orthopedics
Journal of Clinical Medicine - Tập 10 Số 15 - Trang 3283
C Alexandre, Pablo Feito, Laura Corominas, Juan Sánchez‐Soler, Daniel Pérez‐Prieto, Santos Martínez‐Díaz, Albert Alier, Joan Carles Monllau
Background: The use of electric scooters has increased considerably as they are an accessible means of transportation. The number of injuries from falls and collisions has risen significantly. Therefore, the aim of the study was to describe demographics injury patterns of electric scooter accidents produced over one year. Methods: A prospective observational study of electric scooter- rela...... hiện toàn bộ
Gut Microbiota and Risk of Persistent Nonalcoholic Fatty Liver Diseases
Journal of Clinical Medicine - Tập 8 Số 8 - Trang 1089
Han-Na Kim, Eun‐Jeong Joo, Hae Suk Cheong, Yejin Kim, Hyung‐Lae Kim, Ho Cheol Shin, Yoosoo Chang, Seungho Ryu
Gut dysbiosis is regarded as a pathogenetic factor of nonalcoholic fatty liver disease (NAFLD), but its role in NAFLD persistence is unknown. We investigated the influence of the gut microbiota on persistent NAFLD. This cohort study included 766 subjects with 16S ribosomal RNA (rRNA) gene sequencing data from fecal samples at baseline who underwent repeated health check-up examinations. Fa...... hiện toàn bộ
Current Approaches in the Treatment of Relapsed and Refractory Acute Myeloid Leukemia
Journal of Clinical Medicine - Tập 4 Số 4 - Trang 665-695
Nestor R. Ramos, Clifton C. Mo, Judith E. Karp, Christopher S. Hourigan
The limited sensitivity of the historical treatment response criteria for acute myeloid leukemia (AML) has resulted in a different paradigm for treatment compared with most other cancers presenting with widely disseminated disease. Initial cytotoxic induction chemotherapy is often able to reduce tumor burden to a level sufficient to meet the current criteria for “complete” remission. Never...... hiện toàn bộ
A Systematic Review of COVID-19 Infection in Kidney Transplant Recipients: A Universal Effort to Preserve Patients’ Lives and Allografts
Journal of Clinical Medicine - Tập 9 Số 9 - Trang 2986
Smaragdi Marinaki, Stathis Tsiakas, Maria Korogiannou, Konstantinos Grigorakos, Vassilios Papalois, Ioannis Boletis
The coronavirus disease 2019 (COVID-19) pandemic has posed a significant challenge to physicians and healthcare systems worldwide. Evidence about kidney transplant (KTx) recipients is still limited. A systematic literature review was performed. We included 63 articles published from 1 January until 7 July 2020, reporting on 420 adult KTx recipients with confirmed COVID-19. The mean age of ...... hiện toàn bộ
Microvascular and Structural Alterations of the Macula in Early to Moderate Glaucoma: An Optical Coherence Tomography-Angiography Study
Journal of Clinical Medicine - Tập 10 Số 21 - Trang 5017
M. J. Lever, Moritz Glaser, Ying Chen, Christian Halfwassen, Jan Darius Unterlauft, Nikolaos E. Bechrakis, Michael R. R. Böhm
In glaucoma, macular optical coherence tomography (OCT) typically shows a thinning of the three inner segments and OCT-angiography (OCTA) a reduction of the vascular density (VD). It is still unclear if glaucoma directly affects macular VD. This retrospective study included 31 glaucoma patients of early and moderate stage (GS1, GS2, Mills et al.) and 39 healthy individuals. Macular segment...... hiện toàn bộ
Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review
Journal of Clinical Medicine - Tập 10 Số 5 - Trang 1085
Jacques Donnez, Marie‐Madeleine Dolmans
Background: The first objective of this review was to present, based on recent literature, the most frequently applied medical options (oral contraceptive pills (OCPs) and progestogens) for the management of symptomatic endometriosis, and evaluate their effectiveness in treating premenopausal women with endometriosis-associated pelvic pain, dysmenorrhea, non-menstrual pelvic pain and dyspa...... hiện toàn bộ
Current and Prospective Treatment of Adenomyosis
Journal of Clinical Medicine - Tập 10 Số 15 - Trang 3410
Fady I. Sharara, Mira Kheil, Anis Féki, Sara Rahman, Jordan S. Klebanoff, Jean Marc Ayoubi, Gaby Moawad
(1) Background: Adenomyosis is a poorly understood entity which makes it difficult to standardize treatment. In this paper we review and compare the currently approved medical and surgical treatments of adenomyosis and present the evidence behind them. (2) Methods: A PubMed search was conducted to identify papers related to the different treatments of adenomyosis. The search was limited to...... hiện toàn bộ
The Roles of Vitamin A in the Regulation of Carbohydrate, Lipid, and Protein Metabolism
Journal of Clinical Medicine - Tập 3 Số 2 - Trang 453-479
Wei Chen, Guoxun Chen
Currently, two-thirds of American adults are overweight or obese. This high prevalence of overweight/obesity negatively affects the health of the population, as obese individuals tend to develop several chronic diseases, such as type 2 diabetes and cardiovascular diseases. Due to obesity’s impact on health, medical costs, and longevity, the rise in the number of obese people has become a p...... hiện toàn bộ
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