Current Approaches in the Treatment of Relapsed and Refractory Acute Myeloid Leukemia
Tóm tắt
Từ khóa
Tài liệu tham khảo
American Cancer Society (2015). Cancer Facts & Figures 2015, American Cancer Society.
Walter, 2014, Resistance prediction in aml: Analysis of 4601 patients from MRC/NCRI, HOVON/SAKK, SWOC and MD Anderson Cancer Center, Leukemia, 29, 312, 10.1038/leu.2014.242
Bergua, 2014, A prognostic index for patients with refractory or in first relapsed acute myeloid leukemia treated with FLAG-ida or FLAGO-ida, Blood, 124, 1049, 10.1182/blood.V124.21.1049.1049
Breems, 2005, Prognostic index for adult patients with acute myeloid leukemia in first relapse, J. Clin. Oncol., 23, 1969, 10.1200/JCO.2005.06.027
Kurosawa, 2010, Prognostic factors and outcomes of adult patients with acute myeloid leukemia after first relapse, Haematologica, 95, 1857, 10.3324/haematol.2010.027516
Pemmaraju, 2015, Improving outcomes for patients with acute myeloid leukemia in first relapse: A single center experience, Am. J. Hematol., 90, 27, 10.1002/ajh.23858
(2013). Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N. Engl. J. Med., 368, 2059–2074.
Ding, 2012, Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing, Nature, 481, 506, 10.1038/nature10738
Meggendorfer, 2014, Genetic patterns of relapsed aml differ significantly from first manifestation and are dependent on cytogenetic risk groups at diagnosis: Results in 175 patients with paired samples, Blood, 124, 1029, 10.1182/blood.V124.21.1029.1029
Hourigan, 2011, New considerations in the design of clinical trials for the treatment of acute leukemia, Clin. Investig., 1, 509, 10.4155/cli.11.24
Karanes, 1999, A phase III comparison of high dose ARA-C (HIDAC) versus HIDAC plus mitoxantrone in the treatment of first relapsed or refractory acute myeloid leukemia Southwest Oncology Group Study, Leuk. Res., 23, 787, 10.1016/S0145-2126(99)00087-9
Herzig, 1985, High-dose cytosine arabinoside therapy with and without anthracycline antibiotics for remission reinduction of acute nonlymphoblastic leukemia, J. Clin. Oncol., 3, 992, 10.1200/JCO.1985.3.7.992
Lee, 2009, The clinical outcome of flag chemotherapy without idarubicin in patients with relapsed or refractory acute myeloid leukemia, J. Korean Med. Sci., 24, 498, 10.3346/jkms.2009.24.3.498
Montillo, 1998, Fludarabine, cytarabine, and G-CSF (FLAG) for the treatment of poor risk acute myeloid leukemia, Am. J. Hematol., 58, 105, 10.1002/(SICI)1096-8652(199806)58:2<105::AID-AJH3>3.0.CO;2-W
Virchis, 2004, Fludarabine, cytosine arabinoside, granulocyte-colony stimulating factor with or without idarubicin in the treatment of high risk acute leukaemia or myelodysplastic syndromes, Br. J. Haematol., 124, 26, 10.1046/j.1365-2141.2003.04728.x
Milligan, 2006, Fludarabine and cytosine are less effective than standard ade chemotherapy in high-risk acute myeloid leukemia, and addition of G-CSF and ATRA are not beneficial: Results of the MRC AML-HR randomized trial, Blood, 107, 4614, 10.1182/blood-2005-10-4202
Martin, 2009, Cladribine in the treatment of acute myeloid leukemia: A single-institution experience, Clin. Lymphoma Myeloma, 9, 298, 10.3816/CLM.2009.n.058
Robak, 2003, A multicenter, open, non-comparative, phase II study of the combination of cladribine (2-chlorodeoxyadenosine), cytarabine, and G-CSF as induction therapy in refractory acute myeloid leukemia—A report of the polish adult leukemia group (PALG), Eur. J. Haematol., 71, 155, 10.1034/j.1600-0609.2003.00122.x
Price, 2011, Salvage chemotherapy regimens for acute myeloid leukemia: Is one better? Efficacy comparison between CLAG and MEC regimens, Leuk. Res., 35, 301, 10.1016/j.leukres.2010.09.002
Wierzbowska, 2008, Cladribine combined with high doses of arabinoside cytosine, mitoxantrone, and G-CSF (CLAG-M) is a highly effective salvage regimen in patients with refractory and relapsed acute myeloid leukemia of the poor risk: A final report of the polish adult leukemia group, Eur. J. Haematol., 80, 115, 10.1111/j.1600-0609.2007.00988.x
Amadori, 1991, Mitoxantrone, etoposide, and intermediate-dose cytarabine: An effective and tolerable regimen for the treatment of refractory acute myeloid leukemia, J. Clin. Oncol., 9, 1210, 10.1200/JCO.1991.9.7.1210
Trifilio, 2012, Mitoxantrone and etoposide with or without intermediate dose cytarabine for the treatment of primary induction failure or relapsed acute myeloid leukemia, Leuk. Res., 36, 394, 10.1016/j.leukres.2011.10.027
Greenberg, 2004, Mitoxantrone, etoposide, and cytarabine with or without valspodar in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome: A phase III trial (E2995), J. Clin. Oncol., 22, 1078, 10.1200/JCO.2004.07.048
Kohrt, 2010, Second-line mitoxantrone, etoposide, and cytarabine for acute myeloid leukemia: A single-center experience, Am. J. Hematol., 85, 877, 10.1002/ajh.21857
Halpern, 2014, Mitoxantrone, etoposide, and cytarabine (MEC) following epigenetic priming with decitabine in adults with relapsed/refractory acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS): A phase 1 study, Blood, 124, 3730, 10.1182/blood.V124.21.3730.3730
Archimbaud, 1995, Timed sequential chemotherapy for previously treated patients with acute myeloid leukemia: Long-term follow-up of the etoposide, mitoxantrone, and cytarabine-86 trial, J. Clin. Oncol., 13, 11, 10.1200/JCO.1995.13.1.11
Link, 1990, Mitoxantrone, cytosine arabinoside, and vp-16 in 36 patients with relapsed and refractory acute myeloid leukemia, Haematol. Blood Transfus., 33, 322
Clavio, 2014, Liposomal daunorubicin, fludarabine, and cytarabine (FLAD) as bridge therapy to stem cell transplant in relapsed and refractory acute leukemia, Ann. Hematol., 93, 2011, 10.1007/s00277-014-2143-8
Litzow, 2014, A randomized phase II trial of three novel regimens for relapsed/ refractory acute myeloid leukemia (AML) demonstrates encouraging results with a flavopiridol-based regimen: Results of eastern cooperative oncology group (ECOG) trial E1906, Blood, 124, 3742, 10.1182/blood.V124.21.3742.3742
Karp, 2007, Sequential flavopiridol, cytosine arabinoside, and mitoxantrone: A phase II trial in adults with poor-risk acute myelogenous leukemia, Clin. Cancer Res., 13, 4467, 10.1158/1078-0432.CCR-07-0381
Karp, 2011, Phase 1 and pharmacokinetic study of bolus-infusion flavopiridol followed by cytosine arabinoside and mitoxantrone for acute leukemias, Blood, 117, 3302, 10.1182/blood-2010-09-310862
Faderl, 2005, Results of a phase 1-2 study of clofarabine in combination with cytarabine (ARA-C) in relapsed and refractory acute leukemias, Blood, 105, 940, 10.1182/blood-2004-05-1933
Scappini, 2012, Cytarabine and clofarabine after high-dose cytarabine in relapsed or refractory AML patients, Am. J. Hematol., 87, 1047, 10.1002/ajh.23308
Faderl, 2012, Clofarabine plus cytarabine compared with cytarabine alone in older patients with relapsed or refractory acute myelogenous leukemia: Results from the classic I trial, J. Clin. Oncol., 30, 2492, 10.1200/JCO.2011.37.9743
Becker, 2011, Clofarabine with high dose cytarabine and granulocyte colony-stimulating factor (G-CSF) priming for relapsed and refractory acute myeloid leukaemia, Br. J. Haematol., 155, 182, 10.1111/j.1365-2141.2011.08831.x
Becker, 2013, Retrospective comparison of clofarabine versus fludarabine in combination with high-dose cytarabine with or without granulocyte colony-stimulating factor as salvage therapies for acute myeloid leukemia, Haematologica, 98, 114, 10.3324/haematol.2012.063438
Yu, 2013, Homoharringtonine in combination with cytarabine and aclarubicin in the treatment of refractory/relapsed acute myeloid leukemia: A single-center experience, Ann. Hematol., 92, 1091, 10.1007/s00277-013-1758-5
Feldman, 2011, First-in-man study of CPX-351: A liposomal carrier containing cytarabine and daunorubicin in a fixed 5:1 molar ratio for the treatment of relapsed and refractory acute myeloid leukemia, J. Clin. Oncol., 29, 979, 10.1200/JCO.2010.30.5961
Cortes, 2015, Phase II, multicenter, randomized trial of CPX-351 (cytarabine:Daunorubicin) liposome injection versus intensive salvage therapy in adults with first relapse AML, Cancer, 121, 234, 10.1002/cncr.28974
Pemmaraju, 2015, A phase I/II study of the janus kinase (JAK) 1 and 2 inhibitor ruxolitinib in patients with relapsed or refractory acute myeloid leukemia, Clin. Lymphoma Myeloma Leuk., 15, 171, 10.1016/j.clml.2014.08.003
Eghtedar, 2012, Phase 2 study of the JAK kinase inhibitor ruxolitinib in patients with refractory leukemias, including postmyeloproliferative neoplasm acute myeloid leukemia, Blood, 119, 4614, 10.1182/blood-2011-12-400051
Recher, 2005, Antileukemic activity of rapamycin in acute myeloid leukemia, Blood, 105, 2527, 10.1182/blood-2004-06-2494
Liesveld, 2013, A phase I study of decitabine and rapamycin in relapsed/refractory AML, Leuk. Res., 37, 1622, 10.1016/j.leukres.2013.09.002
Park, 2013, A phase Ib GOELAMS study of the mTOR inhibitor RAD001 in association with chemotherapy for aml patients in first relapse, Leukemia, 27, 1479, 10.1038/leu.2013.17
Lowenberg, 2010, Phase I/II clinical study of tosedostat, an inhibitor of aminopeptidases, in patients with acute myeloid leukemia and myelodysplasia, J. Clin. Oncol., 28, 4333, 10.1200/JCO.2009.27.6295
Cortes, 2013, Two dosing regimens of tosedostat in elderly patients with relapsed or refractory acute myeloid leukaemia (OPAL): A randomised open-label phase 2 study, Lancet Oncol., 14, 354, 10.1016/S1470-2045(13)70037-8
Schaefer, 2009, A phase 2 study of vorinostat in acute myeloid leukemia, Haematol. Hematol. J., 94, 1375, 10.3324/haematol.2009.009217
Walter, 2014, Gemtuzumab ozogamicin in combination with vorinostat and azacitidine in older patients with relapsed or refractory acute myeloid leukemia: A phase I/II study, Haematologica, 99, 54, 10.3324/haematol.2013.096545
Gojo, 2013, Translational phase I trial of vorinostat (suberoylanilide hydroxamic acid) combined with cytarabine and etoposide in patients with relapsed, refractory, or high-risk acute myeloid leukemia, Clin. Cancer Res., 19, 1838, 10.1158/1078-0432.CCR-12-3165
Stein, E., Tallman, M., Pollyea, D.A., Flinn, I.W., Fathi, A.T., Stone, R.M., Levine, R.L., Agresta, S., Schenkein, D., and Yang, H. (2014, January 6–8). Clinical safety and activity in a phase I trial of AG-221, a first in class, potent inhibitor of the IDH2-mutant protein, in patients with IDH2 mutant positive advanced hematologic malignancies. Proceedings of the 105th Annual Meeting of the American Association for Cancer Research, San Diego, CA, USA.
Roboz, 2014, International randomized phase III study of elacytarabine versus investigator choice in patients with relapsed/refractory acute myeloid leukemia, J. Clin. Oncol., 32, 1919, 10.1200/JCO.2013.52.8562
Lancet, 2011, A phase Ib study of vosaroxin, an anticancer quinolone derivative, in patients with relapsed or refractory acute leukemia, Leukemia, 25, 1808, 10.1038/leu.2011.157
Ravandi, 2014, Improved survival in patients with first relapsed or refractory acute myeloid leukemia (AML) treated with vosaroxin plus cytarabine versus placebo plus cytarabine: Results of a phase 3 double-blind randomized controlled multinational study (VALOR), Blood, 124, LBA 6, 10.1182/blood.V124.21.LBA-6.LBA-6
Kornblau, 2007, Blockade of adaptive defensive changes in cholesterol uptake and synthesis in AML by the addition of pravastatin to idarubicin + high-dose ARA-C: A phase 1 study, Blood, 109, 2999, 10.1182/blood-2006-08-044446
Advani, 2014, SWOG0919: A phase 2 study of idarubicin and cytarabine in combination with pravastatin for relapsed acute myeloid leukaemia, Br. J. Haematol., 167, 233, 10.1111/bjh.13035
Advani, 2014, Bortezomib + MEC (mitoxantrone, etoposide, cytarabine) for relapsed/refractory acute myeloid leukemia: Final results of an expanded phase 1 trial, Blood, 124, 978, 10.1182/blood.V124.21.978.978
Chen, 2012, A phase II study of lenalidomide alone in relapsed/refractory acute myeloid leukemia or high-risk myelodysplastic syndromes with chromosome 5 abnormalities, Clin. Lymphoma Myeloma Leuk., 12, 341, 10.1016/j.clml.2012.04.001
Pardee, 2014, The mitochondrial metabolism inhibitor CPI-613 is highly active in combination with high dose ARA-C (HIDAC) and mitoxantrone in a phase I study for relapsed or refractory acute myeloid leukemia (AML), Blood, 124, 3744, 10.1182/blood.V124.21.3744.3744
Konopleva, 2014, A phase 2 study of ABT-199 (GDC-0199) in patients with acute myelogenous leukemia (AML), Blood, 124, 118, 10.1182/blood.V124.21.118.118
Thol, 2014, Gemtuzumab ozogamicin in acute myeloid leukemia revisited, Expert. Opin. Biol. Ther., 14, 1185, 10.1517/14712598.2014.922534
Petersdorf, 2009, Preliminary results of Southwest Oncology Group Sstudy S0106: An international intergroup phase 3 randomized trial comparing the addition of gemtuzumab ozogamicin to standard induction therapy versus standard induction therapy followed by a second randomization to post-consolidation gemtuzumab ozogamicin versus no additional therapy for previously untreated acute myeloid leukemia, Blood, 114, 326, 10.1182/blood.V114.22.790.790
Pilorge, 2014, Fractionated gemtuzumab ozogamicin and standard dose cytarabine produced prolonged second remissions in patients over the age of 55 years with acute myeloid leukemia in late first relapse, Am. J. Hematol., 89, 399, 10.1002/ajh.23653
Sutherland, 2013, SGN-CD33A: A novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML, Blood, 122, 1455, 10.1182/blood-2013-03-491506
Stein, 2014, Interim analysis of a phase 1 trial of SGN-CD33A in patients with CD33-positive acute myeloid leukemia (AML), Blood, 124, 623, 10.1182/blood.V124.21.623.623
Feldman, 2005, Phase III randomized multicenter study of a humanized anti-CD33 monoclonal antibody, lintuzumab, in combination with chemotherapy, versus chemotherapy alone in patients with refractory or first-relapsed acute myeloid leukemia, J. Clin. Oncol., 23, 4110, 10.1200/JCO.2005.09.133
Busfield, 2014, Targeting of acute myeloid leukemia in vitro and in vivo with an anti-CD123 mAB engineered for optimal ADCC, Leukemia, 28, 2213, 10.1038/leu.2014.128
Smith, 2014, First-in man, phase 1 study of CSL362 (anti-IL3Rα/anti-CD123 monoclonal antibody) in patients with CD123+ acute myeloid leukemia (AML) in CR at high risk for early relapse, Blood, 124, 120, 10.1182/blood.V124.21.120.120
Laszlo, 2014, Cellular determinants for preclinical activity of a novel CD33/CD3 bispecific T-cell engager (BiTE) antibody, AMG 330, against human AML, Blood, 123, 554, 10.1182/blood-2013-09-527044
Friedrich, 2014, Preclinical characterization of AMG 330, a CD3/CD33-bispecific T-cell-engaging antibody with potential for treatment of acute myelogenous leukemia, Mol. Cancer Ther., 13, 1549, 10.1158/1535-7163.MCT-13-0956
Uy, 2014, A phase I trial of MGD006 in patients with relapsed acute myeloid leukemia (AML), J. Immun. Ther. Cancer, 2, 87, 10.1186/2051-1426-2-S3-P87
Wiernik, 2013, Targeting natural killer cells to acute myeloid leukemia in vitro with a CD16 × 33 bispecific killer cell engager and ADAM17 inhibition, Clin. Cancer Res., 19, 3844, 10.1158/1078-0432.CCR-13-0505
Wang, 2015, Treatment of CD33-directed chimeric antigen receptor-modified T cells in one patient with relapsed and refractory acute myeloid leukemia, Mol. Ther., 23, 184, 10.1038/mt.2014.164
Gill, 2014, Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor-modified T cells, Blood, 123, 2343, 10.1182/blood-2013-09-529537
Pizzitola, 2014, Chimeric antigen receptors against CD33/CD123 antigens efficiently target primary acute myeloid leukemia cells in vivo, Leukemia, 28, 1596, 10.1038/leu.2014.62
Berneman, 2014, Vaccination with WT1 mRNA-electroporated dendritic cells: Report of clinical outcome in 66 cancer patients, Blood, 124, 310, 10.1182/blood.V124.21.310.310
Rosenblat, 2012, Phase II trial of WT1 analog peptide vaccine in patients with acute myeloid leukemia (AML) in complete remission (CR), Blood, 120, 3624, 10.1182/blood.V120.21.3624.3624
Goswami, 2014, Expression of putative targets of immunotherapy in acute myeloid leukemia and healthy tissues, Leukemia, 28, 1167, 10.1038/leu.2014.14
Cilloni, 2009, Real-time quantitative polymerase chain reaction detection of minimal residual disease by standardized WT1 assay to enhance risk stratification in acute myeloid leukemia: A European LeukemiaNet study, J. Clin. Oncol., 27, 5195, 10.1200/JCO.2009.22.4865
Chapuis, A.G., Ragnarsson, G.B., Nguyen, H.N., Chaney, C.N., Pufnock, J.S., Schmitt, T.M., Duerkopp, N., Roberts, I.M., Pogosov, G.L., and Ho, W.Y. (2013). Transferred WT1-reactive CD8+ T cells can mediate antileukemic activity and persist in post-transplant patients. Sci. Transl. Med., 5.
Miller, 2005, Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer, Blood, 105, 3051, 10.1182/blood-2004-07-2974
Armistead, 2009, Quantifying the survival benefit for allogeneic hematopoietic stem cell transplantation in relapsed acute myelogenous leukemia, Biol. Blood Marrow Transplant., 15, 1431, 10.1016/j.bbmt.2009.07.008
Shimoni, 2010, Allogeneic hematopoietic stem-cell transplantation in AML and MDS using myeloablative versus reduced-intensity conditioning: Long-term follow-up, Leukemia, 24, 1050, 10.1038/leu.2010.12
Sebert, 2015, Equivalent outcomes using reduced intensity or conventional myeloablative conditioning transplantation for patients aged 35 years and over with AML, Bone Marrow Transplant., 50, 74, 10.1038/bmt.2014.199
Bejanyan, 2014, Clinical outcomes of aml patients relapsing after matched-related donor and umbilical cord blood transplantation, Bone Marrow Transplant., 49, 1029, 10.1038/bmt.2014.116
Itonaga, 2013, Treatment of relapsed adult T-cell leukemia/lymphoma after allogeneic hematopoietic stem cell transplantation: The Nagasaki Transplant Group experience, Blood, 121, 219, 10.1182/blood-2012-07-444372
Takami, 2014, Donor lymphocyte infusion for the treatment of relapsed acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation: A retrospective analysis by the adult acute myeloid leukemia working group of the Japan Society for Hematopoietic Cell Transplantation, Biol. Blood Marrow Transplant., 20, 1785, 10.1016/j.bbmt.2014.07.010
Schroeder, 2013, Azacitidine and donor lymphocyte infusions as first salvage therapy for relapse of AML or MDS after allogeneic stem cell transplantation, Leukemia, 27, 1229, 10.1038/leu.2013.7
Ghobadi, 2013, A phase I study of azacitidine after donor lymphocyte infusion for relapsed acute myeloid leukemia post allogeneic stem cell transplantation, Blood, 122, 3320, 10.1182/blood.V122.21.3320.3320
Tallman, 2013, Acute myeloid leukemia, version 2.2013, J. Nat. Compr. Cancer Netw., 11, 1047, 10.6004/jnccn.2013.0127
Gandhi, 1993, Fludarabine potentiates metabolism of cytarabine in patients with acute myelogenous leukemia during therapy, J. Clin. Oncol., 11, 116, 10.1200/JCO.1993.11.1.116
Chow, 2003, In AML cell lines ARA-C combined with purine analogues is able to exert synergistic as well as antagonistic effects on proliferation, apoptosis and disruption of mitochondrial membrane potential, Leuk. Lymphoma, 44, 165, 10.1080/1042819021000054670
Thomas, 1999, Granulocyte-macrophage colony-stimulating factor (GM-CSF) to increase efficacy of intensive sequential chemotherapy with etoposide, mitoxantrone and cytarabine (EMA) in previously treated acute myeloid leukemia: A multicenter randomized placebo-controlled trial (EMA91 trial), Leukemia, 13, 1214, 10.1038/sj.leu.2401474
Cooper, 2005, Biochemical modulation of cytarabine triphosphate by clofarabine, Cancer Chemother. Pharmacol., 55, 361, 10.1007/s00280-004-0906-y
Becker, P.S., Medeiros, B.C., Stein, A.S., Othus, M., Appelbaum, F.R., Forman, S.J., Scott, B.L., Hendrie, P.C., Gardner, K.M., and Pagel, J.M. G-CSF priming, clofarabine, and high dose cytarabine (GCLAC) for upfront treatment of acute myeloid leukemia, advanced myelodysplastic syndrome or advanced myeloproliferative neoplasm. Am. J. Hematol., 2014.
Verdonck, 1998, Multidrug-resistant acute leukemia cells are responsive to prolonged exposure of daunorubicin: Implications for liposome-encapsulated daunorubicin, Leuk. Res., 22, 249, 10.1016/S0145-2126(97)00160-4
Ermacora, 2000, Liposome encapsulated daunorubicin (daunoxome) for acute leukemia, Haematologica, 85, 324
Lancet, 2014, A phase 1b/2 study of combination vosaroxin and cytarabine in patients with relapsed or refractory acute myeloid leukemia, Haematologica, 100, 231, 10.3324/haematol.2014.114769
Marcucci, 2010, IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study, J. Clin. Oncol., 28, 2348, 10.1200/JCO.2009.27.3730
Stuart, S.D., Schauble, A., Gupta, S., Kennedy, A.D., Keppler, B.R., Bingham, P.M., and Zachar, Z. (2014). A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process. Cancer Metab., 2.
Schultze, 2013, Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma, Blood, 122, 2443, 10.1182/blood-2013-03-491431
Uy, 2012, A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia, Blood, 119, 3917, 10.1182/blood-2011-10-383406
Konig, 2015, Targeting FLT3 to treat leukemia, Expert Opin. Ther. Targets, 19, 37, 10.1517/14728222.2014.960843
Pratz, 2010, FLT3-mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML, Blood, 115, 1425, 10.1182/blood-2009-09-242859
Cortes, 2013, Phase I study of quizartinib administered daily to patients with relapsed or refractory acute myeloid leukemia irrespective of FMS-like tyrosine kinase 3-internal tandem duplication status, J. Clin. Oncol., 31, 3681, 10.1200/JCO.2013.48.8783
Wander, 2014, The evolving role of FLT3 inhibitors in acute myeloid leukemia: Quizartinib and beyond, Ther. Adv. Hematol., 5, 65, 10.1177/2040620714532123
Cortes, 2013, Results of a phase 2 randomized, open-label, study of lower doses of quizartinib (AC220; ASP2689) in subjects with FLT3-ITD positive relapsed or refractory acute myeloid leukemia (AML), Blood, 122, 494, 10.1182/blood.V122.21.494.494
Levis, 2012, Final results of a phase 2 open-label, monotherapy efficacy and safety study of quizartinib (AC220) in patients with FLT3-ITD positive or negative relapsed/refractory acute myeloid leukemia after second-line chemotherapy or hematopoietic stem cell transplantation, Blood, 120, 673, 10.1182/blood.V120.21.673.673
Röllig, C., Müller-Tidow, C., Hüttmann, A., Noppeney, R., Kunzmann, V., Baldus, C.D., Brandts, C.H., Krämer, A., Schäfer-Eckart, K., and Neubauer, A. (2014). Sorafenib versus placebo in addition to standard therapy in younger patients with newly diagnosed acute myeloid leukemia: Results from 267 patients treated in the randomized placebo-controlled SAL-Soraml trial. 124, 6.
Hourigan, 2014, Back to the future! The evolving role of maintenance therapy after hematopoietic stem cell transplantation, Biol. Blood Marrow Transplant., 20, 154, 10.1016/j.bbmt.2013.11.017
Chen, 2014, Phase I trial of maintenance sorafenib after allogeneic hematopoietic stem cell transplantation for FMS-like tyrosine kinase 3 internal tandem duplication acute myeloid leukemia, Biol. Blood Marrow Transplant., 20, 2042, 10.1016/j.bbmt.2014.09.007
Sammons, 2014, Sorafenib is tolerable and improves clinical outcomes in patients with FLT3-ITD acute myeloid leukemia prior to stem cell transplant and after relapse post-transplant, Am. J. Hematol., 89, 936, 10.1002/ajh.23782
Grunwald, 2013, FLT3 inhibitors for acute myeloid leukemia: A review of their efficacy and mechanisms of resistance, Int. J. Hematol., 97, 683, 10.1007/s12185-013-1334-8
Zimmerman, 2013, Crenolanib is active against models of drug-resistant FLT3-ITD-positive acute myeloid leukemia, Blood, 122, 3607, 10.1182/blood-2013-07-513044
Lee, 2014, G-749, a novel FLT3 kinase inhibitor, can overcome drug resistance for the treatment of acute myeloid leukemia, Blood, 123, 2209, 10.1182/blood-2013-04-493916
Keegan, 2014, Preclinical evaluation of AMG 925, a FLT3/CDK4 dual kinase inhibitor for treating acute myeloid leukemia, Mol. Cancer Ther., 13, 880, 10.1158/1535-7163.MCT-13-0858
Xiang, 2008, Identification of somatic JAK1 mutations in patients with acute myeloid leukemia, Blood, 111, 4809, 10.1182/blood-2007-05-090308
Shadman, 2014, Idarubicin, cytarabine and pravastatin as induction therapy for untreated acute myeloid leukemia and high-risk myelodysplastic syndrome, Blood, 124, 3732, 10.1182/blood.V124.21.3732.3732
Kobune, 2009, Drug resistance is dramatically restored by hedgehog inhibitors in CD34+ leukemic cells, Cancer Sci., 100, 948, 10.1111/j.1349-7006.2009.01111.x
Krupka, 2014, CD33 target validation and sustained depletion of AML blasts in long-term cultures by the bispecific T-cell-engaging antibody AMG 330, Blood, 123, 356, 10.1182/blood-2013-08-523548
Mardiros, 2013, T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia, Blood, 122, 3138, 10.1182/blood-2012-12-474056
Hourigan, 2011, Evaluation of current cancer immunotherapy: Hemato-oncology, Cancer J. (Sudbury, Mass.), 17, 309, 10.1097/PPO.0b013e3182341fde
Jabbour, 2014, Allogeneic stem cell transplantation as initial salvage for patients with acute myeloid leukemia refractory to high-dose cytarabine-based induction chemotherapy, Am. J. Hematol., 89, 395, 10.1002/ajh.23655
Walter, 2013, Significance of minimal residual disease before myeloablative allogeneic hematopoietic cell transplantation for AML in first and second complete remission, Blood, 122, 1813, 10.1182/blood-2013-06-506725
Duval, 2010, Hematopoietic stem-cell transplantation for acute leukemia in relapse or primary induction failure, J. Clin. Oncol., 28, 3730, 10.1200/JCO.2010.28.8852
Luznik, 2008, HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide, Biol. Blood Marrow Transplant., 14, 641, 10.1016/j.bbmt.2008.03.005
Raiola, 2014, Unmanipulated haploidentical transplants compared with other alternative donors and matched sibling grafts, Biol. Blood Marrow Transplant., 20, 1573, 10.1016/j.bbmt.2014.05.029
Craddock, 2014, Activity and tolerability of azacitidine in patients who relapse after allogeneic stem cell transplantation (allo-SCT) for acute myeloid leukemia (AML) and myelodysplasia (MDS): A survey from the european society for blood and marrow transplantation (EBMT), Blood, 124, 2506, 10.1182/blood.V124.21.2506.2506
Sarkozy, 2013, Outcome of older patients with acute myeloid leukemia in first relapse, Am. J. Hematol., 88, 758, 10.1002/ajh.23498
Tawfik, 2014, Efficacy of the hypomethylating agents as frontline, salvage, or consolidation therapy in adults with acute myeloid leukemia (AML), Ann. Hematol., 93, 47, 10.1007/s00277-013-1940-9
Ivanoff, 2013, 5-azacytidine treatment for relapsed or refractory acute myeloid leukemia after intensive chemotherapy, Am. J. Hematol., 88, 601, 10.1002/ajh.23464
Ritchie, 2013, Decitabine in patients with newly diagnosed and relapsed acute myeloid leukemia, Leuk. Lymphoma, 54, 2003, 10.3109/10428194.2012.762093
Bejar, 2014, TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients, Blood, 124, 2705, 10.1182/blood-2014-06-582809
Itzykson, 2011, Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias, Leukemia, 25, 1147, 10.1038/leu.2011.71
Estey, 2014, Primacy of resistance rather than toxicity in determining outcome of therapy for AML, Clin. Lymphoma Myeloma Leuk., 14, S56, 10.1016/j.clml.2014.04.016
Hourigan, 2013, Minimal residual disease in acute myeloid leukaemia, Nat. Rev. Clin. Oncol., 10, 460, 10.1038/nrclinonc.2013.100
Meyers, 2013, Medicare fee-for-service enrollees with primary acute myeloid leukemia: An analysis of treatment patterns, survival, and healthcare resource utilization and costs, Appl. Health Econ. Health Policy, 11, 275, 10.1007/s40258-013-0032-2
Hourigan, 2010, Development of therapeutic agents for older patients with acute myelogenous leukemia, Curr. Opin. Investig. Drugs, 11, 669
Pemovska, 2013, Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia, Cancer Discov., 3, 1416, 10.1158/2159-8290.CD-13-0350
Becker, 2014, Feasibility trial of individualized therapy for relapsed or refractory acute myeloid leukemia based on a high throughput in vitro drug sensitivity assay, Blood, 124, 3748, 10.1182/blood.V124.21.3748.3748
Hourigan, 2013, Personalized therapy for acute myeloid leukemia, Cancer Discov., 3, 1336, 10.1158/2159-8290.CD-13-0832
Konoplev, 2007, Overexpression of CXCR4 predicts adverse overall and event-free survival in patients with unmutated FLT3 acute myeloid leukemia with normal karyotype, Cancer, 109, 1152, 10.1002/cncr.22510
Freeman, 2013, Prognostic relevance of treatment response measured by flow cytometric residual disease detection in older patients with acute myeloid leukemia, J. Clin. Oncol., 31, 4123, 10.1200/JCO.2013.49.1753
Inaba, 2012, Comparative analysis of different approaches to measure treatment response in acute myeloid leukemia, J. Clin. Oncol., 30, 3625, 10.1200/JCO.2011.41.5323
Grimwade, 2014, Defining minimal residual disease in acute myeloid leukemia: Which platforms are ready for “prime time"?, Blood, 124, 3345, 10.1182/blood-2014-05-577593
Ivey, A., Hills, R.K., Simpson, M.A., Jovanovic, J.V., Gilkes, A.F., Patel, Y., Bhudia, N., Farah, H., Mason, J., and Wall, K. (2014). Molecular detection of minimal residual disease provides the most powerful independent prognostic factor irrespective of clonal architecture in nucleophosmin (NPML) mutant acute myeloid leukemia. 124, 70.
Steinbach, 2015, Prospective validation of a new method of monitoring minimal residual disease in childhood acute myeloid leukemia, Clin. Cancer Res., 15, 1353, 10.1158/1078-0432.CCR-14-1999
Goswami, M., McGowan, K.S., Lu, K., Jain, N., Candia, J., Hensel, N.F., Tang, J., Calvo, K.R., Battiwalla, M., and Barrett, A.J. A multigene array for measurable residual disease detection in AML patients undergoing SCT. Bone Marrow Transplant., 2015.
Platzbecker, 2012, Azacitidine for treatment of imminent relapse in MDS or AML patients after allogeneic HSCT: Results of the relaza trial, Leukemia, 26, 381, 10.1038/leu.2011.234