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Incubation Period and Other Epidemiological Characteristics of 2019 Novel Coronavirus Infections with Right Truncation: A Statistical Analysis of Publicly Available Case Data
Tập 9 Số 2 - Trang 538
The geographic spread of 2019 novel coronavirus (COVID-19) infections from the
epicenter of Wuhan, China, has provided an opportunity to study the natural
history of the recently emerged virus. Using publicly available event-date data
from the ongoing epidemic, the present study investigated the incubation period
and other time intervals that govern the epidemiological dynamics of COVID-19
infecti...
People with Suspected COVID-19 Symptoms Were More Likely Depressed and Had Lower Health-Related Quality of Life: The Potential Benefit of Health Literacy
Tập 9 Số 4 - Trang 965 - 2020
The coronavirus disease 2019 (COVID-19) epidemic affects people’s health and
health-related quality of life (HRQoL), especially in those who have suspected
COVID-19 symptoms (S-COVID-19-S). We examined the effect of modifications of
health literacy (HL) on depression and HRQoL. A cross-sectional study was
conducted from 14 February to 2 March 2020. 3947 participants were recruited
from outpatient ...
Tumor Angiogenesis and Anti-Angiogenic Strategies for Cancer Treatment
Tập 9 Số 1 - Trang 84
Angiogenesis is the process through which novel blood vessels are formed from
pre-existing ones and it is involved in both physiological and pathological
processes of the body. Furthermore, tumor angiogenesis is a crucial factor
associated with tumor growth, progression, and metastasis. In this manner, there
has been a great interest in the development of anti-angiogenesis strategies
that could in...
Applications of Functional Near-Infrared Spectroscopy (fNIRS) Neuroimaging in Exercise–Cognition Science: A Systematic, Methodology-Focused Review
Tập 7 Số 12 - Trang 466
For cognitive processes to function well, it is essential that the brain is
optimally supplied with oxygen and blood. In recent years, evidence has emerged
suggesting that cerebral oxygenation and hemodynamics can be modified with
physical activity. To better understand the relationship between cerebral
oxygenation/hemodynamics, physical activity, and cognition, the application of
state-of-the art...
Preeclampsia: Risk Factors, Diagnosis, Management, and the Cardiovascular Impact on the Offspring
Tập 8 Số 10 - Trang 1625
Hypertensive disorders of pregnancy affect up to 10% of pregnancies worldwide,
which includes the 3%–5% of all pregnancies complicated by preeclampsia.
Preeclampsia is defined as new onset hypertension after 20 weeks’ gestation with
evidence of maternal organ or uteroplacental dysfunction or proteinuria. Despite
its prevalence, the risk factors that have been identified lack accuracy in
predicting...
The Immunomodulatory Functions of Mesenchymal Stromal/Stem Cells Mediated via Paracrine Activity
Tập 8 Số 7 - Trang 1025
Mesenchymal stromal/stem cells (MSCs) exist in almost all tissues, possessing
the potential to differentiate into specialized cell types and exert
immunomodulatory functions. Thus, they have attracted much attention as a
promising therapeutic candidate. Recent studies have demonstrated that paracrine
signaling is mainly responsible for the involvement of MSCs in the modulation of
immune responses ...
Association between Cigarette Smoking Status and Composition of Gut Microbiota: Population-Based Cross-Sectional Study
Tập 7 Số 9 - Trang 282
There have been few large-scale studies on the relationship between smoking and
gut microbiota. We investigated the relationship between smoking status and the
composition of gut microbiota. This was a population-based cross-sectional study
using Healthcare Screening Center cohort data. A total of 758 men were selected
and divided into three groups: never (n = 288), former (n = 267), and current
s...
Diaphragm Dysfunction: Diagnostic Approaches and Management Strategies
Tập 5 Số 12 - Trang 113
The diaphragm is the main inspiratory muscle, and its dysfunction can lead to
significant adverse clinical consequences. The aim of this review is to provide
clinicians with an overview of the main causes of uni- and bi-lateral diaphragm
dysfunction, explore the clinical and physiological consequences of the disease
on lung function, exercise physiology and sleep and review the available
diagnosti...
Real World Experiences: Pirfenidone and Nintedanib are Effective and Well Tolerated Treatments for Idiopathic Pulmonary Fibrosis
Tập 5 Số 9 - Trang 78
Idiopathic Pulmonary Fibrosis (IPF) now has two licensed treatments available.
Pirfenidone was the first drug to be licensed and approved for use, followed by
nintedanib. We set out our real world experience with these agents in terms of
their adverse events profile outside the restrictions of a clinical trial. We
have demonstrated in the real world setting, that side effects are common and
predom...
Gender and Sex Are Key Determinants in Osteoarthritis Not Only Confounding Variables. A Systematic Review of Clinical Data
Tập 10 Số 14 - Trang 3178
Many risk factors for osteoarthritis (OA) have been noted, while gender/sex
differences have been understated. The work aimed to systematically review
literature investigating as primary aim the relationship between gender/sex
related discriminants and OA. The search was performed in PubMed, Science Direct
and Web of Knowledge in the last 10 years. Inclusion criteria were limited to
clinical studi...