Preeclampsia: Risk Factors, Diagnosis, Management, and the Cardiovascular Impact on the Offspring
Tóm tắt
Hypertensive disorders of pregnancy affect up to 10% of pregnancies worldwide, which includes the 3%–5% of all pregnancies complicated by preeclampsia. Preeclampsia is defined as new onset hypertension after 20 weeks’ gestation with evidence of maternal organ or uteroplacental dysfunction or proteinuria. Despite its prevalence, the risk factors that have been identified lack accuracy in predicting its onset and preventative therapies only moderately reduce a woman’s risk of preeclampsia. Preeclampsia is a major cause of maternal morbidity and is associated with adverse foetal outcomes including intra-uterine growth restriction, preterm birth, placental abruption, foetal distress, and foetal death in utero. At present, national guidelines for foetal surveillance in preeclamptic pregnancies are inconsistent, due to a lack of evidence detailing the most appropriate assessment modalities as well as the timing and frequency at which assessments should be conducted. Current management of the foetus in preeclampsia involves timely delivery and prevention of adverse effects of prematurity with antenatal corticosteroids and/or magnesium sulphate depending on gestation. Alongside the risks to the foetus during pregnancy, there is also growing evidence that preeclampsia has long-term adverse effects on the offspring. In particular, preeclampsia has been associated with cardiovascular sequelae in the offspring including hypertension and altered vascular function.
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Tài liệu tham khảo
Ananth, 2013, Pre-Eclampsia Rates in the United States, 1980–2010: Age-Period-Cohort Analysis, BMJ, 347, f6564, 10.1136/bmj.f6564
Brown, 2018, Hypertensive Disorders of Pregnancy: ISSHP Classification, Diagnosis, and Management Recommendations for International Practice, Hypertension, 72, 24, 10.1161/HYPERTENSIONAHA.117.10803
National Guideline Alliance (UK) (2019, October 03). Hypertension in Pregnancy: Diagnosis and Management (NG133). Available online: https://www.nice.org.uk/guidance/ng133.
Madazli, 2014, Comparison of Clinical and Perinatal Outcomes in Early- and Late-Onset Preeclampsia, Arch. Gynecol. Obstet., 290, 53, 10.1007/s00404-014-3176-x
Haddad, 2004, Maternal and Perinatal Outcomes during Expectant Management of 239 Severe Preeclamptic Women between 24 and 33 Weeks’ Gestation, Am. J. Obstet. Gynecol., 190, 1590, 10.1016/j.ajog.2004.03.050
Rezk, 2015, Maternal and Fetal Outcome in de Novo Preeclampsia in Comparison to Superimposed Preeclampsia: A Two-Year Observational Study, Hypertens. Pregnancy, 34, 137, 10.3109/10641955.2014.982329
Davis, 2012, Cardiovascular Risk Factors in Children and Young Adults Born to Preeclamptic Pregnancies: A Systematic Review, Pediatrics, 129, e1552, 10.1542/peds.2011-3093
Bartsch, 2016, Clinical Risk Factors for Pre-Eclampsia Determined in Early Pregnancy: Systematic Review and Meta-Analysis of Large Cohort Studies, BMJ, 353, i1753, 10.1136/bmj.i1753
Askie, 2007, Antiplatelet Agents for Prevention of Pre-Eclampsia: A Meta-Analysis of Individual Patient Data, Lancet, 369, 1791, 10.1016/S0140-6736(07)60712-0
Bujold, 2010, Prevention of Preeclampsia and Intrauterine Growth Restriction with Aspirin Started in Early Pregnancy: A Meta-Analysis, Obstet. Gynecol., 116, 402, 10.1097/AOG.0b013e3181e9322a
North, 2011, Clinical Risk Prediction for Pre-Eclampsia in Nulliparous Women: Development of Model in International Prospective Cohort, BMJ, 342, d1875, 10.1136/bmj.d1875
Joham, 2019, Increased Maternal Pregnancy Complications in Polycystic Ovary Syndrome Appear to Be Independent of Obesity-A Systematic Review, Meta-Analysis, and Meta-Regression, Obes. Rev., 20, 659, 10.1111/obr.12829
Yu, 2016, Association between Polycystic Ovary Syndrome and the Risk of Pregnancy Complications: A PRISMA-Compliant Systematic Review and Meta-Analysis, Medicine (Baltimore), 95, e4863, 10.1097/MD.0000000000004863
Qin, 2013, Obstetric Complications in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis, Reprod. Biol. Endocrinol., 11, 56, 10.1186/1477-7827-11-56
Pamidi, 2014, Maternal Sleep-Disordered Breathing and Adverse Pregnancy Outcomes: A Systematic Review and Metaanalysis, Am. J. Obstet. Gynecol., 210, 52, 10.1016/j.ajog.2013.07.033
Rustveld, 2008, Association between Maternal Infections and Preeclampsia: A Systematic Review of Epidemiologic Studies, Matern. Child Health J., 12, 223, 10.1007/s10995-007-0224-1
Bellos, 2018, Helicobacter Pylori Infection Increases the Risk of Developing Preeclampsia: A Meta-Analysis of Observational Studies, Int. J. Clin. Pract., 72, 349, 10.1111/ijcp.13064
Riahi, 2019, Helicobacter Pylori Infection and Risk of Preeclampsia: A Systematic Review and Meta-Analysis, J. Matern. Fetal. Neonatal Med., 32, 324, 10.1080/14767058.2017.1378331
Blazquez, 2016, Is Oocyte Donation a Risk Factor for Preeclampsia? A Systematic Review and Meta-Analysis, J. Assist. Reprod. Genet., 33, 855, 10.1007/s10815-016-0701-9
Jeve, 2016, Donor Oocyte Conception and Pregnancy Complications: A Systematic Review and Meta-Analysis, BJOG, 123, 1471, 10.1111/1471-0528.13910
Masoudian, 2016, Oocyte Donation Pregnancies and the Risk of Preeclampsia or Gestational Hypertension: A Systematic Review and Metaanalysis, Am. J. Obstet. Gynecol., 214, 328, 10.1016/j.ajog.2015.11.020
McGinnis, 2017, Variants in the Fetal Genome near FLT1 Are Associated with Risk of Preeclampsia, Nat. Genet., 49, 1255, 10.1038/ng.3895
Reidy, 2018, Fetal—Not Maternal—APOL1 Genotype Associated with Risk for Preeclampsia in Those with African Ancestry, Am. J. Hum. Genet., 103, 367, 10.1016/j.ajhg.2018.08.002
Martin, 2014, Can the Quantity of Cell-Free Fetal DNA Predict Preeclampsia: A Systematic Review, Prenat. Diagn., 34, 685, 10.1002/pd.4416
Black, 2018, Inflammatory Markers and Preeclampsia: A Systematic Review, Nurs. Res., 67, 242, 10.1097/NNR.0000000000000285
Rebelo, 2013, C-Reactive Protein and Later Preeclampsia: Systematic Review and Meta-Analysis Taking into Account the Weight Status, J. Hypertens., 31, 16, 10.1097/HJH.0b013e32835b0556
Spracklen, 2014, Maternal Hyperlipidemia and the Risk of Preeclampsia: A Meta-Analysis, Am. J. Epidemiol., 180, 346, 10.1093/aje/kwu145
Gallos, 2013, Pre-Eclampsia Is Associated with, and Preceded by, Hypertriglyceridaemia: A Meta-Analysis, BJOG, 120, 1321, 10.1111/1471-0528.12375
Chien, 2000, How Useful Is Uterine Artery Doppler Flow Velocimetry in the Prediction of Pre-Eclampsia, Intrauterine Growth Retardation and Perinatal Death? An Overview, BJOG, 107, 196, 10.1111/j.1471-0528.2000.tb11690.x
Velauthar, 2014, First-Trimester Uterine Artery Doppler and Adverse Pregnancy Outcome: A Meta-Analysis Involving 55,974 Women, Ultrasound Obstet. Gynecol., 43, 500, 10.1002/uog.13275
Askie, 2016, The Performance of Risk Prediction Models for Pre-Eclampsia Using Routinely Collected Maternal Characteristics and Comparison with Models That Include Specialised Tests and with Clinical Guideline Decision Rules: A Systematic Review, BJOG, 123, 1441, 10.1111/1471-0528.14029
Akbari, 2018, Association of Vitamin D Level and Vitamin D Deficiency with Risk of Preeclampsia: A Systematic Review and Updated Meta-Analysis, Taiwan. J. Obstet. Gynecol., 57, 241, 10.1016/j.tjog.2018.02.013
Mirzakhani, 2016, Early Pregnancy Vitamin D Status and Risk of Preeclampsia, J. Clin. Investig., 126, 4702, 10.1172/JCI89031
Ali, 2019, Effect of Vitamin D3 Supplementation in Pregnancy on Risk of Pre-Eclampsia—Randomized Controlled Trial, Clin. Nutr., 38, 557, 10.1016/j.clnu.2018.02.023
Wei, 2013, Maternal Vitamin D Status and Adverse Pregnancy Outcomes: A Systematic Review and Meta-Analysis, J. Matern. Fetal. Neonatal Med., 26, 889, 10.3109/14767058.2013.765849
Purswani, J.M., Gala, P., Dwarkanath, P., Larkin, H.M., Kurpad, A., and Mehta, S. (2017). The Role of Vitamin D in Pre-Eclampsia: A Systematic Review. BMC Pregnancy Childbirth, 17.
Arain, 2015, Review-Vitamin D and the Prevention of Preeclampsia: A Systematic Review, Pak. J. Pharm. Sci., 28, 1015
Nassar, 2011, Systematic Review of First-Trimester Vitamin D Normative Levels and Outcomes of Pregnancy, Am. J. Obstet. Gynecol., 205, e1, 10.1016/j.ajog.2011.03.058
Roth, 2017, Vitamin D Supplementation during Pregnancy: State of the Evidence from a Systematic Review of Randomised Trials, BMJ, 35, j5237, 10.1136/bmj.j5237
Villar, 2006, World Health Organization Randomized Trial of Calcium Supplementation among Low Calcium Intake Pregnant Women, Am. J. Obstet. Gynecol., 194, 639, 10.1016/j.ajog.2006.01.068
Hofmeyr, 2018, Calcium Supplementation during Pregnancy for Preventing Hypertensive Disorders and Related Problems, Cochrane Database Syst. Rev., 10, CD001059
Lowe, 2015, SOMANZ Guidelines for the Management of Hypertensive Disorders of Pregnancy 2014, Aust. N. Z. J. Obstet. Gynaecol., 55, e1
Roberts, 2013, Hypertension in Pregnancy: Executive Summary, Obstet. Gynecol., 122, 1122, 10.1097/01.AOG.0000437382.03963.88
Tenorio, 2018, Oral Antioxidant Therapy for Prevention and Treatment of Preeclampsia: Meta-Analysis of Randomized Controlled Trials, Nutr. Metab. Cardiovasc. Dis., 28, 865, 10.1016/j.numecd.2018.06.002
Xu, 2010, An International Trial of Antioxidants in the Prevention of Preeclampsia (INTAPP), Am. J. Obstet. Gynecol., 202, 239.e1, 10.1016/j.ajog.2010.01.050
Poston, 2006, Vitamin C and Vitamin E in Pregnant Women at Risk for Pre-Eclampsia (VIP Trial): Randomised Placebo-Controlled Trial, Lancet, 367, 1145, 10.1016/S0140-6736(06)68433-X
Villar, 2001, WHO Antenatal Care Randomised Trial for the Evaluation of a New Model of Routine Antenatal Care, Lancet, 357, 1551, 10.1016/S0140-6736(00)04722-X
Chappell, 1999, Effect of Antioxidants on the Occurrence of Pre-Eclampsia in Women at Increased Risk: A Randomised Trial, Lancet, 354, 810, 10.1016/S0140-6736(99)80010-5
Wen, 2018, Effect of High Dose Folic Acid Supplementation in Pregnancy on Pre-Eclampsia (FACT): Double Blind, Phase III, Randomised Controlled, International, Multicentre Trial, BMJ, 362, k3478, 10.1136/bmj.k3478
Saccone, 2016, 5-Methyl-Tetrahydrofolate in Prevention of Recurrent Preeclampsia, J. Matern. Neonatal Med., 29, 916, 10.3109/14767058.2015.1023189
Dodd, J.M., Mcleod, A., Windrim, R.C., and Kingdom, J. (2013). Antithrombotic Therapy for Improving Maternal or Infant Health Outcomes in Women Considered at Risk of Placental Dysfunction. Cochrane Database Syst. Rev.
2016, Efficacy of L-Arginine for Preventing Preeclampsia in High-Risk Pregnancies: A Double-Blind, Randomized, Clinical Trial, Hypertens. Pregnancy, 35, 217, 10.3109/10641955.2015.1137586
Marrs, 2017, Should We Add Pravastatin to Aspirin for Preeclampsia Prevention in High-Risk Women?, Clin. Obstet. Gynecol., 60, 161, 10.1097/GRF.0000000000000248
Steyn, 1997, Randomised Controlled Trial of Ketanserin and Aspirin in Prevention of Pre-Eclampsia, Lancet, 350, 1267, 10.1016/S0140-6736(97)06408-8
Teran, 2009, Coenzyme Q10 Supplementation during Pregnancy Reduces the Risk of Pre-Eclampsia, Int. J. Gynaecol. Obstet., 105, 43, 10.1016/j.ijgo.2008.11.033
Thangaratinam, 2012, Effects of Interventions in Pregnancy on Maternal Weight and Obstetric Outcomes: Meta-Analysis of Randomised Evidence, BMJ, 344, e2088, 10.1136/bmj.e2088
Allen, 2014, Effect of Diet- And Lifestyle-Based Metabolic Risk-Modifying Interventions on Preeclampsia: A Meta-Analysis, Acta Obstet. Gynecol. Scand., 93, 973, 10.1111/aogs.12467
Haugen, 2009, A Dietary Pattern Characterized by High Intake of Vegetables, Fruits, and Vegetable Oils Is Associated with Reduced Risk of Preeclampsia in Nulliparous Pregnant Norwegian Women, J. Nutr., 139, 1162, 10.3945/jn.109.104968
Dodd, 2014, Antenatal Lifestyle Advice for Women Who Are Overweight or Obese: LIMIT Randomised Trial, BMJ, 348, g1285, 10.1136/bmj.g1285
Saccone, 2017, Exercise during Pregnancy and Risk of Gestational Hypertensive Disorders: A Systematic Review and Meta-Analysis, Acta Obstet. Gynecol. Scand., 96, 921, 10.1111/aogs.13151
Meher, 2006, Exercise or Other Physical Activity for Preventing Pre-Eclampsia and Its Complications, Cochrane Database Syst. Rev., 19, CD005942
Althabe, 1999, Cigarette Smoking during Pregnancy and Risk of Preeclampsia: A Systematic Review, Am. J. Obstet. Gynecol., 181, 1026, 10.1016/S0002-9378(99)70341-8
Magee, 2014, Diagnosis, Evaluation, and Management of the Hypertensive Disorders of Pregnancy: Executive Summary, J. Obstet. Gynaecol. Can., 36, 416, 10.1016/S1701-2163(15)30588-0
Tucker, K.L., Taylor, K.S., Crawford, C., Hodgkinson, J.A., Bankhead, C., Carver, T., Ewers, E., Glogowska, M., Greenfield, S.M., and Ingram, L. (2017). Blood Pressure Self-Monitoring in Pregnancy: Examining Feasibility in a Prospective Cohort Study. BMC Pregnancy Childbirth, 17.
Hewison, 2000, Antenatal Home Blood Pressure Monitoring: A Pilot Randomised Controlled Trial, Br. J. Obstet. Gynaecol., 107, 217, 10.1111/j.1471-0528.2000.tb11692.x
Hinton, L., Tucker, K.L., Greenfield, S.M., Hodgkinson, J.A., Mackillop, L., McCourt, C., Carver, T., Crawford, C., Glogowska, M., and Locock, L. (2017). Blood Pressure Self-Monitoring in Pregnancy (BuMP) Feasibility Study; A Qualitative Analysis of Women’s Experiences of Self-Monitoring. BMC Pregnancy Childbirth, 17.
Brown, 2014, Is There a Role for Ambulatory Blood Pressure Monitoring in Pregnancy?, Clin. Exp. Pharmacol. Physiol., 41, 16, 10.1111/1440-1681.12106
Waugh, 2005, Optimal Bedside Urinalysis for the Detection of Proteinuria in Hypertensive Pregnancy: A Study of Diagnostic Accuracy, BJOG, 112, 412, 10.1111/j.1471-0528.2004.00455.x
Menzies, 2007, Current CHS and NHBPEP Criteria for Severe Preeclampsia Do Not Uniformly Predict Adverse Maternal or Perinatal Outcomes, Hypertens. Pregnancy, 26, 447, 10.1080/10641950701521742
Waugh, 2017, Spot Protein-Creatinine Ratio and Spot Albumin-Creatinine Ratio in the Assessment of Pre-Eclampsia: A Diagnostic Accuracy Study with Decision-Analytic Model-Based Economic Evaluation and Acceptability Analysis, Health Technol. Assess., 21, 1, 10.3310/hta21610
Sucu, 2017, Spot Urine Protein-to-Creatinine Ratio to Predict the Magnitude of 24-Hour Total Proteinuria in Preeclampsia of Varying Severity, J. Obstet. Gynaecol. Can., 39, 854, 10.1016/j.jogc.2017.04.035
Kyle, 2008, Comparison of Methods to Identify Significant Proteinuria in Pregnancy in the Outpatient Setting, BJOG, 115, 523, 10.1111/j.1471-0528.2007.01621.x
Brown, 2008, Diagnostic Accuracy of Urinary Spot Protein:Creatinine Ratio for Proteinuria in Hypertensive Pregnant Women: Systematic Review, BMJ, 336, 1003, 10.1136/bmj.39532.543947.BE
Price, 2005, Use of Protein: Creatinine Ratio Measurements on Random Urine Samples for Prediction of Significant Proteinuria: A Systematic Review, Clin. Chem., 51, 1577, 10.1373/clinchem.2005.049742
Karumanchi, 2007, Placental Ischemia and Soluble Fms-like Tyrosine Kinase 1: Cause or Consequence of Preeclampsia?, Kidney Int., 71, 959, 10.1038/sj.ki.5002281
Levine, 2006, Soluble Endoglin and Other Circulating Antiangiogenic Factors in Preeclampsia, N. Engl. J. Med., 355, 992, 10.1056/NEJMoa055352
Chappell, 2013, Diagnostic Accuracy of Placental Growth Factor in Women with Suspected Preeclampsia: A Prospective Multicenter Study, Circulation, 128, 2121, 10.1161/CIRCULATIONAHA.113.003215
Duhig, 2019, Placental Growth Factor Testing to Assess Women with Suspected Pre-Eclampsia: A Multicentre, Pragmatic, Stepped-Wedge Cluster-Randomised Controlled Trial, Lancet, 393, 1807, 10.1016/S0140-6736(18)33212-4
Zeisler, 2016, Predictive Value of the SFlt-1:PlGF Ratio in Women with Suspected Preeclampsia, N. Engl. J. Med., 374, 13, 10.1056/NEJMoa1414838
Phipps, 2019, Pre-Eclampsia: Pathogenesis, Novel Diagnostics and Therapies, Nat. Rev. Nephrol., 15, 275, 10.1038/s41581-019-0119-6
Rana, 2019, Preeclampsia: Pathophysiology, Challenges, and Perspectives, Circ. Res., 124, 1094, 10.1161/CIRCRESAHA.118.313276
(2019). ACOG Practice Bulletin No. 202: Gestational Hypertension and Preeclampsia. Obstet. Gynecol., 133, e1–e25.
Grant, 1989, Routine Formal Fetal Movement Counting and Risk of Antepartum Late Death in Normally Formed Singletons, Lancet, 334, 345, 10.1016/S0140-6736(89)90535-7
Lalor, 2008, Biophysical Profile for Fetal Assessment in High Risk Pregnancies, Cochrane Database Syst. Rev., 23, CD000038
Grivell, R.M., Alfirevic, Z., Gyte, G.M.L., and Devane, D. (2015). Antenatal Cardiotocography for Fetal Assessment. Cochrane Database Syst. Rev.
Nabhan, A.F., and Abdelmoula, Y.A. (2008). Amniotic Fluid Index versus Single Deepest Vertical Pocket as a Screening Test for Preventing Adverse Pregnancy Outcome. Cochrane Database Syst. Rev.
Williams, 2003, Screening for Fetal Well-Being in a High-Risk Pregnant Population Comparing the Nonstress Test with Umbilical Artery Doppler Velocimetry: A Randomized Controlled Clinical Trial, Am. J. Obstet. Gynecol., 188, 1366, 10.1067/mob.2003.305
Alfirevic, Z., Stampalija, T., and Dowswell, T. (2017). Fetal and Umbilical Doppler Ultrasound in High-Risk Pregnancies. Cochrane Database Syst. Rev.
Alfirevic, 1995, Doppler Ultrasonography in High-Risk Pregnancies: Systematic Review with Meta-Analysis, Am. J. Obstet. Gynecol., 172, 1379, 10.1016/0002-9378(95)90466-2
Karsdorp, 1994, Clinical Significance of Absent or Reversed End Diastolic Velocity Waveforms in Umbilical Artery, Lancet, 344, 1664, 10.1016/S0140-6736(94)90457-X
Arduini, 2013, The Development of Abnormal Heart Rate Patterns after Absent End-Diastolic Velocity in Umbilical Artery: Analysis of Risk Factors, Am. J. Obstet. Gynecol., 168, 43, 10.1016/S0002-9378(12)90882-0
Westergaard, 2001, A Critical Appraisal of the Use of Umbilical Artery Doppler Ultrasound in High-Risk Pregnancies: Use of Meta-Analyses in Evidence-Based Obstetrics, Ultrasound Obstet. Gynecol., 17, 466, 10.1046/j.1469-0705.2001.00415.x
Yagel, 2010, The Fetal Venous System, Part II: Ultrasound Evaluation of the Fetus with Congenital Venous System Malformation or Developing Circulatory Compromise, Ultrasound Obstet. Gynecol., 36, 93, 10.1002/uog.7622
Baschat, 2007, Predictors of Neonatal Outcome in Early-Onset Placental Dysfunction, Obstet. Gynecol., 109, 253, 10.1097/01.AOG.0000253215.79121.75
Harrington, 1999, Doppler Fetal Circulation in Pregnancies Complicated by Pre-Eclampsia or Delivery of a Small for Gestational Age Baby: 2. Longitudinal Analysis, BJOG An. Int. J. Obstet. Gynaecol., 106, 453, 10.1111/j.1471-0528.1999.tb08299.x
Ekmen, 1999, Umbilical and Middle Cerebral Artery Doppler Indices in Patients with Preeclampsia, Eur. J. Obstet. Gynecol. Reprod. Biol., 82, 11, 10.1016/S0301-2115(98)00167-5
Eser, 2011, Predictive Value of Middle Cerebral Artery to Uterine Artery Pulsatility Index Ratio in Preeclampsia, Arch. Gynecol. Obstet., 284, 307, 10.1007/s00404-010-1660-5
Simanaviciute, 2006, Fetal Middle Cerebral to Uterine Artery Pulsatility Index Ratios in Normal and Pre-Eclamptic Pregnancies, Ultrasound Obstet. Gynecol., 28, 794, 10.1002/uog.3805
Makhseed, 2000, Middle Cerebral Artery to Umbilical Artery Resistance Index Ratio in the Prediction of Neonatal Outcome, Int. J. Gynecol. Obstet., 71, 119, 10.1016/S0020-7292(00)00262-9
Ebrashy, 2005, Middle Cerebral/Umbilical Artery Resistance Index Ratio as Sensitive Parameter for Fetal Well-Being and Neonatal Outcome in Patients with Preeclampsia: Case-Control Study, Croat. Med. J., 46, 821
Campbell, 1983, New Doppler Technique for Assessing Uteroplacental Blood Flow, Lancet, 321, 675, 10.1016/S0140-6736(83)91970-0
Thangaratinam, 2006, Accuracy of Serum Uric Acid in Predicting Complications of Pre-Eclampsia: A Systematic Review, BJOG, 169, 369, 10.1111/j.1471-0528.2006.00908.x
Thangaratinam, S., Coomarasamy, A., O’Mahony, F., Sharp, S., Zamora, J., Khan, K.S., and Ismail, K.M.K. (2009). Estimation of Proteinuria as a Predictor of Complications of Pre-Eclampsia: A Systematic Review. BMC Med., 7.
Thangaratinam, 2011, Accuracy of Liver Function Tests for Predicting Adverse Maternal and Fetal Outcomes in Women with Preeclampsia: A Systematic Review, Acta Obstet. Gynecol. Scand., 90, 574, 10.1111/j.1600-0412.2011.01112.x
Tsikas, 2018, Inverse Correlation between Maternal Plasma Asymmetric Dimethylarginine (ADMA) and Birthweight Percentile in Women with Impaired Placental Perfusion: Circulating ADMA as an NO-Independent Indicator of Fetal Growth Restriction?, Amino Acids, 50, 341, 10.1007/s00726-017-2522-2
Ali, 2015, Correlation of CRP Levels in Third Trimester with Fetal Birth Weight in Preeclamptic and Normotensive Pregnant Women, J. Coll. Physicians Surg. Pak., 25, 111
Goldenberg, 2008, Epidemiology and Causes of Preterm Birth, Lancet, 371, 75, 10.1016/S0140-6736(08)60074-4
National Guideline Alliance (UK) (2019, October 03). Preterm Labour and Birth (NG25). Available online: https://www.nice.org.uk/guidance/ng25.
Roberts, 2017, Antenatal Corticosteroids for Accelerating Fetal Lung Maturation for Women at Risk of Preterm Birth, Cochrane Database Syst. Rev., 3, CD004454
Brownfoot, F.C., Gagliardi, D.I., Bain, E., Middleton, P., and Crowther, C.A. (2013). Different Corticosteroids and Regimens for Accelerating Fetal Lung Maturation for Women at Risk of Preterm Birth. Cochrane Database Syst. Rev.
Kashanian, 2018, Comparison between Two Doses of Betamethasone Administration with 12 Hours vs. 24 Hours Intervals on Prevention of Respiratory Distress Syndrome: A Randomised Trial, J. Obstet. Gynaecol., 38, 770, 10.1080/01443615.2017.1413080
Porto, 2011, Effectiveness of Antenatal Corticosteroids in Reducing Respiratory Disorders in Late Preterm Infants: Randomised Clinical Trial, BMJ, 342, d1696, 10.1136/bmj.d1696
Saccone, 2016, Antenatal Corticosteroids for Maturity of Term or near Term Fetuses: Systematic Review and Meta-Analysis of Randomized Controlled Trials, BMJ, 355, i5044, 10.1136/bmj.i5044
Kelly, 2012, Antenatal Glucocorticoid Exposure and Long-Term Alterations in Aortic Function and Glucose Metabolism, Pediatrics, 129, e1282, 10.1542/peds.2011-3175
Crowther, 2006, Neonatal Respiratory Distress Syndrome after Repeat Exposure to Antenatal Corticosteroids: A Randomised Controlled Trial, Lancet, 367, 1913, 10.1016/S0140-6736(06)68846-6
Murphy, 2008, Multiple Courses of Antenatal Corticosteroids for Preterm Birth (MACS): A Randomised Controlled Trial, Lancet, 372, 2143, 10.1016/S0140-6736(08)61929-7
Atarod, 2014, Effects of Single Course and Multicourse Betamethasone Prior to Birth in the Prognosis of the Preterm Neonates, J. Res. Med. Sci., 19, 715
Crowther, 2007, Outcomes at 2 Years of Age after Repeat Doses of Antenatal Corticosteroids, N. Engl. J. Med., 357, 1179, 10.1056/NEJMoa071152
Asztalos, 2013, Multiple Courses of Antenatal Corticosteroids for Preterm Birth Study Outcomes in Children at 5 Years of Age (MACS-5), JAMA Pediatr., 167, 1102
Asztalos, 2010, Multiple Courses of Antenatal Corticosteroids for Preterm Birth Study: 2-Year Outcomes, Pediatrics, 126, E1045, 10.1542/peds.2010-0857
Doyle, L.W., Crowther, C.A., Middleton, P., Marret, S., and Rouse, D. (2009). Magnesium Sulphate for Women at Risk of Preterm Birth for Neuroprotection of the Fetus. Cochrane Database Syst. Rev.
Duley, 2002, Do Women with Pre-Eclampsia, and Their Babies, Benefit from Magnesium Sulphate? The Magpie Trial: A Randomised Placebo-Controlled Trial, Lancet, 359, 1877, 10.1016/S0140-6736(02)08778-0
Duley, 2007, The Magpie Trial: A Randomised Trial Comparing Magnesium Sulphate with Placebo for Pre-Eclampsia. Outcome for Children at 18 Months, BJOG, 114, 289, 10.1111/j.1471-0528.2006.01165.x
Bombrys, 2008, Expectant Management of Severe Preeclampsia at Less than 27 Weeks’ Gestation: Maternal and Perinatal Outcomes According to Gestational Age by Weeks at Onset of Expectant Management, Am. J. Obstet. Gynecol., 199, e1, 10.1016/j.ajog.2008.06.086
Budden, 2006, Pregnancy Outcome in Women Presenting with Pre-Eclampsia at Less than 25 Weeks Gestation, Aust. N. Z. J. Obstet. Gynaecol., 46, 407, 10.1111/j.1479-828X.2006.00626.x
Churchill, D., Duley, L., Thornton, J.G., Moussa, M., Ali, H.S.M., and Walker, K.F. (2018). Interventionist versus Expectant Care for Severe Pre-Eclampsia between 24 and 34 Weeks’ Gestation. Cochrane Database Syst. Rev.
Bernardes, 2019, Delivery or Expectant Management for Prevention of Adverse Maternal and Neonatal Outcomes in Hypertensive Disorders of Pregnancy: An Individual Participant Data Meta-Analysis, Ultrasound Obstet. Gynecol., 53, 443, 10.1002/uog.20224
Chappell, 2019, Planned Delivery or Expectant Management for Late Preterm Pre-Eclampsia: Study Protocol for a Randomised Controlled Trial (PHOENIX Trial), Trials, 20, 85, 10.1186/s13063-018-3150-1
Koopmans, 2009, Induction of Labour versus Expectant Monitoring for Gestational Hypertension or Mild Pre-Eclampsia after 36 Weeks’ Gestation (HYPITAT): A Multicentre, Open-Label Randomised Controlled Trial, Lancet, 374, 979, 10.1016/S0140-6736(09)60736-4
Thornton, 2004, GRIT study group. Infant Wellbeing at 2 Years of Age in the Growth Restriction Intervention Trial (GRIT): Multicentred Randomised Controlled Trial, Lancet, 364, 513, 10.1016/S0140-6736(04)16809-8
Kalakoutis, 2003, A Randomised Trial of Timed Delivery for the Compromised Preterm Fetus: Short Term Outcomes and Bayesian Interpretation, BJOG, 110, 27, 10.1046/j.1471-0528.2003.02014.x
Bilardo, 2004, Relationship between Monitoring Parameters and Perinatal Outcome in Severe, Early Intrauterine Growth Restriction, Ultrasound Obstet. Gynecol., 23, 119, 10.1002/uog.965
Lees, 2015, 2 Year Neurodevelopmental and Intermediate Perinatal Outcomes in Infants with Very Preterm Fetal Growth Restriction (TRUFFLE): A Randomised Trial, Lancet, 385, 2162, 10.1016/S0140-6736(14)62049-3
Sameshima, 2008, Antithrombin Improves Fetal Condition in Women with Severe Pre-Eclampsia before 32 Weeks of Gestation; a Randomized, Double-Blind, Placebo-Controlled Trial, J. Obstet. Gynaecol. Res., 34, 34, 10.1111/j.1447-0756.2007.00677.x
Herraiz, 2012, Sildenafil Citrate Improves Perinatal Outcome in Fetuses from Pre-Eclamptic Rats, BJOG, 119, 1394, 10.1111/j.1471-0528.2012.03430.x
Costantine, 2013, Pravastatin for the Prevention of Preeclampsia in High-Risk Pregnant Women, Obstet. Gynecol., 121, 349, 10.1097/AOG.0b013e31827d8ad5
Brownfoot, 2015, Effects of Pravastatin on Human Placenta, Endothelium, and Women with Severe Preeclampsia, Hypertension, 66, 687, 10.1161/HYPERTENSIONAHA.115.05445
Costantine, 2016, Safety and Pharmacokinetics of Pravastatin Used for the Prevention of Preeclampsia in High-Risk Pregnant Women: A Pilot Randomized Controlled Trial, Am. J. Obstet. Gynecol., 214, e17, 10.1016/j.ajog.2015.12.038
Brownfoot, 2016, Metformin as a Prevention and Treatment for Preeclampsia: Effects on Soluble Fms-like Tyrosine Kinase 1 and Soluble Endoglin Secretion and Endothelial Dysfunction, Am. J. Obstet. Gynecol., 214, e15, 10.1016/j.ajog.2015.12.019
Thadhani, 2011, Pilot Study of Extracorporeal Removal of Soluble Fms-like Tyrosine Kinase 1 in Preeclampsia, Circulation, 124, 940, 10.1161/CIRCULATIONAHA.111.034793
Thadhani, 2016, Removal of Soluble Fms-like Tyrosine Kinase-1 by Dextran Sulfate Apheresis in Preeclampsia, J. Am. Soc. Nephrol., 27, 903, 10.1681/ASN.2015020157
Perry, 2018, Preeclampsia and the Cardiovascular System: An Update, Trends Cardiovasc. Med., 28, 505, 10.1016/j.tcm.2018.04.009
Thilaganathan, 2019, Cardiovascular System in Preeclampsia and Beyond, Hypertension, 73, 522, 10.1161/HYPERTENSIONAHA.118.11191
Ahmed, 2014, Pre-Eclampsia and Future Cardiovascular Risk among Women: A Review, J. Am. Coll. Cardiol., 63, 1815, 10.1016/j.jacc.2014.02.529
Davis, 2015, Clinical Cardiovascular Risk during Young Adulthood in Offspring of Hypertensive Pregnancies: Insights from a 20-Year Prospective Follow-up Birth Cohort, BMJ Open, 5, e008136, 10.1136/bmjopen-2015-008136
Ferreira, 2009, Preeclampsia and Increased Blood Pressure in the Offspring: Meta-Analysis and Critical Review of the Evidence, J. Hypertens., 27, 1955, 10.1097/HJH.0b013e328331b8c6
Kajantie, 2009, Pre-Eclampsia Is Associated With Increased Risk of Stroke in the Adult Offspring, Stroke, 40, 1176, 10.1161/STROKEAHA.108.538025
Lazdam, 2012, Unique Blood Pressure Characteristics in Mother and Offspring after Early Onset Preeclampsia, Hypertension, 60, 1338, 10.1161/HYPERTENSIONAHA.112.198366
Lazdam, 2010, Elevated Blood Pressure in Offspring Born Premature to Hypertensive Pregnancy: Is Endothelial Dysfunction the Underlying Vascular Mechanism?, Hypertension, 56, 159, 10.1161/HYPERTENSIONAHA.110.150235
Alsnes, 2017, Hypertension in Pregnancy and Offspring Cardiovascular Risk in Young Adulthood: Prospective and Sibling Studies in the HUNT Study (Nord-Trøndelag Health Study) in Norway, Hypertension, 69, 591, 10.1161/HYPERTENSIONAHA.116.08414
Yu, 2017, Hypertension: Hypertension in Pregnancy: A Risk Factor for the Whole Family?, Nat. Rev. Nephrol., 13, 326, 10.1038/nrneph.2017.54
Davis, 2012, Pre-Eclampsia and Offspring Cardiovascular Health: Mechanistic Insights from Experimental Studies, Clin. Sci., 123, 53, 10.1042/CS20110627
Akcakus, 2010, The Relationship between Abdominal Aortic Intima-Media Thickness and Lipid Profile in Neonates Born to Mothers with Preeclampsia, J. Pediatr. Endocrinol. Metab., 23, 1143, 10.1515/jpem.2010.179
Kvehaugen, 2011, Endothelial Function and Circulating Biomarkers Are Disturbed in Women and Children after Preeclampsia, Hypertension, 58, 63, 10.1161/HYPERTENSIONAHA.111.172387
Jayet, 2010, Pulmonary and Systemic Vascular Dysfunction in Young Offspring of Mothers with Preeclampsia, Circulation, 122, 488, 10.1161/CIRCULATIONAHA.110.941203
Lawlor, 2012, Cardiovascular Biomarkers and Vascular Function during Childhood in the Offspring of Mothers with Hypertensive Disorders of Pregnancy: Findings from the Avon Longitudinal Study of Parents and Children, Eur. Heart J., 33, 335, 10.1093/eurheartj/ehr300
Yu, 2016, Association of Maternal Antiangiogenic Profile at Birth with Early Postnatal Loss of Microvascular Density in Offspring of Hypertensive Pregnancies, Hypertension, 68, 749, 10.1161/HYPERTENSIONAHA.116.07586
Yu, 2018, Neonatal MicroRNA Profile Determines Endothelial Function in Offspring of Hypertensive Pregnancies, Hypertension, 72, 937, 10.1161/HYPERTENSIONAHA.118.11343
Timpka, 2016, Hypertensive Disorders of Pregnancy and Offspring Cardiac Structure and Function in Adolescence, J. Am. Heart Assoc., 5, e003906, 10.1161/JAHA.116.003906
Lewandowski, 2013, Preterm Heart in Adult Life: Cardiovascular Magnetic Resonance Reveals Distinct Differences in Left Ventricular Mass, Geometry, and Function, Circulation, 127, 197, 10.1161/CIRCULATIONAHA.112.126920
Aye, 2018, Neonatal Autonomic Function after Pregnancy Complications and Early Cardiovascular Development, Pediatr. Res., 84, 85, 10.1038/s41390-018-0021-0
Aye, 2017, Disproportionate Cardiac Hypertrophy during Early Postnatal Development in Infants Born Preterm, Pediatr. Res., 82, 36, 10.1038/pr.2017.96
Nathan, 2018, Early Warning System Hypertension Thresholds to Predict Adverse Outcomes in Pre-Eclampsia: A Prospective Cohort Study, Pregnancy Hypertens., 12, 183, 10.1016/j.preghy.2017.11.003