MicroRNAs: Allies or Foes in erythropoiesis?Journal of Cellular Physiology - Tập 227 Số 1 - Trang 7-13 - 2012
John Byon, Thalia Papayannopoulou
AbstractMicroRNAs are small non‐coding RNAs that negatively regulate gene expression through mRNA degradation or translational repression. It is becoming increasingly recognized that miRNAs play central roles in almost all cellular processes, and especially during development. The function of miRNAs in hematopoiesis, including erythropoiesis, is beginning to be elu...... hiện toàn bộ
HMGB1 as a therapeutic target in diseaseJournal of Cellular Physiology - Tập 236 Số 5 - Trang 3406-3419 - 2021
Jiaming Xue, Joelle Sacks Suarez, Michael Minaai, Shuangjing Li, Giovanni Gaudino, Harvey I. Pass, Michele Carbone, Haining Yang
AbstractHigh‐mobility group box 1 (HMGB1) was initially recognized as a ubiquitous nuclear protein involved in maintaining the nucleosome integrity and facilitating gene transcription. HMGB1 has since been reevaluated to be a prototypical damage‐associated molecular pattern (DAMP) protein, and together with its exogenous counterpart, pathogen‐associated molecular p...... hiện toàn bộ
The evolving field of induced pluripotency: Recent progress and future challengesJournal of Cellular Physiology - Tập 228 Số 2 - Trang 267-275 - 2013
Cesar Sommer, Gustavo Mostoslavsky
AbstractThe derivation of patient‐specific pluripotent cell lines through the introduction of a few transcription factors into somatic cells has opened new avenues for the study and treatment of human disorders. Induced pluripotent stem cells (iPSCs) and their derivatives offer a unique platform for disease modeling, drug discovery and toxicology, as well as an inv...... hiện toàn bộ
Estrogen deprivation aggravates intracellular calcium dyshomeostasis in the heart of obese‐insulin resistant ratsJournal of Cellular Physiology - Tập 234 Số 5 - Trang 6983-6991 - 2019
Siripong Palee, Wanitchaya Minta, Duangkamol Mantor, Wissuta Sutham, Sasiwan Kerdphoo, Wasana Pratchayasakul, Siriporn C. Chattipakorn, Nipon Chattipakorn
AbstractThe incidence of cardiovascular disease and metabolic syndrome increases after the onset of menopause, giving evidence for the vital role of estrogen. Intracellular calcium [Ca2+]i regulation plays an important role in the maintenance of left ventricular (LV) contractile function. Although either estrogen deprivation or obesity has been...... hiện toàn bộ
Msx2 induces epithelial‐mesenchymal transition in mouse mammary epithelial cells through upregulation of Cripto‐1Journal of Cellular Physiology - Tập 219 Số 3 - Trang 659-666 - 2009
M.G. di Bari, Erika Ginsburg, Joshua Plant, Luigi Strizzi, David S. Salomon, Barbara K. Vonderhaar
AbstractEpithelial‐mesenchymal transition (EMT) is a process occurring during both embryogenesis and early stages of invasive cancer. Epithelial cells that undergo EMT become more migratory and invasive with a mesenchymal morphology. Herein we assess EMT induction in a mouse mammary epithelial cell line driven by Msx2, a homeobox‐containing transcription factor imp...... hiện toàn bộ
Features that determine telomere homolog oligonucleotide‐induced therapeutic DNA damage‐like responses in cancer cellsJournal of Cellular Physiology - Tập 210 Số 3 - Trang 582-595 - 2007
Norio Ohashi, Mina Yaar, Mark S. Eller, Francesca Truzzi, Barbara A. Gilchrest
AbstractCancer is the second leading cause of death in the USA, with metastatic disease proving a particular management challenge. Treatment modalities for patients with metastatic disease are limited, and survival beyond 5 years is uncommon. We have reported that an 11‐base DNA oligonucleotide 100% homologous to the telomere 3′ overhang can induce apoptosis, senes...... hiện toàn bộ