Journal of Cellular Physiology

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MicroRNAs: Allies or Foes in erythropoiesis?
Journal of Cellular Physiology - Tập 227 Số 1 - Trang 7-13 - 2012
John Byon, Thalia Papayannopoulou
AbstractMicroRNAs are small non‐coding RNAs that negatively regulate gene expression through mRNA degradation or translational repression. It is becoming increasingly recognized that miRNAs play central roles in almost all cellular processes, and especially during development. The function of miRNAs in hematopoiesis, including erythropoiesis, is beginning to be elu...... hiện toàn bộ
LncRNA XIST facilitates proliferation and epithelial–mesenchymal transition of colorectal cancer cells through targeting miR‐486‐5p and promoting neuropilin‐2
Journal of Cellular Physiology - Tập 234 Số 8 - Trang 13747-13761 - 2019
Aihua Liu, Lihua Liu, Hang Lü
AbstractThis study was designed to acertain whether the long noncoding RNA (lncRNA) X‐inactive specific transcript (XIST)/miR‐486‐5p/neuropilin‐2 (NRP‐2) pathway might promote the viability and epithelial–mesenchymal transition (EMT) of colorectal cancer (CRC) cells. In this investigation, we included 317 pathologically confirmed CRC patients and purchased several ...... hiện toàn bộ
HMGB1 as a therapeutic target in disease
Journal of Cellular Physiology - Tập 236 Số 5 - Trang 3406-3419 - 2021
Jiaming Xue, Joelle Sacks Suarez, Michael Minaai, Shuangjing Li, Giovanni Gaudino, Harvey I. Pass, Michele Carbone, Haining Yang
AbstractHigh‐mobility group box 1 (HMGB1) was initially recognized as a ubiquitous nuclear protein involved in maintaining the nucleosome integrity and facilitating gene transcription. HMGB1 has since been reevaluated to be a prototypical damage‐associated molecular pattern (DAMP) protein, and together with its exogenous counterpart, pathogen‐associated molecular p...... hiện toàn bộ
The evolving field of induced pluripotency: Recent progress and future challenges
Journal of Cellular Physiology - Tập 228 Số 2 - Trang 267-275 - 2013
Cesar Sommer, Gustavo Mostoslavsky
AbstractThe derivation of patient‐specific pluripotent cell lines through the introduction of a few transcription factors into somatic cells has opened new avenues for the study and treatment of human disorders. Induced pluripotent stem cells (iPSCs) and their derivatives offer a unique platform for disease modeling, drug discovery and toxicology, as well as an inv...... hiện toàn bộ
Estrogen deprivation aggravates intracellular calcium dyshomeostasis in the heart of obese‐insulin resistant rats
Journal of Cellular Physiology - Tập 234 Số 5 - Trang 6983-6991 - 2019
Siripong Palee, Wanitchaya Minta, Duangkamol Mantor, Wissuta Sutham, Sasiwan Kerdphoo, Wasana Pratchayasakul, Siriporn C. Chattipakorn, Nipon Chattipakorn
AbstractThe incidence of cardiovascular disease and metabolic syndrome increases after the onset of menopause, giving evidence for the vital role of estrogen. Intracellular calcium [Ca2+]i regulation plays an important role in the maintenance of left ventricular (LV) contractile function. Although either estrogen deprivation or obesity has been...... hiện toàn bộ
Msx2 induces epithelial‐mesenchymal transition in mouse mammary epithelial cells through upregulation of Cripto‐1
Journal of Cellular Physiology - Tập 219 Số 3 - Trang 659-666 - 2009
M.G. di Bari, Erika Ginsburg, Joshua Plant, Luigi Strizzi, David S. Salomon, Barbara K. Vonderhaar
AbstractEpithelial‐mesenchymal transition (EMT) is a process occurring during both embryogenesis and early stages of invasive cancer. Epithelial cells that undergo EMT become more migratory and invasive with a mesenchymal morphology. Herein we assess EMT induction in a mouse mammary epithelial cell line driven by Msx2, a homeobox‐containing transcription factor imp...... hiện toàn bộ
Features that determine telomere homolog oligonucleotide‐induced therapeutic DNA damage‐like responses in cancer cells
Journal of Cellular Physiology - Tập 210 Số 3 - Trang 582-595 - 2007
Norio Ohashi, Mina Yaar, Mark S. Eller, Francesca Truzzi, Barbara A. Gilchrest
AbstractCancer is the second leading cause of death in the USA, with metastatic disease proving a particular management challenge. Treatment modalities for patients with metastatic disease are limited, and survival beyond 5 years is uncommon. We have reported that an 11‐base DNA oligonucleotide 100% homologous to the telomere 3′ overhang can induce apoptosis, senes...... hiện toàn bộ
Contribution of functional voltage‐gated Na+ channel expression to cell behaviors involved in the metastatic cascade in rat prostate cancer: II. Secretory membrane activity
Journal of Cellular Physiology - Tập 195 Số 3 - Trang 461-469 - 2003
Maria E. Mycielska, Scott P. Fraser, Marek Szatkowski, Mustafa B.A. Djamgoz
AbstractThe secretory membrane activities of two rat prostate cancer cell lines of markedly different metastatic potential, and corresponding electrophysiological characteristics, were studied in a comparative approach. In particular, voltage‐gated Na+ channels (VGSCs) were expressed in the strongly metastatic MAT‐LyLu but not in the closely re...... hiện toàn bộ
Enhanced sterol synthesis in concanavalin A‐stimulated lymphocytes: Correlation with phospholipid synthesis and DNA synthesis
Journal of Cellular Physiology - Tập 100 Số 1 - Trang 147-157 - 1979
S. Shi-Hua Chen
AbstractIncorporation of (14C)choline and (3H)myo‐inositol into the total lipid fraction, incorporation of (14C)acetate into the sterol fraction and incorporation of (3H)thymidine into DNA were studied in human lymphocyte cultures. Concanavalin A induced an increase in the incorpora...... hiện toàn bộ
Differential gene expression profile in monocytic myeloid‐derived suppressor cells at maternal–fetal interface in a mouse model of spontaneous abortion
Journal of Cellular Physiology - Tập 234 Số 7 - Trang 10789-10799 - 2019
Jiabin Ren, Weihong Zeng, Fu‐Ju Tian, Fan Wu, Siming Zhang, Xiaorui Liu, Yi Lin
AbstractBackgroundMonocytic myeloid‐derived suppressor cells (MO‐MDSCs) play an important role in maintaining normal pregnancy. However, it is still not clear what kind of changes in MO‐MDSCs may lead to miscarriage, and which gene expression changes take place when MO‐MDSCs migrate to the uterus as bone marrow‐derived cells....... hiện toàn bộ
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