Journal of Cellular Physiology
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MicroRNAs: Allies or Foes in erythropoiesis?
Journal of Cellular Physiology - Tập 227 Số 1 - Trang 7-13 - 2012
AbstractMicroRNAs are small non‐coding RNAs that negatively regulate gene
expression through mRNA degradation or translational repression. It is becoming
increasingly recognized that miRNAs play central roles in almost all cellular
processes, and especially during development. The function of miRNAs in
hematopoiesis, including erythropoiesis, is beginning to be elucidated. In this
review, we will ...
LncRNA XIST facilitates proliferation and epithelial–mesenchymal transition of colorectal cancer cells through targeting miR‐486‐5p and promoting neuropilin‐2
Journal of Cellular Physiology - Tập 234 Số 8 - Trang 13747-13761 - 2019
AbstractThis study was designed to acertain whether the long noncoding RNA
(lncRNA) X‐inactive specific transcript (XIST)/miR‐486‐5p/neuropilin‐2 (NRP‐2)
pathway might promote the viability and epithelial–mesenchymal transition (EMT)
of colorectal cancer (CRC) cells. In this investigation, we included 317
pathologically confirmed CRC patients and purchased several human CRC cells
(i.e. HCT116, HT2...
HMGB1 as a therapeutic target in disease
Journal of Cellular Physiology - Tập 236 Số 5 - Trang 3406-3419 - 2021
AbstractHigh‐mobility group box 1 (HMGB1) was initially recognized as a
ubiquitous nuclear protein involved in maintaining the nucleosome integrity and
facilitating gene transcription. HMGB1 has since been reevaluated to be a
prototypical damage‐associated molecular pattern (DAMP) protein, and together
with its exogenous counterpart, pathogen‐associated molecular pattern (PAMP),
completes the body...
The evolving field of induced pluripotency: Recent progress and future challenges
Journal of Cellular Physiology - Tập 228 Số 2 - Trang 267-275 - 2013
AbstractThe derivation of patient‐specific pluripotent cell lines through the
introduction of a few transcription factors into somatic cells has opened new
avenues for the study and treatment of human disorders. Induced pluripotent stem
cells (iPSCs) and their derivatives offer a unique platform for disease
modeling, drug discovery and toxicology, as well as an invaluable source of
cells for regen...
Estrogen deprivation aggravates intracellular calcium dyshomeostasis in the heart of obese‐insulin resistant rats
Journal of Cellular Physiology - Tập 234 Số 5 - Trang 6983-6991 - 2019
AbstractThe incidence of cardiovascular disease and metabolic syndrome increases
after the onset of menopause, giving evidence for the vital role of estrogen.
Intracellular calcium [Ca2+]i regulation plays an important role in the
maintenance of left ventricular (LV) contractile function. Although either
estrogen deprivation or obesity has been shown to strongly affect the metabolic
status and LV ...
Msx2 induces epithelial‐mesenchymal transition in mouse mammary epithelial cells through upregulation of Cripto‐1
Journal of Cellular Physiology - Tập 219 Số 3 - Trang 659-666 - 2009
AbstractEpithelial‐mesenchymal transition (EMT) is a process occurring during
both embryogenesis and early stages of invasive cancer. Epithelial cells that
undergo EMT become more migratory and invasive with a mesenchymal morphology.
Herein we assess EMT induction in a mouse mammary epithelial cell line driven by
Msx2, a homeobox‐containing transcription factor important during mammary gland
devel...
Features that determine telomere homolog oligonucleotide‐induced therapeutic DNA damage‐like responses in cancer cells
Journal of Cellular Physiology - Tập 210 Số 3 - Trang 582-595 - 2007
AbstractCancer is the second leading cause of death in the USA, with metastatic
disease proving a particular management challenge. Treatment modalities for
patients with metastatic disease are limited, and survival beyond 5 years is
uncommon. We have reported that an 11‐base DNA oligonucleotide 100% homologous
to the telomere 3′ overhang can induce apoptosis, senescence and/or
differentiation of s...
Contribution of functional voltage‐gated Na+ channel expression to cell behaviors involved in the metastatic cascade in rat prostate cancer: II. Secretory membrane activity
Journal of Cellular Physiology - Tập 195 Số 3 - Trang 461-469 - 2003
AbstractThe secretory membrane activities of two rat prostate cancer cell lines
of markedly different metastatic potential, and corresponding
electrophysiological characteristics, were studied in a comparative approach. In
particular, voltage‐gated Na+ channels (VGSCs) were expressed in the strongly
metastatic MAT‐LyLu but not in the closely related, but weakly metastatic, AT‐2
cells. Uptake and r...
Enhanced sterol synthesis in concanavalin A‐stimulated lymphocytes: Correlation with phospholipid synthesis and DNA synthesis
Journal of Cellular Physiology - Tập 100 Số 1 - Trang 147-157 - 1979
AbstractIncorporation of (14C)choline and (3H)myo‐inositol into the total lipid
fraction, incorporation of (14C)acetate into the sterol fraction and
incorporation of (3H)thymidine into DNA were studied in human lymphocyte
cultures. Concanavalin A induced an increase in the incorporation of these
labels with the following features: (a) Phospholipid synthesis was increased
promptly. The lag time for...
Differential gene expression profile in monocytic myeloid‐derived suppressor cells at maternal–fetal interface in a mouse model of spontaneous abortion
Journal of Cellular Physiology - Tập 234 Số 7 - Trang 10789-10799 - 2019
AbstractBackgroundMonocytic myeloid‐derived suppressor cells (MO‐MDSCs) play an
important role in maintaining normal pregnancy. However, it is still not clear
what kind of changes in MO‐MDSCs may lead to miscarriage, and which gene
expression changes take place when MO‐MDSCs migrate to the uterus as bone
marrow‐derived cells.MethodsWe used flow sorting technology to obtain MO‐MDSCs
from the matern...
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