Journal of Biochemical and Molecular Toxicology
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Cisplatin‐Induced Testicular Toxicity in Rats: The Protective Effect of Arjunolic Acid
Journal of Biochemical and Molecular Toxicology - Tập 28 Số 11 - Trang 515-521 - 2014
ABSTRACTIn the present study, the effect of arjunolic acid on testicular damage
induced by intraperitoneal injection of rats with 7 mg/kg cisplatin was studied.
Cisplatin induced a significant reduction in testicular weights, plasma
testosterone, and testicular reduced glutathione levels in addition to a
significant elevation of testicular malondialdehyde levels and testicular gene
expressions of ...
RETRACTED: Protective effects of N‐acetyl cysteine on lipid peroxide metabolism on isoproterenol‐induced myocardial infarcted rats
Journal of Biochemical and Molecular Toxicology - Tập 25 Số 3 - Trang 151-157 - 2011
AbstractThe present study was designed to evaluate the preventive effects of
N‐acetyl cysteine on lipid peroxide metabolism in isoproterenol (ISO) induced
myocardial infarcted rats. Male albino Wistar rats were pretreated with N‐acetyl
cysteine (5 and 10 mg/kg) daily for a period of 14 days. After the pretreatment
period, ISO (100 mg/kg) was subcutaneously injected to rats twice at an interval
of ...
Protective effects of N‐acetyl cysteine on membrane‐bound adenosine triphosphatases and minerals in isoproterenol‐induced myocardial‐infarcted rats: An in vivo and in vitro study
Journal of Biochemical and Molecular Toxicology - Tập 26 Số 7 - Trang 276-281 - 2012
AbstractThe present study was aimed to evaluate the protective effects of
N‐acetyl cysteine (NAC) on changes in the activities/levels of adenosine
triphosphatases and minerals in isoproterenol‐induced myocardial‐infarcted rats.
Male albino Wistar rats were pretreated with NAC (10 mg/kg body weight) daily
for a period of 14 days. After pretreatment period, rats were induced myocardial
infarction (M...
RETRACTED: Preventive effect of naringin on cardiac mitochondrial enzymes during isoproterenol‐induced myocardial infarction in rats: A transmission electron microscopic study
Journal of Biochemical and Molecular Toxicology - Tập 21 Số 6 - Trang 354-361 - 2007
AbstractDietary flavonoids intake has been reported inversely related to the
incidence of cardiovascular diseases (CVD). The present study is undertaken to
evaluate the preventive role of naringin on mitochondrial enzymes in
isoproterenol (ISO)‐induced myocardial infarction in male albino Wistar rats.
Rats subcutaneously injected with ISO (85 mg/kg) at an interval of 24 h for 2
days, resulting in ...
Protective effects of thymol on altered plasma lipid peroxidation and nonenzymic antioxidants in isoproterenol‐induced myocardial infarcted rats
Journal of Biochemical and Molecular Toxicology - Tập 26 Số 9 - Trang 368-373 - 2012
AbstractThis study evaluates the protective effects of thymol on altered plasma
lipid peroxidation products and nonenzymic antioxidants in isoproterenol
(ISO)‐induced myocardial infarcted rats. Male albino Wistar rats were pre and
cotreated with thymol (7.5 mg/kg body weight) daily for 7 days. ISO (100 mg/kg
body weight) was subcutaneously injected into rats on 6th and 7th day to induce
myocardial...
Characterization of Cd‐induced molecular events prior to cellular damage in primary rat hepatocytes in culture: Activation of the stress activated signal protein JNK and transcription factor AP‐1
Journal of Biochemical and Molecular Toxicology - Tập 18 Số 3 - Trang 133-142 - 2004
AbstractThe effect of Cadmium (Cd) on the expression of c‐Jun N‐terminal kinase
(JNK), c‐jun, and activator protein‐1 (AP‐1) has been investigated. We
previously reported that Cd causes cell damage as indicated by increases in the
cytotoxic parameters, lactate dehydrogenase and lipid peroxidation, and this
damage was mediated by decreases in cellular concentration of glutathione. In
the present st...
A Comparison between the Nephrotoxic Profile of Gentamicin and Gentamicin Nanoparticles in Mice
Journal of Biochemical and Molecular Toxicology - Tập 29 Số 2 - Trang 57-62 - 2015
ABSTRACTAminoglycoside antibiotics are widely used against Gram‐negative
infections. On the other hand, nephrotoxicity is a deleterious side effect
associated with aminoglycoside therapy. Gentamicin is the most nephrotoxic
aminoglycoside. Because of serious health complications ensue the nephrotoxicity
induced by aminoglycosides, finding new therapeutic strategies against this
problem has a great ...
Genes of Innate Immunity and the Biological Response to Inhaled Ozone
Journal of Biochemical and Molecular Toxicology - Tập 27 Số 1 - Trang 3-16 - 2013
ABSTRACTAmbient ozone has a significant impact on human health. We have made
considerable progress in understanding the fundamental mechanisms that regulate
the biological response to ozone. It is increasingly clear that genes of innate
immunity play a central role in both infectious and noninfectious lung disease.
The biological response to ambient ozone provides a clinically relevant
environment...
Proteomics analysis of liver samples from puffer fish Takifugu rubripes exposed to excessive fluoride: An insight into molecular response to fluorosis
Journal of Biochemical and Molecular Toxicology - Tập 24 Số 1 - Trang 21-28 - 2010
AbstractComparative proteomics was performed to identify proteins in the liver
of Takifugu rubripes in response to excessive fluoride exposure. Sixteen fish
were randomly divided into a control group and an experimental group. The
control group was raised in soft water alone (F− = 0.4 mg/L), and the
experimental group was raised in the same water with sodium fluoride at a high
concentration of 35 ...
Molecular cloning and characterization of alpha‐class glutathione S‐transferase gene from the liver of silver carp, bighead carp, and other major chinese freshwater fishes
Journal of Biochemical and Molecular Toxicology - Tập 20 Số 3 - Trang 114-126 - 2006
AbstractTwo full‐length cDNAs encoding glutathione S‐transferase (GST) were
cloned and sequenced from the hepatopancreas of planktivorous silver carp
(Hypophthalmichthys molitrix) and bighead carp (Aristichthys nobilis). The
silver carp and bighead carp GST cDNA were 920 and 978 bp in length,
respectively, and both contained an open reading frame that encoding 223 amino
acids. Partial GST cDNA seq...
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