Journal of Biochemical and Molecular Toxicology
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Characterization of triacsin C inhibition of short‐, medium‐, and long‐chain fatty acid:CoA ligases of human liverAbstract Short‐, medium‐, and long‐chain fatty acid:CoA ligases from human liver were tested for their sensitivity to inhibition by triacsin C. The short‐chain fatty acid:CoA ligase was inhibited less than 10% by concentrations of triacsin C as high as 80 μM. The two mitochondrial xenobiotic/medium‐chain fatty acid:CoA ligases (XM‐ligases), HXM‐A and HXM‐B, were par... ... hiện toàn bộ
Journal of Biochemical and Molecular Toxicology - Tập 18 Số 2 - Trang 100-106 - 2004
Protective Effects of 7‐Hydroxycoumarin on Dyslipidemia and Cardiac Hypertrophy in Isoproterenol‐Induced Myocardial Infarction in RatsABSTRACT This study evaluates the protective effects of 7‐hydroxycoumarin (7‐HC) on dyslipidemia and cardiac hypertrophy in isoproterenol (ISO) induced myocardial infarction (MI) in rats. Rats were pre‐ and co treated with 7‐HC (16 mg/kg) daily for 8 days. ISO (100 mg/kg) was subcutaneously injected into rats on seventh and eighth days to induce MI. Increased activi... ... hiện toàn bộ
Journal of Biochemical and Molecular Toxicology - Tập 30 Số 3 - Trang 120-127 - 2016
Antioxidant role of coumarin on streptozotocin–nicotinamide‐induced type 2 diabetic ratsAbstract The purpose of this study was to investigate the antioxidant role of coumarin on streptozotocin–nicotinamide‐induced Type 2 diabetic rats. In experimental rats, the levels of plasma glucose, insulin, and the levels of thiobarbituric acid reactive substances, lipid hydroperoxides, conjugated dienes, and the activities of superoxide dismutase, catalase, gluta... ... hiện toàn bộ
Journal of Biochemical and Molecular Toxicology - Tập 25 Số 6 - Trang 355-361 - 2011
Effect of subchronic acrylamide exposure on the expression of neuronal and inducible nitric oxide synthase in rat brainAbstract Acrylamide (ACR) is a known industrial neurotoxic chemical. Evidence suggests that ACR neurotoxic effect is related to brain neurotransmission disturbances. Since nitric oxide (NO) acts as a neurotransmission modulator and is produced by nitric oxide synthase (NOS), the neuronal NOS (nNOS) and inducible NOS (iNOS) expression pattern were determined in rat c... ... hiện toàn bộ
Journal of Biochemical and Molecular Toxicology - Tập 19 Số 3 - Trang 162-168 - 2005
The effects of mesenchymal stem cell mitochondrial transplantation on doxorubicin‐mediated nephrotoxicity in ratsAbstract The effect of dysfunctional mitochondria in several cell pathologies has been reported in renal diseases, including diabetic nephropathy and acute kidney injury. Previous studies have reported that mitochondrial transplantation provided surprising results in myocardial and liver ischemia, as well as in Parkinson's disease. We aimed to investigate the benefi... ... hiện toàn bộ
Journal of Biochemical and Molecular Toxicology - Tập 35 Số 1 - 2021
Epigallocatechin gallate and coenzyme Q10 attenuate cisplatin‐induced hepatotoxicity in rats via targeting mitochondrial stress and apoptosisAbstract Despite the extensive use of cisplatin (CP) as a chemotherapeutic agent, its clinical use is often restricted by undesirable side effects, such as toxicity to normal tissues. The aim of this study was to probe the effect of a combinatorial treatment of low multiple doses of antioxidants on CP‐induced toxicity and the mitochondrial apoptotic pathway in hepat... ... hiện toàn bộ
Journal of Biochemical and Molecular Toxicology - Tập 35 Số 4 - 2021
A Comparison between the Nephrotoxic Profile of Gentamicin and Gentamicin Nanoparticles in MiceABSTRACT Aminoglycoside antibiotics are widely used against Gram‐negative infections. On the other hand, nephrotoxicity is a deleterious side effect associated with aminoglycoside therapy. Gentamicin is the most nephrotoxic aminoglycoside. Because of serious health complications ensue the nephrotoxicity induced by aminoglycosides, finding new therapeutic strategies ... ... hiện toàn bộ
Journal of Biochemical and Molecular Toxicology - Tập 29 Số 2 - Trang 57-62 - 2015
Generation of an oxidative stress precedes caspase activation during 7β‐hydroxycholesterol‐induced apoptosis in U937 cellsAbstract The oxysterol 7beta‐hydroxycholesterol (7β‐OH) has been shown to induce apoptosis in a number of cell lines. Though not fully elucidated, the mechanism through which this oxysterol induces cell death is thought to involve the generation of an oxidative stress leading to perturbation of the mitochondrion and release of cytochrome c into the cytosol. Cytochro... ... hiện toàn bộ
Journal of Biochemical and Molecular Toxicology - Tập 18 Số 1 - Trang 50-59 - 2004
The role of calcium in apoptosis induced by 7β‐hydroxycholesterol and cholesterol‐5β,6β‐epoxideAbstract Oxysterols, such as 7β‐hydroxy‐cholesterol (7β‐OH) and cholesterol‐5β,6β‐epoxide (β‐epoxide), may have a central role in promoting atherogenesis. This is thought to be predominantly due to their ability to induce apoptosis in cells of the vascular wall and in monocytes/macrophages. Although there has been extensive research regarding the mechanisms through ... ... hiện toàn bộ
Journal of Biochemical and Molecular Toxicology - Tập 23 Số 5 - Trang 324-332 - 2009
Hepatotoxicity and cholestasis in rats induced by the sesquiterpene, 9‐oxo‐10,11‐dehydroageraphorone, isolated from Eupatorium adenophorumAbstract Eupatorium adenophorum leaves cause hepatotoxicity and cholestasis in rats. The hepatotoxicant has been characterized as 9‐oxo‐10,11‐dehydroageraphorone (ODA), a cadinene sesquiterpene. Oral administration of ODA, mixed in feed to rats, caused jaundice in 24 h. The liver of the intoxicated animals had focal areas of hepatocellular...
Journal of Biochemical and Molecular Toxicology - Tập 15 Số 5 - Trang 279-286 - 2001
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