Cisplatin‐Induced Testicular Toxicity in Rats: The Protective Effect of Arjunolic Acid

Journal of Biochemical and Molecular Toxicology - Tập 28 Số 11 - Trang 515-521 - 2014
Iman O. Sherif1, Azza Abdel‐Aziz2, Osama Sarhan3
1Department of Biochemistry, Mansoura University, Mansoura, Egypt
2Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt
3Urology and Nephrology Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Tóm tắt

ABSTRACTIn the present study, the effect of arjunolic acid on testicular damage induced by intraperitoneal injection of rats with 7 mg/kg cisplatin was studied. Cisplatin induced a significant reduction in testicular weights, plasma testosterone, and testicular reduced glutathione levels in addition to a significant elevation of testicular malondialdehyde levels and testicular gene expressions of inducible nitric oxide synthase (iNOS), tumor necrosis factor‐α (TNF‐α), and p38 mitogen‐activated protein kinase (MAPK) when compared with the control group (p < 0.05). Lower tubular diameters and depletion of germ cells and irregular small seminiferous tubules with Sertoli cells only were observed in the cisplatin group. Arjunolic acid administration significantly corrected the changes in both biochemical and histopathological parameters. Arjunolic acid plays a significant protective role against cisplatin‐induced testicular injury by attenuating oxidative stress parameters along with downregulation of iNOS, TNF‐α, and p38‐MAPK testicular expressions.

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Thông tin
Thông tin xuất bản

Journal of Biochemical and Molecular Toxicology

Tập 28 Số 11

515-521

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