Protective effects of thymol on altered plasma lipid peroxidation and nonenzymic antioxidants in isoproterenol‐induced myocardial infarcted rats

Journal of Biochemical and Molecular Toxicology - Tập 26 Số 9 - Trang 368-373 - 2012
Mohamed Fizur Nagoor Meeran1, P. Stanely Mainzen Prince1
1Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar—608 002, Tamil Nadu, India

Tóm tắt

AbstractThis study evaluates the protective effects of thymol on altered plasma lipid peroxidation products and nonenzymic antioxidants in isoproterenol (ISO)‐induced myocardial infarcted rats. Male albino Wistar rats were pre and cotreated with thymol (7.5 mg/kg body weight) daily for 7 days. ISO (100 mg/kg body weight) was subcutaneously injected into rats on 6th and 7th day to induce myocardial infarction (MI). Increased activity/levels of serum creatine kinase‐MB (CK‐MB), plasma thiobarbituric acid reactive substances, lipid hydroperoxides, and conjugated dienes with decreased levels of plasma reduced glutathione (GSH), vitamin C, and vitamin E were observed in ISO‐induced myocardial infarcted rats. Pre and cotreatment with thymol (7.5 mg/kg body weight) showed normalized activity of serum CK‐MB and near normalized levels of plasma lipid peroxidation products, reduced GSH, vitamin C, and vitamin E in myocardial infarcted rats. Furthermore, the in vitro study on reducing power of thymol confirmed its potent antioxidant action. Thus, thymol protects ISO‐induced MI in rats by its antilipid peroxidation and antioxidant properties. © 2012 Wiley Periodicals, Inc. J Biochem Mol Toxicol 26:368–373, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.21431

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Tài liệu tham khảo

10.1016/j.ejphar.2010.06.065

10.1016/j.tox.2006.09.005

10.1016/j.ejphar.2011.02.037

10.1016/j.ejphar.2008.02.057

10.1016/j.phymed.2008.11.007

10.1016/j.mrgentox.2011.08.007

10.1016/j.ecoenv.2008.10.005

10.1016/j.ejphar.2011.08.017

10.1016/j.seppur.2009.08.005

10.1007/BF00598073

10.1016/S0731-7085(98)00300-8

10.1016/j.ejphar.2011.09.036

10.1016/0009-3084(87)90071-5

10.1016/0003-2697(92)90122-N

10.1016/0014-4800(68)90041-5

10.1016/0003-9861(59)90090-6

10.1016/0076-6879(79)62181-X

Baker H, 1980, Plasma tocopherol in man at various times after ingesting free or acetylated tocopherol, Nutr Rep Int, 21, 531

10.5264/eiyogakuzashi.44.307

10.1016/j.tox.2006.04.039

10.1016/j.foodchem.2005.05.077

10.1016/j.foodchem.2006.01.004

Thông tin
Thông tin xuất bản

Journal of Biochemical and Molecular Toxicology

Tập 26 Số 9

368-373

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