Genes of Innate Immunity and the Biological Response to Inhaled Ozone

Journal of Biochemical and Molecular Toxicology - Tập 27 Số 1 - Trang 3-16 - 2013
Zhuowei Li1, Robert M. Tighe1, Feifei Feng1,2, Julie G. Ledford1, John W. Hollingsworth3,1
1Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
2Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China
3Department of Immunology, Duke University Medical Center, Durham, NC 27710 USA

Tóm tắt

ABSTRACTAmbient ozone has a significant impact on human health. We have made considerable progress in understanding the fundamental mechanisms that regulate the biological response to ozone. It is increasingly clear that genes of innate immunity play a central role in both infectious and noninfectious lung disease. The biological response to ambient ozone provides a clinically relevant environmental exposure that allows us to better understand the role of innate immunity in noninfectious airways disease. In this brief review, we focus on (1) specific cell types in the lung modified by ozone, (2) ozone and oxidative stress, (3) the relationship between genes of innate immunity and ozone, (4) the role of extracellular matrix in reactive airways disease, and (5) the effect of ozone on the adaptive immune system. We summarize recent advances in understanding the mechanisms that ozone contributes to environmental airways disease. © 2012 Wiley Periodicals, Inc. J BiochemMol Toxicol 27:3‐16, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.21453

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Tài liệu tham khảo

10.1088/1748-9326/6/2/024006

10.1080/19338244.2011.598888

10.1136/bjsm.35.4.214

10.1016/j.amepre.2011.04.017

10.1164/rccm.200908-1201OC

10.1164/rccm.201102-0227OC

10.1152/japplphysiol.00337.2011

10.1001/jama.292.19.2372

10.1056/NEJMoa0803894

10.1164/rccm.200809-1484OC

10.1164/rccm.201011-1813OC

10.3390/ijerph7072866

Foster WM, 2000, Bronchial reactivity of healthy subjects: 18–20 h postexposure to ozone, J Appl Physiol, 89, 1804, 10.1152/jappl.2000.89.5.1804

10.1152/japplphysiol.00172.2007

10.1152/ajplung.00101.2004

10.1164/arrd.1984.130.2.214

10.1371/journal.pone.0010235

10.1164/ajrccm/138.1.140

10.1111/j.1365-2125.2011.03968.x

10.1016/0013-9351(78)90127-5

10.1046/j.1365-2257.2001.00401.x

10.4049/jimmunol.179.7.4367

10.1378/chest.65.4_Supplement.11S

Foster WM, 1996, Regional clearance of solute from the respiratory epithelia: 18–20 h postexposure to ozone, J Appl Physiol, 81, 1143, 10.1152/jappl.1996.81.3.1143

Kehrl HR, 1987, Ozone exposure increases respiratory epithelial permeability in humans, Am Rev Respir Dis, 135, 1124

Foster WM, 1987, Ozone exposure alters tracheobronchial mucociliary function in humans, J Appl Physiol, 63, 996, 10.1152/jappl.1987.63.3.996

10.1034/j.1600-065X.2000.917304.x

Leikauf GD, 1995, Airway epithelial cell responses to ozone injury, Environ Health Perspect, 103, 91

10.1093/toxsci/60.2.356

Devlin RB, 1994, Ozone‐induced release of cytokines and fibronectin by alveolar macrophages and airway epithelial cells, Am J Physiol, 266, L612

10.1183/09031936.96.09112298

10.1165/ajrcmb/4.1.72

10.1165/rcmb.2008-0353OC

10.1080/019021499270394

10.1165/rcmb.2007-0250OC

10.1165/ajrcmb.13.2.7542894

10.3109/01902148909069605

10.1165/ajrcmb.13.1.7598938

10.1164/rccm.200509-1527OC

10.1164/ajrccm.164.4.2001016

10.1172/JCI29968

10.1007/PL00007597

10.1164/ajrccm.164.3.2009055

10.1165/rcmb.2005-0241OC

10.4049/jimmunol.180.4.2562

10.1165/rcmb.2010-0471OC

10.4049/jimmunol.1101312

10.1038/nri1733

10.1016/j.taap.2012.06.009

10.1084/jem.20060943

10.1016/0891-5849(95)02033-7

10.1289/ehp.10294

10.1289/ehp.11813

10.1080/01902140701364367

10.1016/j.yexmp.2012.01.004

10.4049/jimmunol.1101312

10.1152/jappl.2001.91.4.1694

10.1006/taap.1996.0152

10.1006/taap.2002.9514

10.1074/jbc.274.4.2234

10.1006/taap.1996.0307

10.1164/ajrccm.153.2.8564103

10.1164/ajrccm.155.2.9032175

10.1006/taap.1998.8418

10.1164/ajrccm.160.6.9902025

10.1021/tx010183i

10.1164/ajrccm.163.6.2006056

10.1183/09031936.00160806

10.1136/oem.2007.035253

10.1016/j.bbrc.2010.04.105

10.1165/rcmb.2008-0381OC

10.1152/ajpcell.2001.280.3.C659

10.1016/S0003-9861(02)00716-6

10.1073/pnas.96.22.12731

10.1016/j.freeradbiomed.2011.11.027

10.1038/1751125b0

10.3181/00379727-95-23156

10.1038/nri1528

10.1165/ajrcmb/2.1.91

10.1146/annurev.physiol.63.1.521

Leikauf GD, 1995, Activation of eicosanoid metabolism in human airway epithelial cells by ozonolysis products of membrane fatty acids, Res Rep Health Eff Inst, 1

10.1074/jbc.M005322200

10.1016/j.taap.2006.12.017

10.1186/1465-9921-9-77

10.1186/1465-9921-7-85

10.1289/ehp.0211079

10.1021/bi036023i

10.1021/bi062304p

Oosting RS, 1991, Structural and functional changes of surfactant protein A induced by ozone, Am J Physiol, 261, L77

10.1016/0005-2760(90)90236-Q

Balis JU, 1991, Ozone stress initiates acute perturbations of secreted surfactant membranes, Am J Pathol, 138, 847

Oosting RS, 1992, Exposure of surfactant protein A to ozone in vitro and in vivo impairs its interactions with alveolar cells, Am J Physiol, 262, L63

10.1152/ajplung.00288.2007

Su WY, 1996, Alterations in surfactant protein A after acute exposure to ozone, J Appl Physiol, 80, 1560, 10.1152/jappl.1996.80.5.1560

10.1046/j.1365-2362.1998.00342.x

10.1074/jbc.M807268200

10.1074/jbc.M513041200

10.4049/jimmunol.180.12.7847

10.4049/jimmunol.168.12.5989

10.1615/CritRevEukarGeneExpr.v19.i2.30

Silveyra P, Genetic variant associations of human SP‐A and SP‐D with acute and chronic lung injury, Front Biosci., 17, 407, 10.2741/3935

10.1183/09031936.97.10091983

10.1164/ajrccm/142.5.1158

Kulle TJ, 1985, Ozone response relationships in healthy nonsmokers, Am Rev Respir Dis, 132, 36

10.1126/science.282.5396.2085

10.1016/S1074-7613(00)80119-3

10.1074/jbc.M310859200

10.1074/jbc.M100099200

10.4049/jimmunol.167.5.2887

10.1007/s10753-007-9035-1

10.1165/ajrcmb.22.5.3912

10.1152/ajplung.2001.280.2.L326

10.1164/rccm.200311-1499OC

10.1152/japplphysiol.00172.2007

10.1371/journal.pone.0027137

10.4049/jimmunol.176.8.4950

10.1172/JCI28139

10.1080/08958370600822466

10.1289/ehp.1003326

10.1074/jbc.M403581200

10.1164/ajrccm/148.5.1363

10.1164/ajrccm/139.2.407

Al‐Hegelan M, Ambient ozone and pulmonary innate immunity, Immunol Res., 49, 173

10.1152/ajplung.00348.2003

10.1164/rccm.200903-0381OC

10.1016/j.freeradbiomed.2011.05.006

10.3109/08958378.2011.584919

10.1016/0041-008X(90)90335-R

10.1038/ni1021

10.1182/blood-2005-04-1658

10.4049/jimmunol.180.9.6255

10.1038/sj.emboj.7601289

10.1189/jlb.0208135

10.1289/ehp.1003339

10.1172/JCI119054

10.1074/jbc.M110.135194

10.1164/rccm.200405-652OC

10.1038/nm1315

10.1089/ars.2007.1906

10.1007/BF00174118

Sahu S, 1978, Hyaluronic acid in the pulmonary secretions of patients with asthma, Biochem J, 173, 565, 10.1042/bj1730565

10.1016/j.jaci.2011.04.006

10.1136/thx.2003.020842

10.1074/jbc.M802400200

10.1164/rccm.200903-0381OC

10.1164/ajrccm/147.3.753

10.1080/15287398509530723

10.1371/journal.pone.0035108

10.4049/jimmunol.1000283

10.1089/ars.2011.4066

10.1016/j.jaci.2010.06.043

10.1136/oem.55.8.541

10.1093/oxfordjournals.aje.a010280

10.1016/S0013-9351(02)00004-X

10.1016/j.envres.2011.01.014

10.1164/ajrccm.151.5.7735583

10.1016/S0091-6749(96)70090-8

10.1016/S0091-6749(97)70277-X

10.1165/ajrcmb.23.2.3898

Osebold JW, 1980, Studies on the enhancement of allergic lung sensitization by inhalation of ozone and sulfuric acid aerosol, J Environ Pathol Toxicol, 3, 221

10.3181/00379727-188-42733

10.1159/000232766

10.1016/S0041-008X(03)00218-7

Biagini RE, 1986, Ozone enhancement of platinum asthma in a primate model, Am Rev Respir Dis, 134, 719

10.1084/jem.20021340

10.1016/j.jaci.2010.03.001

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Journal of Biochemical and Molecular Toxicology

Tập 27 Số 1

3-16

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