International Journal of Developmental Neuroscience

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Stimulation of neurite outgrowth in vitro by a glycero‐ganglioside
International Journal of Developmental Neuroscience - Tập 6 - Trang 319-326 - 1988
Michael S. Cannella, Aureliu J. Acher, Robert W. Ledeen
AbstractA glycerol‐containing analog of ganglioside, with sialic acid attached to a diglyceride‐like structure possessing two ether‐linked alkyl chains, was prepared synthetically and applied exogenously to three culture systems; neuro‐2A neuroblastoma cells, PC12 cells and dorsal root ganglia. This resulted in pronounced stimulation of neun...... hiện toàn bộ
Age‐ and region‐dependent patterns of Ca2+ accumulations following status epilepticus
International Journal of Developmental Neuroscience - Tập 26 - Trang 779-790 - 2008
Linda K. Friedman, Aleksandr Saghyan, Alex Peinado, Robert Keesey
AbstractElevated Ca2+ concentrations have been implicated in cell death mechanisms following seizures, however, the age and brain region of intracellular Ca2+ accumulations [Ca2+]i, may influence whether or not they are toxic. Therefore, we examined regional ...... hiện toàn bộ
Anti‐apoptotic role of omega‐3‐fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model
International Journal of Developmental Neuroscience - Tập 27 - Trang 377-383 - 2009
Rohit A. Sinha, Priyanka Khare, Asit Rai, Shailendra Kumar Maurya, Amrita Pathak, Vishwa Mohan, Geet Kumar Nagar, Mohana Krishna Reddy Mudiam, Madan M. Godbole, Sanghamitra Bandyopadhyay
AbstractInadequate maternal intake of omega‐3‐fatty acids (ω3 FAs) causes adverse neurodevelopmental outcome in the progeny; however, their molecular mechanism of action is obscure. Since ω3 FAs are known to inhibit neuronal apoptosis during neuro‐degeneration, we investigated their possible contribution in regulating neuronal apoptosis during brain development. Us...... hiện toàn bộ
Role of glucocorticoids in the chromaffin‐neuron developmental decision
International Journal of Developmental Neuroscience - Tập 7 - Trang 475-483 - 1989
David J Anderson, Arie Michelsohn
AbstractChromaffin cells and sympathetic neurons develop from a common neural crest‐derived progenitor cell. The developmental fate of this cell differs depending upon whether it migrates to the sympathetic ganglion or to the adrenal gland primordium, suggesting that local environmental signals control its differentiation. Glucocorticoid (GC...... hiện toàn bộ
Developmental profiles of ornithine decarboxylase activity in the hippocampus, neocortex and cerebellum: Modulation following lead exposure
International Journal of Developmental Neuroscience - Tập 12 Số 1 - Trang 25-30 - 1994
Nasser H. Zawia, L. B. Evers, G. Jean Harry
AbstractOrnithine decarboxylase (ODC) is a growth‐associated enzyme which is critical for cell growth and transformation. ODC activity follows a specific ontogenetic pattern of activity in distinct brain regions according to their developmental stage. Perturbations in the pattern of ODC activity have been associated with brain damage includi...... hiện toàn bộ
Development of taurine biosynthesizing system in cerebral cortical neurons in primary culture
International Journal of Developmental Neuroscience - Tập 4 - Trang 383-389 - 1986
S Ohkuma, S Tomono, Y Tanaka, K Kuriyama, T Mukainaka
Ethyl pyruvate protects against lipopolysaccharide‐induced white matter injury in the developing rat brain
International Journal of Developmental Neuroscience - Tập 31 - Trang 181-188 - 2013
Yingyan Wang, Ping Yin, Shanying Huang, Jiwen Wang, Ruopeng Sun
AbstractThe neuroprotective effects of ethyl pyruvate (EP) have been proved in several brain injury models, yet very little is known about its action on neonatal white matter injury. To investigate the effect of EP on white matte damage, a stereotactic intracerebral injection of lipopolysaccharide (LPS, 1 mg/kg) was performed on postnatal day 5 Sprague–Dawley rat p...... hiện toàn bộ
Lack of retrograde axonal transport of the heparin‐binding growth factors by chick ciliary neurones
International Journal of Developmental Neuroscience - Tập 9 - Trang 243-250 - 1991
I.A. Hendry, D.A. Belford
AbstractIn view of the likelihood that the heparin‐binding growth factors of fibroblast growth factors are neurotrophic for the neurones of the chick ciliary ganglion a study has been made of the retrograde axonal transport of the acidic and basic fibroblast growth factors by these neurones. No high capacity retrograde axonal transport of th...... hiện toàn bộ
Hanging drop culture enhances differentiation of human adipose‐derived stem cells into anterior neuroectodermal cells using small molecules
International Journal of Developmental Neuroscience - Tập 59 - Trang 21-30 - 2017
Noushin Amirpour, Shahnaz Razavi, Ebrahim Esfandiari, Batoul Hashemibeni, Mohammad Kazemi, Hossein Salehi
AbstractInspired by in vivo developmental process, several studies were conducted to design a protocol for differentiating of mesenchymal stem cells into neural cells in vitro. Human adipose‐derived stem cells (hADSCs) as mesenchymal stem cells are a promising source for this purpose. At current study, we applied a defined neural induction medium by using small mol...... hiện toàn bộ
Phenylalanine and phenylpyruvate inhibit ATP diphosphohydrolase from rat brain cortex
International Journal of Developmental Neuroscience - Tập 19 - Trang 649-653 - 2001
Simone Luisa Berti, Carla Denise Bonan, Flávio Laporta da Silva, Ana Maria Oliveira Battastini, João José Freitas Sarkis, Clóvis Milton Duval Wannmacher
AbstractThe main objective of the present study was to characterize the inhibition by phenylalanine and phenylpyruvate of ATP diphosphohydrolase activity in synaptosomes from the brain cortex of rats. This enzyme participates together with a 5′‐nucleotidase in adenosine formation from the neurotransmitter, ATP, in the synaptic cleft. The inhibition of ATP diphospho...... hiện toàn bộ
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