International Journal of Developmental Neuroscience
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Stimulation of neurite outgrowth in vitro by a glycero‐ganglioside
International Journal of Developmental Neuroscience - Tập 6 - Trang 319-326 - 1988
AbstractA glycerol‐containing analog of ganglioside, with sialic acid attached
to a diglyceride‐like structure possessing two ether‐linked alkyl chains, was
prepared synthetically and applied exogenously to three culture systems;
neuro‐2A neuroblastoma cells, PC12 cells and dorsal root ganglia. This resulted
in pronounced stimulation of neunte outgrowth in all three, demonstrating that
sialo‐lipid...
High plasma neopterin levels in Chinese children with autism spectrum disorders
International Journal of Developmental Neuroscience - Tập 41 - Trang 92-97 - 2015
AbstractBackgroundNeopterin, a pteridine mainly synthesized by activated
macrophages, is a marker of inflammation, immune system activation and an active
participant in Autism spectrum disorders (ASD). The aim of this study was to
assess the clinical significance of plasma neopterin levels in ASD.MethodsEighty
patients diagnosed with ASD and 80 sex and age matched typically developing
children wer...
Spatial control of neuronal cell attachment and differentiation on covalently patterned laminin oligopeptide substrates
International Journal of Developmental Neuroscience - Tập 12 - Trang 725-735 - 1994
AbstractThe spatial control of neuronal cell attachment and differentiation via
specific receptor mediated interactions, may provide an effective means for the
in vitro reconstruction of neuronal cell architecture. In this study,
receptor‐specific oligopeptide sequences derived from the extracellular matrix
(ECM) molecule laminin, a potent neural cell attachment and differentiation
promoter were c...
Phản ứng in vitro khác nhau đối với rIL‐1β của tế bào thái dương não chuột con và chuột trưởng thành Dịch bởi AI
International Journal of Developmental Neuroscience - Tập 9 - Trang 501-507 - 1991
Tóm tắtTrong tài liệu gần đây, các lymphokine đã được báo cáo có khả năng thúc
đẩy cả sự phát triển và trưởng thành của một số quần thể thần kinh đệm. Trong
bài viết này, chúng tôi so sánh hiệu ứng của rIL-1 trên tế bào thần kinh đệm của
chuột con và chuột trưởng thành in vitro. Ở chuột con, nhưng không ở tế bào thần
kinh đệm trưởng thành, 100 U/ml rIL-1β làm tăng sự tích hợp [3H]thymidine với
phả...
Stress and the adaptive self‐organization of neuronal connectivity during early childhood
International Journal of Developmental Neuroscience - Tập 16 - Trang 297-306 - 1998
AbstractA conceptual framework is proposed for a better understanding of the
biological role of the stress‐response and the relationship between stress and
brain development. According to this concept environmental stimuli (in children
mainly psychosocial challenges and demands) exert profound effects on neuronal
connectivity through repeated or long‐lasting changes in the release of
especially su...
The neurotrophic peptide Org 2766 does not influence the expression of the immediate early gene c‐fos following sciatic nerve crush in the rat
International Journal of Developmental Neuroscience - Tập 12 - Trang 117-125 - 1994
AbstractThe neurotrophic peptide Org 2766 accelerates the regeneration of
peripheral nerves. Although the mechanism of action of this neuropeptide is not
yet understood, functional, pharmacological, and morphological evidence has
demonstrated that Org 2766 exerts its beneficial effect during the early stages
of nerve regeneration. The induction of some members of the Immediate Early Gene
(IEG) fam...
Regulation and function of central nervous system chemokines
International Journal of Developmental Neuroscience - Tập 13 - Trang 153-165 - 1995
AbstractIn this paper, we discuss the potential involvement of a new family of
cytokines, termed chemokines, in CNS inflammatory pathology. Chemokines are a
family of proinflammatory cytokines which are able to stimulate
target‐cell‐specific directional migration of leukocytes. Because of this
feature, chemokines may be potent mediators of inflammatory processes. We have
previously reported observ...
Restricted growth and insulin‐like growth factor‐1 deficiency in mice lacking presenilin‐1 in the neural crest cell lineage
International Journal of Developmental Neuroscience - Tập 27 - Trang 837-843 - 2009
AbstractPresenilin‐1 (PS1) is a transmembrane protein that is in many cases
responsible for the development of early‐onset familial Alzheimer's disease. PS1
is essential for neurogenesis, somitogenesis, angiogenesis, and cardiac
morphogenesis. We report here that PS1 is also required for maturation and/or
maintenance of the pituitary gland. We generated PS1‐conditional knockout
(PS1‐cKO) mice by c...
Emerging roles for TGF‐β1 in nervous system development
International Journal of Developmental Neuroscience - Tập 23 - Trang 413-424 - 2005
AbstractTransforming growth factor betas (TGF‐βs) are known as multifunctional
growth factors, which participate in the regulation of key events of
development, disease and tissue repair. In central nervous system (CNS), TGF‐β1
has been widely recognized as an injury‐related cytokine, specially associated
with astrocyte scar formation in response to brain injury. TGF‐βs family is
represented by th...
Prenatal methamphetamine exposure affects the mesolimbic dopaminergic system and behavior in adult offspring
International Journal of Developmental Neuroscience - Tập 27 - Trang 525-530 - 2009
AbstractMethamphetamine is a commonly abused psychostimulant that causes
addiction and is often abused by pregnant women. Acute or chronic administration
of methamphetamine elevates the levels of the extracellular monoamine
neurotransmitters, such as dopamine.The aim of the present study was to show
whether prenatal exposure to methamphetamine (5 mg/kg, entire gestation) or
saline in Wistar rats i...
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