International Journal of Developmental Neuroscience

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Stimulation of neurite outgrowth in vitro by a glycero‐ganglioside
International Journal of Developmental Neuroscience - Tập 6 - Trang 319-326 - 1988
Michael S. Cannella, Aureliu J. Acher, Robert W. Ledeen
AbstractA glycerol‐containing analog of ganglioside, with sialic acid attached to a diglyceride‐like structure possessing two ether‐linked alkyl chains, was prepared synthetically and applied exogenously to three culture systems; neuro‐2A neuroblastoma cells, PC12 cells and dorsal root ganglia. This resulted in pronounced stimulation of neun...... hiện toàn bộ
High plasma neopterin levels in Chinese children with autism spectrum disorders
International Journal of Developmental Neuroscience - Tập 41 - Trang 92-97 - 2015
Hong-xiang Zhao, Sha-sha Yin, Jin-gang Fan
AbstractBackgroundNeopterin, a pteridine mainly synthesized by activated macrophages, is a marker of inflammation, immune system activation and an active participant in Autism spectrum disorders (ASD). The aim of this study was to assess the clinical significance of plasma neopterin levels in ASD.... hiện toàn bộ
Spatial control of neuronal cell attachment and differentiation on covalently patterned laminin oligopeptide substrates
International Journal of Developmental Neuroscience - Tập 12 - Trang 725-735 - 1994
John P. Ranieri, Ravi Bellamkonda, Evan J. Bekos, Joseph A. Gardella, Hans J. Mathieu, Laurence Ruiz, Patrick Aebischer
AbstractThe spatial control of neuronal cell attachment and differentiation via specific receptor mediated interactions, may provide an effective means for the in vitro reconstruction of neuronal cell architecture. In this study, receptor‐specific oligopeptide sequences derived from the extracellular matrix (ECM) m...... hiện toàn bộ
Phản ứng in vitro khác nhau đối với rIL‐1β của tế bào thái dương não chuột con và chuột trưởng thành Dịch bởi AI
International Journal of Developmental Neuroscience - Tập 9 - Trang 501-507 - 1991
M. Colasanti, Maria T. Ramacci, Piero Foresta, Giuliana M. Lauro
Tóm tắtTrong tài liệu gần đây, các lymphokine đã được báo cáo có khả năng thúc đẩy cả sự phát triển và trưởng thành của một số quần thể thần kinh đệm. Trong bài viết này, chúng tôi so sánh hiệu ứng của rIL-1 trên tế bào thần kinh đệm của chuột con và chuột trưởng thành in vitro. Ở chuột con, nhưng không ở tế bào th...... hiện toàn bộ
Stress and the adaptive self‐organization of neuronal connectivity during early childhood
International Journal of Developmental Neuroscience - Tập 16 - Trang 297-306 - 1998
Gerald Huether
AbstractA conceptual framework is proposed for a better understanding of the biological role of the stress‐response and the relationship between stress and brain development. According to this concept environmental stimuli (in children mainly psychosocial challenges and demands) exert profound effects on neuronal connectivity through repeate...... hiện toàn bộ
The neurotrophic peptide Org 2766 does not influence the expression of the immediate early gene c‐fos following sciatic nerve crush in the rat
International Journal of Developmental Neuroscience - Tập 12 - Trang 117-125 - 1994
L.C. Plantinga, J. Verhaagen, S.L. Wong, P.M. Edwards, P.R. Bär, W.H. Gispen
AbstractThe neurotrophic peptide Org 2766 accelerates the regeneration of peripheral nerves. Although the mechanism of action of this neuropeptide is not yet understood, functional, pharmacological, and morphological evidence has demonstrated that Org 2766 exerts its beneficial effect during the early stages of nerve regeneration. The induct...... hiện toàn bộ
Regulation and function of central nervous system chemokines
International Journal of Developmental Neuroscience - Tập 13 - Trang 153-165 - 1995
A.R. Glabinski, M. Tani, S. Aras, M.H. Stoler, V.K. Tuohy, R.M. Ransohoff
AbstractIn this paper, we discuss the potential involvement of a new family of cytokines, termed chemokines, in CNS inflammatory pathology. Chemokines are a family of proinflammatory cytokines which are able to stimulate target‐cell‐specific directional migration of leukocytes. Because of this feature, chemokines may be potent mediators of i...... hiện toàn bộ
Restricted growth and insulin‐like growth factor‐1 deficiency in mice lacking presenilin‐1 in the neural crest cell lineage
International Journal of Developmental Neuroscience - Tập 27 - Trang 837-843 - 2009
Mitsunari Nakajima, Sono Watanabe, Satoshi Okuyama, Jie Shen, Yoshiko Furukawa
AbstractPresenilin‐1 (PS1) is a transmembrane protein that is in many cases responsible for the development of early‐onset familial Alzheimer's disease. PS1 is essential for neurogenesis, somitogenesis, angiogenesis, and cardiac morphogenesis. We report here that PS1 is also required for maturation and/or maintenance of the pituitary gland. We generated PS1‐conditi...... hiện toàn bộ
Emerging roles for TGF‐β1 in nervous system development
International Journal of Developmental Neuroscience - Tập 23 - Trang 413-424 - 2005
Flávia Carvalho Alcantara Gomes, Vivian de Oliveira Sousa, Luciana Romão
AbstractTransforming growth factor betas (TGF‐βs) are known as multifunctional growth factors, which participate in the regulation of key events of development, disease and tissue repair. In central nervous system (CNS), TGF‐β1 has been widely recognized as an injury‐related cytokine, specially associated with astrocyte scar formation in response to brain injury. T...... hiện toàn bộ
Prenatal methamphetamine exposure affects the mesolimbic dopaminergic system and behavior in adult offspring
International Journal of Developmental Neuroscience - Tập 27 - Trang 525-530 - 2009
Vera Bubenikova-Valesova, Petr Kacer, Kamila Syslova, Lukas Rambousek, Martin Janovsky, Barbora Schutova, Lenka Hruba, Romana Slamberova
AbstractMethamphetamine is a commonly abused psychostimulant that causes addiction and is often abused by pregnant women. Acute or chronic administration of methamphetamine elevates the levels of the extracellular monoamine neurotransmitters, such as dopamine.The aim of the present study was to show whether prenatal exposure to methamphetamine (5 m...... hiện toàn bộ
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