Stimulation of neurite outgrowth in vitro by a glycero‐ganglioside

Michael S. Cannella1, Aureliu J. Acher1, Robert W. Ledeen1
1Departments of Neurology and Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, U.S.A.

Tóm tắt

AbstractA glycerol‐containing analog of ganglioside, with sialic acid attached to a diglyceride‐like structure possessing two ether‐linked alkyl chains, was prepared synthetically and applied exogenously to three culture systems; neuro‐2A neuroblastoma cells, PC12 cells and dorsal root ganglia. This resulted in pronounced stimulation of neunte outgrowth in all three, demonstrating that sialo‐lipids(s) lacking ceramide and possessing sialic acid as the sole carbohydrate are able to promote neuritogenesis in approximately the same manner as naturally occurring gangliosides.

Tài liệu tham khảo

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