International Journal of Developmental Neuroscience
SCIE-ISI SCOPUS (SonsInc.)
0736-5748
Cơ quản chủ quản: WILEY , John Wiley & Sons Inc.
Lĩnh vực:
Developmental NeuroscienceDevelopmental Biology
Các bài báo tiêu biểu
Developmental deficits in social perception in autism: the role of the amygdala and fusiform face areaAbstract Autism is a severe developmental disorder marked by a triad of deficits, including impairments in reciprocal social interaction, delays in early language and communication, and the presence of restrictive, repetitive and stereotyped behaviors. In this review, it is argued that the search for the neurobiological bases of the autism spectrum disorders should ... ...
Tập 23 Số 2-3 - Trang 125-141 - 2005
Essential fatty acids and the brain: possible health implicationsAbstract Linoleic and α ‐linolenic acid are essential for normal cellular function, and act as precursors for the synthesis of longer chained polyunsaturated fatty acids (PUFAs) such as arachidonic (AA), eicosapentaenoic (EPA) and docosahexaenoic acids (DHA), which have been shown to partake in numerous cellular func...
Tập 18 Số 4-5 - Trang 383-399 - 2000
The teratology of autismAbstract Autism spectrum disorders affect behaviors that emerge at ages when typically developing children become increasingly social and communicative, but many lines of evidence suggest that the underlying alterations in the brain occur long before the period when symptoms become obvious. Studies of the behavior of children in the first year of life demonstrate th... ...
Tập 23 Số 2-3 - Trang 189-199 - 2005
Involvement of astrocytes in purine‐mediated reparative processes in the brainAbstract Astrocytes are involved in multiple brain functions in physiological conditions, participating in neuronal development, synaptic activity and homeostatic control of the extracellular environment. They also actively participate in the processes triggered by brain injuries, aimed at limiting and repairing brain damages. Purines may play...
Tập 19 Số 4 - Trang 395-414 - 2001
The biological basis of injury and neuroprotection in the fetal and neonatal brainAbstract A compromised intrauterine environment that delivers low levels of oxygen and/or nutrients, or is infected or inflammatory, can result in fetal brain injury, abnormal brain development and in cases of chronic compromise, intrauterine growth restriction. Preterm birth can also be associated with injury to the developing brain and affect the normal trajectory... ...
Tập 29 Số 6 - Trang 551-563 - 2011
The effects of maternal inflammation on neuronal development: possible mechanismsAbstract That maternal inflammation adversely affects fetal brain development is well established. Less well understood are the mechanisms that account for neurodevelopmental disorders arising from maternal inflammation. This review seeks to begin an examination of possible sites and mechanisms of action whereby inflammatory cytokines – produ...
Tập 25 Số 7 - Trang 415-425 - 2007
The 22q11.2 microdeletion: Fifteen years of insights into the genetic and neural complexity of psychiatric disordersAbstract Over the last fifteen years it has become established that 22q11.2 deletion syndrome (22q11DS) is a true genetic risk factor for schizophrenia. Carriers of deletions in chromosome 22q11.2 develop schizophrenia at rate of 25–30% and such deletions account for as many as 1–2% of cases of sporadic schizophrenia in the general population. Access to a relatively... ...
Tập 29 Số 3 - Trang 259-281 - 2011
Social deficits in BTBR T + tf/J mice are unchanged by cross‐fostering with C57BL/6J mothersAbstract Inbred strains of mice are useful model systems for studying the interactions of genetic and environmental contributions during neurodevelopmental stages. We recently reported an inbred strain, BTBR T + tf /J (BTBR), which, as compared to the commonly used C57BL/6J (B6) strain, dis...
Tập 25 Số 8 - Trang 515-521 - 2007
Shaping synaptic plasticity: The role of activity‐mediated epigenetic regulation on gene transcriptionAbstract Learning and memory are basic functions of the brain that allowed human evolution. It is well accepted that during learning and memory formation the dynamic establishment of new active synaptic connections is crucial. Persistent synaptic activation leads to molecular events that include increased release of neurotransmitters, increased expression of recepto... ...
Tập 31 Số 6 - Trang 359-369 - 2013
A review of gene linkage, association and expression studies in autism and an assessment of convergent evidenceAbstract Autism is a neurodevelopmental disorder with high heritability and a likely complex genetic architecture. Much genetic evidence has accumulated in the last 20 years but no gene has been unequivocally identified as containing risk variants for autism. In this article we review the past and present literature on neuro‐pathological, gen...
Tập 25 Số 2 - Trang 69-85 - 2007