Genes Chromosomes and Cancer
SCIE-ISI SCOPUS (1989-2025)
1098-2264
1045-2257
Mỹ
Cơ quản chủ quản: Wiley-Liss Inc. , WILEY
Lĩnh vực:
GeneticsCancer Research
Các bài báo tiêu biểu
Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors
Tập 10 Số 4 - Trang 231-243 - 1994
AbstractComparative genomic hybridization (CGH) is a powerful new method for
molecular cytogenetic analysis of cancer. In a single hybridization, CGH
provides an overview of DNA sequence copy number changes (losses, deletions,
gains, amplifications) in a tumor specimen and maps these changes on normal
chromosomes. CGH is based on the in situ hybridization of differentially labeled
total genomic tu...
Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene‐expression subtypes of breast cancer
Tập 45 Số 11 - Trang 1033-1040 - 2006
AbstractBreast cancer is a leading cause of cancer‐death among women, where the
clinicopathological features of tumors are used to prognosticate and guide
therapy. DNA copy number alterations (CNAs), which occur frequently in breast
cancer and define key pathogenetic events, are also potentially useful
prognostic or predictive factors. Here, we report a genome‐wide array‐based
comparative genomic ...
CDKN2A, NF2, and JUN are dysregulated among other genes by miRNAs in malignant mesothelioma—A miRNA microarray analysis
Tập 48 Số 7 - Trang 615-623 - 2009
AbstractMalignant mesothelioma (MM) is an aggressive cancer arising from
mesothelial cells, mainly due to former asbestos exposure. Little is known about
the microRNA (miRNA) expression of MM. miRNAs are small noncoding RNAs, which
play an essential role in the regulation of gene expression. This study was
carried out to analyze the miRNA expression profile of 17 MM samples using miRNA
microarray....
t( 12;21): A new recurrent translocation in acute lymphoblastic leukemia
Tập 9 Số 3 - Trang 186-191 - 1994
AbstractA t(12;21)(p11 ‐p12;q22) was detected by chromosome painting in three
patients with acute lymphoblastic leukemia (ALL) among eight ALL cases with 12p‐
abnormalities. The three leukemias had similar immunophenotypes (DR+, CD10 +,
CD19 + ). Fluorescence in situ hybridization (FISH) experiments using YAC clones
from 21q21‐q22 were performed to better localize the breakpoint on chromosome
21. ...
Identification of gains and losses of DNA sequences in primary bladder cancer by comparative genomic hybridization
Tập 12 Số 3 - Trang 213-219 - 1995
AbstractComparative genomic hybridization (CGH) makes it possible to detect
losses and gains of DNA sequences along all chromosomes in a tumor specimen
based on the hybridization of differentially labeled tumor and normal DNA to
normal human metaphase chromosomes. In this study, CGH analysis was applied to
the identification of genomic imbalances in 26 bladder cancers in order to gain
information ...
Chromosome analysis of 97 primary breast carcinomas: Identification of eight karyotypic subgroups
Tập 12 Số 3 - Trang 173-185 - 1995
AbstractChromosome banding analysis of 97 short‐term cultured primary breast
carcinomas revealed clonal aberrations in 79 tumors, whereas 18 were
karyotypically normal. In 34 of the 79 tumors with abnormalities, two to eight
clones per case were detected; unrelated clones were present in 27 (34%) cases,
whereas only related clones were found in seven. These findings indicate that a
substantial pro...
Germline hypermethylation of MLH1 and EPCAM deletions are a frequent cause of Lynch syndrome
Tập 48 Số 8 - Trang 737-744 - 2009
AbstractIt was shown that Lynch syndrome can be caused by germline
hypermethylation of the MLH1 and MSH2 promoters. Furthermore, it has been
demonstrated very recently that germline deletions of the 3′ region of EPCAM
cause transcriptional read‐through which results in silencing of MSH2 by
hypermethylation. We wanted to determine the prevalence of germline MLH1
promoter hypermethylation and of ger...
Gene dosage alterations revealed by cDNA microarray analysis in cervical cancer: Identification of candidate amplified and overexpressed genes
Tập 46 Số 4 - Trang 373-384 - 2007
AbstractCervical cancer (CC) cells exhibit complex karyotypic alterations, which
is consistent with deregulation of numerous critical genes in its formation and
progression. To characterize this karyotypic complexity at the molecular level,
we used cDNA array comparative genomic hybridization (aCGH) to analyze 29 CC
cases and identified a number of over represented and deleted genes. The aCGH
anal...
Tumor mutational burden standardization initiatives: Recommendations for consistent tumor mutational burden assessment in clinical samples to guide immunotherapy treatment decisions
Tập 58 Số 8 - Trang 578-588 - 2019
AbstractCharacterization of tumors utilizing next‐generation sequencing methods,
including assessment of the number of somatic mutations (tumor mutational burden
[TMB]), is currently at the forefront of the field of personalized medicine.
Recent clinical studies have associated high TMB with improved patient response
rates and survival benefit from immune checkpoint inhibitors; hence, TMB is
emerg...
Neuroblastoma consensus deletion maps to 1p36.1–2
Tập 1 Số 2 - Trang 159-166 - 1989
AbstractAt least 70% of human neuroblastomas display cytogenetically visible
aberrations in the short arm of chromosome 1. We have used a panel of probes
detecting polymorphic DNA loci, most of which were derived from a library of
microdissected distal 1p chromosome fragments, to compare the hybridization
pattern of DNA on nine different tumors and the corresponding normal tissue. In
eight of the ...