Genes Chromosomes and Cancer
SCIE-ISI SCOPUS (1989-2023)
1098-2264
1045-2257
Mỹ
Cơ quản chủ quản: Wiley-Liss Inc. , WILEY
Lĩnh vực:
GeneticsCancer Research
Các bài báo tiêu biểu
Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumorsAbstract Comparative genomic hybridization (CGH) is a powerful new method for molecular cytogenetic analysis of cancer. In a single hybridization, CGH provides an overview of DNA sequence copy number changes (losses, deletions, gains, amplifications) in a tumor specimen and maps these changes on normal chromosomes. CGH is based on the in situ hybridization of differ... ...
Tập 10 Số 4 - Trang 231-243 - 1994
Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene‐expression subtypes of breast cancerAbstract Breast cancer is a leading cause of cancer‐death among women, where the clinicopathological features of tumors are used to prognosticate and guide therapy. DNA copy number alterations (CNAs), which occur frequently in breast cancer and define key pathogenetic events, are also potentially useful prognostic or predictive factors. Here, we report a genome‐wide... ...
Tập 45 Số 11 - Trang 1033-1040 - 2006
CDKN2A, NF2, and JUN are dysregulated among other genes by miRNAs in malignant mesothelioma—A miRNA microarray analysisAbstract Malignant mesothelioma (MM) is an aggressive cancer arising from mesothelial cells, mainly due to former asbestos exposure. Little is known about the microRNA (miRNA) expression of MM. miRNAs are small noncoding RNAs, which play an essential role in the regulation of gene expression. This study was carried out to analyze the miRNA expression profile of 17 M... ...
Tập 48 Số 7 - Trang 615-623 - 2009
t( 12;21): A new recurrent translocation in acute lymphoblastic leukemiaAbstract A t(12;21)(p11 ‐p12;q22) was detected by chromosome painting in three patients with acute lymphoblastic leukemia (ALL) among eight ALL cases with 12p‐ abnormalities. The three leukemias had similar immunophenotypes (DR+, CD10 +, CD19 + ). Fluorescence in situ hybridization (FISH) experiments using YAC clones from 21q21‐q22 were performed to better localize ... ...
Tập 9 Số 3 - Trang 186-191 - 1994
Identification of gains and losses of DNA sequences in primary bladder cancer by comparative genomic hybridizationAbstract Comparative genomic hybridization (CGH) makes it possible to detect losses and gains of DNA sequences along all chromosomes in a tumor specimen based on the hybridization of differentially labeled tumor and normal DNA to normal human metaphase chromosomes. In this study, CGH analysis was applied to the identification of genomic imbalances in 26 bladder canc... ...
Tập 12 Số 3 - Trang 213-219 - 1995
Chromosome analysis of 97 primary breast carcinomas: Identification of eight karyotypic subgroupsAbstract Chromosome banding analysis of 97 short‐term cultured primary breast carcinomas revealed clonal aberrations in 79 tumors, whereas 18 were karyotypically normal. In 34 of the 79 tumors with abnormalities, two to eight clones per case were detected; unrelated clones were present in 27 (34%) cases, whereas only related clones were found in seven. These finding... ...
Tập 12 Số 3 - Trang 173-185 - 1995
Germline hypermethylation of MLH1 and EPCAM deletions are a frequent cause of Lynch syndromeAbstract It was shown that Lynch syndrome can be caused by germline hypermethylation of the MLH1 and MSH2 promoters. Furthermore, it has been demonstrated very recently that germline deletions of the 3′ region of EPCAM cause transcriptional read‐through which results in silencing of ...
Tập 48 Số 8 - Trang 737-744 - 2009
Gene dosage alterations revealed by cDNA microarray analysis in cervical cancer: Identification of candidate amplified and overexpressed genesAbstract Cervical cancer (CC) cells exhibit complex karyotypic alterations, which is consistent with deregulation of numerous critical genes in its formation and progression. To characterize this karyotypic complexity at the molecular level, we used cDNA array comparative genomic hybridization (aCGH) to analyze 29 CC cases and identified a number of over represented... ...
Tập 46 Số 4 - Trang 373-384 - 2007
Tumor mutational burden standardization initiatives: Recommendations for consistent tumor mutational burden assessment in clinical samples to guide immunotherapy treatment decisionsAbstract Characterization of tumors utilizing next‐generation sequencing methods, including assessment of the number of somatic mutations (tumor mutational burden [TMB]), is currently at the forefront of the field of personalized medicine. Recent clinical studies have associated high TMB with improved patient response rates and survival benefit from immune checkpoin... ...
Tập 58 Số 8 - Trang 578-588 - 2019
Neuroblastoma consensus deletion maps to 1p36.1–2Abstract At least 70% of human neuroblastomas display cytogenetically visible aberrations in the short arm of chromosome 1. We have used a panel of probes detecting polymorphic DNA loci, most of which were derived from a library of microdissected distal 1p chromosome fragments, to compare the hybridization pattern of DNA on nine different tumors and the correspondin... ...
Tập 1 Số 2 - Trang 159-166 - 1989