t( 12;21): A new recurrent translocation in acute lymphoblastic leukemia

Genes Chromosomes and Cancer - Tập 9 Số 3 - Trang 186-191 - 1994
Serge Romana1, Maryvonne Le Coniat1, Roland Berger1
1INSERM U 301 and SDI No. 159541 CNRS Institut de Génétique Moléculaire, Paris, France

Tóm tắt

AbstractA t(12;21)(p11 ‐p12;q22) was detected by chromosome painting in three patients with acute lymphoblastic leukemia (ALL) among eight ALL cases with 12p‐ abnormalities. The three leukemias had similar immunophenotypes (DR+, CD10 +, CD19 + ). Fluorescence in situ hybridization (FISH) experiments using YAC clones from 21q21‐q22 were performed to better localize the breakpoint on chromosome 21. This breakpoint was localized to 21q22.2 in one patient. Although only one case of ALL with t( 12;21) has been reported previously, the present results suggest that t( 12;21) is a recurrent translocation in ALL. Genes Chrom Cancer 9:186‐191 (1994). © 1994 Wiley‐Liss, Inc.

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Thông tin xuất bản

Genes Chromosomes and Cancer

Tập 9 Số 3

186-191

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