Neuroblastoma consensus deletion maps to 1p36.1–2

Genes Chromosomes and Cancer - Tập 1 Số 2 - Trang 159-166 - 1989
Andreas Weith1, Tommy Martinsson2, Celina Cziepluch3, Silke Brüderlein3, Lukas C. Amler3, Frank Berthold4, Manfred Schwab5
1Deutsches Krebsforschungszentrum, Institut für Experimentelle Pathologie, Heidelberg, FRG.
2Department of Clinical Genetics
3Deutsches Krebsforschungszentrum, Institut für experimentelle Pathologie, Heidelberg
4UNIVERSITY OF COLOGNE
5Functional and Structural Genomics

Tóm tắt

AbstractAt least 70% of human neuroblastomas display cytogenetically visible aberrations in the short arm of chromosome 1. We have used a panel of probes detecting polymorphic DNA loci, most of which were derived from a library of microdissected distal 1p chromosome fragments, to compare the hybridization pattern of DNA on nine different tumors and the corresponding normal tissue. In eight of the neuroblastomas allelic loss was observed with at least two probes. The deletions were of different size. Since a consensus deletion in all eight tumors included the segment 1p36.1–2, we conclude that genetic information related to neuroblastoma tumorigenesis is located within this approximately 10 megabase segment. Previous studies have revealed the amplification of MYCN in neuroblastomas. Our study did not provide evidence for a correlation between MYCN amplification and the 1p deletion, suggesting that the two genetic alterations result from molecular mechanisms that are not directly related to each other.

Từ khóa


Tài liệu tham khảo

10.1126/science.2649981

10.1016/0168-9525(87)90294-0

Bishop CE, 1987, The use of specific DNA probes to analyse the Sxr mutation in the mouse, Development, 101, 167, 10.1242/dev.101.Supplement.167

10.1056/NEJM198710293171803

Brodeur GM, 1981, Cytogenetic features of human neuroblastoma cell lines, Cancer Res, 41, 4678

10.1038/305779a0

10.1016/0092-8674(87)90158-9

10.1016/0165-4608(88)90188-4

10.1002/1097-0142(197102)27:2<374::AID-CNCR2820270221>3.0.CO;2-G

10.1038/309176a0

10.1126/science.2889267

10.1073/pnas.86.10.3753

10.1038/323643a0

10.1038/bjc.1988.176

Heim S, 1987, Cancer Cytogenetics, 318

10.1038/332278a0

Kaneko Y, 1985, Chromosome findings in human neuroblastomas xenografted in nude mice, Jpn J Cancer Res, 76, 359

10.1038/309170a0

10.1038/316330a0

10.1126/science.3823889

10.1002/gcc.2870010111

10.1038/318069a0

10.1038/309172a0

10.1016/0168-9525(85)90103-9

Schwab M, 1989, Genetic principles of tumor suppression, Biochim Biophys Acta (Rev Cancer), 37, 397

10.1038/305245a0

10.1093/nar/13.6.1905

Suzuki T, 1989, Frequent loss of heterozygosity on chromosome 14q in neuroblastoma, Cancer Res, 49, 1095

10.1007/978-3-662-02489-8

10.1002/j.1460-2075.1987.tb02367.x

10.1038/327721a0

Thông tin
Thông tin xuất bản

Genes Chromosomes and Cancer

Tập 1 Số 2

159-166

Thông tin tác giả