AbstractBackgroundNatural plants and plant-derived formulations have been used by mankind from the ancient period of time. For the past few years, many investigations elaborated the therapeutic potential of various secondary chemicals present in the plants. Literature revealed that the various sec...... hiện toàn bộ
AbstractBackgroundVarious bioactive aromatic compounds containing the indole nucleus showed clinical and biological applications. Indole scaffold has been found in many of the important synthetic drug molecules which gave a valuable idea for treatment and binds with high affinity to the multiple receptors helpful in developing new...... hiện toàn bộ
AbstractBackgroundThe natural antioxidants from Chlorella have potent therapeutic implication in several diseases. However, the anti-bacterial activity and their molecular mode of action have not been investigated yet. The present study focussed on the assessment of anti...... hiện toàn bộ
AbstractBackgroundIncreased attention has been focused on the continuous development and improvement of mesalamine colonic specific delivery systems, for the effective treatment of inflammatory bowel diseases; thus enhancing therapeutic efficacy and reducing potential side effects. Mesalamine is a class IV drug, according to the...... hiện toàn bộ
AbstractBackgroundScientists are constantly looking for the introduction of unique drug delivery systems for the existing drug molecule. Since the skin is one of the primary and essential organs of the human body, it needs successful research development for the delivery of the drug. While the ski...... hiện toàn bộ
Ravishankar Yadav, Indu Lata Kanwar, Tanweer Haider, Vikas Pandey, Vishal Gour, Vandana Soni
AbstractBackgroundPeriodontitis is a microbial disease that leads to inflammation in the tooth-supporting tissues of the oral cavity that is common among the elderly. It is initiated by oral inflammation induced by bacterial dysbiosis. Choosing an appropriate antimicrobial agent with the right cou...... hiện toàn bộ
Abduljelil Ajala, Adamu Uzairu, Gideon A. Shallangwa, Stephen E. Abechi
Alzheimer disease (AD) is an ailment that disturbs mainly people of old age. The fundamental remedial way to deal with AD depends on the utilization of AChEI. The design of new intense and particular AChEI is critical in drug discovery. In silico technique will be used to solve the above problem. A new method was established to discover novel agents with better biological activity against Alzheime...... hiện toàn bộ
Mubarak Hussaini Ahmad, Abubakar Ibrahim Jatau, Garba M. Khalid, Omar Alshargi
AbstractBackgroundThe plant Cochlospermum tinctorium A. Rich is a sub-shrub that belongs to the family Cochlospermaceae. The plant has been used in traditional medicine for the treatment of malaria, rickets, stomachache, diarrhea, gastric ulcer, parasitic infestations, l...... hiện toàn bộ
Muhammad Ibrahim, Adamu Uzairu, Gideon Adamu Shallangwa
AbstractBackgroundLung cancer remains the leading and deadly type of cancer worldwide. It was estimated to account for about 25% of the 7 million people that died as a result of cancer-related issues/mortality every year in the world. Non-small cell lung cancer (NSCLC) is the lethal/deadly class o...... hiện toàn bộ
AbstractBackgroundThe inhibition of dopamine transporter is known to play a significant role in the treatment of schizophrenia-related and other mental disorders. In a continuing from our previous study, computational drug design approach, molecular docking simulation, and pharmacokinetics study w...... hiện toàn bộ