Smart invasome synthesis, characterizations, pharmaceutical applications, and pharmacokinetic perspective: a review

Future Journal of Pharmaceutical Sciences - Tập 6 Số 1 - 2020
Sopan Nangare1, Shailesh Dugam2
1Department of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule, MS, 425405, India
2Institute of Chemical Technology, Matunga, Mumbai, MS, 400019, India

Tóm tắt

Abstract Background Scientists are constantly looking for the introduction of unique drug delivery systems for the existing drug molecule. Since the skin is one of the primary and essential organs of the human body, it needs successful research development for the delivery of the drug. While the skin is assumed a human body’s multifunctional organ, it has minimal permeability across the stratum corneum (SC). Since this is an influential barrier for the active agent, several carrier platforms to surmount this obstacle have been created. Invasomes are the liposomal vesicles, which incorporate small quantities of ethanol and terpenes or a mixture of terpenes, as potentials for improved penetration of the skin. The rate of penetration of invasomes through the skin is significantly greater than that of liposomes and ethosomes. Invasomes focus on providing a series of benefits namely enhanced drug effectiveness, increased conformity, and ease for patients. Main body The present article portrays insights of invasomes which include composition and preparation methods of invasomes. The article gives a brief review of the penetration mechanism, synthesis process, and characterizations of invasomes. The article gives a point by point audit about pharmaceutical applications, viz. anticancer, antihypertensive, anti-acne, vitamin analog, anticholinergic, antioxidant, etc. The pharmacokinetic properties of invasomes have also been described. Conclusion The key goal of an invasome-based delivery system is not only to strengthen the efficacy and safety of the drug but also to dramatically increase patient conformity and the therapeutic value to a significant extent. The delivery of drugs via the skin membrane in advanced drug delivery systems is a fascinating fact. Many pharmaceutical studies have shown that plentiful drug molecules are less soluble, have less bioavailability and stability, have less penetration, etc. Therefore, a new form of dosage with exceptional characteristics like invasomes can be created. Graphical abstract

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Future Journal of Pharmaceutical Sciences

Tập 6 Số 1

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