Future Journal of Pharmaceutical Sciences
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Evaluation of in vitro and in vivo anthelmintic efficacy of Cyperus compressus Linn., a traditionally used anthelmintic plant in parasite-animal models
Future Journal of Pharmaceutical Sciences - Tập 6 - Trang 1-6 - 2020
The decoction of the roots of Cyperus compressus (Cyperaceae) is used to treat helminth infection by the Santhal tribe of Assam. The study evaluated the anthelmintic efficacy claims of the plant C. compressus through pre-clinical in vitro and in vivo studies employing available parasite-animal models such as Hymenolepis diminuta-Wistar rat (cestode) and Syphacia obvelata-Swiss mice (nematode) mode......
In vitro free radical scavenging and antidiabetic activity of aqueous and ethanolic leaf extracts: a comparative evaluation of Argyreia pierreana and Matelea denticulata
Future Journal of Pharmaceutical Sciences - Tập 5 - Trang 1-11 - 2019
Oxidation is believed to play a vital role in the pathogenesis of diabetes mellitus by lipid peroxidation; DNA and protein damage leads to the development of vascular complications like coronary heart disease, stroke, neuropathy, retinopathy, and nephropathy. The herbal preparations are complementary and alternative medicines to allopathic drugs which are believed to cause adverse events. Therefor......
Development and validation of stability-indicating HPLC method for simeltaneous determination of Lamivudine, Tenofovir, and Dolutegravir in bulk and their tablet dosage form
Future Journal of Pharmaceutical Sciences - Tập 1 - Trang 73-77 - 2015
A review on phytoconstituents of marine brown algae
Future Journal of Pharmaceutical Sciences - Tập 6 - Trang 1-11 - 2020
From the last few years, the development and discovery of bioactive compounds and their potential properties from marine algae have been enhanced significantly. The coastal area is a huge storehouse for propitious algae. It has been the genuine reality that the consequence of marine algae as a source of different compounds is increasing. Numerous advanced research devices are available for the dis......
Những hiểu biết về các phương pháp gần đây trong chiến lược khám phá thuốc và các mục tiêu thuốc chưa được khai thác chống lại tình trạng kháng thuốc Dịch bởi AI
Future Journal of Pharmaceutical Sciences - Tập 7 - Trang 1-25 - 2021
Mặc dù đã có nhiều chiến lược được thực hiện trong thực hành lâm sàng, tỷ lệ tử vong do vi khuẩn kháng kháng sinh đã tăng đáng kể trên toàn cầu. Bên cạnh vi khuẩn kháng đa thuốc (MDR), các chủng vi khuẩn “ESKAPE” cũng đang nổi lên. Dĩ nhiên, nhiễm trùng do ESKAPE gây ra không thể được điều trị ngay cả với các liều kháng sinh cao nhất. Hiện nay, tình trạng kháng thuốc cũng đang gia tăng trong các l......
A novel LC-MS method development and validation for the determination of phenyl vinyl sulfone in eletriptan hydrobromide
Future Journal of Pharmaceutical Sciences - Tập 7 - Trang 1-6 - 2021
The aim of the present method is to develop and validate a specific, sensitive, precise, and accurate liquid chromatography-mass spectrometry (LC-MS) method for the estimation of the phenyl vinyl sulfone in the eletriptan hydrobromide. The effective separation of the phenyl vinyl sulfone was achieved by the Symmetry C18 (50 × 4.6 mm, 3.5 μm) column and a mobile phase composition of 0.1%v/v ammonia......
Qualitative and quantitative phytochemical composition, antimicrobial activity, and brine shrimp cytotoxicity of different solvent extracts of Acanthus polystachyus, Keetia gueinzii, and Rhynchosia elegans
Future Journal of Pharmaceutical Sciences - Tập 7 - Trang 1-11 - 2021
The root, root bark, and root tubers of Acanthus polystachyus, Keetia gueinzii, and Rhynchosia elegans are used for managing bacterial and fungal infections among the Luo community of Kisumu East Sub County in Kenya. However, data on the efficacy of these plants against common bacterial and fungal pathogens is not available. The safety of these plants is also not known. This study aimed to investi......
Cocrystallization of gliclazide with improved physicochemical properties
Future Journal of Pharmaceutical Sciences - Tập 7 - Trang 1-13 - 2021
Cocrystallization is one of the crystal engineering strategies used to alter the physicochemical properties of drugs that are poorly water-soluble. Gliclazide (GLZ), an antidiabetic drug, belongs to Biopharmaceutical Classification System class-II (low solubility and high permeability) and has low bioavailability, resulting in poor therapeutic effects in patients. Therefore, to impart better solub......
Chlorzoxazone reduced the paracetamol-induced toxicity via competitive inhibition of CYP2E1-mediated metabolism
Future Journal of Pharmaceutical Sciences - - 2023
Drug metabolism is crucial to attaining the therapeutic index of any drug. The metabolism and elimination of the drugs are governed mainly by P-glycoprotein (P-gp) and Cytochrome P450 (CYP). Paracetamol is mostly used as analgesic and antipyretic agent. The metabolism of paracetamol is primarily via Glucuronidation and sulphation at therapeutic doses. About 5–10% of paracetamol is metabolized via ......
Synthesis and in vitro antimicrobial activity of new steroidal hydrazone derivatives
Future Journal of Pharmaceutical Sciences - Tập 8 - Trang 1-10 - 2022
For many years, various drugs have been used for the treatment of infectious diseases but some bacterial microorganisms have induced resistance to several drugs. In a search of new antimicrobial agents, a series of new steroidal hydrazones were designed and synthesized. The structures of the compounds were established based on the spectral data. The in vitro antimicrobial activity of some newly sy......
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