Frontiers in Biology

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Proximate composition and elemental analysis in soft tissues of freshwater mussels (Anodonta anatina) from the Chashma Lake, River Indus Pakistan
Frontiers in Biology - Tập 11 Số 4 - Trang 331-337 - 2016
Muhammad Sohail, Muhammad Naeem Khan, AS Chaudhry, Khurram Shahzad
Hedgehog signaling: mechanisms and evolution
Frontiers in Biology - Tập 6 - Trang 504-521 - 2011
Xuan Ye, Aimin Liu
The Hedgehog (Hh) family of secreted proteins plays essential roles in the development of a wide variety of animal species and underlies multiple human birth defects and cancers. To ensure the proper range of signaling, the Hh proteins are modified with lipids, assembled into water-soluble multimers, and interact with multiple cell surface proteins. In the target cells, a largely conserved intrace...... hiện toàn bộ
Beclin 1-Vps34 complex architecture: Understanding the nuts and bolts of therapeutic targets
Frontiers in Biology - Tập 10 - Trang 398-426 - 2015
Deanna H. Morris, Calvin K. Yip, Yi Shi, Brian T. Chait, Qing Jun Wang
Autophagy is an important lysosomal degradation pathway that aids in the maintenance of cellular homeostasis by breaking down and recycling intracellular contents. Dysregulation of autophagy is linked to a growing number of human diseases. The Beclin 1-Vps34 protein-protein interaction network is critical for autophagy regulation and is therefore essential to cellular integrity. Manipulation of au...... hiện toàn bộ
Gene positioning and genome function
Frontiers in Biology - Tập 9 - Trang 255-268 - 2014
Nidhi Vishnoi, Jie Yao
The eukaryotic genome is packaged as chromatin within the three-dimensional nuclear space. Decades of cytological studies have revealed that chromosomes and genes are non-randomly localized within the nucleus and such organizations have important roles on genome function. However, several fundamental questions remain to be resolved. For example, what is required for the preferential localization o...... hiện toàn bộ
Complete mitochondrial genome of Ampittia dioscorides (Lepidoptera: Hesperiidae) and its phylogenetic analysis
Frontiers in Biology - Tập 12 - Trang 71-81 - 2017
Xin-Min Qin, Xiao-Wen Yang, Li-Xia Hou, Hui-Min Li
The complete mitochondrial genome of Ampittia dioscorides (Lepidoptera: Hesperiidae) was determined. The sequenced genome is a circular molecule of 15313 bp, containing 13 protein-coding genes (PCGs), 22 tRNA genes, two rRNA genes, and an A + T-rich region. The gene arrangements and transcribing directions are identical to those in most of the reported lepidopteran mitogenomes. The base compositio...... hiện toàn bộ
Process optimization of benzo[ghi]perylene biodegradation by yeast consortium in presence of ZnO nanoparticles and produced biosurfactant using Box-Behnken design
Frontiers in Biology - Tập 13 - Trang 418-424 - 2018
Sanjeeb Kumar Mandal, Nupur Ojha, Nilanjana Das
Benzo[ghi]perylene (BghiP), a polycyclic aromatic hydrocarbon (PAH) containing six fused benzene rings is considered as priority pollutant because of its carcinogenicity, mutagenicity and acute toxicity. The synthesis of ZnO nanoparticles was done following the standard method. Biosurfactant production by yeast consortium YC04 in MSM was confirmed by various tests viz. drop collapse test, methylen...... hiện toàn bộ
Microglia activation-induced mesencephalic dopaminergic neurodegeneration — an in vitro model for Parkinson’s disease
Frontiers in Biology - Tập 7 - Trang 404-411 - 2012
Bin Xing, Guoying Bing
Uncontrolled and chronic microglia activation has been implicated in the process of dopaminergic neuron degeneration in sporadic Parkinson’s disease (PD). Elevated proinflammatory mediators, presumably from activated microglia (e.g., cytokines, PGE2, nitric oxide, and superoxide radical), have been observed in PD patients and are accompanied by dopaminergic neuronal loss. Preclinical studies have ...... hiện toàn bộ
Epigenetic regulation of neuronal dendrite and dendritic spine development
Frontiers in Biology - Tập 5 Số 4 - Trang 304-323 - 2010
Richard D. Smrt, Xinyu Zhao
Out of step: The function of TALE homeodomain transcription factors that regulate shoot meristem maintenance and meristem identity
Frontiers in Biology - Tập 7 - Trang 144-154 - 2012
Shang Wu, Harley M. S. Smith
The indeterminate growth pattern displayed by shoots is mediated by the proper maintenance of the shoot meristem. Meristem maintenance is dependent upon the balance of stem cell perpetuation in the central zone (CZ) and organogenesis in the peripheral zone (PZ). Although the mechanisms that coordinate CZ and PZ function is not understood, meristem cell fate is likely achieved by the spatial interp...... hiện toàn bộ
MicroRNAs in erythropoiesis and red blood cell disorders
Frontiers in Biology - Tập 10 - Trang 321-332 - 2015
Javad Mohammdai-asl, Abolfazl Ramezani, Fatemeh Norozi, Amal Saki Malehi, Ali Amin Asnafi, Mohammad Ali Jalali Far, Seyed Hadi Mousavi, Najmaldin Saki
MicroRNAs (miRNAs) are 19-24 nucleotide non-coding ribonucleic acids binding DNA or RNA and controlling gene expression via mRNA degradation or its transcription inhibition. Erythropoies is a multi step differentiation process of erythroid progenitors to nucleate red blood cells. Maturation, proliferation and differentiation of red blood cells is affected by erythroid factors, signaling pathways i...... hiện toàn bộ
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