European Journal of Haematology

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Red blood cell permeability to thiol compounds following oxidative stress
European Journal of Haematology - Tập 57 Số 3 - Trang 241-246 - 1996
Dalia Mazor, Erez Golan, V. Philip, Maya Katz, A. Jafe, Zvi Ben‐Zvi, Naomi Meyerstein
Abstract:  The permeability of red blood cells (RBCs) to thiol containing compounds, reduced glutathione (GSH) and N‐acetyl cysteine (NAC), has been studied in control adult and neonatal cells and after oxidative stress. NAC penetrates the cell membrane easily while GSH hardly permeates. We measured their capacity to enhance intracellular non‐protein thiols (NPSH), after inducing damage to the mem... hiện toàn bộ
Biology of the hemopoietic microenvironment
European Journal of Haematology - Tập 49 Số 5 - Trang 225-233 - 1992
Héctor Mayani, Larry J. Guilbert, Anna Janowska‐Wieczorek
Abstract: In adult mammals, hemopoiesis takes place primarily in the bone marrow. The steady‐state production of blood cells depends to a large extent on the interaction between hemopoietic stem/progenitor cells (HPC) and the different components of the microenvironment present in the medullary cavity. During the last three decades, in vivo and in vitro studies have allowed significant advances in... hiện toàn bộ
Treatment of painful bone lesions and hypercalcemia
European Journal of Haematology - Tập 43 Số S51 - Trang 135-139 - 1989
Edoardo Ascari, Giuseppe Attardo-Parrinello, Giampaolo Merlini
The control of myeloma bone disease has been an important therapeutic problem. Bisphosphonates are potentially active for the control of myeloma bone resorption. Athough several studies proved the efficacy of short‐term bisphosphonate treatment in inhibiting myeloma bone destruction, data on the long‐term efficacy are scanty. We present the results of a prospective pilot study for the evaluation o... hiện toàn bộ
Arterial elastorrhexis in β‐thalassaemia intermedia, sickle cell thalassaemia and hereditary spherocytosis
European Journal of Haematology - Tập 67 Số 3 - Trang 135-141 - 2001
K. Tsomi, Markissia Karagiorga‐Lagana, Fotis Karabatsos, Christina Fragodimitri, C. Van Vliet‐Konstantinidou, Evangelos Premetis, Alexandra Stamoulakatou
Abstract: Arterial and stromal elastorrhexis, an elastic tissue disorder, was recently described in β‐thalassaemia major. Histopathological material from 10 patients with thalassaemia intermedia, 14 with sickle cell thalassaemia and 18 with hereditary spherocytosis was examined in order to investigate the specificity of the arteriopathy. Histological re‐examination was made in a total of 42 spleen... hiện toàn bộ
Transfusional hemosiderosis and combined chelation therapy in sickle thalassemia
European Journal of Haematology - Tập 75 Số 4 - Trang 355-358 - 2005
Maria Tsironi, Katerina Polonifi, Spyros Deftereos, Dimitrios Farmakis, Panagiotis Andriopoulos, Ioannis Moyssakis, Athanasios Aessopos
Abstract:  Although the indications for transfusions in sickle cell syndromes are well listed, and chronic transfusion has become practicable since the recent advances in chelation therapy have essentially eliminated the risk of secondary iron overload, multi‐transfused, non‐compliant to long‐term chelation therapy patients confront the complication of iron overload and secondary hemosiderosis. In... hiện toàn bộ
Fulminant thrombotic thrombocytopenic purpura in two patients with systemiclupus erythematosus and phospholipid autoantibodies
European Journal of Haematology - Tập 64 Số 6 - Trang 433-435 - 2000
Masriany Musa, Randa Nounou, Entezam Sahovic, P Seth, Abdulelah Qadi, Mahmoud Aljurf
Clinical findings and magnetic resonance imaging in severe cyclosporine‐related neurotoxicity after allogeneic bone marrow transplantation
European Journal of Haematology - Tập 67 Số 2 - Trang 94-99 - 2001
Fabienne Trullemans, Ferre Grignard, Benjamin Van Camp, Ann De Becker
Abstract: Objectives: Severe neurotoxicity is a recognized complication of cyclosporin A (cyclosporine, CSA). Neuroimaging studies typically show reversible brain lesions, predominantly confined to the white matter. Our aim was to delineate clinical characteristics and to specify results of magnetic resonance imaging (MRI) and computerised tomography (CT) scan findings. Methods: Cases of severe cy... hiện toàn bộ
Prenatal diagnosis of recessive congenital methaemoglobinaemia type II: novel mutation in the NADH‐cytochrome b5 reductase gene leading to stop codon read‐through
European Journal of Haematology - Tập 74 Số 5 - Trang 389-395 - 2005
Alena Leroux, France Leturcq, Nathalie Deburgrave, Marie‐France Szajnert
Abstract:  A case of type II recessive congenital methaemoglobinaemia (RCM) observed in a Lebanese subject with a novel mutation in NADH‐cytochrome b5 reductase gene is described. A homozygous mutation CAC to AA identified at Thr 295 with an out‐of‐frame 1‐bp deletion leads to a frameshift with translational read‐through of the natural stop codon. The molecular mechanism is demonstrated by an in v... hiện toàn bộ
Compound heterozygosity of two missense mutations in the NADH‐cytochrome b5 reductase gene of a Polish patient with type I recessive congenital methaemoglobinaemia
European Journal of Haematology - Tập 70 Số 6 - Trang 404-409 - 2003
Dorota Grabowska, Danuta Płochocka, E Jabłońska-Skwiecinśka, Anna Chełstowska, Irmina Lewandowska, K Staniszewska, Z Majewska, Iwona Witos, Beata Burzyńska
Abstract:A case of type I methaemoglobinaemia observed in a Polish subject with compound heterozygosity for two mutations in the reduced nicotinamide adenine dinucleotide (NADH) cytochrome b5 reductase (b5R) gene is described. One is a novel mutation 647T→C which leads to substitution of isoleucine by threonine at position 215 (I215T). This maternal mutation was found in several family members. A ... hiện toàn bộ
Risk factors and implications of oral mucositis in recipients of allogeneic hematopoietic stem cell transplantation
European Journal of Haematology - Tập 103 Số 4 - Trang 402-409 - 2019
Roni Shouval, Elizaveta Kouniavski, Joshua Fein, Ivetta Danylesko, Noga Shem‐Tov, Mika Geva, Ronit Yerushalmi, Avichai Shimoni, Arnon Nagler
AbstractBackgroundOral mucositis (OM) is a common toxicity of stem cell transplantation (SCT). We sought to evaluate OM burden, risk factors, and implications in a cohort of allogeneic‐SCT recipients.MethodsThis was a single‐center study including 115 adult allogeneic‐SCT transplanted between 2016 and 2018 for various hematological conditions. Conditioning intensity was categorized as myeloablativ... hiện toàn bộ
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