European Journal of Haematology

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Biology of the hemopoietic microenvironment
European Journal of Haematology - Tập 49 Số 5 - Trang 225-233 - 1992
Héctor Mayani, Larry J. Guilbert, Anna Janowska‐Wieczorek
Abstract: In adult mammals, hemopoiesis takes place primarily in the bone marrow. The steady‐state production of blood cells depends to a large extent on the interaction between hemopoietic stem/progenitor cells (HPC) and the different components of the microenvironment present in the medullary cavity. During the last three decades, in vivo... hiện toàn bộ
Prenatal diagnosis of recessive congenital methaemoglobinaemia type II: novel mutation in the NADH‐cytochrome b5 reductase gene leading to stop codon read‐through
European Journal of Haematology - Tập 74 Số 5 - Trang 389-395 - 2005
Alena Leroux, France Leturcq, Nathalie Deburgrave, Marie‐France Szajnert
Abstract:  A case of type II recessive congenital methaemoglobinaemia (RCM) observed in a Lebanese subject with a novel mutation in NADH‐cytochrome b5 reductase gene is described. A homozygous mutation CAC to AA identified at Thr 295 with an out‐of‐frame 1‐bp deletion leads to a frameshift with translational read‐through of the natural stop codon. The molecular mecha...... hiện toàn bộ
Compound heterozygosity of two missense mutations in the NADH‐cytochrome b5 reductase gene of a Polish patient with type I recessive congenital methaemoglobinaemia
European Journal of Haematology - Tập 70 Số 6 - Trang 404-409 - 2003
Dorota Grabowska, Danuta Płochocka, E Jabłońska-Skwiecinśka, Anna Chełstowska, Irmina Lewandowska, K Staniszewska, Z Majewska, Iwona Witos, Beata Burzyńska
Abstract:A case of type I methaemoglobinaemia observed in a Polish subject with compound heterozygosity for two mutations in the reduced nicotinamide adenine dinucleotide (NADH) cytochrome b5 reductase (b5R) gene is described. One is a novel mutation 647T→C which leads to substitution of isoleucine by threonine at position 215 (I215T). This maternal mutation was fo...... hiện toàn bộ
Risk factors and implications of oral mucositis in recipients of allogeneic hematopoietic stem cell transplantation
European Journal of Haematology - Tập 103 Số 4 - Trang 402-409 - 2019
Roni Shouval, Elizaveta Kouniavski, Joshua Fein, Ivetta Danylesko, Noga Shem‐Tov, Mika Geva, Ronit Yerushalmi, Avichai Shimoni, Arnon Nagler
AbstractBackgroundOral mucositis (OM) is a common toxicity of stem cell transplantation (SCT). We sought to evaluate OM burden, risk factors, and implications in a cohort of allogeneic‐SCT recipients.MethodsThis was a single‐center study including 115 adult allogeneic‐...... hiện toàn bộ
FcR‐mediated clearance in thrombopenic and non‐thrombopenic patients with hemophilia A and possible relation of thrombopenia to HIV seropositivity
European Journal of Haematology - Tập 39 Số 5 - Trang 440-446 - 1987
D. Auch, Ulrich Budde, U. Hammerstein, D. Niese, Reinhold Schmidt, H.‐H. Brackmann, H. J. Dengler
As morbidity of thrombopenia in hemophilia A patients is increasing, the pathogenetic influence of the reticuloendothelial system (RES) was measured using autologous anti‐Rh0(D)‐coated erythrocytes (EA) in 17 patients with or without thrombopenia. Mean survival of EA in patients was reduced to 53% of healthy controls (53.2 ± 46.1 min vs 100.5 ± 12.2 min; patients vs co...... hiện toàn bộ
IDH1 and IDH2 mutations confer an adverse effect in patients with acute myeloid leukemia lacking the NPM1 mutation
European Journal of Haematology - Tập 92 Số 6 - Trang 471-477 - 2014
Shunichiro Yamaguchi, Eisaku Iwanaga, Kenji Tokunaga, Tomoko Nanri, Taizo Shimomura, Hitoshi Suzushima, Hiroaki Mitsuya, Norio Asou
AbstractWe examined the incidence and prognostic effect of IDH1 and IDH2 mutations in 233 Japanese adults with acute myeloid leukemia (AML... hiện toàn bộ
Defensins
European Journal of Haematology - Tập 44 Số 1 - Trang 1-8 - 1990
Tomas Ganz, Michael E. Selsted, Robert I. Lehrer
Abstract: Defensins are a family of small, variably cationic proteins which are highly abundant in the granules of mammalian phagocytes. Three defensins, HNP‐1, 2, and 3, comprise 30–50% of total protein in azurophil granules of human neutrophils. Some defensins are broadly antimicrobial, antiviral and cytotoxic, while others are chemotactic, opsonic, or may modulat...... hiện toàn bộ
Intravenous immunoglobulin treatment in hematological diseases
European Journal of Haematology - Tập 60 Số 2 - Trang 73-85 - 1998
Antonius T. Otten, Patrick M. Bossuyt, M. Vermeulen, A Brand
Abstract: In the last decade large amounts of intravenous immunoglobulin (IVIg) have been used worldwide. Doubts exist as to whether this increased use is paralleled by a comparable growth of reliable data on the therapeutic effectiveness of IVIg. We performed a literature search using MEDLINE from January 1981 to January 1997 and analysed articles on the use of IVI...... hiện toàn bộ
Incidence of myelodysplastic syndromes in a Swedish population
European Journal of Haematology - Tập 54 Số 3 - Trang 153-156 - 1995
Anders Rådlund, T Thiede, Søren Naaby Hansen, Magnus Carlsson, Leif Engquist
Abstract: The myelodysplastic syndromes (MDS) have attracted great interest during the last decade. Unfortunately there is not much material published concerning the incidence of these conditions. We present epidemiologic data on MDS based on case registration of patients in a well‐defined population and as a comparison similar data on acute myeloid leukaemia (AML)....... hiện toàn bộ
Expression of activation markers CD23 and CD69 in B‐cell non‐Hodgkin's lymphoma
European Journal of Haematology - Tập 60 Số 2 - Trang 125-132 - 1998
Martin Erlanson, Elisabeth Grönlund, Eva Löfvenberg, Göran Roos, Jack Lindh
Abstract: The activation associated proteins CD23 and CD69 are expressed on cells of different lineages upon mitogenic stimulation. CD23 is a well characterized multifunctional protein in lymphocyte development recognized as a diagnostic marker for chronic lymphocytic leukaemia. CD69 is one of the earliest markers expressed after activation of T cells, but its funct...... hiện toàn bộ
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