Expression of activation markers CD23 and CD69 in B‐cell non‐Hodgkin's lymphoma

European Journal of Haematology - Tập 60 Số 2 - Trang 125-132 - 1998
Martin Erlanson1, Elisabeth Grönlund2, Eva Löfvenberg3, Göran Roos2, Jack Lindh1
1Departments of Oncology, Umeå University. S-901 87 Umeå, Sweden
2Departments of Pathology, Umeå University. S-901 87 Umeå, Sweden
3Departments of Medicine, Umeå University. S‐901 87 Umeå, Sweden

Tóm tắt

Abstract: The activation associated proteins CD23 and CD69 are expressed on cells of different lineages upon mitogenic stimulation. CD23 is a well characterized multifunctional protein in lymphocyte development recognized as a diagnostic marker for chronic lymphocytic leukaemia. CD69 is one of the earliest markers expressed after activation of T cells, but its function is unclear. The aim of this study was to investigate the expression of these antigens in B‐cell non‐Hodgkin's lymphomas (NHL) in relation to clinical behaviour. Ninety samples from 84 patients with NHL of B cell type were studied for the expression of CD23 and CD69 in CD20+ B cells by flow cytometric dual parameter analysis. In individual lymphomas the CD23 and CD69 antigens showed an “on or off” pattern with most or very few cells positive for each antigen. The CD23 antigen was expressed in 23 of 53 (43%) indolent lymphomas and in 2 of 37 (5%) aggressive cases. Most indolent lymphomas (81%) and about half the aggressive cases (53%) expressed the CD69 antigen. Thus, both markers were associated with indolent type. CD23 expression correlated with chronic lymphocytic leukaemia subtype and CD69 expression with male gender, advanced stage, newly diagnosed lymphoma and shorter survival.

Từ khóa


Tài liệu tham khảo

10.1016/0167-5699(89)90135-7

Gordon J., 1991, Monogr Allergy, 156

Pallesen G., 1987, Leucocyte typing III, 383

10.1002/eji.1830160908

GustavssonS.The role of CD21 and CD23 in immune responses.Thesis Uppsala University 1996.

10.1182/blood.V84.5.1361.1361

10.1200/JCO.1994.12.10.2146

Testi R., 1989, T cell activation via Leu‐23 (CD69), J Immunol, 143, 1123, 10.4049/jimmunol.143.4.1123

Testi R., 1989, Leu 23 induction as an early marker of functional CD3/T cell antigen receptor triggering, J Immunol, 142, 1854, 10.4049/jimmunol.142.6.1854

10.1093/intimm/2.7.603

10.1016/0008-8749(92)90153-G

10.1016/1043-4666(92)90034-O

10.1016/S0140-6736(88)90367-4

Hiddeman W., 1996, Lymphoma classification – the gap between biology and clinical management is closing, Blood, 88, 4085, 10.1182/blood.V88.11.4085.bloodjournal88114085

10.1002/cyto.990030503

10.1093/ajcp/100.4.373

10.1016/S0065-2776(08)60663-X

Inghirami G., 1991, Autoantibody‐associated cross‐reactive idiotype‐bearing human B lymphocytes: distribution and characterisation, including IgVH gene and CD5 antigen expression, Blood, 71, 1503, 10.1182/blood.V78.6.1503.1503

Yukawa K., 1987, A B‐cell specific differentiation antigen, CD23, is a receptor for IgE (FceR) on lymphocytes, J Immunol, 138, 2576, 10.4049/jimmunol.138.8.2576

10.1016/S0308-2261(82)80005-2

10.1002/path.1711540304

10.1111/j.1600-0609.1989.tb00335.x

Carlsson M., 1992, Hairy cell leukemia (HCL) associated antigen B‐ly7 is an activation/differentiation‐associated antigen on HCL and normal B cells but not B‐type chronic lymphocytic leukemia (B‐CLL) cells, Leuk Lymph, 6, 133

10.1200/JCO.1995.13.10.2530

10.1016/0959-8049(95)00076-3

10.1093/oxfordjournals.annonc.a058153

Thông tin
Thông tin xuất bản

European Journal of Haematology

Tập 60 Số 2

125-132

Thông tin tác giả