Renal failure in multiple myeloma: reversibility and impact on the prognosis Tập 65 Số 3 - Trang 175-181 - 2000
Lene Meldgaard Knudsen, Martin Hjorth, Erik Hippe
Abstract: The purpose of the present study was to analyse the importance and
prognostic value of renal failure in multiple myeloma patients. The frequency
and reversibility of renal failure in 775 multiple myeloma patients diagnosed
between 1984–86 and 1990–92 in the Nordic countries were studied. Renal failure,
defined as plasma creatinine >130μmol/l, was observed in 29% of the cases at the
time ... hiện toàn bộ
Isolation and characterization of a tumor necrosis factor binding protein from urine Tập 42 Số 3 - Trang 270-275 - 1989
Inge Olsson, Mikael Lantz, Eva Nilsson, Christina Peetre, Hans Thysell, Anders Grubb, G.R. Adolf
Tumor necrosis factor (TNF)/cachectin can produce both beneficial and harmful
manifestations. Mechanisms may operate to counteract potentially harmful effects
such as shock and cachexia. The TNF binding protein (TNF‐BP), which is found at
increased levels in serum and urine of patients with chronic renal failure, may
play such a role. TNF‐BP was purified 1000000–fold to homogeneity from urine of
p... hiện toàn bộ
Defensins Tập 44 Số 1 - Trang 1-8 - 1990
Tomas Ganz, Michael E. Selsted, Robert I. Lehrer
Abstract: Defensins are a family of small, variably cationic proteins which are
highly abundant in the granules of mammalian phagocytes. Three defensins, HNP‐1,
2, and 3, comprise 30–50% of total protein in azurophil granules of human
neutrophils. Some defensins are broadly antimicrobial, antiviral and cytotoxic,
while others are chemotactic, opsonic, or may modulate hormonal responses. The
defens... hiện toàn bộ
Differential expression of microRNAs in hematopoietic cell lineages Tập 81 Số 4 - Trang 304-310 - 2008
Michaela Dostálová Merkerová, Monika Beličková, Hana Votavová
AbstractObjectives: MicroRNAs (miRNAs) play key roles in a wide variety of
normal and pathological cellular processes. A number of studies identified
hematopoietic‐specific miRNAs that are necessary for correct function of blood
cells. Out of our microarray data, we chose 13 miRNAs that showed differential
expression in peripheral blood cells (miR‐15b, miR‐16, miR‐24, miR‐30c,
miR‐106b, miR‐142‐3... hiện toàn bộ
Biology of the hemopoietic microenvironment Tập 49 Số 5 - Trang 225-233 - 1992
Héctor Mayani, Larry J. Guilbert, Anna Janowska‐Wieczorek
Abstract: In adult mammals, hemopoiesis takes place primarily in the bone
marrow. The steady‐state production of blood cells depends to a large extent on
the interaction between hemopoietic stem/progenitor cells (HPC) and the
different components of the microenvironment present in the medullary cavity.
During the last three decades, in vivo and in vitro studies have allowed
significant advances in... hiện toàn bộ
Circulating endothelial cells in vascular disorders: new insights into an old concept Tập 65 Số 4 - Trang 215-220 - 2000
Françoise Dignat‐George
Abstract: The endothelial contribution to vascular disorders has been widely
documented in experimental models. However, its implication in human pathology
is difficult to investigate, owing to the paucity of non‐invasive methods and of
specific endothelial markers. The enumeration of circulating endothelial cells
(CEC) released in peripheral blood after vascular injury represents a direct
explora... hiện toàn bộ
Tình trạng tim mạch ở bệnh nhân thalassemia nặng được điều trị tốt Dịch bởi AI Tập 73 Số 5 - Trang 359-366 - 2004
Athanasios Aessopos, Dimitrios Farmakis, Antonia Hatziliami, Christina Fragodimitri, Fotis Karabatsos, Jacqueline Joussef, Eftichia Mitilineou, Evanthia Diamanti‐Kandaraki, John Meletis, Markisia Karagiorga
Tóm tắt: Mục tiêu: Đánh giá tình trạng tim mạch ở một nhóm lớn bệnh nhân
thalassemia nặng đã được điều trị theo cách tiêu chuẩn từ khi còn nhỏ với liệu
pháp truyền máu tích cực và chelat deferoxamine, những người có tuân thủ tốt
phác đồ điều trị này. Phương pháp và Kết quả: Chúng tôi đã tiến hành đánh giá
lâm sàng và siêu âm tim cho 202 bệnh nhân thalassemia nặng tuổi trung bình 27,3
± 6,3 năm và... hiện toàn bộ
Veno‐occlusive disease of the liver after hemopoietic cell transplantation Tập 64 Số 5 - Trang 281-291 - 2000
Enric Carreras
Abstract: The clinical syndrome of veno‐occlusive disease (VOD) after
hemopoietic cell transplantation is characterised by jaundice, painful liver
enlargement, and fluid retention with weight gain. Cytoreductive therapy is
presumably the primary cause of VOD, but several other agents (and a special
susceptibility of the liver) can also play a role in its genesis. The risk of
VOD can be predicted b... hiện toàn bộ
Prophylactic heparin does not prevent liver veno‐occlusive disease following autologous bone marrow transplantation Tập 47 Số 5 - Trang 346-354 - 1991
L. Marsa‐Vila, Norbert Claude Gorin, J.P. Laporte, Myriam Labopin, M. C. Dupuy‐Montbrun, L Fouillard, F Isnard, A Najman
Abstract: Veno‐occlusive disease (VOD) is a major cause of toxic death after
autologous bone marrow transplantation (ABMT). We studied the potential role of
continuous administration of low‐dose heparin for VOD prevention in 234
consecutive patients who underwent ABMT in our institution. The population
consisted of 98 patients autografted before October 1984 who did not receive
heparin, and a seri... hiện toàn bộ