FcR‐mediated clearance in thrombopenic and non‐thrombopenic patients with hemophilia A and possible relation of thrombopenia to HIV seropositivity

European Journal of Haematology - Tập 39 Số 5 - Trang 440-446 - 1987
D. Auch1, Ulrich Budde, U. Hammerstein, D. Niese, Reinhold Schmidt, H.‐H. Brackmann, H. J. Dengler
1Institut für Genetik, Universität Köln, FRG.

Tóm tắt

As morbidity of thrombopenia in hemophilia A patients is increasing, the pathogenetic influence of the reticuloendothelial system (RES) was measured using autologous anti‐Rh0(D)‐coated erythrocytes (EA) in 17 patients with or without thrombopenia. Mean survival of EA in patients was reduced to 53% of healthy controls (53.2 ± 46.1 min vs 100.5 ± 12.2 min; patients vs controls, mean ± S.D.). Survival of EA was not significantly different either in thrombopenic vs non‐thrombopenic nor anti‐HIV (human immunodeficiency virus) positive vs negative patients. Thrombopenia, elevated serum IgG and circulating immune complexes were related to the presence of anti‐HIV antibodies. EA survival was also decreased in the absence of anti‐HIV antibodies. This indicates activation of RES by a mechanism different from retroviral infection by HIV (1).

Từ khóa


Tài liệu tham khảo

Bender BS, 1984, Acquired immune deficiency syndrome (AIDS), Clin Res, 32, 511A

10.1056/NEJM198302243080808

Budde U, 1983, Gehäuftes Vorkommen und Immunthrombopenien bei Patienten mit Hämophilie A, 213

Kelton JG, 1984, The relationship among platelet‐associated IgG, platelet lifespan and reticuloendothelial cell function, Blood, 63, 1434, 10.1182/blood.V63.6.1434.1434

10.1111/j.1600-0609.1986.tb01785.x

10.1056/NEJM197903083001002

10.1016/S0308-2261(21)00394-5

10.1016/0022-1759(82)90119-3

10.1016/0090-1229(80)90197-X

10.1007/BF01726916

10.1126/science.6324345

10.1126/science.6200937

10.1056/NEJM198301133080205

10.1056/NEJM198301133080206

10.1056/NEJM198409063111004

Kröniger A, 1982, Faktor‐VIII Konzentrate. Problematik und protein‐chemische Charakterisierung, Med Welt, 33, 1027

10.1084/jem.157.6.1844

Ceuppens JL, 1984, Immunological alterations in haemophiliacs treated with lyophilized factor VIII cryroprecipitate from volunteer donors, Thromb Haemostas, 51, 207, 10.1055/s-0038-1661060

Thông tin
Thông tin xuất bản

European Journal of Haematology

Tập 39 Số 5

440-446

Thông tin tác giả