Endocrine Reviews
1945-7189
0163-769X
Mỹ
Cơ quản chủ quản: The Endocrine Society , ENDOCRINE SOC
Lĩnh vực:
Endocrinology, Diabetes and MetabolismEndocrinology
Phân tích ảnh hưởng
Thông tin về tạp chí
Endocrine Reviews publishes bimonthly, including concise timely reviews updating key mechanistic and clinical concepts, as well as more comprehensive, authoritative review articles spanning both experimental and clinical endocrinology themes. Endocrine Reviews will consider topics that inform clinical practice based on emerging and established evidence from clinical research as well as reviews of advances in endocrine science emanating from studies of cell biology, immunology, pharmacology, genetics, molecular biology, neuroscience, reproductive medicine, and pediatric endocrinology.
Các bài báo tiêu biểu
Prolactin (PRL) and Its Receptor: Actions, Signal Transduction Pathways and Phenotypes Observed in PRL Receptor Knockout Mice
Tập 19 Số 3 - Trang 225-268 - 1998
Bile Acid Regulation of Gene Expression: Roles of Nuclear Hormone Receptors
Tập 23 Số 4 - Trang 443-463 - 2002
Recent Progress in Understanding the Hormonal Regulation of Phosphodiesterases
Tập 16 Số 3 - Trang 370-389 - 1995
Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses For decades, studies of endocrine-disrupting chemicals (EDCs) have challenged traditional concepts in toxicology, in particular the dogma of “the dose makes the poison,” because EDCs can have effects at low doses that are not predicted by effects at higher doses. Here, we review two major concepts in EDC studies: low dose and nonmonotonicity. Low-dose effects were defined by the National Toxicology Program as those that occur in the range of human exposures or effects observed at doses below those used for traditional toxicological studies. We review the mechanistic data for low-dose effects and use a weight-of-evidence approach to analyze five examples from the EDC literature. Additionally, we explore nonmonotonic dose-response curves, defined as a nonlinear relationship between dose and effect where the slope of the curve changes sign somewhere within the range of doses examined. We provide a detailed discussion of the mechanisms responsible for generating these phenomena, plus hundreds of examples from the cell culture, animal, and epidemiology literature. We illustrate that nonmonotonic responses and low-dose effects are remarkably common in studies of natural hormones and EDCs. Whether low doses of EDCs influence certain human disorders is no longer conjecture, because epidemiological studies show that environmental exposures to EDCs are associated with human diseases and disabilities. We conclude that when nonmonotonic dose-response curves occur, the effects of low doses cannot be predicted by the effects observed at high doses. Thus, fundamental changes in chemical testing and safety determination are needed to protect human health.
Tập 33 Số 3 - Trang 378-455 - 2012
The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The Hypothesis of PCOS as Functional Ovarian Hyperandrogenism Revisited
Tập 37 Số 5 - Trang 467-520 - 2016
The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis*
Tập 7 Số 3 - Trang 284-301 - 1986
Hypothalamic Control of Adrenocorticotropin Secretion: Advances since the Discovery of 41-Residue Corticotropin-Releasing Factor
Tập 7 Số 4 - Trang 351-378 - 1986
Physiological Functions of Glucocorticoids in Stress and Their Relation to Pharmacological Actions*
Tập 5 Số 1 - Trang 25-44 - 1984