Evanthia Diamanti‐Kandarakis, J P Bourguignon, Linda C. Giudice, Russ Hauser, Gail S. Prins, Ana M. Soto, R. Thomas Zoeller, Andrea C. Gore
AbstractThere is growing interest in the possible health threat posed by
endocrine-disrupting chemicals (EDCs), which are substances in our environment,
food, and consumer products that interfere with hormone biosynthesis,
metabolism, or action resulting in a deviation from normal homeostatic control
or reproduction. In this first Scientific Statement of The Endocrine Society, we
present the evide... hiện toàn bộ
Laura N. Vandenberg, Theo Colborn, Thomas R. Hayes, Jerrold J. Heindel, David R. Jacobs, Duk‐Hee Lee, Toshi Shioda, Ana M. Soto, Frederick S. vom Saal, Wade V. Welshons, R. Thomas Zoeller, John Peterson Myers
For decades, studies of endocrine-disrupting chemicals (EDCs) have challenged
traditional concepts in toxicology, in particular the dogma of “the dose makes
the poison,” because EDCs can have effects at low doses that are not predicted
by effects at higher doses. Here, we review two major concepts in EDC studies:
low dose and nonmonotonicity. Low-dose effects were defined by the National
Toxicolog... hiện toàn bộ
Joseph L. Evans, Ira D. Goldfine, Betty A. Maddux, Gerold M. Grodsky
AbstractIn both type 1 and type 2 diabetes, the late diabetic complications in
nerve, vascular endothelium, and kidney arise from chronic elevations of glucose
and possibly other metabolites including free fatty acids (FFA). Recent evidence
suggests that common stress-activated signaling pathways such as nuclear
factor-κB, p38 MAPK, and NH2-terminal Jun kinases/stress-activated protein
kinases und... hiện toàn bộ