Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement
Tóm tắt
There is growing interest in the possible health threat posed by endocrine-disrupting chemicals (EDCs), which are substances in our environment, food, and consumer products that interfere with hormone biosynthesis, metabolism, or action resulting in a deviation from normal homeostatic control or reproduction. In this first Scientific Statement of The Endocrine Society, we present the evidence that endocrine disruptors have effects on male and female reproduction, breast development and cancer, prostate cancer, neuroendocrinology, thyroid, metabolism and obesity, and cardiovascular endocrinology. Results from animal models, human clinical observations, and epidemiological studies converge to implicate EDCs as a significant concern to public health. The mechanisms of EDCs involve divergent pathways including (but not limited to) estrogenic, antiandrogenic, thyroid, peroxisome proliferator-activated receptor γ, retinoid, and actions through other nuclear receptors; steroidogenic enzymes; neurotransmitter receptors and systems; and many other pathways that are highly conserved in wildlife and humans, and which can be modeled in laboratory in vitro and in vivo models. Furthermore, EDCs represent a broad class of molecules such as organochlorinated pesticides and industrial chemicals, plastics and plasticizers, fuels, and many other chemicals that are present in the environment or are in widespread use. We make a number of recommendations to increase understanding of effects of EDCs, including enhancing increased basic and clinical research, invoking the precautionary principle, and advocating involvement of individual and scientific society stakeholders in communicating and implementing changes in public policy and awareness.
Từ khóa
Tài liệu tham khảo
Kuiper, 1998, Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β., Endocrinology, 139, 4252, 10.1210/endo.139.10.6216
Dickerson, 2007, Estrogenic environmental endocrine-disrupting chemical effects on reproductive neuroendocrine function and dysfunction across the life cycle., Rev Endocr Metab Disord, 8, 143, 10.1007/s11154-007-9048-y
Cao, 2009, Isoflavones in urine, saliva and blood of infants—data from a pilot study on the estrogenic activity of soy formula., J Expo Sci Environ Epidemiol, 19, 223, 10.1038/jes.2008.44
Calafat, 2007, 253
Porte, 2006, Endocrine disruptors in marine organisms: approaches and perspectives., Comp Biochem Physiol C Toxicol Pharmacol, 143, 303, 10.1016/j.cbpc.2006.03.004
Stahlhut, 2009, Bisphenol A data in NHANES suggest longer than expected half-life, substantial non-food exposure, or both., Environ Health Perspect, 117, 784, 10.1289/ehp.0800376
Gore, 2009
Barker, 2003, The developmental origins of adult disease., Eur J Epidemiol, 18, 733, 10.1023/A:1025388901248
Crews, 2003, Animal models for the study of the effects of mixtures, low doses, and the embryonic environment on the action of endocrine disrupting chemicals., Pure and Applied Chemistry, SCOPE/IUPAC Project Implications of Endocrine Active Substances for Humans and Wildlife, 75, 2305
Sheehan, 1999, No threshold dose for estradiol-induced sex reversal of turtle embryos: how little is too much?, Environ Health Perspect, 107, 155, 10.1289/ehp.99107155
Saal, 2007, Chapel Hill Bisphenol A Expert Panel Consensus Statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure., Reprod Toxicol, 24, 131, 10.1016/j.reprotox.2007.07.005
Anway, 2006, Epigenetic transgenerational actions of endocrine disruptors, Endocrinology, 147, S43, 10.1210/en.2005-1058
Thornton, 2001, Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions., Proc Natl Acad Sci USA, 98, 5671, 10.1073/pnas.091553298
Bay, 2006, Testicular dysgenesis syndrome: possible role of endocrine disrupters., Best Pract Res Clin Endocrinol Metab, 20, 77, 10.1016/j.beem.2005.09.004
Toppari, 2001, Trends in the incidence of cryptorchidism and hypospadias, and methodological limitations of registry-based data., Hum Reprod Update, 7, 282, 10.1093/humupd/7.3.282
Hemminki, 2002, Cancer risks in second-generation immigrants to Sweden., Int J Cancer, 99, 229, 10.1002/ijc.10323
Parent, 2003, The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends and changes after migration., Endocr Rev, 24, 668, 10.1210/er.2002-0019
Herbst, 1971, Adenocarcinoma of vagina. Association of maternal stilbestrol therapy with tumor appearance in young women., N Engl J Med, 284, 878, 10.1056/NEJM197104222841604
Sharpe, 2006, Pathways of endocrine disruption during male sexual differentiation and masculinisation., Best Pract Res Clin Endocrinol Metab, 20, 91, 10.1016/j.beem.2005.09.005
Skakkebaek, 2001, Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects., Hum Reprod, 16, 972, 10.1093/humrep/16.5.972
Gray Jr, 2000, Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat., Toxicol Sci, 58, 350, 10.1093/toxsci/58.2.350
Swan, 2005, Decrease in anogenital distance among male infants with prenatal phthalate exposure., Environ Health Perspect, 113, 1056, 10.1289/ehp.8100
Maffini, 2006
Buck Louis, 2008, Environmental factors and puberty timing: expert panel research needs, Pediatrics, 121, S192, 10.1542/peds.1813E
Colón, 2000, Identification of phthalate esters in the serum of young Puerto Rican girls with premature breast development., Environ Health Perspect, 108, 895
Rasier, 2007, Early maturation of gonadotropin-releasing hormone secretion and sexual precocity after exposure of infantile female rats to estradiol or dichlorodiphenyltrichloroethane., Biol Reprod, 77, 734, 10.1095/biolreprod.106.059303
Li, 2003, Environmental exposure, DNA methylation and gene regulation. Lessons from diethylstilbestrol-induced cancers., Ann NY Acad Sci, 983, 161, 10.1111/j.1749-6632.2003.tb05971.x
McLachlan, 2006, Endocrine disrupters and female reproductive health., Best Pract Res Clin Endocrinol Metab, 20, 63, 10.1016/j.beem.2005.09.009
Darbre, 2006, Environmental oestrogens, cosmetics and breast cancer., Best Pract Res Clin Endocrinol Metab, 20, 121, 10.1016/j.beem.2005.09.007
Fenton, 2006, Endocrine-disrupting compounds and mammary gland development: Early exposure and later life consequences, Endocrinology, 147, S18, 10.1210/en.2005-1131
Newbold, 2007, Long-term adverse effects of neonatal exposure to bisphenol A on the murine female reproductive tract., Reprod Toxicol, 24, 253, 10.1016/j.reprotox.2007.07.006
Crews, 2006, Epigenetics, evolution, endocrine disruption, health, and disease, Endocrinology, 147, S4, 10.1210/en.2005-1122
Anway, 2008, Transgenerational effects of the endocrine disruptor vinclozolin on the prostate transcriptome and adult onset disease., Prostate, 68, 517, 10.1002/pros.20724
Anway, 2005, Epigenetic transgenerational actions of endocrine disruptors and male fertility., Science, 308, 1466, 10.1126/science.1108190
Christiansen, 2008, Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat., Int J Androl, 31, 241, 10.1111/j.1365-2605.2008.00866.x
Shono, 2004, Short-time exposure to vinclozolin in utero induces testicular maldescent associated with a spinal nucleus alteration of the genitofemoral nerve in rat., J Pediatr Surg, 39, 217, 10.1016/j.jpedsurg.2003.10.014
Monosson, 1999, Peripubertal exposure to the antiandrogenic fungicide, vinclozolin, delays puberty, inhibits the development of androgen-dependent tissues, and alters androgen receptor function in the male rat., Toxicol Ind Health, 15, 65, 10.1177/074823379901500107
Newbold, 1998, Increased tumors but uncompromised fertility in the female descendants of mice exposed developmentally to diethylstilbestrol., Carcinogenesis, 19, 1655, 10.1093/carcin/19.9.1655
Kadlubar, 2003, The CYP3A4*1B variant is related to the onset of puberty, a known risk factor for the development of breast cancer., Cancer Epidemiol Biomarkers Prev, 12, 327
Rivas, 2002, Induction of reproductive tract developmental abnormalities in the male rat by lowering androgen production or action in combination with a low dose of diethylstilbestrol: evidence for importance of the androgen-estrogen balance., Endocrinology, 143, 4797, 10.1210/en.2002-220531
Ceccarelli, 2007, Estrogenic chemicals at puberty change ERα in the hypothalamus of male and female rats., Neurotoxicol Teratol, 29, 108, 10.1016/j.ntt.2006.10.011
Atanassova, 2001, Age-, cell- and region- specific immunoexpression of estrogen receptor α (but not estrogen receptor β) during postnatal development of the epididymis and vas deferens of the rat and disruption of this pattern by neonatal treatment with diethylstilbestrol., Endocrinology, 142, 874, 10.1210/endo.142.2.7978
Khurana, 2000, Exposure of newborn male and female rats to environmental estrogens: delayed and sustained hyperprolactinemia and alterations in estrogen receptor expression., Endocrinology, 141, 4512, 10.1210/endo.141.12.7823
Kester, 2002, Potent inhibition of estrogen sulfotransferase by hydroxylated metabolites of polyhalogenated aromatic hydrocarbons reveals alternative mechanism for estrogenic activity of endocrine disrupters., J Clin Endocrinol Metab, 87, 1142, 10.1210/jcem.87.3.8311
Waring, 2005, Endocrine disrupters: a human risk?, Mol Cell Endocrinol, 244, 2, 10.1016/j.mce.2005.02.007
Odum, 2004, Cumulative dietary energy intake determines the onset of puberty in female rats., Environ Health Perspect, 112, 1472, 10.1289/ehp.7039
Kortenkamp, 2008, Low dose mixture effects of endocrine disrupters: implications for risk assessment and epidemiology., Int J Androl, 31, 233, 10.1111/j.1365-2605.2007.00862.x
Woodruff, 2008, Proceedings of the Summit on Environmental Challenges to Reproductive Health and Fertility: Executive Summary., Fertil Steril, 89, 281, 10.1016/j.fertnstert.2007.10.002
Woodruff, 2008, Fetal and early postnatal environmental exposures and reproductive health effects in the female, Fertil Steril, 89, e47, 10.1016/j.fertnstert.2007.12.029
Caserta, 2008, Impact of endocrine disruptor chemicals in gynaecology., Hum Reprod Update, 14, 59, 10.1093/humupd/dmm025
Crain, 2008, Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing., Fertil Steril, 90, 911, 10.1016/j.fertnstert.2008.08.067
Foster, 2008, Environmental contaminants and human infertility: hypothesis or cause for concern., J Toxicol Environ Health B Crit Rev, 11, 162, 10.1080/10937400701873274
Mendola, 2008, Science linking environmental contaminant exposures with fertility and reproductive health impacts in the adult female, Fertil Steril, 89, e81, 10.1016/j.fertnstert.2007.12.036
2003, consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)., Hum Reprod, 19, 41
Azziz, 2006, Position statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome. An Androgen Excess Society guideline., J Clin Endocrinol Metab, 91, 4237, 10.1210/jc.2006-0178
Legro, 2006, A twenty-first century research agenda for polycystic ovary syndrome., Best Pract Res Clin Endocrinol Metab, 20, 331, 10.1016/j.beem.2006.03.001
Franks, 2000, Follicular dynamics in the polycystic ovary syndrome., Mol Cell Endocrinol, 163, 49, 10.1016/S0303-7207(99)00239-7
Yildiz, 2008, Impact of obesity on the risk for polycystic ovary syndrome., J Clin Endocrinol Metab, 93, 162, 10.1210/jc.2007-1834
Dumesic, 2007, Polycystic ovary syndrome and its developmental origins., Rev Endocr Metab Disord, 8, 127, 10.1007/s11154-007-9046-0
Abbott, 2005, Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome?, Hum Reprod Update, 11, 357, 10.1093/humupd/dmi013
West, 2001, Intra-follicular activin availability is altered in prenatally-androgenized lambs, Mol Cell Endocrinol, 185, 51, 10.1016/S0303-7207(01)00632-3
Chen, 2008, Triclocarban enhances testosterone action: a new type of endocrine disruptor?, Endocrinology, 149, 1173, 10.1210/en.2007-1057
Diamanti-Kandarakis, 2005, Genetics of polycystic ovary syndrome: searching for the way out of the labyrinth., Hum Reprod Update, 11, 631, 10.1093/humupd/dmi025
Azziz, 2004, The prevalence and features of the polycystic ovary syndrome in an unselected population., J Clin Endocrinol Metab, 89, 2745, 10.1210/jc.2003-032046
Diamanti-Kandarakis, 1999, A survey of the polycystic ovary syndrome in the Greek island of Lesbos: hormonal and metabolic profile., J Clin Endocrinol Metab, 84, 4006, 10.1210/jcem.84.11.6148
Asunción, 2000, A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain., J Clin Endocrinol Metab, 85, 2434
Azziz, 2005, Health care-related economic burden of the polycystic ovary syndrome during the reproductive life span., J Clin Endocrinol Metab, 90, 4650, 10.1210/jc.2005-0628
Takeuchi, 2004, Positive relationship between androgen and the endocrine disruptor, bisphenol A, in normal women and women with ovarian dysfunction., Endocr J, 51, 165, 10.1507/endocrj.51.165
Takeuchi, 2006, Elevated serum bisphenol A levels under hyperandrogenic conditions may be caused by decreased UDP-glucuronsyltransferase activity., Endocr J, 53, 485, 10.1507/endocrj.K06-032
Ikezuki, 2002, Determination of bisphenol A concentrations in human biological fluids reveals significant early prenatal exposure., Hum Reprod, 17, 2839, 10.1093/humrep/17.11.2839
McNatty, 2006, perspective., Soc Reprod Fertil Suppl, 64, 55
Kaipia, 1997, Regulation of ovarian follicle atresia., Annu Rev Physiol, 59, 349, 10.1146/annurev.physiol.59.1.349
Reddy, 2008, Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool., Science, 319, 611, 10.1126/science.1152257
Hunt, 2003, Bisphenol A exposure causes meiotic aneuploidy in the female mouse., Curr Biol, 13, 546, 10.1016/S0960-9822(03)00189-1
Susiarjo, 2007, Bisphenol A exposure in utero disrupts early oogenesis in the mouse, PLoS Genet, 3, e5, 10.1371/journal.pgen.0030005
McLachlan, 1982, Reduced fertility in female mice exposed transplacentally to diethylstilbestrol (DES)., Fertil Steril, 38, 364, 10.1016/S0015-0282(16)46520-9
Hatch, 2006, Age at natural menopause in women exposed to diethylstilbestrol in utero., Am J Epidemiol, 164, 682, 10.1093/aje/kwj257
Sharara, 1998, Environmental toxicants and female reproduction., Fertil Steril, 70, 613, 10.1016/S0015-0282(98)00253-2
Genuis, 2006, Health issues and the environment—an emerging paradigm for providers of obstetrical and gynaecological health care., Hum Reprod, 21, 2201, 10.1093/humrep/del181
Shi, 2007, Ovarian endocrine disruption underlies premature reproductive senescence following environmentally relevant chronic exposure to the aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin., Biol Reprod, 76, 198, 10.1095/biolreprod.106.053991
Chandra, 2002, National Survey of Family Growth., Vital Health Stat, 23, 1
Kwintkiewicz, 2009, The interplay of insulin-like growth factors, gonadotropins, and endocrine disruptors in ovarian follicular development and function., Semin Reprod Med, 27, 43, 10.1055/s-0028-1108009
Minegishi, 2003, Effect of IGF-1 and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the expression of LH receptors during cell differentiation in cultured granulosa cells., Mol Cell Endocrinol, 202, 123, 10.1016/S0303-7207(03)00073-X
Holloway, 2007, Influence of dichlorodiphenylchloroethylene on vascular endothelial growth factor and insulin-like growth factor in human and rat ovarian cells., Reprod Toxicol, 24, 359, 10.1016/j.reprotox.2007.05.003
Kwintkiewicz
Kwintkiewicz
Swan, 2000, Intrauterine exposure to diethylstilbestrol: long-term effects in humans., APMIS, 108, 793, 10.1111/j.1600-0463.2000.tb00001.x
Jefferies, 1984, Structural anomalies of the cervix and vagina in women enrolled in the Diethylstilbestrol Adenosis (DESAD) Project., Am J Obstet Gynecol, 148, 59, 10.1016/S0002-9378(84)80033-2
Johnson, 1979, Vaginal adenosis in stillborns and neonates exposed to diethylstilbestrol and steroidal estrogens and progestins., Obstet Gynecol, 53, 671
Couse, 2001, Estrogen receptor-α knockout mice exhibit resistance to the developmental effects of neonatal diethylstilbestrol exposure on the female reproductive tract., Dev Biol, 238, 224, 10.1006/dbio.2001.0413
Ma, 1998, Abdominal B (AbdB) Hoxa genes: regulation in adult uterus by estrogen and progesterone and repression in müllerian duct by the synthetic estrogen diethylstilbestrol (DES)., Dev Biol, 197, 141, 10.1006/dbio.1998.8907
Block, 2000, In utero diethylstilbestrol (DES) exposure alters Hox gene expression in the developing müllerian system., FASEB J, 14, 1101, 10.1096/fasebj.14.9.1101
Schrager, 2004, Diethylstilbestrol exposure., Am Fam Physician, 69, 2395
Buttram Jr, 1981, Uterine leiomyomata: etiology, symptomatology, and management., Fertil Steril, 36, 433, 10.1016/S0015-0282(16)45789-4
2007
Wise, 2005, Risk of benign gynecologic tumors in relation to prenatal diethylstilbestrol exposure., Obstet Gynecol, 105, 167, 10.1097/01.AOG.0000147839.74848.7c
Baird, 2005, Prenatal diethylstilbestrol (DES) exposure is associated with uterine leiomyoma development., Reprod Toxicol, 20, 81, 10.1016/j.reprotox.2005.01.002
Newbold, 2002, Characterization of uterine leiomyomas in CD-1 mice following developmental exposure to diethylstilbestrol (DES)., Toxicol Pathol, 30, 611, 10.1080/01926230290105839
Everitt, 1995, Rodent model of reproductive tract leiomyomata. Clinical and pathological features., Am J Pathol, 146, 1556
Cook, 2007, Identification of a sensitive period for developmental programming that increases risk for uterine leiomyoma in Eker rats., Reprod Sci, 14, 121, 10.1177/1933719106298401
Cook, 2005, Interaction between genetic susceptibility and early-life environmental exposure determines tumor-suppressor-gene penetrance, Proc Natl Acad Sci USA, 102, 8644, 10.1073/pnas.0503218102
Bäcklin, 2003, Histology of uterine leiomyoma and occurrence in relation to reproductive activity in the Baltic gray seal (Halichoerus grypus)., Vet Pathol, 40, 175, 10.1354/vp.40-2-175
Simoens, 2007, Endometriosis: cost estimates and methodological perspective., Hum Reprod Update, 13, 395, 10.1093/humupd/dmm010
Missmer, 2004, In utero exposures and the incidence of endometriosis., Fertil Steril, 82, 1501, 10.1016/j.fertnstert.2004.04.065
Rier, 1993, Endometriosis in rhesus monkeys (Macaca mulatta) following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin., Fundam Appl Toxicol, 21, 433, 10.1006/faat.1993.1119
Rier, 2001, Serum levels of TCDD and dioxin-like chemicals in Rhesus monkeys chronically exposed to dioxin: correlation of increased serum PCB levels with endometriosis., Toxicol Sci, 59, 147, 10.1093/toxsci/59.1.147
Guo, 2004, The link between exposure to dioxin and endometriosis: a critical reappraisal of primate data., Gynecol Obstet Invest, 57, 157, 10.1159/000076374
Yang, 2000, Subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin modulates the pathophysiology of endometriosis in the cynomolgus monkey., Toxicol Sci, 56, 374, 10.1093/toxsci/56.2.374
Cummings, 1996, Promotion of endometriosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats and mice: time-dose dependence and species comparison., Toxicol Appl Pharmacol, 138, 131, 10.1006/taap.1996.0106
Nayyar, 2007, Developmental exposure of mice to TCDD elicits a similar uterine phenotype in adult animals as observed in women with endometriosis., Reprod Toxicol, 23, 326, 10.1016/j.reprotox.2006.09.007
Cobellis, 2003, High plasma concentrations of di-(2-ethylhexyl)-phthalate in women with endometriosis., Hum Reprod, 18, 1512, 10.1093/humrep/deg254
Reddy, 2006, Association of phthalate esters with endometriosis in Indian women., BJOG, 113, 515, 10.1111/j.1471-0528.2006.00925.x
Burney, 2008, 253
Davis, 1993, Medical hypothesis: xenoestrogens as preventable causes of breast cancer., Environ Health Perspect, 101, 372, 10.1289/ehp.93101372
Sharpe, 1993, Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?, Lancet, 341, 1392, 10.1016/0140-6736(93)90953-E
Williams, 1990, Short term increase in risk of breast cancer associated with full term pregnancy., BMJ, 300, 578, 10.1136/bmj.300.6724.578
Lambe, 1996, Parity, age at first and last birth, and risk of breast cancer: a population-based study in Sweden., Breast Cancer Res Treat, 38, 305, 10.1007/BF01806150
Trichopoulos, 1990, Is breast cancer initiated in utero?, Epidemiology, 1, 95, 10.1097/00001648-199003000-00001
Ho, 2006, Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4., Cancer Res, 66, 5624, 10.1158/0008-5472.CAN-06-0516
Sonnenschein, 1999
Sonnenschein, 2008, Theories of carcinogenesis: an emerging perspective., Semin Cancer Biol, 18, 372, 10.1016/j.semcancer.2008.03.012
Soto, 2004, The somatic mutation theory of cancer: growing problems with the paradigm?, Bioessays, 26, 1097, 10.1002/bies.20087
Maffini, 2005, Stromal regulation of neoplastic development: age-dependent normalization of neoplastic mammary cells by mammary stroma., Am J Pathol, 167, 1405, 10.1016/S0002-9440(10)61227-8
Markey, 2002, Endocrine disruptors: from wingspread to environmental developmental biology., J Steroid Biochem Mol Biol, 83, 235, 10.1016/S0960-0760(02)00272-8
Vandenberg, 2007, Exposure to environmentally relevant doses of the xenoestrogen bisphenol-A alters development of the fetal mouse mammary gland., Endocrinology, 148, 116, 10.1210/en.2006-0561
Høyer, 1998, Organochlorine exposure and risk of breast cancer., Lancet, 352, 1816, 10.1016/S0140-6736(98)04504-8
Cohn, 2007, DDT and breast cancer in young women: new data on the significance of age at exposure., Environ Health Perspect, 115, 1406, 10.1289/ehp.10260
Ibarluzea Jm, 2004, Breast cancer risk and the combined effect of environmental estrogens, Cancer Causes Control, 15, 591, 10.1023/B:CACO.0000036167.51236.86
Meyer, 1977, Cell proliferation in normal human breast ducts, fibroadenomas, and other ductal hyperplasias measured by nuclear labeling with tritiated thymidine. Effects of menstrual phase, age, and oral contraceptive hormones., Hum Pathol, 8, 67, 10.1016/S0046-8177(77)80066-X
Maffini, 2004, Rat mammary gland chemical carcinogenesis: the stroma as a crucial target., J Cell Sci, 117, 1495, 10.1242/jcs.01000
Palmer, 2002, Risk of breast cancer in women exposed to diethylstilbestrol in utero: preliminary results (United States)., Cancer Causes Control, 13, 753, 10.1023/A:1020254711222
Palmer, 2006, Prenatal diethylstilbestrol exposure and risk of breast cancer., Cancer Epidemiol Biomarkers Prev, 15, 1509, 10.1158/1055-9965.EPI-06-0109
Boylan, 1979, Mammary tumorigenesis in the rat following prenatal exposure to diethylstilbestrol and postnatal treatment with 7,12-dimethylbenz[a]anthracene., J Toxicol Environ Health, 5, 1059, 10.1080/15287397909529814
Rothschild, 1987, Transplacental effects of diethylstilbestrol on mammary development and tumorigenesis in female ACI rats., Cancer Res, 47, 4508
Halakivi-Clarke, 2000, Maternal exposure to tamoxifen during pregnancy increases carcinogen-induced mammary tumorigenesis among female rat offspring., Clin Cancer Res, 6, 305
Ohtake, 2003, Modulation of oestrogen receptor signalling by association with the activated dioxin receptor., Nature, 423, 545, 10.1038/nature01606
Brown, 1998, Prenatal TCDD and predisposition to mammary cancer in the rat., Carcinogenesis, 19, 1623, 10.1093/carcin/19.9.1623
Vandenberg, 2007, Human exposure to bisphenol A (BPA)., Reprod Toxicol, 24, 139, 10.1016/j.reprotox.2007.07.010
Calafat, 2008, Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003–2004., Environ Health Perspect, 116, 39, 10.1289/ehp.10753
Richter, 2007, In vivo effects of bisphenol A in laboratory rodent studies., Reprod Toxicol, 24, 199, 10.1016/j.reprotox.2007.06.004
Zalko, 2003, Biotransformations of bisphenol A in a mammalian model: answers and new questions raised by low-dose metabolic fate studies in pregnant CD1 mice., Environ Health Perspect, 111, 309, 10.1289/ehp.5603
Muñoz-de-Toro, 2005, Perinatal exposure to bisphenol-A alters peripubertal mammary gland development in mice., Endocrinology, 146, 4138, 10.1210/en.2005-0340
Markey, 2001, In utero exposure to bisphenol A alters the development and tissue organization of the mouse mammary gland., Biol Reprod, 65, 1215, 10.1093/biolreprod/65.4.1215
Vandenberg, 2008, Perinatal exposure to the xenoestrogen bisphenol-A induces mammary intraductal hyperplasias in adult CD-1 mice., Reprod Toxicol, 26, 210, 10.1016/j.reprotox.2008.09.015
Murray, 2007, Induction of mammary gland ductal hyperplasia and carcinoma in situ following fetal bisphenol A exposure., Reprod Toxicol, 23, 383, 10.1016/j.reprotox.2006.10.002
Durando, 2007, Prenatal bisphenol A exposure induces preneoplastic lesions in the mammary gland in Wistar rats., Environ Health Perspect, 115, 80, 10.1289/ehp.9282
Jenkins, 7 2009
Słowikowska-Hilczer, 2001, Testicular pathology in 46,XY dysgenetic male pseudohermaphroditism: an approach to pathogenesis of testis cancer., J Androl, 22, 781, 10.1002/j.1939-4640.2001.tb02581.x
Carlsen, 1992, Evidence for decreasing quality of semen during past 50 years., BMJ, 305, 609, 10.1136/bmj.305.6854.609
Auger, 1995, Decline in semen quality among fertile men in Paris during the past 20 years., N Engl J Med, 332, 281, 10.1056/NEJM199502023320501
Swan, 1997, Have sperm densities declined? A reanalysis of global trend data., Environ Health Perspect, 105, 1228, 10.1289/ehp.971051228
Fisch, 1996, Semen analyses in 1,283 men from the United States over a 25-year period: no decline in quality., Fertil Steril, 65, 1009, 10.1016/S0015-0282(16)58278-8
Paulsen, 1996, Data from men in greater Seattle area reveals no downward trend in semen quality: further evidence that deterioration of semen quality is not geographically uniform., Fertil Steril, 65, 1015, 10.1016/S0015-0282(16)58279-X
David, 2001, 635
Adibi, 2003, Prenatal exposures to phthalates among women in New York City and Krakow, Poland., Environ Health Perspect, 111, 1719, 10.1289/ehp.6235
Rudel, 2003, Phthalates, alkylphenols, pesticides, polybrominated diphenyl ethers, and other endocrine-disrupting compounds in indoor air and dust., Environ Sci Technol, 37, 4543, 10.1021/es0264596
Green, 2005, Use of di(2-ethylhexyl) phthalate-containing medical products and urinary levels of mono(2-ethylhexyl) phthalate in neonatal intensive care unit infants., Environ Health Perspect, 113, 1222, 10.1289/ehp.7932
Duty, 2003, Phthalate exposure and human semen parameters., Epidemiology, 14, 269, 10.1097/01.EDE.0000059950.11836.16
Hauser, 2006, Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolites., Epidemiology, 17, 682, 10.1097/01.ede.0000235996.89953.d7
Jönsson, 2005, Urinary phthalate metabolites and biomarkers of reproductive function in young men., Epidemiology, 16, 487, 10.1097/01.ede.0000164555.19041.01
Longnecker, 1997, The human health effects of DDT (dichlorodiphenyltrichloroethane) and PCBS (polychlorinated biphenyls) and an overview of organochlorines in public health., Annu Rev Public Health, 18, 211, 10.1146/annurev.publhealth.18.1.211
Brown, 1994, Determination of PCB metabolic, excretion, and accumulation rates for use as indicators of biological response and relative risk., Environ Sci Technol, 28, 2295, 10.1021/es00062a013
Phillips, 1989, Half-life of polychlorinated biphenyls in occupationally exposed workers., Arch Environ Health, 44, 351, 10.1080/00039896.1989.9935905
Kato, 1998, Reduction of thyroid hormone levels by methylsulfonyl metabolites of polychlorinated biphenyl congeners in rats., Arch Toxicol, 72, 541, 10.1007/s002040050540
Hansen, 1998, Stepping backward to improve assessment of PCB congener toxicities., Environ Health Perspect, 106(Suppl 1), 171
Dallinga, 2002, Decreased human semen quality and organochlorine compounds in blood., Hum Reprod, 17, 1973, 10.1093/humrep/17.8.1973
Richthoff, 2003, Serum levels of 2,2′,4,4′,5,5′-hexachlorobiphenyl (CB-153) in relation to markers of reproductive function in young males from the general Swedish population., Environ Health Perspect, 111, 409, 10.1289/ehp.5767
Hauser, 2003, The relationship between human semen parameters and environmental exposure to polychlorinated biphenyls and p,p’-DDE., Environ Health Perspect, 111, 1505, 10.1289/ehp.6175
Rignell-Hydbom, 2004, Exposure to CB-153 and p,p’-DDE and male reproductive function., Hum Reprod, 19, 2066, 10.1093/humrep/deh362
Guo, 2000, Semen quality after prenatal exposure to polychlorinated biphenyls and dibenzofurans., Lancet, 356, 1240, 10.1016/S0140-6736(00)02792-6
Hsu, 2003, Sperm changes in men exposed to polychlorinated biphenyls and dibenzofurans., JAMA, 289, 2943, 10.1001/jama.289.22.2943
Mocarelli, 2008, Dioxin exposure, from infancy through puberty, produces endocrine disruption and affects human semen quality., Environ Health Perspect, 116, 70, 10.1289/ehp.10399
Abell, 2000, Semen quality and sexual hormones in greenhouse workers., Scand J Work Environ Health, 26, 492, 10.5271/sjweh.573
Juhler, 1999, Human semen quality in relation to dietary pesticide exposure and organic diet., Arch Environ Contam Toxicol, 37, 415, 10.1007/s002449900533
Oliva, 2001, Contribution of environmental factors to the risk of male infertility., Hum Reprod, 16, 1768, 10.1093/humrep/16.8.1768
Larsen, 1998, A longitudinal study of semen quality in pesticide spraying Danish farmers. The ASCLEPIOS Study Group., Reprod Toxicol, 12, 581, 10.1016/S0890-6238(98)00047-1
Padungtod, 2000, Occupational pesticide exposure and semen quality among Chinese workers., J Occup Environ Med, 42, 982, 10.1097/00043764-200010000-00004
Kamijima, 2004, A survey of semen indices in insecticide sprayers., J Occup Health, 46, 109, 10.1539/joh.46.109
Lifeng, 2006, Effects of fenvalerate exposure on semen quality among occupational workers., Contraception, 73, 92, 10.1016/j.contraception.2005.06.067
Whorton, 1979, Testicular function among carbaryl-exposed exployees., J Toxicol Environ Health, 5, 929, 10.1080/15287397909529802
Wyrobek, 1981, Sperm shape abnormalities in carbaryl-exposed employees., Environ Health Perspect, 40, 255, 10.1289/ehp.8140255
Tan, 2005, [Effects of carbaryl production exposure on the sperm and semen quality of occupational male workers]., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, 23, 87
Swan, 2003, Semen quality in relation to biomarkers of pesticide exposure., Environ Health Perspect, 111, 1478, 10.1289/ehp.6417
Meeker, 2004, The relationship of urinary metabolites of carbaryl/naphthalene and chlorpyrifos with human semen quality., Environ Health Perspect, 112, 1665, 10.1289/ehp.7234
Boisen, 2004, Difference in prevalence of congenital cryptorchidism in infants between two Nordic countries., Lancet, 363, 1264, 10.1016/S0140-6736(04)15998-9
Paulozzi, 1999, International trends in rates of hypospadias and cryptorchidism, Environ Health Perspect, 107, 297, 10.1289/ehp.99107297
Thonneau, 2003, Cryptorchidism: incidence, risk factors, and potential role of environment; an update., J Androl, 24, 155, 10.1002/j.1939-4640.2003.tb02654.x
Barthold, 2003, The epidemiology of congenital cryptorchidism, testicular ascent and orchidopexy., J Urol, 170, 2396, 10.1097/01.ju.0000095793.04232.d8
Dolk, 2004, Toward the effective surveillance of hypospadias., Environ Health Perspect, 112, 398, 10.1289/ehp.6398
Aho, 2000, Is the incidence of hypospadias increasing? Analysis of Finnish hospital discharge data 1970–1994., Environ Health Perspect, 108, 463, 10.1289/ehp.00108463
Martínez-Frías, 2004, Secular decreasing trend of the frequency of hypospadias among newborn male infants in Spain., Birth Defects Res A Clin Mol Teratol, 70, 75, 10.1002/bdra.10149
Longnecker, 2002, Maternal serum level of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene and risk of cryptorchidism, hypospadias, and polythelia among male offspring., Am J Epidemiol, 155, 313, 10.1093/aje/155.4.313
Bhatia, 2005, Organochlorine pesticides and male genital anomalies in the child health and development studies., Environ Health Perspect, 113, 220, 10.1289/ehp.7382
Mol, 2002, Spermaturia and serum hormone concentrations at the age of puberty in boys prenatally exposed to polychlorinated biphenyls., Eur J Endocrinol, 146, 357, 10.1530/eje.0.1460357
Hosie, 2000, Is there a correlation between organochlorine compounds and undescended testes?, Eur J Pediatr Surg, 10, 304, 10.1055/s-2008-1072381
Garry, 1996, Pesticide appliers, biocides and birth defects in rural Minnesota., Environ Health Perspect, 104, 394, 10.1289/ehp.96104394
García-Rodríguez, 1996, Exposure to pesticides and cryptorchidism: geographical evidence of a possible association., Environ Health Perspect, 104, 1090
Kristensen, 1997, Birth defects among offspring of Norwegian farmers, 1967–1991., Epidemiology, 8, 537, 10.1097/00001648-199709000-00011
Weidner, 1998, Cryptorchidism and hypospadias in sons of gardeners and farmers., Environ Health Perspect, 106, 793, 10.1289/ehp.98106793
Pierik, 2004, Maternal and paternal risk factors for cryptorchidism and hypospadias: a case-control study in newborn boys., Environ Health Perspect, 112, 1570, 10.1289/ehp.7243
Carbone, 2006, Cryptorchidism and hypospadias in the Sicilian district of Ragusa and the use of pesticides., Reprod Toxicol, 22, 8, 10.1016/j.reprotox.2006.01.006
Diamanti-Kandarakis, 2008, Increased serum advanced glycation end-products is a distinct finding in lean women with polycystic ovary syndrome (PCOS)., Clin Endocrinol (Oxf), 69, 634, 10.1111/j.1365-2265.2008.03247.x
Adami, 1994, Testicular cancer in nine northern European countries., Int J Cancer, 59, 33, 10.1002/ijc.2910590108
Huyghe, 2003, Increasing incidence of testicular cancer worldwide: a review., J Urol, 170, 5, 10.1097/01.ju.0000053866.68623.da
Richiardi, 2004, Testicular cancer incidence in eight northern European countries: secular and recent trends., Cancer Epidemiol Biomarkers Prev, 13, 2157, 10.1158/1055-9965.2157.13.12
McGlynn, 2003, Trends in the incidence of testicular germ cell tumors in the United States., Cancer, 97, 63, 10.1002/cncr.11054
Hemminki, 2002, Cancer risks in Nordic immigrants and their offspring in Sweden., Eur J Cancer, 38, 2428, 10.1016/S0959-8049(02)00496-3
Henderson, 1979, Risk factors for cancer of the testis in young men., Int J Cancer, 23, 598, 10.1002/ijc.2910230503
Weir, 2000, Pre-natal and peri-natal exposures and risk of testicular germ-cell cancer., Int J Cancer, 87, 438, 10.1002/1097-0215(20000801)87:3<438::AID-IJC20>3.0.CO;2-1
Hardell, 2003, Increased concentrations of polychlorinated biphenyls, hexachlorobenzene, and chlordanes in mothers of men with testicular cancer., Environ Health Perspect, 111, 930, 10.1289/ehp.5816
Hardell, 2006, In utero exposure to persistent organic pollutants in relation to testicular cancer risk., Int J Androl, 29, 228, 10.1111/j.1365-2605.2005.00622.x
Moore, 1947
Huggins, 1941, Studies on prostatic cancer. I. The effect of castration, of estrogen, and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate., Cancer Res, 1, 293
Leav, 1988, Biochemical alterations in sex hormone-induced hyperplasia and dysplasia of the dorsolateral prostates of Noble rats., J Natl Cancer Inst, 80, 1045, 10.1093/jnci/80.13.1045
Thomas, 1994, Effects of estrogens on the prostate., J Androl, 15, 97, 10.1002/j.1939-4640.1994.tb00409.x
Modugno, 2001, Allelic variants of aromatase and the androgen and estrogen receptors: toward a multigenic model of prostate cancer risk., Clin Cancer Res, 7, 3092
Raghow, 2002, Toremifene prevents prostate cancer in the transgenic adenocarcinoma of mouse prostate model., Cancer Res, 62, 1370
Steiner, 2003, Phase IIA clinical trial to test the efficacy and safety of toremifene in men with high-grade prostatic intraepithelial neoplasia., Clin Prostate Cancer, 2, 24, 10.3816/CGC.2003.n.009
Prins, 2008, The role of estrogens and estrogen receptors in normal prostate growth and disease., Steroids, 73, 233, 10.1016/j.steroids.2007.10.013
Henderson, 1988, The early in utero oestrogen and testosterone environment of blacks and whites: potential effects on male offspring., Br J Cancer, 57, 216, 10.1038/bjc.1988.46
Henderson, 1991, Toward the primary prevention of cancer., Science, 254, 1131, 10.1126/science.1957166
Prins, 2007, Developmental estrogen exposures predispose to prostate carcinogenesis with aging., Reprod Toxicol, 23, 374, 10.1016/j.reprotox.2006.10.001
Morrison, 1993, Farming and prostate cancer mortality., Am J Epidemiol, 137, 270, 10.1093/oxfordjournals.aje.a116674
Meyer, 2007, A case-control study of farming and prostate cancer in African-American and Caucasian men., Occup Environ Med, 64, 155, 10.1136/oem.2006.027383
Alavanja, 2003, Use of agricultural pesticides and prostate cancer risk in the Agricultural Health Study cohort., Am J Epidemiol, 157, 800, 10.1093/aje/kwg040
Van Maele-Fabry, 2006, Review and meta-analysis of risk estimates for prostate cancer in pesticide manufacturing workers., Cancer Causes Control, 17, 353, 10.1007/s10552-005-0443-y
Mahajan, 2006, Phorate exposure and incidence of cancer in the agricultural health study, Environ Health Perspect, 114, 1205, 10.1289/ehp.8911
Usmani, 2003, Inhibition and activation of the human liver microsomal and human cytochrome P450 3A4 metabolism of testosterone by deployment-related chemicals., Drug Metab Dispos, 31, 384, 10.1124/dmd.31.4.384
Usmani, 2006, Inhibition of the human liver microsomal and human cytochrome P450 1A2 and 3A4 metabolism of estradiol by deployment-related and other chemicals., Drug Metab Dispos, 34, 1606, 10.1124/dmd.106.010439
Kester, 2000, Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs., Endocrinology, 141, 1897, 10.1210/endo.141.5.7530
Noble, 1977, The development of prostatic adenocarcinoma in Nb rats following prolonged sex hormone administration., Cancer Res, 37, 1929
Driscoll, 1980, Effects of prenatal maternal estrogen on the male urogenital system., Obstet Gynecol, 56, 537
Yonemura, 1995, Temporal and spatial factors in diethylstilbestrol-induced squamous metaplasia in the developing human prostate. II. Persistent changes after removal of diethylstilbestrol., Acta Anat (Basel), 153, 1, 10.1159/000147709
Giusti, 1995, Diethylstilbestrol revisited: a review of the long-term health effects., Ann Intern Med, 122, 778, 10.7326/0003-4819-122-10-199505150-00008
Arai, 1983, Long-term effects of perinatal exposure to sex steroids and diethylstilbestrol on the reproductive system of male mammals., Int Rev Cytol, 84, 235, 10.1016/S0074-7696(08)61019-0
Rajfer, 1978, Sex steroid imprinting of the immature prostate. Long-term effects., Invest Urol, 16, 186
Prins, 2001, Influence of neonatal estrogens on rat prostate development., Reprod Fertil Dev, 13, 241, 10.1071/RD00107
Huang, 2004, Estrogenic regulation of signaling pathways and homeobox genes during rat prostate development., J Androl, 25, 330, 10.1002/j.1939-4640.2004.tb02796.x
Gupta, 2000, The role of estrogen receptor, androgen receptor and growth factors in diethylstilbestrol-induced programming of prostate differentiation., Urol Res, 28, 223, 10.1007/s002400000107
Lemmen, 2004, In vivo imaging of activated estrogen receptors in utero by estrogens and bisphenol A., Environ Health Perspect, 112, 1544, 10.1289/ehp.7155
Kurosawa, 2002, The activity of bisphenol A depends on both the estrogen receptor subtype and the cell type., Endocr J, 49, 465, 10.1507/endocrj.49.465
Song, 2002, Endocrine disruptor bisphenol A induces orphan nuclear receptor Nur77 gene expression and steroidogenesis in mouse testicular Leydig cells., Endocrinology, 143, 2208, 10.1210/endo.143.6.8847
Walsh, 2005, Estrogen receptor independent rapid non-genomic effects of environmental estrogens on [Ca2+]i in human breast cancer cells., Mol Cell Endocrinol, 230, 23, 10.1016/j.mce.2004.11.006
Keri, 2007, An evaluation of evidence for the carcinogenic activity of bisphenol A., Reprod Toxicol, 24, 240, 10.1016/j.reprotox.2007.06.008
Wetherill, 2005, Xenoestrogen action in prostate cancer: pleiotropic effects dependent on androgen receptor status., Cancer Res, 65, 54, 10.1158/0008-5472.54.65.1
Wetherill, 2006, Bisphenol A facilitates bypass of androgen ablation therapy in prostate cancer., Mol Cancer Ther, 5, 3181, 10.1158/1535-7163.MCT-06-0272
Prins, 2008, Perinatal exposure to oestradiol and bisphenol A alters the prostate epigenome and increases susceptibility to carcinogenesis., Basic Clin Pharmacol Toxicol, 102, 134, 10.1111/j.1742-7843.2007.00166.x
Hardell, 2006, Adipose tissue concentrations of persistent organic pollutants and the risk of prostate cancer., J Occup Environ Med, 48, 700, 10.1097/01.jom.0000205989.46603.43
Prince, 2006, Mortality and exposure response among 14,458 electrical capacitor manufacturing workers exposed to polychlorinated biphenyls (PCBs)., Environ Health Perspect, 114, 1508, 10.1289/ehp.9175
Ritchie, 2003, Organochlorines and risk of prostate cancer., J Occup Environ Med, 45, 692, 10.1097/01.jom.0000071510.96740.0b
Charles, 2003, Electromagnetic fields, polychlorinated biphenyls, and prostate cancer mortality in electric utility workers., Am J Epidemiol, 157, 683, 10.1093/aje/kwg044
Schlumpf, 2004, Endocrine activity and developmental toxicity of cosmetic UV filters–an update., Toxicology, 205, 113, 10.1016/j.tox.2004.06.043
Schlumpf, 2004, Estrogenic activity and estrogen receptor β binding of the UV filter 3-benzylidene camphor. Comparison with 4-methylbenzylidene camphor., Toxicology, 199, 109, 10.1016/j.tox.2004.02.015
Hofkamp, 2008, Region-specific growth effects in the developing rat prostate following fetal exposure to estrogenic ultraviolet filters., Environ Health Perspect, 116, 867, 10.1289/ehp.10983
Parent, 2001, Occupation and prostate cancer., Epidemiol Rev, 23, 138, 10.1093/oxfordjournals.epirev.a000779
Benbrahim-Tallaa, 2007, Estrogen signaling and disruption of androgen metabolism in acquired androgen-independence during cadmium carcinogenesis in human prostate epithelial cells., Prostate, 67, 135, 10.1002/pros.20479
Waalkes, 2000, Cadmium carcinogenesis in review., J Inorg Biochem, 79, 241, 10.1016/S0162-0134(00)00009-X
Watson, 2007, Arsenic: extension of its endocrine disruption potential to interference with estrogen receptor-mediated signaling., Toxicol Sci, 98, 1, 10.1093/toxsci/kfm111
Davey, 2007, Arsenic as an endocrine disruptor: effects of arsenic on estrogen receptor-mediated gene expression in vivo and in cell culture., Toxicol Sci, 98, 75, 10.1093/toxsci/kfm013
Benbrahim-Tallaa, 2007, Mechanisms of acquired androgen independence during arsenic-induced malignant transformation of human prostate epithelial cells., Environ Health Perspect, 115, 243, 10.1289/ehp.9630
Lewis, 1999, Drinking water arsenic in Utah: a cohort mortality study., Environ Health Perspect, 107, 359, 10.1289/ehp.99107359
Kavlock, 2005, Mode of action: inhibition of androgen receptor function—vinclozolin-induced malformations in reproductive development., Crit Rev Toxicol, 35, 721, 10.1080/10408440591007377
Yu, 2004, Reproductive disorders in pubertal and adult phase of the male rats exposed to vinclozolin during puberty., J Vet Med Sci, 66, 847, 10.1292/jvms.66.847
Cowin, 2008, Early-onset endocrine disruptor-induced prostatitis in the rat., Environ Health Perspect, 116, 923, 10.1289/ehp.11239
Cocco, 1998, Mortality from cancer of the male reproductive tract and environmental exposure to the anti-androgen p,p’-dichlorodiphenyldichloroethylene in the United States., Oncology, 55, 334, 10.1159/000011872
Gore, 2007
Walker, 2007, 63
Gore, 2008, Neuroendocrine systems as targets for environmental endocrine-disrupting chemicals, Fertil Steril, 89, e101, 10.1016/j.fertnstert.2007.12.039
Gore, 2002
Wintermantel, 2006, Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility., Neuron, 52, 271, 10.1016/j.neuron.2006.07.023
Mellon, 1990, Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis., Neuron, 5, 1, 10.1016/0896-6273(90)90028-E
Gore, 2002, A novel mechanism for endocrine-disrupting effects of polychlorinated biphenyls: direct effects on gonadotropin-releasing hormone neurones., J Neuroendocrinol, 14, 814, 10.1046/j.1365-2826.2002.00845.x
Gore, 2002, Organochlorine pesticides directly regulate gonadotropin-releasing hormone gene expression and biosynthesis in the GT1–7 hypothalamic cell line., Mol Cell Endocrinol, 192, 157, 10.1016/S0303-7207(02)00010-2
Cook, 2006, The importance of hormesis to public health., Environ Health Perspect, 114, 1631, 10.1289/ehp.8606
Gore, 2006, Endocrine disruption for endocrinologists (and others), Endocrinology, 147, S1, 10.1210/en.2005-1367
Rasier, 2008, Mechanisms of interaction of endocrine-disrupting chemicals with glutamate-evoked secretion of gonadotropin-releasing hormone., Toxicol Sci, 102, 33, 10.1093/toxsci/kfm285
McGarvey, 2001, Phytoestrogens and gonadotropin-releasing hormone pulse generator activity and pituitary luteinizing hormone release in the rat., Endocrinology, 142, 1202, 10.1210/endo.142.3.8015
Patisaul, 2007, Differential disruption of nuclear volume and neuronal phenotype in the preoptic area by neonatal exposure to genistein and bisphenol-A., Neurotoxicology, 28, 1, 10.1016/j.neuro.2006.10.001
Gore, 2001, Environmental toxicant effects on neuroendocrine function., Endocrine, 14, 235, 10.1385/ENDO:14:2:235
Bisenius, 2006, Sex differences and the development of the rabbit brain: effects of vinclozolin., Biol Reprod, 75, 469, 10.1095/biolreprod.106.052795
Khan, 1254, involves inhibition of hypothalamic tryptophan hydroxylase activity., Biol Reprod, 64, 955, 10.1095/biolreprod64.3.955
Gore, 2008, Developmental programming and endocrine disruptor effects on reproductive neuroendocrinology., Front Neuroendocrinol, 29, 358, 10.1016/j.yfrne.2008.02.002
George, 1978, Conversion of androgen to estrogen by the human fetal ovary., J Clin Endocrinol Metab, 47, 550, 10.1210/jcem-47-3-550
Steinberg, 2007, The effects of prenatal PCBs on adult female paced mating reproductive behaviors in rats., Horm Behav, 51, 364, 10.1016/j.yhbeh.2006.12.004
Chung, 1999, Effects of perinatal exposure to polychlorinated biphenyls on development of female sexual behavior., Bull Environ Contam Toxicol, 62, 664, 10.1007/s001289900925
Chung, 2001, Effects of neonatal polychlorinated biphenyl exposure on female sexual behavior., Physiol Behav, 74, 363, 10.1016/S0031-9384(01)00579-0
Patisaul, 2004, A soy supplement and tamoxifen inhibit sexual behavior in female rats., Horm Behav, 45, 270, 10.1016/j.yhbeh.2003.12.006
Whitten, 1995, Phytoestrogen influences on the development of behavior and gonadotropin function., Proc Soc Exp Biol Med, 208, 82, 10.3181/00379727-208-43836
Kouki, 2005, Suppressive effect of neonatal treatment with a phytoestrogen, coumestrol, on lordosis and estrous cycle in female rats., Brain Res Bull, 64, 449, 10.1016/j.brainresbull.2004.10.002
Crews, 2007, Transgenerational epigenetic imprints on mate preference., Proc Natl Acad Sci USA, 104, 5942, 10.1073/pnas.0610410104
Harvey, 2007, Adrenal toxicology: a strategy for assessment of functional toxicity to the adrenal cortex and steroidogenesis., J Appl Toxicol, 27, 103, 10.1002/jat.1221
Zoeller, 2007, General background on the hypothalamic-pituitary-thyroid (HPT) axis., Crit Rev Toxicol, 37, 11, 10.1080/10408440601123446
Khan, 2003, Ortho-substituted polychlorinated biphenyl (PCB) congeners (95 or 101) decrease pituitary response to thyrotropin releasing hormone., Toxicol Lett, 144, 173, 10.1016/S0378-4274(03)00203-0
Kuriyama, 2007, Developmental exposure to low-dose PBDE-99: tissue distribution and thyroid hormone levels., Toxicology, 242, 80, 10.1016/j.tox.2007.09.011
Sørmo, 2005, Thyroid hormone status in gray seal (Halichoerus grypus) pups from the Baltic Sea and the Atlantic Ocean in relation to organochlorine pollutants., Environ Toxicol Chem, 24, 610, 10.1897/04-017R.1
Newbold, 2006, Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations, Endocrinology, 147, S11, 10.1210/en.2005-1164
Noaksson, 2001, Evidence for endocrine disruption in perch (Perca fluviatilis) and roach (Rutilus rutilus) in a remote Swedish lake in the vicinity of a public refuse dump., Toxicol Appl Pharmacol, 174, 160, 10.1006/taap.2001.9194
Simerly, 1990, Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study., J Comp Neurol, 294, 76, 10.1002/cne.902940107
Quadros, 2002, Sex differences in progesterone receptor expression: a potential mechanism for estradiol-mediated sexual differentiation., Endocrinology, 143, 3727, 10.1210/en.2002-211438
Chakraborty, 2004, Aging-related changes in ovarian hormones, their receptors, and neuroendocrine function., Exp Biol Med (Maywood), 229, 977, 10.1177/153537020422901001
Tokumoto, 2007, Interactions of diethylstilbestrol (DES) and DES analogs with membrane progestin receptor-α and the correlation with their nongenomic progestin activities, Endocrinology, 148, 3459, 10.1210/en.2006-1694
Thomas, 2004, Disruption of rapid, nongenomic steroid actions by environmental chemicals: interference with progestin stimulation of sperm motility in Atlantic croaker., Environ Sci Technol, 38, 6328, 10.1021/es0403662
Watson, 2007, Xenoestrogens are potent activators of nongenomic estrogenic responses., Steroids, 72, 124, 10.1016/j.steroids.2006.11.002
Brucker-Davis, 1998, Effects of environmental synthetic chemicals on thyroid function., Thyroid, 8, 827, 10.1089/thy.1998.8.827
Howdeshell, 2002, A model of the development of the brain as a construct of the thyroid system., Environ Health Perspect, 110(Suppl 3), 337, 10.1289/ehp.02110s3337
Delange, 1989
Gaitan, 1989
Carrasco, 2000, 8, 52
Zimmermann, 2007, The adverse effects of mild-to-moderate iodine deficiency during pregnancy and childhood: a review., Thyroid, 17, 829, 10.1089/thy.2007.0108
2005
Murray, 2008, US Food and Drug Administration’s Total Diet Study: dietary intake of perchlorate and iodine., J Expo Sci Environ Epidemiol, 18, 571, 10.1038/sj.jes.7500648
Blount, 2007, Perchlorate exposure of the US population, 2001–2002., J Expo Sci Environ Epidemiol, 17, 400, 10.1038/sj.jes.7500535
Greer, 2002, Health effects assessment for environmental perchlorate contamination: the dose response for inhibition of thyroidal radioiodine uptake in humans., Environ Health Perspect, 110, 927, 10.1289/ehp.02110927
Blount, 2006, Urinary perchlorate and thyroid hormone levels in adolescent and adult men and women living in the United States., Environ Health Perspect, 114, 1865, 10.1289/ehp.9466
Steinmaus, 2007, Impact of smoking and thiocyanate on perchlorate and thyroid hormone associations in the 2001–2002 national health and nutrition examination survey., Environ Health Perspect, 115, 1333, 10.1289/ehp.10300
Zoeller, 2004, Timing of thyroid hormone action in the developing brain: clinical observations and experimental findings., J Neuroendocrinol, 16, 809, 10.1111/j.1365-2826.2004.01243.x
Pearce, 2007, Breast milk iodine and perchlorate concentrations in lactating Boston-area women., J Clin Endocrinol Metab, 92, 1673, 10.1210/jc.2006-2738
Ginsberg, 2007, Evaluation of the U.S. EPA/OSWER preliminary remediation goal for perchlorate in groundwater: focus on exposure to nursing infants., Environ Health Perspect, 115, 361, 10.1289/ehp.9533
Amitai, 2007, Gestational exposure to high perchlorate concentrations in drinking water and neonatal thyroxine levels., Thyroid, 17, 843, 10.1089/thy.2006.0336
Wolff, 1998, Perchlorate and the thyroid gland., Pharmacol Rev, 50, 89
De Groef, 2006, Perchlorate versus other environmental sodium/iodide symporter inhibitors: potential thyroid-related health effects., Eur J Endocrinol, 155, 17, 10.1530/eje.1.02190
Taurog, 2000, 61
Taurog, 1964, The biosynthesis of thyroxine., Mayo Clin Proc, 39, 569
Cooper, 2003, Antithyroid drugs in the management of patients with Graves’ disease: an evidence-based approach to therapeutic controversies., J Clin Endocrinol Metab, 88, 3474, 10.1210/jc.2003-030185
Mestman, 1998, Hyperthyroidism in pregnancy., Endocrinol Metab Clin North Am, 27, 127, 10.1016/S0889-8529(05)70303-0
Engler, 1982, Mechanism of inactivation of thyroid peroxidase by thioureylene drugs., Biochem Pharmacol, 31, 3801, 10.1016/0006-2952(82)90296-9
Doerge, 2002, Goitrogenic and estrogenic activity of soy isoflavones., Environ Health Perspect, 110(Suppl 3), 349, 10.1289/ehp.02110s3349
Labib, 1989, Dietary maladvice as a cause of hypothyroidism and short stature., Brit Med J, 298, 232, 10.1136/bmj.298.6668.232
Chorazy, 1995, Persistent hypothyroidism in an infant receiving a soy formula: case report and review of the literature., Pediatrics, 96, 148
Jabbar, 1997, Abnormal thyroid function tests in infants with congenital hypothyroidism: the influence of soy-based formula., J Am Coll Nutr, 16, 280, 10.1080/07315724.1997.10718686
Fort, 1990, Breast and soy-formula feedings in early infancy and the prevalence of autoimmune thyroid disease in children., J Am Coll Nutr, 9, 164, 10.1080/07315724.1990.10720366
Boker, 2002, Intake of dietary phytoestrogens by Dutch women., J Nutr, 132, 1319, 10.1093/jn/132.6.1319
Vranckx, 1990, Characterization of a major development-regulated serum thyroxine-binding globulin in the euthyroid mouse., Biochem J, 271, 373, 10.1042/bj2710373
Robbins, 2000, 105
Refetoff, 1989, Inherited thyroxine-binding globulin abnormalities in man., Endocr Rev, 10, 275, 10.1210/edrv-10-3-275
Mendel, 1987, Thyroid hormone-binding proteins in plasma facilitate uniform distribution of thyroxine within tissues: a perfused rat liver study., Endocrinology, 120, 1742, 10.1210/endo-120-5-1742
Power, 2000, Evolution of the thyroid hormone-binding protein, transthyretin., Gen Comp Endocrinol, 119, 241, 10.1006/gcen.2000.7520
Zheng, 2001, Transthyretin, thyroxine, and retinol-binding protein in human cerebrospinal fluid: effect of lead exposure., Toxicol Sci, 61, 107, 10.1093/toxsci/61.1.107
Robbins, 2002, Transthyretin from discovery to now., Clin Chem Lab Med, 40, 1183, 10.1515/CCLM.2002.208
Palha, 2002, Thyroid hormone distribution in the mouse brain: the role of transthyretin., Neuroscience, 113, 837, 10.1016/S0306-4522(02)00228-2
Palha, 2000, Transthyretin regulates thyroid hormone levels in the choroid plexus, but not in the brain parenchyma: study in a transthyretin-null mouse model., Endocrinology, 141, 3267, 10.1210/endo.141.9.7659
Meerts, 2000, Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro., Toxicol Sci, 56, 95, 10.1093/toxsci/56.1.95
Chauhan, 2000, Assessing the role of ortho-substitution on polychlorinated biphenyl binding to transthyretin, a thyroxine transport protein., Toxicol Appl Pharmacol, 162, 10, 10.1006/taap.1999.8826
Lans, 1993, Structure-dependent, competitive interaction of hydroxy-polychlorobiphenyls, -dibenzo-p-dioxins, and -dibenzofurans with human transthyretin., Chem Biol Interact, 88, 7, 10.1016/0009-2797(93)90081-9
Brouwer, 1998, Interactions of persistent environmental organohalogens with the thyroid hormone system: mechanisms and possible consequences for animal and human health., Toxicol Ind Health, 14, 59, 10.1177/074823379801400107
Richardson, 2007, Cell division and apoptosis in the adult neural stem cell niche are differentially affected in transthyretin null mice., Neurosci Lett, 421, 234, 10.1016/j.neulet.2007.05.040
Meerts, 2002, Placental transfer of a hydroxylated polychlorinated biphenyl and effects on fetal and maternal thyroid hormone homeostasis in the rat., Toxicol Sci, 68, 361, 10.1093/toxsci/68.2.361
Fisher, 2006, Effect of PCB 126 on hepatic metabolism of thyroxine and perturbations in the hypothalamic-pituitary-thyroid axis in the rat., Toxicol Sci, 90, 87, 10.1093/toxsci/kfj069
Glatt, 2005, Molecular characterization of thyroid toxicity: anchoring gene expression profiles to biochemical and pathologic end points., Environ Health Perspect, 113, 1354, 10.1289/ehp.7690
Tseng, 2008, Developmental exposure to decabromodiphenyl ether (PBDE 209): effects on thyroid hormone and hepatic enzyme activity in male mouse offspring., Chemosphere, 70, 640, 10.1016/j.chemosphere.2007.06.078
Kretschmer, 2005, CAR and PXR: xenosensors of endocrine disrupters?, Chem Biol Interact, 155, 111, 10.1016/j.cbi.2005.06.003
Rathore, 2002, Burden of organochlorine pesticides in blood and its effect on thyroid hormones in women., Sci Total Environ, 295, 207, 10.1016/S0048-9697(02)00094-3
Langer, 2008, Persistent organochlorinated pollutants (PCB, DDE, HCB, dioxins, furans) and the thyroid—review 2008., Endocr Regul, 42, 79
Köhrle, 2007, Thyroid hormone transporters in health and disease: advances in thyroid hormone deiodination., Best Pract Res Clin Endocrinol Metab, 21, 173, 10.1016/j.beem.2007.04.001
Schwartz, 2005, Allan-Herndon-Dudley syndrome and the monocarboxylate transporter 8 (MCT8) gene., Am J Hum Genet, 77, 41, 10.1086/431313
St Germain, 2005, Insights into the role of deiodinases from studies of genetically modified animals., Thyroid, 15, 905, 10.1089/thy.2005.15.905
Schneider, 2001, Targeted disruption of the type 2 selenodeiodinase gene (DIO2) results in a phenotype of pituitary resistance to T4., Mol Endocrinol, 15, 2137, 10.1210/mend.15.12.0740
Kato, 2004, A possible mechanism for decrease in serum thyroxine level by polychlorinated biphenyls in Wistar and Gunn rats., Toxicol Sci, 81, 309, 10.1093/toxsci/kfh225
Morse, 1996, Alterations in rat brain thyroid hormone status following pre- and postnatal exposure to polychlorinated biphenyls (Aroclor 1254)., Toxicol Appl Pharmacol, 136, 269, 10.1006/taap.1996.0034
McKinney, 1994, Polychlorinated biphenyls as hormonally active structural analogues., Environ Health Perspect, 102, 290, 10.1289/ehp.94102290
Chana, 2002, Computational studies on biphenyl derivatives. Analysis of the conformational mobility, molecular electrostatic potential, and dipole moment of chlorinated biphenyl: searching for the rationalization of the selective toxicity of polychlorinated biphenyls (PCBs)., Chem Res Toxicol, 15, 1514, 10.1021/tx025596d
Breivik, 2002, Towards a global historical emission inventory for selected PCB congeners—a mass balance approach. 1. Global production and consumption., Sci Total Environ, 290, 181, 10.1016/S0048-9697(01)01075-0
Huisman, 1995, Neurological condition in 18-month-old children perinatally exposed to polychlorinated biphenyls and dioxins., Early Hum Dev, 43, 165, 10.1016/0378-3782(95)01674-0
Jackson, 1997, The partial agonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the corepressors N-CoR or SMRT., Mol Endocrinol, 11, 693, 10.1210/mend.11.6.0004
Osius, 1999, Exposure to polychlorinated biphenyls and levels of thyroid hormones in children., Environ Health Perspect, 107, 843, 10.1289/ehp.99107843
Ayotte, 2003, Assessment of pre- and postnatal exposure to polychlorinated biphenyls: lessons from the Inuit Cohort Study., Environ Health Perspect, 111, 1253, 10.1289/ehp.6054
Walkowiak, 2001, Environmental exposure to polychlorinated biphenyls and quality of the home environment: effects on psychodevelopment in early childhood., Lancet, 358, 1602, 10.1016/S0140-6736(01)06654-5
Zoeller, 2000, Developmental exposure to polychlorinated biphenyls exerts thyroid hormone-like effects on the expression of RC3/neurogranin and myelin basic protein messenger ribonucleic acids in the developing rat brain., Endocrinology, 141, 181, 10.1210/endo.141.1.7273
Goldey, 1995, Developmental exposure to polychlorinated biphenyls (Aroclor 1254) reduces circulating thyroid hormone concentrations and causes hearing deficits in rats., Toxicol Appl Pharmacol, 135, 77, 10.1006/taap.1995.1210
Bastomsky, 1977, Enhanced thyroxine metabolism and high uptake goiters in rats after a single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin., Endocrinology, 101, 292, 10.1210/endo-101-1-292
Crofton, 2004, Developmental disruption of thyroid hormone: correlations with hearing dysfunction in rats., Risk Anal, 24, 1665, 10.1111/j.0272-4332.2004.00557.x
Brouwer, 1999, Characterization of potential endocrine-related health effects at low-dose levels of exposure to PCBs., Environ Health Perspect, 107(Suppl 4), 639
Schell, 2008, Relationship of thyroid hormone levels to levels of polychlorinated biphenyls, lead, p,p’- DDE, and other toxicants in Akwesasne Mohawk youth., Environ Health Perspect, 116, 806, 10.1289/ehp.10490
Herbstman, 2008, Birth delivery mode modifies the associations between prenatal polychlorinated biphenyl (PCB) and polybrominated diphenyl ether (PBDE) and neonatal thyroid hormone levels., Environ Health Perspect, 116, 1376, 10.1289/ehp.11379
Herbstman, 2008, Maternal, infant, and delivery factors associated with neonatal thyroid hormone status., Thyroid, 18, 67, 10.1089/thy.2007.0180
Goldey, 1254, in rats., Toxicol Sci, 45, 94
Koibuchi, 2000, Thyroid hormone action and brain development, Trends Endocrinol Metab, 11, 123, 10.1016/S1043-2760(00)00238-1
Nguon, 2005, Perinatal exposure to polychlorinated biphenyls differentially affects cerebellar development and motor functions in male and female rat neonates., Cerebellum, 4, 112, 10.1080/14734220510007860
Granholm, 1985, Effects of thyroid hormone deficiency on glial constituents in developing cerebellum of the rat., Exp Brain Res, 59, 451
Stewart, 2003, Prenatal PCB exposure, the corpus callosum, and response inhibition., Environ Health Perspect, 111, 1670, 10.1289/ehp.6173
Berbel, 1994, Role of thyroid hormones in the maturation of interhemispheric connections in rats., Behav Brain Res, 64, 9, 10.1016/0166-4328(94)90114-7
Gauger, 2004, Polychlorinated biphenyls (PCBs) exert thyroid hormone-like effects in the fetal rat brain but do not bind to thyroid hormone receptors., Environ Health Perspect, 112, 516, 10.1289/ehp.6672
Bansal, 2005, Maternal thyroid hormone increases HES expression in the fetal rat brain: an effect mimicked by exposure to a mixture of polychlorinated biphenyls (PCBs)., Brain Res Dev Brain Res, 156, 13, 10.1016/j.devbrainres.2005.01.007
Kitamura, 2005, Thyroid hormone-like and estrogenic activity of hydroxylated PCBs in cell culture., Toxicology, 208, 377, 10.1016/j.tox.2004.11.037
Fritsche, 2005, Polychlorinated biphenyls disturb differentiation of normal human neural progenitor cells: clue for involvement of thyroid hormone receptors., Environ Health Perspect, 113, 871, 10.1289/ehp.7793
Arulmozhiraja, 2004, Structure-activity relationships for the toxicity of polychlorinated dibenzofurans: approach through density functional theory-based descriptors., Chem Res Toxicol, 17, 348, 10.1021/tx0300380
Kimura-Kuroda, 2005, Hydroxylated metabolites of polychlorinated biphenyls inhibit thyroid-hormone-dependent extension of cerebellar Purkinje cell dendrites., Brain Res Dev Brain Res, 154, 259, 10.1016/j.devbrainres.2004.11.004
Bogazzi, 2003, Effects of a mixture of polychlorinated biphenyls (Aroclor 1254) on the transcriptional activity of thyroid hormone receptor., J Endocrinol Invest, 26, 972, 10.1007/BF03348194
Iwasaki, 2002, Polychlorinated biphenyls suppress thyroid hormone-induced transactivation., Biochem Biophys Res Commun, 299, 384, 10.1016/S0006-291X(02)02659-1
Miyazaki, 2004, Polychlorinated biphenyls suppress thyroid hormone receptor-mediated transcription through a novel mechanism., J Biol Chem, 279, 18195, 10.1074/jbc.M310531200
Frumess, 1975, Correlation of serum triodothyronine (T3) and thyroxine (T4) with biologic effects of thyroid hormone replacement in propylthiouracil-treated rats., Metabolism, 24, 547, 10.1016/0026-0495(75)90079-7
Howe, 1998, Potential exposure to bisphenol A from food-contact use of epoxy coated cans., J Coat Tech, 70, 69, 10.1007/BF02720503
Lewis, 1999, Identification and characterization of estrogen-like components in commercial resin-based dental restorative materials., Clin Oral Investig, 3, 107, 10.1007/s007840050087
Schönfelder, 2002, Parent bisphenol A accumulation in the human maternal-fetal-placental unit, Environ Health Perspect, 110, A703, 10.1289/ehp.021100703
Thomsen, 2002, Brominated flame retardants in archived serum samples from Norway: a study on temporal trends and the role of age., Environ Sci Technol, 36, 1414, 10.1021/es0102282
Moriyama, 2002, Thyroid hormone action is disrupted by bisphenol A as an antagonist., J Clin Endocrinol Metab, 87, 5185, 10.1210/jc.2002-020209
Staples, 1998, A review of the environmental fate, effects, and exposures of bisphenol A., Chemosphere, 36, 2149, 10.1016/S0045-6535(97)10133-3
Krishnan, 1993, Bisphenol-A: an estrogenic substance is released from polycarbonate flasks during autoclaving., Endocrinology, 132, 2279, 10.1210/endo.132.6.8504731
Gaido, 1997, Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay., Toxicol Appl Pharmacol, 143, 205, 10.1006/taap.1996.8069
Wetherill, 2007, In vitro molecular mechanisms of bisphenol A action., Reprod Toxicol, 24, 178, 10.1016/j.reprotox.2007.05.010
Kitamura, 2002, Thyroid hormonal activity of the flame retardants tetrabromobisphenol A and tetrachlorobisphenol A., Biochem Biophys Res Commun, 293, 554, 10.1016/S0006-291X(02)00262-0
Zoeller, 2005, Bisphenol-A, an environmental contaminant that acts as a thyroid hormone receptor antagonist in vitro, increases serum thyroxine, and alters RC3/neurogranin expression in the developing rat brain., Endocrinology, 146, 607, 10.1210/en.2004-1018
Cheng, 2005, Thyroid hormone receptor mutations and disease: beyond thyroid hormone resistance., Trends Endocrinol Metab, 16, 176, 10.1016/j.tem.2005.03.008
Seiwa, 2004, Bisphenol A exerts thyroid-hormone-like effects on mouse oligodendrocyte precursor cells., Neuroendocrinology, 80, 21, 10.1159/000080663
Vermiglio, 2004, Attention deficit and hyperactivity disorders in the offspring of mothers exposed to mild-moderate iodine deficiency: a possible novel iodine deficiency disorder in developed countries., J Clin Endocrinol Metab, 89, 6054, 10.1210/jc.2004-0571
Siesser, 2005, Hyperactivity, impaired learning on a vigilance task, and a differential response to methylphenidate in the TRβPV knock-in mouse., Psychopharmacology (Berl), 181, 653, 10.1007/s00213-005-0024-5
Ishido, 2004, Bisphenol A causes hyperactivity in the rat concomitantly with impairment of tyrosine hydroxylase immunoreactivity., J Neurosci Res, 76, 423, 10.1002/jnr.20050
Dowling, 2000, Acute changes in maternal thyroid hormone induce rapid and transient changes in gene expression in fetal rat brain., J Neurosci, 20, 2255, 10.1523/JNEUROSCI.20-06-02255.2000
Dowling, 2001, Maternal hypothyroidism selectively affects the expression of neuroendocrine-specific protein A messenger ribonucleic acid in the proliferative zone of the fetal rat brain cortex., Endocrinology, 142, 390, 10.1210/endo.142.1.7871
Dowling, 2000, Thyroid hormone of maternal origin regulates the expression of RC3/neurogranin mRNA in the fetal rat brain., Brain Res Mol Brain Res, 82, 126, 10.1016/S0169-328X(00)00190-X
Wu, 2003, Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors., Dev Dyn, 226, 675, 10.1002/dvdy.10278
Schuurmans, 2002, Molecular mechanisms underlying cell fate specification in the developing telencephalon., Curr Opin Neurobiol, 12, 26, 10.1016/S0959-4388(02)00286-6
Talsness, 2008, Overview of toxicological aspects of polybrominated diphenyl ethers: a flame-retardant additive in several consumer products., Environ Res, 108, 158, 10.1016/j.envres.2008.08.008
Marsh, 1998
Newbold, 2007, Developmental exposure to endocrine disruptors and the obesity epidemic., Reprod Toxicol, 23, 290, 10.1016/j.reprotox.2006.12.010
Newbold, 2007, Perinatal exposure to environmental estrogens and the development of obesity., Mol Nutr Food Res, 51, 912, 10.1002/mnfr.200600259
De Ferranti, 2007, Epidemiology of paediatric metabolic syndrome and type 2 diabetes mellitus., Diabetes Vasc Dis Res, 4, 285, 10.3132/dvdr.2007.055
Baillie-Hamilton, 2002, Chemical toxins: a hypothesis to explain the global obesity epidemic., J Altern Complement Med, 8, 185, 10.1089/107555302317371479
Grün, 2006, Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling, Endocrinology, 147, S50, 10.1210/en.2005-1129
Tabb, 2006, New modes of action for endocrine-disrupting chemicals., Mol Endocrinol, 20, 475, 10.1210/me.2004-0513
Buresova, 2006, Genetic relationship between placental and fetal weights and markers of the metabolic syndrome in rat recombinant inbred strains., Physiol Genomics, 26, 226, 10.1152/physiolgenomics.00056.2006
Moura, 2005, Neonatal programming of body weight regulation and energetic metabolism., Biosci Rep, 25, 251, 10.1007/s10540-005-2888-3
Cooke, 2004, Role of estrogens in adipocyte development and function., Exp Biol Med, 229, 1127, 10.1177/153537020422901107
Wada, 2007, Life style-related diseases of the digestive system: Endocrine disruptors stimulate lipid accumulation in target cells related to metabolic syndrome., J Pharmacol Sci, 105, 133, 10.1254/jphs.FM0070034
Knouff, 2004, Peroxisome proliferator-activated receptor-γ calls for activation in moderation: lessons from genetics and pharmacology., Endocr Rev, 25, 899, 10.1210/er.2003-0036
Kanayama, 2005, Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor -γ /retinoid X receptor pathway., Mol Pharmacol, 67, 766, 10.1124/mol.104.008409
Grün, 2006, Endocrine-disrupting organotin compounds are potent inducers of adipogenesis in vertebrates., Mol Endocrinol, 20, 2141, 10.1210/me.2005-0367
Dang, 2003, Peroxisome proliferator-activated receptor γ (PPAR-γ) as a molecular target for the soy phytoestrogen genistein., J Biol Chem, 278, 962, 10.1074/jbc.M209483200
Penza, 2006, Genistein affects adipose tissue deposition in a dose-dependent and gender-specific manner., Endocrinology, 147, 5740, 10.1210/en.2006-0365
Alonso-Magdalena, 2006, The estrogenic effect of bisphenol-A disrupts pancreatic β-cell function in vivo and induces insulin resistance., Environ Health Perspect, 114, 106, 10.1289/ehp.8451
Rosenbloom, 1999, Emerging epidemic of type 2 diabetes in youth., Diabetes Care, 22, 345, 10.2337/diacare.22.2.345
Remillard, 2002, Linking dioxins to diabetes: epidemiology and biologic plausibility., Environ Health Perspect, 110, 853, 10.1289/ehp.02110853
Hugo, 2008, Bisphenol A at environmentally relevant doses inhibits adiponectin release from human adipose tissue explants and adipocytes., Environ Health Perspect, 116, 1642, 10.1289/ehp.11537
Alonso-Magdalena, 2005, Low doses of bisphenol A and diethylstilbestrol impair Ca2+ signals in pancreatic α-cells through a nonclassical membrane estrogen receptor within intact islets of Langerhans., Environ Health Perspect, 113, 969, 10.1289/ehp.8002
Poirier, 2003, Waist circumference, visceral obesity, and cardiovascular risk., J Cardiopulm Rehabil, 23, 161, 10.1097/00008483-200305000-00001
Gardner, 2008, Cardioprotection in female rats subjected to chronic volume overload: synergistic interaction of estrogen and phytoestrogens, Am J Physiol Heart Circ Physiol, 294, H198, 10.1152/ajpheart.00281.2007
Deodato, 1999, Cardioprotection by the phytoestrogen genistein in experimental myocardial ischaemia-reperfusion injury., Br J Pharmacol, 128, 1683, 10.1038/sj.bjp.0702973
Chan, 2007, Isoflavone intake in persons at high risk of cardiovascular events: implications for vascular endothelial function and the carotid atherosclerotic burden., Am J Clin Nutr, 86, 938, 10.1093/ajcn/86.4.938
Kleijn, 2002, Dietary intake of phytoestrogens is associated with a favorable metabolic cardiovascular risk profile in postmenopausal U.S. women: the Framingham study., J Nutr, 132, 276, 10.1093/jn/132.2.276
Cerami, 1997, Tobacco smoke is a source of toxic reactive glycation products., Proc Natl Acad Sci USA, 94, 13915, 10.1073/pnas.94.25.13915
Koschinsky, 1997, Orally absorbed reactive glycation products (glycotoxins): an environmental risk factor in diabetic nephropathy., Proc Natl Acad Sci USA, 94, 6474, 10.1073/pnas.94.12.6474
Sandu, 2005, Insulin resistance and type 2 diabetes in high-fat-fed mice are linked to high glycotoxin intake., Diabetes, 54, 2314, 10.2337/diabetes.54.8.2314
Diamanti-Kandarakis, 2007, Accumulation of dietary glycotoxins in the reproductive system of normal female rats., J Mol Med, 85, 1413, 10.1007/s00109-007-0246-6
Uribarri, 2007, Single oral challenge by advanced glycation end products acutely impairs endothelial function in diabetic and nondiabetic subjects., Diabetes Care, 30, 2579, 10.2337/dc07-0320
McLachlan, 2006, Commentary: prenatal exposure to diethylstilbestrol (DES): a continuing story., Int J Epidemiol, 35, 868, 10.1093/ije/dyl140
Lang, 2008, Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults., JAMA, 300, 1303, 10.1001/jama.300.11.1303
Emmen, 2000, Involvement of insulin-like factor 3 (Insl3) in diethylstilbestrol-induced cryptorchidism., Endocrinology, 141, 846, 10.1210/endo.141.2.7379
Ben Rhouma, 2001, Reproductive toxicity of DDT in adult male rats., Hum Exp Toxicol, 20, 393, 10.1191/096032701682692946
Fisher, 2003, Human testicular dysgenesis syndrome: a possible model using in-utero exposure of the rat to dibutyl phthalate., Hum Reprod, 18, 1383, 10.1093/humrep/deg273
Parks, 2000, The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat., Toxicol Sci, 58, 339, 10.1093/toxsci/58.2.339
Gupta, 2000, Reproductive malformation of the male offspring following maternal exposure to estrogenic chemicals., Proc Soc Exp Biol Med, 224, 61, 10.1046/j.1525-1373.2000.22402.x
Timms, 2005, Estrogenic chemicals in plastic and oral contraceptives disrupt development of the fetal mouse prostate and urethra., Proc Natl Acad Sci USA, 102, 7014, 10.1073/pnas.0502544102
Ramos, 2001, Prenatal exposure to low doses of bisphenol A alters the periductal stroma and glandular cell function in the rat ventral prostate., Biol Reprod, 65, 1271, 10.1095/biolreprod65.4.1271
Cohn, 2003, DDT and DDE exposure in mothers and time to pregnancy in daughters., Lancet, 361, 2205, 10.1016/S0140-6736(03)13776-2
Markey, 2005, Long-term effects of fetal exposure to low doses of the xenoestrogen bisphenol-A in the female mouse genital tract., Biol Reprod, 72, 1344, 10.1095/biolreprod.104.036301
Honma, 2002, Low dose effect of in utero exposure to bisphenol A and diethylstilbestrol on female mouse reproduction., Reprod Toxicol, 16, 117, 10.1016/S0890-6238(02)00006-0
Zsarnovszky, 2005, Ontogeny of rapid estrogen-mediated extracellular signal-regulated kinase signaling in the rat cerebellar cortex: potent nongenomic agonist and endocrine disrupting activity of the xenoestrogen bisphenol A., Endocrinology, 146, 5388, 10.1210/en.2005-0565
Steinberg, 2008, The effects of perinatal PCBs on adult female rat reproduction: development, reproductive physiology, and second generational effects., Biol Reprod, 78, 1091, 10.1095/biolreprod.107.067249
Jenkins, 2007, Prenatal TCDD exposure predisposes for mammary cancer in rats., Reprod Toxicol, 23, 391, 10.1016/j.reprotox.2006.10.004
Mizuyachi, 2002, Alteration in ovarian gene expression in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin: reduction of cyclooxygenase-2 in the blockage of ovulation., Reprod Toxicol, 16, 299, 10.1016/S0890-6238(02)00024-2
Newbold, 1995, Cellular and molecular effects of developmental exposure to diethylstilbestrol: implications for other environmental estrogens., Environ Health Perspect, 103(Suppl 7), 83
Kaufman, 1982, Structural changes of the genital tract associated with in utero exposure to diethylstilbestrol., Obstet Gynecol Annu, 11, 187
Krstevska-Konstantinova, 2001, Sexual precocity after immigration from developing countries to Belgium: evidence of previous exposure to organochlorine pesticides., Hum Reprod, 16, 1020, 10.1093/humrep/16.5.1020
Blanck, 2000, Age at menarche and Tanner stage in girls exposed in utero and postnatally to polybrominated biphenyl., Epidemiology, 11, 641, 10.1097/00001648-200011000-00005
Martin, 2007, Forum: human health and endocrine disruption: a simple multicriteria framework for the qualitative assessment of end point-specific risks in a context of scientific uncertainty., Toxicol Sci, 98, 332, 10.1093/toxsci/kfm008